• Korean Journal of Psychosomatic Medicine
• /
• v.2 no.1
• /
• pp.34-45
• /
• 1994

The author reviewed psychosomatic aspects of bronchial asthma including psychological aspect of bronchial asthma, patients' reactions to illness, reactions of therapists and families, effect of bronchial asthma on mental function, psychotherapy and pharmacotherapy. The therapists' understanding of these aspects is likely to be helpful in their predicting and understanding the type of adaptation their asthmatic patients are making to their illness. Thus, the therapists need to recognize the asthmatics' psychological needs. They also should understand the vicious cycle of anxiety-hyperventilation-panic-fear-avoidance in patients with bronchial asthma and should try to break this cycle. To make it possible, the patients' panic-fear level should be assessed and sometimes it will require psychiatrists' advice. On the other hand, the asthmatics should be trained to be shaped to relate subjective feeling of pulmonary function with objective pulmonary measures, which will enable these patients to perceive their early symptoms and to cope with asthma attack effectively. The therapists need to pay attention to their emotion during evaluation and treatment of patients with bronchial asthma, because they are less likely to perceive stress and express their emotion.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.10
• /
• pp.4245-4250
• /
• 2014

Emerging evidence has suggested that glycolysis is enhanced in cancer-associated fibroblasts (CAF), and miR-186 is downregulated during the CAF formation. However, it is not clear whether miR-186 is involved in the regulation of glycolysis and what the role of miR-186 plays during the CAF formation. In this study, quantitative PCR analysises show miR-186 is downregulated during the CAF formation. Moreover, miR-186 targets the 3' UTR of Glut1, and its overexpression results in the degradation of Glut1 mRNA, which eventually reduces the level of Glut1 protein. On the other hand, knockdown of miR-186 increased the expression of Glut1. Both time course and dose response experiments also demonstrated that the protein and mRNA levels of Glut1 increase during CAF formation, according to Western blot and quantitative PCR analyses, respectively. Most importantly, besides the regulation on cell cycle progression, miR-186 regulates glucose uptake and lactate production which is mediated by Glut1. These observations suggest that miR-186 plays important roles in glycolysis regulation as well as cell cycle checkpoint activation.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.28 no.7
• /
• pp.299-304
• /
• 2016

In recent years, heat source systems which have a principal effect on the performance of buildings are difficult to design optimally as a great number of design factors and constraints in large and complicated buildings need to be considered. On the other hand, it is necessary to design an optimum system combination and operation planning for energy efficiency considering Life Cycle Cost (LCC). This study suggests a multi-level and multi-objective optimization method to minimize both LCC and investment cost using a genetic algorithm targeting an office building which requires a large cooling load. The optimum method uses a two stage process to derive the system combination and the operation schedule by utilizing the input data of cooling and heating load profile and system performance characteristics calculated by dynamic energy simulation. The results were assessed by Pareto analysis and a number of Pareto optimal solutions were determined. Moreover, it was confirmed that the derived operation schedule was useful for operating the heat source systems efficiently against the building energy requirements. Consequently, the proposed optimization method is determined by a valid way if the design process is difficult to optimize.

• Publications of The Korean Astronomical Society
• /
• v.13 no.1 s.14
• /
• pp.181-208
• /
• 1998

We have analyzed the sunspot and aurora data recorded in Go-Ryer-Sa. We have collected 35 records of sunspot observations for 46 days, and 232 records of auroral observations. To objectively estimate the periods of the solar activity appearing in these records a method of calculating the one-dimensional power spectrum from inhomogeneous data is developed, and applied to the sunspot and auroral data. We have found statistically significant 10.5 and 10 year periodicities in the distributions of sunspot and aurora records, respectively. These periods are consistent with the well-known solar activity cycle. There are indications of the long-term variations, but the period is not certain. We have also calculated the cross-correlations between the sunspot and auroral data. In particular, we have divided the aurora data into several subgroups to study their nature. We conclude that the historical records of strong auroral activity correspond to non-recurrent magnetic storms related to the sunspots. On the other hand, the records of weak auroral activity are thought to be related with the recurrent magnetic storms which occur frequently due to the coronal hole near the sunspot minimum.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.16 no.4
• /
• pp.416-422
• /
• 2006

Most of the existing statistical models of software manpower profile are based on the assumptions of the usage and development process. Therefore, there is no universally applicable estimation and prediction model. To develop a prediction model, this paper suggests the predictive filter as a prediction model for software manpower profile. Firs of all, we investigate the software manpower profile and we suggest the input-output of predictive filter and method for parameter determination. Then, its usefulness is empirically verified by analyzing the actual data obtained from the software projects. Based on the average relative prediction error and Pred(0.25), the suggested predictive filter is compared with other well-known statistical estimation models. As a result, the predictive filter generally has a simple structure and on the other hand, it adapts the software manpower profile very well.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.27 no.6
• /
• pp.960-968
• /
• 2003

The objective of this study is to investigate the effect of AE activities in the crack opening and closure during the fatigue test. The laboratory experiments for various materials and test conditions were carrie out to identify AE characteristics of fatigue crack propagation. Compact tension specimens of SWS 490B and Al 7075-T6 alloy were prepared for fatigue test. AE activities were analyzed based on the phase of the loading cycle. In case of SWS 490B, the most of AE was generated when the crack began opening and the crack closed fully, whereas a few in the full opening of the crack. On the other hand, in case of Al 7075-T6, a distinct AE activity was observed during crack opening process. AE activity in the peak loading of cycle was different with each specimen. However, in the same material, AE activity was not affected by the change of cyclic frequency (0.1, 0.2, 1.0 ㎐). It was found that AE activities during crack opening and closure depend on material properties such as micro-structure, yield strength and elongation.

