• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.79-90
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• 2014

Objectives : This study was carried out to evaluate the repeated dose oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats. Methods : Male and female rats were administered orally with Alismatis Rhizoma water extract of 500 mg/kg(low dosage group), 1,000 mg/kg(middle dosage group) and 2,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 14 days(twice a day). After 14 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight. Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not repeated dose oral toxicity and oral LD50 value was over 2,000 mg/kg in SD rats. As a result, we can determine Alismatis Rhizoma is a relatively safe substance.

• Mycobiology
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• 제51권4호
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• pp.246-255
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• 2023

Genus Penicillium comprising the most important and extensively studied fungi has been well-known as a rich source of secondary metabolites. Our study aimed to analyze and investigate biological activities, including in vitro anti-cancer, anti-inflammatory and anti-diabetic properties, of metabolites from a marine-derived fungus belonging to P. levitum. The chemical compounds in the culture broth of P. levitum strain N33.2 were extracted with ethyl acetate. Followingly, chemical analysis of the extract leaded to the isolation of three ergostane-type steroid components, namely cerevisterol (1), ergosterol peroxide (2), and (3β,5α,22E)-ergosta-6,8(14),22-triene-3,5-diol (3). Among these, (3) was the most potent cytotoxic against human cancer cell lines Hep-G2, A549 and MCF-7 with IC₅₀ values of 2.89, 18.51, and 16.47 ㎍/mL, respectively, while the compound (1) showed no significant effect against tested cancer cells. Anti-inflammatory properties of purified compounds were evaluated based on NO-production in LPS-induced murine RAW264.7 macrophages. As a result, tested compounds performed diverse inhibitory effects on NO production by the macrophages, with the most significant inhibition rate of 81.37±1.35% at 25 ㎍/mL by the compound (2). Interestingly, compounds (2) and (3) exhibited inhibitory activities against pancreatic lipase and α-glucosidase enzymes in vitro assays. Our study brought out new data concerning the chemical properties and biological activities of isolated steroids from a P. levitum fungus.

• Fisheries and Aquatic Sciences
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• 제27권9호
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• pp.580-587
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• 2024

Spotted scat Scatophagus argus has a high nutritional value and is among the most widely consumed fish species in Asia. This study was conducted to learn more about the solution for stimulating digestive enzyme synthesis with commercial probiotics. Three different methods of probiotic supplementations of Probai A (Bayer) (feeding - OR, feeding and environment - OE, environment - EN) and control treatment (no probiotic applied) - CT were performed in triplicates by using a completely randomization design method. The results showed no differences in growth performance and survival rates of spotted scat at the fingerling stage among the treatments (p > 0.05). The hepatosomatic index (HSI) and conditional factor did not depend on the probiotic supplementation methods (p > 0.05), but these values had a significant difference between experimental treatments compared to control treatments (p < 0.05). After 15-45 days, only amylase activity in the stomach was significantly higher than those of the control group (p < 0.05). Amylase activity in the intestine and trypsin activity in both the stomach and intestine of experimental treatments were significantly higher than those of the control treatment during 15-30 days (p < 0.05), and then no significant differences were found from day 30 to day 45 (p > 0.05). Our findings indicate that probiotic administration through feeding was the best way to increase the growth weight of spotted scat at the fingerling stage. Further research on the mechanism of stimulating digestive enzyme synthesis when probiotics are used in commercial fish seed production is required.

