• 한국식생활문화학회지
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• 제23권5호
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• pp.655-661
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• 2008

The prevalence of atopic dermatitis (AD) in children has increased dramatically in recent years. Although AD has genetic determinants, this rapid increase is most likely due to changes in environmental influences--for example, dietary changes. The purpose of this case-control study was to assess the relationship between the risk of developing AD and dietary factors, including eating habits, food intake, and the consumption of various functional foods in children at ages of 7 or 8 years. 143 AD patients and 335 healthy children participated in this study. A mini-dietary assessment was utilized to evaluate the food intake and dietary patterns of the children, and other information, including demographic and socioeconomic characteristics, eating habits, and the frequency of functional food use was collected using a questionnaire. The results demonstrated that, among the demographic and socioeconomic factors assessed in this study, female gender, mother's employment, and the family history of AD significantly increased the risk of AD. However, no differences in dietary habits and specific food intake between AD patients and healthy controls were identified. On the other hand, the frequencies of taking multivitamin supplements, Spirulina, or gamma-linoleic acid were significantly higher in AD patients than in the controls. These data indicate that alterations in eating habits and the intake of certain foods may not be a critical cause associated with the risk of AD in school-age children, and caution should be taken in recommending food elimination diets for the purpose of preventing AD. Further studies are required in order to determine whether the intake of specific nutrients could contribute to the increase or prevention of the development of AD in school-age children.

• 한국식생활문화학회지
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• 제30권6호
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• pp.797-803
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• 2015

Atopic dermatitis (AD) is usually caused by foods such as wheat, egg, milk, and peanuts, leading to common health problems in early childhood with complications like urtication. The aim of this study was to evaluate ethanol extracts of rice and rice snacks concentrated until the ethanol was completely eliminated and hot-air dried. In vitro analyses were carried out using murine macrophage RAW 264.7 cells. We measured cytotoxicity, nitric oxide (NO) production, and inflammatory cytokine level. The NO level of the cells exposed to lipopolysaccharide (LPS) was significantly reduced by rice and rice snack extracts. $TNF-{\alpha}$ level decreased in contrast to the LPS group, although a significant difference was not observed. On the other hand, IL-6 significantly decreased in both rice and rice snack extracts in a dose-dependent manner. The results of the present study suggest that rice and rice snack decreased NO and inflammatory cytokine levels. Therefore, rice could be useful as a raw material for relieving child atopic dermatitis caused by snacks made from wheat.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.575-590
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• 2018

The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc., dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics. On the other hand, host variations like geographical locations, food habits etc. could also affect the expected results from probiotic usage. Thus, there is a glaring deficiency in our approach to establish probiotics as an irrefutable treatment avenue for suitable disorders. In this review, we explicate on the reported probiotics and their effects on certain allergic diseases like atopic dermatitis, food allergy and asthma to establish their utility. We propose possible measures like elucidation of effector molecules and functional mechanisms of probiotics towards establishing probiotics for therapeutic use. Certain probiotics studies have led to very alarming outcomes which could have been precluded, had effective guidelines been in place. Thus, we also propose ways to secure the safety of probiotics. Overall, our efforts tend to propose necessary discovery and quality assurance guidelines for developing probiotics as potential immunomodulatory 'Pharmabiotics.'

• 생약학회지
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• 제37권3호
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• pp.212-216
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• 2006

The effect of aqueous extracts of medicinal plants $AMP-365^{TM}$ was tested for immune system regulating activity based on anti-inflammatory activity, anti-oxidant, macrophage proliferation and T-lymphocyte proliferation activity. $AMP-365^{TM}$ dose-dependently increased proliferation of RAW264.7 macrophage cells and its nitric oxide production as well as DPPH radical scavenging activity. On the other hand, T-lymphocyte proliferation activity was decreased on dose-dependent manner. Passive cutaneous anaphylaxis reaction was alleviated by 49% by administering 250 mg/kg of $AMP-365^{TM}$. The results suggest that $AMP-365^{TM}$ can be beneficial in the treatment of immediate allergic reactions as an adjuvant supplement material.

