• Journal of Sensor Science and Technology
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• v.21 no.1
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• pp.53-58
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• 2012

Biological and chemical assays(e.g., clinical tests for medical diagnosis) are needed to handle small liquid volume with high accuracy and high reliability. Many micro-dispensing systems using various actuation methods have been developed and applied. In this research, we confirm repeatability of the cartridge-type dispensing system with various measuring methods for guarantee of an acceptable reliability. We systematically examine the dispensed volume variation and dispense rate during 500,000 shots of sequential actuation. Using the same method, we confirm the repeatability of dispensed volume while varying operating conditions and design parameter(i.e., outlet size) of the dispensing system. Also, we examine the consistency of the dispensed volume of droplet while varying the operating pressures. Furthermore, we repeatedly measure differences between an actual dispensed volume and a target volume. According to our results, it is expected that the stable and reliable performance of our dispensing system can effectively be used in various applications containing bio-solutions.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.79-85
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• 2009

Polyphenolic compounds are reported to have various pharmacological activities such as anti-oxidative, anti-cancerous, anti-inflammatory and anti-aging effects. Although numerous papers explore their functional roles in many different cellular actions, not many studies handle their structural features in anti-inflammatory responses. In this study, therefore, we examined structural role of substituted transstilbenes in their NO inhibitory and NF-${\kappa}B$ suppressive activities. Of 10 compounds tested, 4 compounds (cinnamic acid, resveratrol, piceatannol and curcumin) displayed NO inhibitory activities in a dose-dependent manner. Similarly, these compounds blocked LPS-induced cytotoxicity of RAW264.7 cells. All NO inhibitory compounds also inhibited $I{\kappa}B{\alpha}$ phosphorylation, a hallmark for NF-${\kappa}B$ activation. However, these inhibitory compounds exhibited distinct suppressive pattern in tumor necrosis factor (TNF)-${\alpha}$- or phorbol-12-myristate-13-acetate (PMA)-induced NF-${\kappa}B$ and AP-1 activation. According to structure-activity relationship study, polarity and size of ring B seem to be important for diminishing NO production. Therefore, our data suggest that substituted trans-stilbenes can be developed as novel anti-inflammatory drug or further developed as lead compounds for another improvement.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.7 s.172
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• pp.164-169
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• 2005

The micro-gripper system is one of the systems that should be improved in the respect of performance for practical usage. In the previous works, the important issues are considered and presented using axiomatic design approach. In this paper, the functional requirements and design parameters are evaluated in order to improve the performance and efficiency of the system. The evaluation is a very difficult task since many variables are related to the outcomes. To provide a basis for correct design decisions, axiomatic design principles have been advanced. Since the framework of axiomatic design makes design issues easier to understand when they are analyzed, we used those as an evaluation tool. The object of the system is to handle micro-size parts. Main device is a micro-gripper using two bender-typed and one stack-typed PZTs as actuators. And it has three tips made of tungsten wires fur holding function. Also the system must satisfy other functional requirements for appropriate handling performance. The results of this study show design improvements of micro-gripper system such as structural change of gripper, additional element, and integration of physical parts. Axiomatic design guides presented suitable design parameters corresponding to functional requirements and made the design elements improve through diagrams of whole system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.4
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• pp.601-607
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• 2003

The column type is used as the sensing element of the load cell to measure the large force in the range of 10$^4$~ 10$^{7}$ N. However. it is not easy to handle the load with large capacity due to its size. It is, therefore, necessary to design a compact load cell with a low aspect ratio. Thus this paper showed the characteristic evaluation of compact load cell with respect to the shape of supporting plate. The supporting plate of the load cell was an annular type with inner(D$_{i}$) and outer(D$_{o}$) diameters. Using the strain distribution obtained from FEM. the supporting plate was designed to get the stable output voltage of the load cell. The three designed supporting plates were manufactured, and the result of characteristic experiment of the load cell, using the 10 MN hydraulic force standard machine, was compared with FEM.M.M.