• 한국경영과학회지
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• 제1권1호
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• pp.151-170
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• 1976

There are many cases of production processes which intermittently produce several different kinds of products for stock through one set of physical facility. In this case, an important question is what size of production run should be prduced once we do set-up for a product in order to minimize the total cost, that is, the sum of the set-up, carrying, and stock-out costs. This problem is used to be called scheduling of multiple products through a single facility in the production management field. Despite the very common occurrence of this type of production process, no one has yet devised a method for determining the optimal production schedule. The purpose of this study is to develop quantitative analytical models which can be used practically and give us rational production schedules. The study is to show improved models with application to a can-manufacturing plant. In this thesis the economic production quantity (EPQ) model was used as a basic model to develop quantitative analytical models for this scheduling problem and two cases, one with stock-out cost, the other without stock-out cost, were taken into consideration. The first analytical model was developed for the scheduling of products through a single facility. In this model we calculate No, the optimal number of production runs per year, minimizing the total annual cost above all. Next we calculate No$_{i}$ is significantly different from No, some manipulation of the schedule can be made by trial and error in order to try to fit the product into the basic (No schedule either more or less frequently as dictated by) No$_{i}$, But this trial and error schedule is thought of inefficient. The second analytical model was developed by reinterpretation by reinterpretation of the calculating process of the economic production quantity model. In this model we obtained two relationships, one of which is the relationship between optimal number of set-ups for the ith item and optimal total number of set-ups, the other is the relationship between optimal average inventory investment for the ith item and optimal total average inventory investment. From these relationships we can determine how much average inventory investment per year would be required if a rational policy based on m No set-ups per year for m products were followed and, alternatively, how many set-ups per year would be required if a rational policy were followed which required an established total average inventory inventory investment. We also learned the relationship between the number of set-ups and the average inventory investment takes the form of a hyperbola. But, there is no reason to say that the first analytical model is superior to the second analytical model. It can be said that the first model is useful for a basic production schedule. On the other hand, the second model is efficient to get an improved production schedule, in a sense of reducing the total cost. Another merit of the second model is that, unlike the first model where we have to know all the inventory costs for each product, we can obtain an improved production schedule with unknown inventory costs. The application of these quantitative analytical models to PoHang can-manufacturing plants shows this point.int.

• 한국정보과학회논문지:소프트웨어및응용
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• 제27권5호
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• pp.510-520
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• 2000

내용 기반의 비디오 인덱싱 및 검색을 위해서는 비디오 데이타를 셧(shot)으로 분할하고, 또 각 셧을 나타내는 대표 프레임을 선택하는 것이 필요하다. 하지만, 대표 프레임을 선택하는 것은 주관적이어서 일관되게 자동적으로 대표 프레임을 선택하는 것은 쉬운 문제가 아니다. 본 논문에서는 각 프레임에서의 영역을 바탕으로한 컨텐트 정보 및 시간 축 상의 변화를 이용하여 계층적으로 대표 프레임을 선택하는 방법을 제안한다. 먼저, 비디오 셧에서 카메라 모션을 검출하여 이에 따라 비디오 셧을 분류한다. 다음, 분류된 비디오 셧에 컨텐트의 중요도를 계산하기 위한 퍼지 규칙을 적용하여 대표 프레임을 선택한다. 끝으로, 선택되는 대표 프레임의 수는 브라우징 상세도(detailness)에 따라 계층적으로 선택되게끔 한다.

• 한국운동역학회지
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• 제26권2호
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• pp.183-190
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• 2016

Objective: The objective of this study is to present a scientific basis for ballet dancer training methods by analyzing the relationships between subjective assessment of the ballet movement 'Grand pas de chat' and kinematic and electromyographic factors. Method: The subjects were 14 professional dancers with 15 years of experience on average. Four cameras and a wireless electromyogram were used to examine kinematic factors, and the filmed videos were analyzed by 3 experts for subjective assessment. Results: Although no differences in kinematic factors were found between the excellent dancer group and the non-excellent dancer group divided based on the experts' assessment, some difference was found in electromyographic factors, especially in relation to the gastrocnemius muscle, rectus femoris muscle, and erector spinae muscle. A relationship between subjective assessment and kinematic and electromyographic factors was found, and factors such as right-side rectus femoris activation, time required, left-side gastrocnemius activation, and front-back displacement affected subjective assessment. Conclusion: This study showed a relationship between subjective assessment and kinematic and electromyographic factors. To receive higher scores in subjective assessment, it is necessary to extend the hang time by using the lower limb muscles. The findings of this study also indicate the necessity of weight training in order to improve dancing techniques.

