• Journal of Periodontal and Implant Science
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• 제46권5호
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• pp.337-349
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• 2016

Purpose: The aim of this study was to compare and analyze the peri-implant tissue conditions and prospective clinical outcomes associated with 2 types of hydroxyapatite (HA)-coated implants: (1) fully HA-coated implants and (2) partially HA-coated implants with resorbable blast medium on the coronal portion of the threads. Methods: Forty-four partially edentulous patients were randomly assigned to undergo the placement of 62 HA-coated implants, and were classified as the control group (partially HA-coated, n=30) and the test group (fully HA-coated, n=32). All patients had chronic periodontitis with moderate crestal bone loss around the edentulous area. The stability and clinical outcomes of the implants were evaluated using the primary and secondary implant stability quotient (ISQ), as well as radiographic, mobility, and peri-implant soft tissue assessments around the implants. The Wilcoxon signed-rank test and the Mann-Whitney test were used to evaluate differences between and within the 2 groups, with P values <0.05 considered to indicate statistical significance. Results: The fully HA-coated implants displayed good retention of crestal bone, and insignificant differences were found in annual marginal bone loss between the 2 types of HA-coated implants (P>0.05). No significant differences were found in the survival rate (group I, 100%; group II, 100%) or the success rate (group I, 93.3%; group II, 93.8%). The fully HA-coated implants also did not significantly increase the risk of peri-implantitis (P>0.05). Conclusions: The fully HA-coated implants did not lead to an increased risk of peri-implantitis and showed good retention of the crestal bone, as well as good survival and success rates. Our study suggests that fully HA-coated implants could become a reliable treatment alternative for edentulous posterior sites and are capable of providing good retention of the crestal bone.

• 환경생물
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• 제30권2호
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• pp.121-127
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• 2012

지리산국립공원 산림생태계의 탄소 수지에 관한 기초자료를 확보하기 위해 낙엽활엽수림에 대한 탄소저장량을 추정하였다. 지리산국립공원의 대표 낙엽활엽수림 군락을 중심으로 뱀사골 지구, 중산리 지구, 성삼재 지구로 나누어 조사구 ($30m{\times}30m$, 3지점)를 설치, 식생권과 토양권의 탄소저장량을 추정하였다. 식생권의 탄소량은 $107{\sim}119tC\;ha^{-1}$의 범위로 평균 약 $112tC\;ha^{-1}$ 정도의 양을 축적하고 있다. 또한 토양권의 탄소량은 $64{\sim}77tC\;ha^{-1}$의 범위로 평균 약 $66tC\;ha^{-1}$ 정도의 양을 축적하고 있다. 토양권과 식생권을 포함한 생태계 전체의 탄소저장량은 $167{\sim}184tC\;ha^{-1}$의 범위로 평균 약 $178tC\;ha^{-1}$ 정도의 양을 축적하고 있다. 값의 범위에서 알 수 있듯이 지구별 차이는 크게 나타나지 않았다. 다른 연구 결과와 비교하여 설악산국립공원을 비롯한 강원권 생태계를 제외하고 매우 많은 양의 탄소가 저장되어 있음을 알 수 있다.

• 환경영향평가
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• 제18권1호
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• pp.41-50
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• 2009

Using the "Statistical Yearbooks of Korean forestry", we assessed the uptake of nitrogen and base cations by Korean forest. Combined amount of base cations uptake by forest tress during its growth and that of at the time of harvest reached to 1,034 eq/ha/yr. The base cations uptake in the range of 900 ~ 1,100 eq/ha/yr occupied approximately 48.6% out of total. Coniferous forest in the range of 170 ~ 200 eq/ha/yr was 59.9%, deciduous forest in the range of 430 ~ 530 eq/ha/yr was 42.6%, and mixed forest in the range of 270 ~ 370 eq/ha/yr was 35.7% out of total. Deciduous forest recorded higher uptake rate of nitrogen and base cation than coniferous forest in Korea. Combined amounts of nitrogen uptake by forest tress during growth and that at the time of forest, was 1,108 eq/ha/yr and nitrogen uptake was in the range of 1,000 ~ 1,200 eq/ha/yr, Within Korea, forest with nitrogen uptake in the range of 1,000 ~ 1,200 eq/ha/yr account for 45.7% of the entire country. Locations in the range of 320 ~ 390 eq/ha/yr occupied 43.9% of all coniferous forest while deciduous forest in the range of 470 ~ 570 eq/ha/yr was 40.4% of total deciduous forest. As for mixed forest in the range of 270 ~ 370 eq/ha/yr, it occupied 35.9% of all mixed forest of Korea.

