• Title/Summary/Keyword: Hair growth

Search Result 385, Processing Time 0.046 seconds

The Experimental Study on the Effect of Herbal Exrtacts on Hair Growth and Acnes (복분자(覆盆子), 석창포(石菖蒲), 상침자 및 숙지황(熟地黃)이 모발성장(毛髮成長)과 면포에 미치는 실험적(實驗的) 연구(硏究))

  • Oh, Young-Sun;Roh, Sek-Seun;Oh, Min-Suck
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
    • /
    • v.19 no.3 s.31
    • /
    • pp.34-54
    • /
    • 2006
  • The effects of four extracts of medicinal herbs, Rubus coreanum, Acorus calamus, Morus alba and Rehmannia glutinosa on hair growth activity and acnes control were investigated. In the course of screening natural extracts for hair growth, we found that the extract of dried root of Rubus coreanum has the hair growth promoting effect. After topical application of these extracts to the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. The growth of dermal papilla cells and mouse vibrissae hair follicle cultured in vitro, however, was not affected by treatment of these extracts. Furthermore these extracts do not possesspotent inhibitory effect on $5{\alpha}-reductase$ I and II activity and anti-bacterial effect on Escherichia coli , Propionibacterium acnes, Pityrosporum ovale, Staphylococcus aureus, Staphylococcus epidemidis, and Candida albicans. RT-PCR analysis showed that these extracts did notinduce mRNA levels of growth factors such as insulin-like growth factor-I, keratinocyte growth factor, hepatocyte growth factor and vascular endothelial growth factor in dermal papilla cells. These results suggest that Rubus coreanum has hair growth promoting effect. However, the effects of these materials on the hair growth promotion are not mediated through inhibition of $5{\alpha}-reductase$ I and II activity, stimulation of hair follicle cells and expression of growth factors in the dermal papilla cells.

  • PDF

Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues

  • Choi, Seong-Hyun;Moon, Jeong-Su;Jeon, Byung-Suk;Jeon, Yeon-Jeong;Yoon, Byung-Il;Lim, Chang-Jin
    • Biomolecules & Therapeutics
    • /
    • v.23 no.2
    • /
    • pp.174-179
    • /
    • 2015
  • BP201, porcine lung tissue-derived phospholipids, consists of phosphatidylcholine as a major phospholipid species. BP201 promoted hair growth after application onto the shaved backs of BALB/c and C3H mice. Its effect was enhanced when applied together with minoxidil (MNX) in C3H mice. When the tissue specimens prepared from the shaved skins of BP201-treated and control mice were microscopically examined, the total numbers of hair follicles in both anagen and telogen phases of BP201-treated mice were significantly higher than those of control mice. The numbers of hair follicles in the anagen phase of BP201-treated mice were also higher than those of control mice. In combination with MNX, BP201 further increased the total number of hair follicles, but did not alter the percentage of hair follicles in the anagenic phase. BP201 also increased the proliferation of human hair follicle dermal papilla cells. Collectively, BP201 possesses hair growth promoting potential, which would suggest its use singly or in combination for hair growth products.

Effect of natural plant extract (Abelmo) on action mechanism and hair growth activities in C57BL/6 mice (C57BL/6 마우스에서 천연 식물성추출물(아벨모)의 발모효능 및 작용 메카니즘)

  • Park, Sang-Oh;Park, Byung-Sung;Noh, Ga-Yeong
    • Journal of the Korean Applied Science and Technology
    • /
    • v.31 no.4
    • /
    • pp.653-662
    • /
    • 2014
  • This study was determined the hair growth effect and mode of action of a complex extract (abelmo), extracted from various natural plants including Acorus calamus var. angustatus. 30 six-week old C57BL/6 mice were randomly assigned into three treatment groups with ten mice per treatment group repeatedly. The treatment group is a control group, and was classified into saline-applied, minoxidil 5%-applied, and abelmo-applied groups. Hair growth started from the abelmo-applied and minoxidil 5% -applied groups on the 9th day, compared to the saline-applied group. Hair growth rate was 17.06% and 19.15% in those two groups, respectively, and the abelmo-applied group's hair growth rate was higher. The density, length and thickness of hair were significantly higher in the order of abelmo-applied group, minoxidil 5%-applied group and saline-applied group on the 9th day, and hair root was strongly maintained in the abelmo-applied group. The density, length and thickness of hair in the abelmo-applied group were significantly higher by 599.8, 122.2 and 181.8% on the 9th day compared to the saline-applied group, and 166.7, 171.4 and 200.2% on the 12th day, and 136.6, 216.9 and 180.7%, respectively on the 15th day. As for hair follicle and the length of hair shaft from the dosal skin histopathology manifestation, the abelmo-applied group was more excellent than the saline-applied group and minoxidil 5%-applied group. This result actually confirmed the fact that abelmo promotes hair growth and strongly maintains hair root simultaneously.

