• Progress in Medical Physics
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• v.35 no.2
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• pp.36-44
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• 2024

Purpose: This study assessed and compared the dosimetric performance of HyperArc and RapidArc in stereotactic radiosurgery (SRS) for a single brain metastasis. Methods: Twenty patients with intracranial brain metastases, each presenting a distinct target volume, were retrospectively selected. Subsequently, volumetric modulated arc therapy (VMAT) plans were designed using RapidArc (VMAT_RA) and HyperArc (VMAT_HA) for each patient. For planning comparisons, dose-volumetric histogram (DVH) parameters for planning target volumes (PTVs) and normal brain regions were computed across all VMAT plans. Subsequently, their total monitor units (MUs), total beam-on times, and modulation complexity scores for the VMAT (MCS_v) were compared. A statistical test was used to evaluate the dosimetric disparities in the DVH parameters, total MUs, total beam-on times, and MCS_v between the VMAT_HA and VMAT_RA plans. Results: For the PTVs, VMAT_HA presented a higher homogeneity index (HI) than VMAT_RA. Moreover, VMAT_HA presented significantly smaller gradient index (GI) values (P<0.001) than VMAT_RA. Thus, VMAT_HA demonstrated better performance in the DVH parameters for the PTV than VMAT_RA. For normal brain tissues, VMAT_HA presented lower volume receiving 50% of the prescription dose and V_2Gy to the normal brain tissues than VMAT_RA (P<0.0001). While the total MUs required for VMAT_HA was significantly higher than those for VMAT_RA, the total beam-on time for VMAT_HA was superior to that for VMAT_RA. Conclusions: Thus, VMAT_HA exhibited superior performance in achieving rapid dose fall-offs (as indicated by the GI) and a higher HI at the PTV compared to VMAT_RA in brain SRS. This advancement positions HyperArc as a significant development in the field of radiation therapy, offering optimized treatment outcomes for brain SRS.

• Korean Journal of Weed Science
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• v.18 no.2
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• pp.171-178
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• 1998

Growth response and acetolactate synthase(ALS) activity were examined to determine the resistance of corn cultivars to primisulfuron when primisulfuron and/ or insecticide Terbufos were applied. Pioneer 3571 IR showed resistance to primisulfuron regardless of Terbufos treatment, but Pioneer 3571 was greatly injured with primisulfuron plus Terbufos treatment. Suwon 118 was relatively tolerant to primisulfuron compared to Chalok 2, but crop injury was occurred at both cultivars by primisulfuron plus Terbufos treatment. ALS activity at Pioneer 3751 IR was very high in primisulfuron and/ or Terbufos treatment. Suwon 118 also showed higher ALS activity compared to Pioneer 3751 and Chalok 2, but ALS activities were greatly decreased by primisulfuron plus Terbufos treatment at Suwon 118 and Chalok 2. The $I_{50}$ concentration for 50% inhibition of the ALS enzyme was 10.0, 0.06, 7.75, and 0.04${\mu}M$ for Pioneer 3751 IR, Pioneer 3751, Suwon 118, and Chalok 2, respectively. Consequently, resistance of corn cultivars to primisulfuron was significantly related to ALS activity. Crop injury and lower ALS activity were recognized in susceptible corn cultivars by primisulfuron plus Terbufos treatment.

• Journal of the Korean Wood Science and Technology
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• v.44 no.5
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• pp.776-784
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• 2016

In this study, green Larix kaempferi lumber was heat-treated by using superheated steam (SHS) at a pilot scale and then various physico-mechanical properties of the heat-treated wood were evaluated and compared with the properties of conventional hot air (HA) heat-treated wood. Decay resistance of brown rot fungi and compressive strength parallel to the grain of the SHS heat-treated wood without occurrence of drying check from green lumber were increased. On the other hand, density, equilibrium moisture content, shrinkage, and bending strength of the SHS heat-treated wood were lower than those of the conventional HA heat-treated wood. Because heat transfer and thermal hydrolysis of SHS heat treatment was accelerated by a large amount of water, the effect of SHS heat treatment on the physico-mechanical properties was higher than that of HA heat treatment at the similar conditions of temperature and time. From the results of this study, because green lumber can be heat-treated without occurrence of cracks or checks by using SHS and similar heat treatment effect on the physico-mechanical properties of wood can be produced despite a low temperature or short time of heat treatment, it is expected that heat time and energy consumption could be reduced by using SHS.

