• Molecules and Cells
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• v.45 no.11
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• pp.806-819
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• 2022

Synaptic accumulation of α-synuclein (α-Syn) oligomers and their interactions with VAMP2 have been reported to be the basis of synaptic dysfunction in Parkinson's disease (PD). α-Syn mutants associated with familial PD have also been known to be capable of interacting with VAMP2, but the exact mechanisms resulting from those interactions to eventual synaptic dysfunction are still unclear. Here, we investigate the effect of α-Syn mutant oligomers comprising A30P, E46K, and A53T on VAMP2-embedded vesicles. Specifically, A30P and A53T oligomers cluster vesicles in the presence of VAMP2, which is a shared mechanism with wild type α-Syn oligomers induced by dopamine. On the other hand, E46K oligomers reduce the membrane mobility of the planar bilayers, as revealed by single-particle tracking, and permeabilize the membranes in the presence of VAMP2. In the absence of VAMP2 interactions, E46K oligomers enlarge vesicles by fusing with one another. Our results clearly demonstrate that α-Syn mutant oligomers have aberrant effects on VAMP2-embedded vesicles and the disruption types are distinct depending on the mutant types. This work may provide one of the possible clues to explain the α-Syn mutant-type dependent pathological heterogeneity of familial PD.

• International Journal of Computer Science & Network Security
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• v.23 no.5
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• pp.163-171
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• 2023

The intelligent transportation system has made a huge leap in the level of human services, which has had a positive impact on the quality of life of users. On the other hand, these services are becoming a new source of risk due to the use of data collected from vehicles, on which intelligent systems rely to create automatic contextual adaptation. Most of the popular privacy protection methods, such as Dummy and obfuscation, cannot be used with many services because of their impact on the accuracy of the service provided itself, they depend on changing the number of vehicles or their physical locations. This research presents a new approach based on the shuffling Nicknames of vehicles. It fully maintains the quality of the service and prevents tracking users permanently, penetrating their privacy, revealing their whereabouts, or discovering additional details about the nature of their behavior and movements. Our approach is based on creating a central Nicknames Pool in the cloud as well as distributed subpools in fog nodes to avoid intelligent delays and overloading of the central architecture. Finally, we will prove by simulation and discussion by examples the superiority of the proposed approach and its ability to adapt to new services and provide an effective level of protection. In the comparison, we will rely on the wellknown privacy criteria: Entropy, Ubiquity, and Performance.

• Journal of Korea Entertainment Industry Association
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• v.5 no.2
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• pp.87-95
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• 2011

Recently, the issue has been tangible game environment due to the various interactive interface developments. In this paper, we propose the multi card touch based interactive arcade system by using marker recognition interface and multi-touch interaction interface. For our system, the card's location and orientation information is recognized through DI-based recognition algorithm. In addition, the user's hand gesture tracking informations are provided by the various interaction metaphors. The system provides the user with a higher engagement offers a new experience. Therefore, our system will be used in the tangible arcade game machine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.685-691
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• 2020

In this study, an algorithm that recognizes numbers from 0 to 9 was developed using the data obtained after tracking hand movements using the echo signal of a millimeter-wave radar sensor at 77 GHz. The echo signals obtained from the radar sensor by detecting the motion of a hand gesture revealed a cluster of irregular dots due to the difference in scattering cross-sectional area. A valid center point was obtained from them by applying a K-Means algorithm using 3D coordinate values. In addition, the obtained center points were connected to produce a numeric image. The recognition rate was compared by inputting the obtained image and an image similar to human handwriting by applying the smoothing technique to a CNN (Convolutional Neural Network) model trained with MNIST (Modified National Institute of Standards and Technology database). The experiment was conducted in two ways. First, in the recognition experiments using images with and without smoothing, average recognition rates of 77.0% and 81.0% were obtained, respectively. In the experiment of the CNN model with augmentation of learning data, a recognition rate of 97.5% and 99.0% on average was obtained in the recognition experiment using the image with and without smoothing technique, respectively. This study can be applied to various non-contact recognition technologies using radar sensors.

• Journal of Korea Multimedia Society
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• v.16 no.6
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• pp.720-734
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• 2013

In this paper, we suggest an augmented reality authoring tool system that users can easily make augmented reality contents using hand gesture and marker-based interaction methods. The previous augmented reality authoring tools are focused on augmenting a virtual object and to interact with this kind of augmented reality contents, user used the method utilizing marker or sensor. We want to solve this limited interaction method problem by applying marker based interaction method and gesture interaction method using depth sensing camera, Kinect. In this suggested system, user can easily develop simple form of marker based augmented reality contents through interface. Also, not just providing fragmentary contents, this system provides methods that user can actively interact with augmented reality contents. This research provides two interaction methods, one is marker based method using two markers and the other is utilizing marker occlusion. In addition, by recognizing and tracking user's bare hand, this system provides gesture interaction method which can zoom-in, zoom-out, move and rotate object. From heuristic evaluation about authoring tool and compared usability about marker and gesture interaction, this study confirmed a positive result.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.7
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• pp.4463-4468
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• 2014

To increase the efficiency of a solar module, the development of solar concentrator using a lens or reflection plate is being proceeded actively and the concentrator pursues the a concentration using a lens or an optical device of a concentration rate and designing as a solar tracking system. On the other hand, as the energy density being dissipated as a heat according to the concentration rate increases, the cares should be taken to cool the solar concentrator to prevent the lowering of efficiency of solar cell by the increasing temperature of the solar cell. This study, researched and developed an economical concentrator module system using a low priced reflection optical device. A concentrator was used as a general module to increase the generation efficiency of the solar module and heat generated was emitted by the concentration through the cooling system. To increase the efficiency of the solar concentrator, the cooling system was designed and manufactured. The features of the micro cooling system (MCS) are a natural circulation method by the capillary force, which does not require external power. By using the potential heat in the case of changing the fluid, it is available to realize high performance cooling. The 117W solar modules installed on the reflective plate and the cooling device in the cooling module and the module unit was not compared. The cooling device was installed in the module resulted in a 28% increase in power output.