A Study of Hair Density and Growth Rate Change to Ayurvedic Treatment (아유베르딕 관리에 의한 모발 밀도 및 성장속도 변화에 관한 연구)

  • Jang, Young-Hye;Yoo, Tae-Soon;Jung, Youn
    • Fashion & Textile Research Journal
    • /
    • v.9 no.4
    • /
    • pp.425-430
    • /
    • 2007
  • This study was to present these results as basic data for the effects of Ayurvedic oil and the development of alopecia treatment programs. The results were as follows: 1) After Ayurvedic treatment, the hair density of vertex and occiput were 264.2 hair/$cm^2$ and 299.8 hair/$cm^2$ each. There was the increase of total 29.2% in hair density. 2) The hair growth rates on vertex and occiput after Ayurvedic treatment were 310.8 ${\mu}m$/day and 345.8 ${\mu}m$/day respectively, there was the increase of total 79% in hair growth.

Efficacy of Caffeine in Promoting Hair Growth by Enhancing Intracellular Activity of Hair Follicles

  • Kim, Sehyun;Kim, Su Na;Jeong, Gyusang;Hong, Min Jung;Lee, Yonghee;Shin, Seung Hyun;Park, Hyeokgon;Jung, Yu Chul;Kim, Eun Joo;Park, Byung Cheol;Kim, Hyoung-June
    • Korea Journal of Cosmetic Science
    • /
    • v.1 no.1
    • /
    • pp.11-18
    • /
    • 2019
  • Caffeine is widely used in cosmetics and hair care products. Although its efficacy in stimulating hair growth has been confirmed in recent studies, its mechanism of action remains unelucidated. The present study aimed to determine the effects of caffeine on hair growth, with a focus on intracellular hair follicle activity. Experiments included in vitro and ex vivo tests, and a clinical study. Caffeine enhanced the cellular activity and potassium channel opening. It also promoted human hair follicle elongation. Immunohistochemical staining showed that the Ki-67 signal was significantly higher in cells treated with caffeine. These efficacies of caffeine were comprehensively demonstrated in clinical results, wherein caffeine-containing shampoo improved hair density after 24 weeks of testing. Collectively, the results of this study demonstrated that caffeine promoted hair growth and inhibited the progression of hair loss by enhancing intracellular activity of hair follicles.

The Functional Effects for the Prevention and Treatment on Hair Loss from Astringent Persimmon Fruit Extracts (떫은감 추출물의 발모 및 탈모의 기능성 효과)

  • Im, Hyung SiK
    • The Journal of the Convergence on Culture Technology
    • /
    • v.4 no.3
    • /
    • pp.253-259
    • /
    • 2018
  • Astrigent persimmon fruit resources have been used traditionally to treat different systemic diseases and acclaimed for various biological activities including hair growth. This study investigates the hair restoration efficacy of astrigent persimmon fruit extracts on genetically predisposed to balding pattern Black mice model. Water extract of astrigent persimmon fruit(10 mg/mouse/day) with standardized vehicle formulation, only vehicle and positive control minoxidil (2%) were applied daily until completion of two full hair growth generations. The changing pattern of hair growth were observed through two hair growth generations of C57BL/6 Black mice. The hair existing area and hair length was increased significantly (P > 0.001) in astrigent persimmon fruit treated mice than vehicle-treated control mice. Furthermore, histological assessment revealed that the number of hair follicles did not remarkably increase after astrigent persimmon fruit treatment in compare to control mice. Thus, our data revealed that the topical application of astrigent persimmon fruit may promote hair growth in nude mice by extend the hair existing area and increase hair length which is an indicator of prolong anagen phase.

Ethanol extract of Sinsun-yukza-hwan, a Korean medicinal prescription, promotes hair growth in C57BL/6 mice, an alopecia animal model