• Journal of Communications and Networks
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• v.17 no.3
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• pp.247-255
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• 2015

In this paper, we propose an adaptive time division multiple access based medium access control (MAC) protocol, called bitmap-assisted shortest job first based MAC (BS-MAC), for hierarchical wireless sensor networks (WSNs). The main contribution of BS-MAC is that: (a) It uses small size time slots. (b) The number of those time slots is more than the number of member nodes. (c) Shortest job first (SJF) algorithm to schedule time slots. (d) Short node address (1 byte) to identify members nodes. First two contributions of BS-MAC handle adaptive traffic loads of all members in an efficient manner. The SJF algorithm reduces node's job completion time and to minimize the average packet delay of nodes. The short node address reduces the control overhead and makes the proposed scheme an energy efficient. The simulation results verify that the proposed BS-MAC transmits more data with less delay and energy consumption compared to the existing MAC protocols.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.3
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• pp.170-175
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• 2012

Power MOSFET is develop in power savings, high efficiency, small size, high reliability, fast switching, low noise. Power MOSFET can be used high-speed switching transistors devices. Recently attention to the motor and the application of various technologies. Power MOSFET is devices the voltage-driven approach switching devices are design to handle on large power, power supplies, converters, motor controllers. In this paper, design the 600 V Planar type, and design the trench type for realization of low on-resistance. For both structures, by comparing and analyzing the results of the simulation and characterization.

• Journal of Welding and Joining
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• v.32 no.2
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• pp.54-62
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• 2014

Manhole cover, which is usually made of grey cast iron and consists of frame and cover, should have enough strength to support the heavy traffic load. The manhole cover made of cast iron has heavy weight to handle manually and is vulnerable to impact force with its brittle characteristics. Moreover, its production process of casting has been regulated in terms of environmental pollution. In this study, steel manhole cover is proposed to substitute the cast cover with a series of structural analyses to confirm its strength to support the test load for manhole cover. The cover of the proposed steel manhole cover is made of thin circular pate and stiffeners below the plate. Rectangular columns and hollow circular plate were selected for the shape of the stiffener. In order to give enough strength for the cover to behave within elastic range in the loading, strengthening structures of the cover were varied with increasing the number and the size of the stiffeners. The results of the analyses revealed that when both the hollow circular stiffener and cross stiffeners were additionally applied at the same time to the steel cover with longitudinal stiffeners, the maximum stress level in the cover could be reduced to that level presented in the cast cover.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.4
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• pp.391-406
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• 2014

The performance of General-Purpose computation on Graphics Processing Units (GPGPU) is heavily dependent on the memory access behavior. This sensitivity is due to a combination of the underlying Massively Parallel Processing (MPP) execution model present on GPUs and the lack of architectural support to handle irregular memory access patterns. Application performance can be significantly improved by applying memory-access-pattern-aware optimizations that can exploit knowledge of the characteristics of each access pattern. In this paper, we present an algorithmic methodology to semi-automatically find the best mapping of memory accesses present in serial loop nest to underlying data-parallel architectures based on a comprehensive static memory access pattern analysis. To that end we present a simple, yet powerful, mathematical model that captures all memory access pattern information present in serial data-parallel loop nests. We then show how this model is used in practice to select the most appropriate memory space for data and to search for an appropriate thread mapping and work group size from a large design space. To evaluate the effectiveness of our methodology, we report on execution speedup using selected benchmark kernels that cover a wide range of memory access patterns commonly found in GPGPU workloads. Our experimental results are reported using the industry standard heterogeneous programming language, OpenCL, targeting the NVIDIA GT200 architecture.

• Korean Journal of Computational Design and Engineering
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• v.14 no.6
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• pp.404-414
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• 2009

In the computational molecular analysis, 3D structural comparison for protein searching plays a very important role. As protein databases have been grown rapidly in size, exhaustive search methods cannot provide satisfactory performance. Because exhaustive search methods try to handle the structure of protein by using sphere set which is converted from atoms set, the similarity calculation about two sphere sets is very expensive. Instead, the filter-and-refine paradigm offers an efficient alternative to database search without compromising the accuracy of the answers. In recent, a very fast algorithm based on the inter-atomic distance has been suggested by Ballester and Richard. Since they adopted the moments of distribution with inter-atomic distance between atoms which are rotational invariant, they can eliminate the structure alignment and orientation fix process and perform the searching faster than previous methods. In this paper, we propose a new 3D shape descriptor. It has properties of the general shape distribution and useful property in screening the molecular database. We show some experimental results for the validity of our method.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.3
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• pp.487-492
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• 2016

In this paper, a device for analyzing the pressure distribution during walking was produced by using the pressure sensor on the heel. This device was limited to a frequency band by using the 1st low-pass filter. And an algorithm to analyze the value of the quantity to pressure using a analog to digital converter. It is used by using the threshold voltage of pressure sensor, it is suggested the algorithm. The algorithm is detected the peak which is exceeded the threshold voltage. and thus in accordance, it is detected the number of steps. And the calorie consumption were detected by using it. Also it used an MCU and Bluetooth. And by confirming the data at the LCD of the other MCU, it was to reduce the size of the device. According to this algorithm, it has the advantage that there is no restriction on the activity than when using an imaging device and it is inexpensive than other sensors such as an acceleration sensor or a gyro and it is easy to handle.