• Korean Journal of Soil Science and Fertilizer
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• v.38 no.4
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• pp.218-221
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• 2005

The present study was investigated in the Chittagong hill forest of Bangladesh to assess the feasibility of ginger cultivation under multipurpose forest and fruit tree species. There were three treatments such as i) ginger grown under open field condition, ie. full sunlight (T1), ii) ginger grown under Gamar tree (spacing of $90{\times}90cm$ (T2) and iii) ginger grown under guava tree (spacing $180{\times}180cm$) tree (T3). The experiment was laid out in randomized block design (RBD) and each treatment was replicated three times. From data it was observed that some morphological parameters of ginger such as plant height, number of leaves per plant, leaf length and leaf breadth were higher in the treatments T2 and T3 as compared to the treatment T1. A positive and linear relationship was observed between the weight of rhizome and yield of ginger which caused the highest yield of ginger ($23.63Mg\;ha^{-1}$) under guava tree species at partial shaded condition in the T3 treatment ($180{\times}180cm$), whereas the lowest yield ($15.64Mg\;ha^{-1}$) was recorded in the T2 treatment when ginger was cultivated under Gamar tree species at closer spacing ($90{\times}90cm$). Therefore, it was revealed that partial shaded condition favoured the optimum growth and yield of ginger, whereas the dense shade from intensively planted tree species badly affected the dry matter production and yield of ginger.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.3
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• pp.141-154
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• 2015

Objective : In this paper, we investigated the anti-oxidative capacities and protective effects of water extract of palmul-tang (PMT) against Ultraviolet B(UVB)-induced oxidative damage in human keratinocytes(HaCaT). Method : To evaluate the anti-oxidative activities of PMT, we measured scavenging activities on 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, hydroxyl radical, hydrogen peroxide, superoxide anion, lipid peroxidation and reducing power of PMT. To give an oxidative stress to HaCaT cells, UVB was irradiated with $40mJ/cm^2$ to HaCaT cells. To detect the protective effects of PMT against UVB, we measured cell viability, apoptotic bodies and reactive oxygen species(ROS) generation. Results : PMT showed the anti-oxidative activities by scavenging DPPH radical, hydroxyl radical, hydrogen peroxide, superoxide anion, lipid peroxidation. Also PMT showed high reducing values. The UVB-induced oxidative conditions led to the cell apoptosis. However, treatment with PMT reduced oxidative stress conditions, including inhibition of cell apoptosis and expression of ROS. Conclusion : PMT had anti-oxidative activities and exhibited protective effects against UVB on HaCaT cells. PMT would be useful for the development of cosmetics treating UVB-induced skin aging.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.5
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• pp.589-593
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• 2016

Propionibacterium acnes infection in skin tissue often causes acne vulgaris, commonly characterized by inflammatory papules, pustules, and nodules. Chitosan and its derivatives possess strong anti-inflammatory effects. In this study, the anti-inflammatory activity of chitosan-phytochemical conjugates on P. acnes-infected human skin keratinocytes (HaCaT) was evaluated. We designed a model of P. acnes-induced inflammation in viable HaCaT cells. Nitric oxide (NO), an inflammatory marker, was successfully elevated by P. acnes infection in HaCaT cells in a dose-dependent manner. Furthermore, the levels of NO were reduced by treatment with chitosan-phytochemical conjugates (chitosan-caffeic acid, -ferulic acid and -sinapic acid) in a dose-dependent manner. Among these conjugates, chitosan-caffeic acid exhibited the strongest NO suppression in HaCaT cells infected with P. acnes. The results obtained in this study suggest that chitosan-phytochemical conjugates could be used as a potential therapeutic agent against acne vulgaris.

• Korean Journal of Materials Research
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• v.17 no.8
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• pp.408-413
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• 2007

Process of the hydroxyapapite(HA) precipitation on bioactive titanium metal prepared by NaOH in a modified-simulated body fluid(mSBF) was investigated by high resolution transmission electron microscope (HRTEM) attached with energy dispersive X-ray spectrometer(EDX). The amorphous titanate phase on titanium surface is form by NaOH treatment and an amorphous titanate incorporated calcium and phosphate ions in the liquid to form an amorphous calcium phosphate. With increasing of soaking time in the liquid, the HA particles are observed in amorphous calcium phosphate phase with a Ca/P atomic ratio of I.30. The octacalcium phosphate (OCP) structure is not detected in HRTEM image and electron diffraction pattern. After a long soaking time, the HA particles grow as needle-like shape on titanium surface and a large particle-like aggregates of needle-like substance were observed to form on titanium surface within needle-like shape. A long axis of needle parallels to c-direction of the hexagonal HA structure.