• 한국수의병리학회지
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• 제7권1호
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• pp.5-9
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• 2003

Malignant catarrhal fever (MCF) is a systemic disease of ruminants caused by a gamma herpesvirus, ovine herpesvirus 2 (OvHV-2). Four 1-year old goats (Capra hircus), which were infected with MCF virus, OvHV-2, by being housed together with MCF virus-infected seep, were referred with a I-month history of chronic dermatitis. On the other hand, MCF virus-negative goats, which were isolated for negative control, had not those kinds of skin problems. Examination of the affected goats revealed generalized alopecia, patchy erythema, and superficial erosions with histologic evidence of mural folliculitis. Fungal culture tests and external parasite tests with the scraping skin samples were negative. However, polymerase chain reaction revealed the existence of MCF virus DNAs in the lesion. These results suggested that MCF virus may induce mural folliculitis and alopecia in goat.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.127-130
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• 2004

Pompholyx is a special vesicular type of hand and foot dermatitis. It is an acute, chronic or recurrent dermatosis of the fingers, palms and soles, characterized by a sudden onset of many deep-seated pruritic clear vesicles. We diagnosed a patient with pompholyx as damp heat and treated with wet dressing by gauze soaked in distilled solution of Gamihwangryunhaedok-tang(Jiaweihuanglianjiedu-tang). After treatment with wet dressing, we observed the improvement. Based on this study, it is considered that wet dressing with Gamihwangryunhaedok-tang(Jiaweihuanglianjiedu-tang) can be applied to the treatment of pompholyx.

• 한국미생물·생명공학회지
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• 제43권2호
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• pp.150-157
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• 2015

본 연구는 BALB/c mice의 등 쪽 부위에 반복적인 DNCB 도포를 통해 유발시킨 아토피 피부염에 있어서 참모자반 물 추출물의 효능에 대해 연구하였다. 참모자반 물 추출물을 2주 동안 지속적으로 처리하고 IL-4 및 IFN-γ cytokine의 분비량, 비장세포 증식능, 혈청 중 총 IgE 함량, 육안 평가 및 skin clinical severity score, 조직관찰을 실시하였다. 그 결과 참모자반 물 추출물을 지속적으로 도포함으로써 IL-4 cytokine과 총 IgE 함량이 현저히 감소하는 것을 확인할 수 있었으며 IFN-γ cytokine은 유의적으로 증가하는 것을 확인하였다. 비장세포 증식능에는 참모자반 물 추출물의 도포처리가 큰 영향을 미치지 않는 것으로 나타났다. 육안평가 및 skin clinical severity score 결과, 참모자반 물 추출물을 2주간 지속적으로 도포 처리하였을 때, 그 증상이 눈에 띄게 완화되는 것을 확인할 수 있었으며 score 또한 DNCB 단독 처리군과 비교 시 유의적으로 감소하였다. 등 조직 관찰에서도 참모자반 물 추출물에 의해 DNCB로 유발된 아토피 동물 실험군의 경피 및 진피 조직 두께 및 진피에서의 mast cell의 침윤 정도가 감소되었음을 확인하였다. 이상 결과를 종합 해볼 때, 참모자반 물 추출물이 아토피 피부염 치료제로서 이용 가능성이 있을 것으로 사료된다.

• 동서간호학연구지
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• 제2권1호
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• pp.37-53
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• 1997