• Korean Journal of Acupuncture
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• 제22권4호
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• pp.91-107
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• 2005

To study the effects of EF(Eriobotryae Folium) herbal acupuncture on asthma, we injected EF-HAS into Jok-samni(ST36) of C57BL/6 mice Objective : The aim of this study was to investigate the effect of EF-HA(herbal acupuncture) at ST36 on ovalbumin-induced asthma in mice Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). Experimental groups were treated with concentrations(1%) of EF-HA at Jok-samni(ST36) for the later 8 weeks(3times/week). Result : 1. The weight and total cells of lung of the mice group treated with EF-HA decreased significantly compared with that of Control group. 2. Total Leukocytes and Eosinophils in BALF of the mice group treated with EF-HA decreased significantly compared with those of Control group. 3. The sticking of collagen on histological analysis of lung sections, the mice group treated with EF-HA decreased significantly compared with those of Control group. 4. The concentration of IgE, IL-4, IL-5 in BALF of the mice group treated with EF-HA decreased significantly compared with those of Control group. 5. The concentration of IL-4, IL-5, IL-13 in Serum of the mice group treated with EF-HA decreased significantly compared with those of Control group. 6. The number of $Gr-1^+/CD11b^+,\;CD3^-/CCR3^+,\;CD4^+,\;CD8^+,\;CD3e^+/CD69^+$ cells in the lungs of the mice group treated with EF-HA decreased significantly compared with those of Control group. 7. The cytokine's manifestation of mRNA of the mice group treated with EF-HA with RT-PCR decreased significantly compared with that of Control group. Conclusion : We conclude that EF-HA is effective on OVA-induced asthma of C57BL/6 mouse.

• 생명과학회지
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• 제23권4호
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• pp.495-500
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• 2013

본 연구에서는 무당벌레 유충으로부터 분리된 항균 펩타이드 유전자의 일부 영역인 HaGF를 이용하여 대식세포의 염증에 미치는 영향을 조사하였다. 세포는 LPS 처리 후 한 시간 뒤에 HaGF를 처리를 하여, 세포 독성이 나타나지 않는 농도인 5, 25, 50, 100 ${\mu}g/ml$을 사용하였다. 그 결과 HaGF가 염증성 cytokine의 생성을 감소시키는 것을 확인 하였으며 iNOS와 COX-2 역시 100 ${\mu}g$/ml의 농도에서 각각 51%, 49% 저해율을 보였다. 따라서, HaGF는 LPS로 유도된 대식세포주인 Raw 264.7 세포에서의 염증 반응 억제 효과를 기대할 수 있었다.

• 대한본초학회지
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• 제28권4호
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• pp.57-62
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• 2013

Objectives : Lonicerae Japonicae Flos (LJF) has been shown anti-oxidant, anti-inflammatory, anti-viral, anti-rheumatoid properties. However, it is still largely unknown whether LJF inhibits skin injury against oxidative stress in human keratinocyte, HaCaT cells. The purpose of this study was to evaluate the protective effects of LJF against hydrogen peroxide($H_2O_2$)-induced oxidative stress in human keratinocytes, HaCaT cells. Methods : To evaluate out the protective effects of LJF on oxidative injury in HaCaT cells, an oxidative stress model of HaCaT cells was established under a suitable concentration (500 ${\mu}M$) hydrogen peroxide. HaCaT keratinocyte cells were pre-treated with LJF (0.1, 0.25 or 0.5 mg/ml), and then stimulated with $H_2O_2$. Then, the cells were harvested to measure the cell viability, DNA damage, and release of reactive oxygen species (ROS). Results : LJF (0.1, 0.25 or 0.5 mg/ml) itself did not show any significant toxicity in HaCaT cells. The treatment of $H_2O_2$ caused the oxidative stress, leading to the cell death, and DNA injury. However, pretreatment with LJF reduced cell death, and DNA injury. The stimulation of $H_2O_2$ on HaCaT cells resulted in excessive release of ROS, which is the main factor of oxidative stress. The excessive release of ROS was inhibited by LJF treatment significantly. Conclusions : These results could suggest that LJF exhibited the protective effects of HaCaT cells against $H_2O_2$-induced oxidative stress by inhibiting ROS release. It could be explained that LJF inhibit skin damages against oxidative stress. Thus, LJF would be useful for the development of drug or cosmetics treating skin troubles.