  • Kim, Ji Yoon;Kim, Mi Ryeo
    • The Korea Journal of Herbology
    • /
    • v.33 no.3
    • /
    • pp.1-9
    • /
    • 2018
  • Objectives : In Korean medicine, a prescription of Sinsun-yukza-hwan (Shenxian-liuzi-wan, SSY) has been used in clinic for treatment of alopecia via oral. This study was performed to determine transdermal effects of the ethanol extract from SSY on hair growth and -related gene expressions in mice. Methods : We analyzed index compound, 5-hydroxy-methyl-2-furaldehyde (HMF), in SSY extract by ultra performance liquid chromatography (UPLC). 6 weeks old C57BL/6 mice with removed hair were used as an alopecia animal model. Mice were divided into 3 experimental groups including normal (3 water: 1 ethanol: 2 polyethylene glycol mixture as a vehicle), SSY extract and 5% minoxidil (as a positive control), treated groups. SSY was applied topically on the hair-shaved skin of C57BL/6 mice every day for 15 days. The color, thickness and density of hair were monitored every $5^{th}$ day by naked eye, photograph and phototrichogram using folliscope. Also hair growth-associated gene expressions were measured by immunoblotting assay. Results : Hair density of minoxidil or SSY-treated group was significantly increased compared to that of vehicle application on the $15^{th}$ day, respectively. And hair thickness of minoxidil and SSY groups was increased compared to that of vehicle treated group on the $15^{th}$ day, respectively. Induction of insulin-like-growth factor 1(IGF-1) and vascular endothelial growth factor (VEGF) were also significantly accelerated by SSY extract compared to those of vehicle-applied group. Conclusions : These results provide scientific evidence to support the potent multi-application of SSY as a cosmeceutical material for promoting hair growth.

Hair growth Effect of Mori Cortex Radicis extract on Cytarabine-induced alopecia (Cytarabine으로 유도된 탈모증에 대한 상백피 추출물의 육모촉진 효과)

  • 이희삼;문재유
    • YAKHAK HOEJI
    • /
    • v.44 no.1
    • /
    • pp.66-70
    • /
    • 2000
  • This study was designed to examine the effect of Mori cortex radicis extract on cytarabine induced alopecia in young rat. cytarabine (50 mg/kg) was injected to Eight-day-old rats everyday for 7 days. After the injection, Mori cortex radicis extract was spread on the alopecia young rats for 12 days topically. The stimulative effect of hair growth was observed on 12th day of topical application. The stimulative effect of hair growth was best in MeOH extract group. And the same result was obtained in the experiment of hair follicle cross section.

  • PDF

Promoting Effect of a Mixture of 8 Herbal Extracts (SPELA 707) on Hair Growth

  • Choi, Eun-Young;Park, Soo-Nam;Park, Sung-Uk;Choi, Seong-Won;Ro, Byung-In;Chung, Myung-Hee
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.7 no.2
    • /
    • pp.91-96
    • /
    • 2003
  • In Korean folk medicine, several herbs, Glycyrrhizae Radix, Persicae Semen, Salviae Radix, Angelicae Gigantis Radix, Zanthoxyli Fructus, Ginseng Radix Alba, Cnidii Rhizoma, and Carthami Flos, are known to enhance blood circulation and have wound healing or anti-inflammatory effects. These pharmacological actions prompted us to investigate whether these herbs might stimulate hair growth. Thus, using a mixture of their extracts called SPELA 707, we investigated their effects and found that SPELA 707 possessed significant hair cycle converting activity from the telogen phase to the anagen phase in C3H mice. Furthermore, we found that SPELA 707 enhanced the hair density in subjects with hair loss and also promoted the conversion of hair into the anagen phase in subjects with androgenetic alopecia. In addition, hair growth promotion effect of SPELA 707 occurred through inhibition of steroid $5{\alpha}$-reductase activity, which is known to block hair growth. Taken together, these results suggest that SPELA 707 has a potential to be used for the treatment of hair loss.

Hair Growth Promotion with Black Soybean Extracts: case series

  • Sung, Ho-young;Kim, Kyeong Han
    • Journal of Pharmacopuncture
    • /
    • v.25 no.1
    • /
    • pp.63-67
    • /
    • 2022
  • Black soybean (BS) is widely thought to prevent or alleviate hair loss, which has been demonstrated by in vitro experiments. However, few clinical studies have directly assessed the effect of BS on hair growth. To assess the safety and efficacy of BS, we administered BS extract to 10 adult patients for 3 months without any other hair products and treatments. The number and diameter of hair lost from washing were examined every 4 weeks. In addition, the participants' satisfaction with their hair condition was also measured using the VAS (1 to 10) before and after treatment. The mean number of lost hair was 140.7 (SD 59.4) at baseline and 38.8 (SD 54.4) after 12 weeks, and the diameter of lost hair was 72.4 ㎛ (SD 11.9) at baseline and 80.4 ㎛ (SD 8.8) after 12 weeks, which indicated a statistically significant improvement (p = 0.002, p = 0.022, paired t-test). The satisfaction score was significantly increased from 6.10 (SD 1.2) to 8.2 (SD 1.1) after 12 weeks. These results suggest that BS extract may promote hair growth and prevent hair loss.