The purpose is to inspect the personal medicines in Cheju island that are used traditionally and to get their characteristics. The subjectives are 39 Cheju people, men 10, women 29, who were horned, grown up in Cheju and agreed with this study. The ranges of age are 10 persons(m : 1, w: 9) over 40 less 50 years old, 14(m : 7, w : 7) over 50 less 60, 5(m : 1, w : 4) over 60 less 70, 6(m : 0, w : 6) over 70 less 80, and 4(m : 1, w : 3) over 80. The average age is 64.5 years old. The method to collect the data is 20 structured opening questionaires that are based on references. The duration to collect datas is 11days from 4th, Aprill 1997 to 14th, Aprill 1997. The workers who are trainned the interview methods went their villages and got answers after explaining the purpose and contents to them. Somtimes they used to record the answers. The analysis was identified the subjectives to four regions of Cheju, arranged answers with items, rearranged the same answers, counted with number and percentage. And classified the materials and characteristics. The results of this study are followed: The things that is used as personal medicines are the effects through experiences ans misteries that have hand down by word of mouth, even though they are not scientific. People used the materials arround their circumference. It is an accumulation of experiences. The ways used in eating, doing acupuncture or sting, exposing to smoke, wheedling, fixing after pounding. Almost materials are plants. Mugwort is effective in fever, gastritis, hemorrhoid, diarrhea, edematous hands or feet and dermatitis. Citron and Arrowroot in fever, gastritis. Seeds of Pumpkin in indigestive, hemorrhoid, edematous hands or feet. Gallic in fever, diarrhea, frostbite, dermatitis, and toothache. Motherwort in diarrhea, gastritis. Radish juice in indigestive, jaundice. Bean paste in burn, wound. Acupuncture in fever, gastritis, indigestive, back pain, edematous hands or feet. Sting as similar with it in fever, indigestive, edematous hands or feet. Cigarrette in hemorrhoid, wound, toothache. Cowstools in edematous hands or feet, wound. Sault is usded a lot in fever, gastritis, indigestive, hemorrhoid, uneffective voiding, edematous hands or feet, dermatitis, having a boil around the mouth, toothache, and eye disease. Japanese Parsley in fever, gastritis. Egg Apple in diarrhea, edematous hands or feet, frostbite. And Wild Chrysanthemum is effective in jaundice. In the conclusion, people used the things arround. A things is effective in several symptoms. If these are not effective, they would used the magic as god's anger. As locally, they used the grasses and fruits in the middle of Mt. Halla and seafood on the sea village.

• 한국건강관리협회지
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• 제2권1호
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• pp.93-104
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• 2004

Purpose : This study was conducted to understand the health status and health behaviors of preschoolers to provide baseline data for developing health promotion programs. Method 'Parents of children attending day-care centers and guardians of preschoolers were recruited for the study. Data were collected from June to August2002 using a structured questionnaire. Result . Among 754 preschoolers, 17,3% were overweight, while 18.2% were underweight, while 15.9% and 23.2% were overweight and underweight respectively, among 85 children living with guardians. The most frequent infectious diseases that children have had previously were hand-foot-mouth disease, chicken pox, and measles. Current health conditions that children have frequently are respiratory disease and atopic dermatitis for bother groups. Only 54%-61% brush their teeth everyday at bedtime, 49%-54% wash their hands every time after returning home, 4.5%-8.8%wear bicycle helmets, 9,3%-11.1% use a child car seat, and 3.5%-8.1% eat fruits and vegetables five times a day, Children living with guardians were less likely toper form positive health behaviors compared with children in day-care centers. Conclusion 'Based on the study results, health professionals could plan and develop health promotion programs to change unhealthy behaviors of preschoolers targeting high-risk groups.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.181-191
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• 2011

Backgrounds : Pompholyx is a distinctive reaction pattern presenting as symmetric vesicular hand and foot dermatitis. Other than acute symptoms like itching and vesicles, chronic changes with scaling, fissure and pain may follow. As patients are treated by steroid for a long period, it tends to present side effects after quitting steroid treatment. Objectives : This study was carried out to investigate the effect of carbon arc lamp therapy and oriental medical therapy that venesection therapy, ointments and herbal medicine on chronic plantar pompholyx including steroids side effects. Methods : We treated one case of chronic plantar pompholyx which had continued about 10 years, including steroids side effects with venesection therapy, carbon arc lamp therapy, ointments and herbal medicine. To evaluate the results of this treatment, we categorized symptoms into six items which are vesicles, itching, fissures, pain, erosions and scales. Results : Except mild itching, vesicles and scales in a small area, all the symptoms were subsided. Conclusions : It is considered that various kinds of oriental medical therapy including carbon arc lamp therapy could replace steroid therapy which has many side effects.