• Korean Institute of Interior Design Journal
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• v.26 no.2
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• pp.22-32
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• 2017

This research is to analyze the spatial information search features which shown by Eye fixation and movement and conducted eye tracking experiment for targeting sports shop spatial images which it are same but looks different. This is able to find out the eye movement feature according to placement of goods from the eye movement and movement distance of spatial visitor, and the result can be defined as following. First, the whole original-reverse left / right images have a higher number of observations in the [IN] area than in the [OUT] area. This is because after eye taking high observations in LA area of [IN] have been jump-over [OUT], performed search activities in low eye fixation without high eye fixation. Second, there was a difference in the frequency of the observation data as the composition of the images changed. The original image has been often fixed the eyes in LA area, and the one that has been observed for a long time is reverse left / right image. Also, fixation point was shown higher at the reverse left / right image as jump-over from [OUT] area to [IN] area. If LA area seen as reverse left / right image, it is located in right-hand side. The case where the dominant area is on the right side has a characteristic that the eye fixation is longer. This can be understand that the arrangement of products for attract the customer's attention in the commercial space might be more effective when it is on the right side. Third, the moving distance(IN ${\rightarrow}$ OUT) of the sight pointed to external from LA area was long in the both original-reverse left / right images, but it is no relation with search direction([IN${\rightarrow}$OUT] [IN${\rightarrow}$OUT]) of the sight. In other words, the sight that entered in LA area can be seen as visual perception activity for re-searching after big jump-over, in the case go in to outward (OUT area) after searching for more than certain time. The fact that the moving distance of eye is relatively short in the [IN ${\rightarrow}$ OUT] process considered as that the gaze that stays outside the LA area naturally enters in to LA area.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.3
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• pp.1-12
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• 2011

Large-sized multi-touch screen is usually made using infrared rays. That is because it has technical constraints or cost problems to make the screen with the other ways using such as existing resistive overlays, capacitive overlay, or acoustic wave. Using infrared rays to make multi-touch screen is easy, but is likely to have technical limits to be implemented. To make up for these technical problems, two other methods were suggested through Surface project, which is a next generation user-interface concept of Microsoft. One is Frustrated Total Internal Reflection (FTIR) which uses infrared cameras, the other is Diffuse Illumination (DI). FTIR and DI are easy to be implemented in large screens and are not influenced by the number of touch points. Although FTIR method has an advantage in detecting touch-points, it also has lots of disadvantages such as screen size limit, quality of the materials, the module for infrared LED arrays, and high consuming power. On the other hand, DI method has difficulty in detecting touch-points because of it's structural problems but makes it possible to solve the problem of FTIR. In this thesis, we study the algorithms for effectively correcting the distort phenomenon of optical lens, and image processing algorithms in order to solve the touch detecting problem of the original DI method. Moreover, we suggest calibration algorithms for improving the accuracy of multi-touch, and a new tracking technique for accurate movement and gesture of the touch device. To verify our approaches, we implemented a table-based multi touch screen.

• Journal of Korea Society of Industrial Information Systems
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• v.24 no.6
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• pp.1-10
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• 2019

This paper proposes a method to improve the detectable distance by reducing noise to perform a signal processing technique on the received signals. To increase the radar detection range, the noise component of the received signal has to be reduced. The proposed method reduces the noise component by employing two methods. First, the radar signals received with multiple pulses are accumulated. As the number of additions increases, the noise component gradually decreases due to noise randomness. On the other hand, the signal term gradually increases and thus signal to noise ratio increases. Secondly, after converting the accumulated signal into the frequency spectrum, a Least Mean Square (LMS) filter is applied. In the case of the radar received signal, desired signal exists in a specific part and most of the rest is a noise. Therefore, if the LMS filter is applied in the time domain, the noise increases. To prevent this, the LMS filter is applied after converting the received signal into the entire frequency spectrum. The LMS filter output is then transformed into the time domain and then range estimation algorithm is performed. Simulation results show that the proposed scheme reduces the noise component by about 25 dB. The experiment was conducted by comparing the proposed results with the conventional results of the radars held by the Korea Aerospace Research Institute for the international space station.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.2
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• pp.247-258
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• 2014

To evaluate the influence of the external force components on the littoral currents in the Gusipo beach, Jeonbuk, West Coast of Korea where a wide tidal sand flat developed, a coupled hydrodynamic model considered real time tidal currents and wave-induced currents was constructed in which the EFDC for tides and tidal currents, the SWAN for waves and the SHORECIRC for wave-induced currents were used as the hindcasting models. A series of field observations for tides, tidal currents and incident waves were carried out and especially to observe the littoral currents in the tidal sand flat, the GPS mounted and light weight drogues were used. Also wind data were collected from the adjacent weather station. To analyze the littoral current components, the numerical drogue tracking results considered real time winds, tides and waves were compared with the field drogue data. The drift speed of numerical drogues was reproduced as the range of 68.0~105.2% compared with the field data and the velocity error of main direction component showed a good result as -16.7~10.0%. As a result, in the mild slope tidal flat including wide surf zone, the tides and winds were the major affection component of the littoral currents, on the other hand, the wave-induced currents seemed the minor component when the incident wave heights were relatively small.