• 한국멀티미디어학회논문지
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• 제18권5호
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• pp.599-609
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• 2015

As smartphone usage has increased recently, so has smartphone addiction. Many of the smartphone users, however, do not even recognize the risk of smartphone addiction. In this experiment, smartphone users have been categorized into two groups by smartphone addiction measure (S-measure) developed by 2011 National Information Society Agency (NIA): A high risk group and a normal group. The changes of brain waves have been observed when the subjects were watching emotional videos of anger, sadness, happiness, and fear. The results show that the values of FP1 and FP2 (frontal lobe) theta band of the high risk group have been measured to be high, which indicate anxiety disorder. Although happiness and fear videos showed no difference between these groups, sadness and anger videos showed significantly different results for these groups: the brain waves of the high risk group showed higher values than those of the normal group. Therefore, this experiment showed that the high risk group takes feelings of sadness and anger more sensitively than the normal group.

• 한국초등과학교육학회지:초등과학교육
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• 제30권1호
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• pp.93-101
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• 2011

The purpose of this research is to find out the change in graduate students' perceptions before and after they take a class on qualitative research. The class on qualitative research was held by the researcher in the winter semester of 2009. The subjects are nine graduate students (two male and eight female) and all elementary school teachers. An open-ended questionnaire with 5 items was used. The responses were interpreted, analyzed and categorized into several main conceptions. The results are as follow: First, some students perceived qualitative research as the counterpart for quantitative research, some perceived that qualitative research supplements quantitative research, while the rest of them had no concept of either before they took the class. Second, they all agreed that qualitative research is necessary in gifted education after they took the class. In order to better understand what is happening in classrooms, in terms of gifted education, a well organized curriculum for gifted education should be developed and conducted in graduate schools.

• The Journal of Asian Finance, Economics and Business
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• 제7권12호
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• pp.409-422
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• 2020

In the global trend toward economic integration, Vietnamese enterprises desire to attract investment and increase competitiveness in the global market, so they have been required to provide transparent, high-quality financial reports following the International Financial Reports Standards (IFRS). Based on the roadmap drawn by the Vietnam Ministry of Finance, the foreign-invested enterprises, listed enterprises and state-owned enterprises will be applying IFRS in 2030. However, some enterprises in Vietnam have applied IFRS in the presentation of financial statements at the request of related parties for a while. The main research objective of this paper focused on examining the factors affecting the implementation of IFRS in Vietnamese enterprises through descriptive statistics tools, Cronbach's Alpha testing, EFA and logistics regression analysis with the sample collected from 254 Vietnamese enterprises. The methodology in this research was the mixed qualitative and quantitative method. The results show that the higher the profitability, debt ratio and firm size of the enterprise, the more likely it is to apply IFRS. From the results of this study, the appropriate recommendations have been made to promote the implementation of IFRS by Vietnamese enterprises effectively and following the IFRS application roadmap of the Ministry of Finance of Vietnam.

• 상하수도학회지
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• 제18권4호
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• pp.500-507
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• 2004

This study was conducted to evaluate the equity of the flow distribution from rapid mixing basin to the flocculation basins. Also, several types of inlet structures of the open channel affecting the flow pattern and distribution trend were studied using Computational Fluid Dynamics (CFD) simulation. For investigating the factual phenomena in distribution channel, we selected a certain domestic water treatment plant with capacity of $361,000m^3/d$. From the measurements of flow discharge, it is investigated that this existing inlet geometry resulted in significant inequitable distribution. The both largest deviations in the basins and rows were over 10%. In order to reduce the these deviation, this study suggested installing a baffle against the influent, and showed the effectiveness which the largest deviation was less than 3%. Also, it was concluded that the existing design method of open channel could be improved by three-dimensional hydrodynamic analysis for optimizing the even flow.