• Clinical and Experimental Reproductive Medicine
• /
• v.39 no.3
• /
• pp.95-106
• /
• 2012

It has been revealed that multiple cohorts of tertiary follicles develop during some animal estrous cycle and the human menstrual cycle. To reach developmental competence, oocytes need the support of somatic cells. During embryogenesis, the primordial germ cells appear, travel to the gonadal rudiments, and form follicles. The female germ cells develop within the somatic cells of the ovary, granulosa cells, and theca cells. How the oocyte and follicle cells support each other has been seriously studied. The latest technologies in genes and proteins and genetic engineering have allowed us to collect a great deal of information about folliculogenesis. For example, a few web pages (http://www.ncbi.nlm. nih.gov; http://mrg.genetics.washington.edu) provide access to databases of genomes, sequences of transcriptomes, and various tools for analyzing and discovering genes important in ovarian development. Formation of the antrum (tertiary follicle) is the final phase of folliculogenesis and the transition from intraovarian to extraovian regulation. This final step coordinates with the hypothalamic-pituitary-ovarian axis. On the other hand, currently, follicle physiology is under intense investigation, as little is known about how to overcome women's ovarian problems or how to develop competent oocytes from in vitro follicle culture or transplantation. In this review, some of the known roles of hormones and some of the genes involved in tertiary follicle growth and the general characteristics of tertiary follicles are summarized. In addition, in vitro culture of tertiary follicles is also discussed as a study model and an assisted reproductive technology model.

• Journal of Auto-vehicle Safety Association
• /
• v.10 no.1
• /
• pp.45-51
• /
• 2018

There are some ambiguities of the information on the fuel economy provided to the consumers because the standard and the detailed regulations for the fuel economy of the two-wheeled vehicle have not been established in Korea. Since Korea has been a signatory of World Forum for Harmonization of Vehicle Regulations since 1998, it is possible to remove the ambiguities by adopting the WMTC (Worldwide-harmonized Motorcycle Test Cycle) measurement method for the fuel economy of the two-wheel vehicle. As a preliminary study on the WMTC mode fuel economy, road loads measured by coast down method and table method were compared for the two types of two-wheeled motorcycles on sales in domestic market. In the same model, it was confirmed that the deviation of WMTC mode fuel efficiency was below -5% between products. On the other hand, the difference of WMTC fuel economy exceeded 5% between the coast down method and table method.

• Tribology and Lubricants
• /
• v.29 no.4
• /
• pp.213-217
• /
• 2013

As commercial atomic force microscopy (AFM) probes made of Si and $Si_3N_4$ have low stiffness, it is difficult to induce sufficient elastic deformation on the surface of a specimen in a tapping mode. Therefore, high-guality phase contrast images can not obtained. On the other hand, a tungsten AFM probe has relatively higher stiffness than a commercial AFM probe. Accordingly, it is expected to provide an enhanced phase contrast image, which is an effective tool for achieving a better understanding of the micromechanical properties of worn surfaces and wear mechanisms. In this study, on electrochemical etching method was optimized to fabricate tungsten probe tips for an AFM. Electrochemical etching was performed by applying pulse waves with a 20% duty cycle at various voltages instead of only a DC voltage, which has been commonly used.

• Journal of the korean society of oceanography
• /
• v.32 no.3
• /
• pp.156-161
• /
• 1997

The biogeochemical cycle of silver has rarely been reviewed, even though the silver ion (Ag$^{\times}$) is extremly toxic to some organisms. Its concentration is still rising sharply because of increased anthropogenic activity, specifically the discharge from the film industry (mainly, silver thiosulfate: Ag (S$_2$O$_3$)${^3-}_2$). Recently, a number of researchers have quantified the major fluxes and reservoirs of silver in the open ocean, bays, and estuaries. A review of the available information for Ag cycling in the open ocean shows that the riverine input (from human activity and weathering processes: 7${\times}$10$^6$ kg/yr and 5${\times}$10$^6$ kg/yr, respectively) is the dominant source of Ag to estuarine and coastal regions. Most of the silver (90% of riverine input silver) is removed in coastal sediments by the physical-chemical character of silver due to its high partitioning with particulate matter. On the other hand, in the open ocean the atmospheric input (wet and dry deposition: 1.48${\times}$10$^6$ kg/yr and 1.94${\times}$ 10$^5$ kg/yr, respectively) becomes more important as a source of silver than riverine input. The residence time of silver calculated from available data is 1250 yrs in the deep ocean below 500 m, but only 3 yrs in the surface ocean.