• Journal of radiological science and technology
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• v.47 no.4
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• pp.271-278
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• 2024

This study aimed to evaluate the impact of changes in beam arrangement and arc counts on dosimetric factors in volumetric modulated arc therapy (VMAT) inverse radiation therapy planning for hippocampal-avoidance whole brain radiation therapy (HA-WBRT) by using the Elekta Monaco radiation therapy planning system (RTPs). For coplanar VMAT, both the arc per beam (APB) method and the beam determined arc(BDA) method, which is determined by the number of beams, were applied. For non-coplanar VMAT, the BDA method was utilized, and a total of 9 treatment plans were established by varying the arc counts. All radiation therapy plans met the radiation oncology group (RTOG) 0933 protocol standards, and 14 dosimetric factors were compared and analyzed. The results showed that the BDA-NC VMAT method demonstrated superior performance in terms of planning target volume (PTV) coverage and protection of normal organs, while APB-VMAT was advantageous in terms of hippocampal protection, monitor unit and delivery time. This study is expected to contribute to the efficient establishment of HA-WBRT plans considering the changes in beam arrangement and rotation arc numbers in Monaco RTPs.

• The Journal of Internal Korean Medicine
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• v.18 no.1
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• pp.255-269
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• 1997

This study has been carried out to investigate the cause, pathological mechanism and treatment of CVA in Youmunsachin(儒門事親), written by Changjongjung(張從政) The results were follows : 1. The cause of CVA in Youmunsachin(儒門事親) was quotated from the theory of Naekyung(內經), Guel-eum-pung-mok(厥陰風木) and exogenous wind evil(外感風邪) on weakness of human body. 2. The pathological mechenism of CVA was that flows of Ki(氣) were obstructive, or executive heart(心) suppress lung(肺) and weakened lung(金) did not control liver(肝), executive liver brought to Gan-pung-nae-dong(肝風內動), and he thought that onset of CVA was frequent in 3nd, 4th, 9th. 10th, 12th lunar month. 3. In treatment of CVA, Han-to-ha-bub(汗吐不法, sweating vomiting passing stool method to remove evil) was used. His treatment was divided into ten sweating vomiting passing stool method by medication for internal use, one vomiting method by medication for external use and one sweating method by using acupuncture. 4. In treatment of CVA, when emergency time, vomiting and passing stool method were used, and then, method of Yangheulgeopung(養血祛風), Chungeulgeodam(淸熱去痰), Pyorissanghae(表裏雙解), Whalheultonglak(活血通絡) was used. 5. In the form of prescription, he used the form of Hwan, San(丸, 散), and he used toxic agent frequently.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.2
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• pp.109-112
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• 2002

The signal pathways involved in the regulation of AP-1 DNA binding activity in long-term nicotine stimulated bovine adrenal medullary chromaffin (BAMC) cells have not been well characterized. To understand the involvement of second messengers in the regulation of AP-1 DNA binding activity, the present study was designed to define the time-course for inhibition of nicotine-induced responses by cholinergic antagonists, $Ca^{2+}$ and calmodulin (CaM) antagonists, and calcium/calmodulin-dependent protein kinase (CaMK) II inhibitor using electrophoretic mobility shift assay. Nicotine $(10{\mu}M)$ stimulation increased AP-1 DNA binding activity at 24 hr after treatment. Posttreatment with hexamethonium (1 mM) plus atropine $(1{\mu}M)$ (HA), nimodipine $(1{\mu}M),$ or calmidazolium $(1{\mu}M)$ at 0.5, 3, and 6 hr after the nicotine treatment significantly inhibited the AP-1 DNA binding activity increased by long-term nicotine stimulation. However, posttreatment with HA, nimodipine, or calmidazolium at 9 or 12 hr after the nicotine treatment did not affect the nicotine-induced increase of AP-1 DNA binding activity. The pretreatment of BAMC cells with various concentrations of KN-62 inhibited the increase of AP-1 DNA binding activity induced by nicotine in a concentration-dependent manner. KN-62 $(10{\mu}M)$ posttreatment beginning at 0.5, 3, or 6 hr after the nicotine treatment significantly inhibited the increase of AP-1 DNA binding activity. However, KN-62 posttreatment beginning at 9 or 12 hr after the nicotine treatment did not affect the increase of AP-1 DNA binding activity. This study suggested that stimulation (for at least 6 hr) of nicotinic receptors on BAMC cells was necessary for increase of AP-1 DNA binding activity, and activation of $Ca^{2+},$ CaM, and CaMK II up to 6 hr at least seemed to be required for the increase of nicotine-induced AP-1 DNA binding activity.