• 동의신경정신과학회지
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• 제33권3호
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• pp.259-266
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• 2022

Objectives: The combination of Harm-Avoidance (HA) and Self-Directedness (SD) of Temperament and Character Inventory (TCI) has been reported pivotal for mental health; however its clinical usefulness in integrative medicine has not sufficiently reported. The purpose of this study was to illustrate multi-phasic mental health of subjective satisfaction with life, emotional well-being, and psychopathology, following the HA-SD profile groups. Methods: A total of 527 Korean university students reported HA and SD scores as to render their HA-SD profile, and multi-phasic mental health characteristics using Satisfaction with Life Scale (SWLS), Positive Affect and Negative Affect Schedule (PANAS), and Beck Depression Inventory (BDI) with composite well-being scales of SC (Sum of Self-Directedness and Cooperativeness score) and HI (Happiness Index, subtraction of Negative Affect (NA) score from Positive Affect (PA) score) as standardized. Pearson's correlation was used to report correlation coefficient, and the ANCOVA with age and sex as covariates, to show significant differences in mental health and well-being between the HA-SD profile groups. Results: The HA-SD profile groups showed distinctive multi-phasic mental health characteristics; health related scores of SWLS, PA, SC and HI decreased following the order of hS (low HA and high SD), HS (high HA and high SD), hs (low HA and low SD) and Hs (high HA and low SD) profile groups; however the non-health related scores of NA and BDI showed contrasting order. Conclusions: The HA-SD profile was found to be clinically useful for examining multi-phasic mental health and well-being status, and the TCI may be an imperative personality inventory for integrative medicine.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.312-324
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• 2022

Purpose: The role of hard-type crosslinked hyaluronic acid (HA) with particulate bone substitutes in bone regeneration for combined inlay-onlay grafts has not been fully investigated. We aimed to evaluate the effect of hard-type crosslinked HA used with bone substitute in terms of new bone formation and space maintenance. Methods: A 15-mm-diameter round defect was formed in the calvaria of 30 New Zealand White rabbits. All animals were randomly assigned to 1 of 3 groups: the control group (spontaneous healing without material, n=10), the biphasic calcium phosphate (BCP) graft group (BCP, n=10), and the BCP graft with HA group (BCP/HA, n=10). The animals were evaluated 4 and 12 weeks after surgery. Half of the animals from each group were sacrificed at 4 and 12 weeks after surgery. Samples were evaluated using micro-computed tomography, histology, and histomorphometry. Results: The BCP group showed higher bone volume/tissue volume (BV/TV) values than the control and BCP/HA groups at both 4 and 12 weeks. The BCP and BCP/HA groups showed higher bone surface/tissue volume (BS/TV) values than the control group at both 4 and 12 weeks. The BCP group showed higher BS/TV values than the control and BCP/HA groups at both 4 and 12 weeks. No statistically significant difference in newly formed bone was found among the 3 groups at 4 weeks. The BCP group showed significantly higher new bone formation than the BCP/HA group at 12 weeks. Conclusions: Hard-type crosslinked HA did not show a positive effect on new bone formation and space maintenance. The negative effect of hard-type crosslinked HA may be due to the physical properties of HA that impede osteogenic potential.

• 멤브레인
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• 제33권6호
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• pp.416-426
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• 2023

본 연구에서는 산화 방지 특성이 있는 가리워진 아민기를 함유한 산화 그래핀(hindered amine grafted graphene oxide, HA-GO)을 합성하여 이를 도입한 나피온(Nafion) 기반의 복합 막을 제조한 후 고분자 전해질 막 연료전지 시스템에 응용하였다. HA-GO는 4-아미노-2, 2, 6, 6-테트라메틸-4-피페리딘(4-amino-2, 2, 6, 6-tetramethyl piperidine)에 존재하는 아민기와 GO 표면에 존재하는 에폭시기의 개환 반응을 통해 제조하였으며, 합성된 HA-GO의 함량을 달리한 복합 막을 제조하여 순수 Nafion 막과 성능 특성을 비교하였다. HA-GO가 첨가된 복합 막은 Nafion 단일 막에 비해 기계적 물성, 화학적 안정성 및 수소이온 전도 특성이 향상되었다. 특히 HA-GO의 산화 방지 특성으로 인해 HA-GO가 첨가된 복합 막은 펜톤 평가(Fenton's test) 이후 수소이온 전도도의 유지 특성이 Nafion 단일 막에 비해 큰 폭으로 향상된 것을 확인할 수 있었다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2001년도 가을 학술발표논문집 Vol.28 No.2 (3)
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• pp.433-435
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• 2001

IETF Mobile IP는 이동 컴퓨팅 환경에서 IP 멀티캐스트를 지원하기 위한 메커니즘으로 HA 기반 라우팅과 FA 기반 라우팅을 간략히 언급하고 있다. FA 기반 라우팅의 경우, 단말기 이동 시 멀티캐스트 트리를 재구성하는 오버헤드가 존재하는 단점이 있다. 반면. HA 기반 라우팅의 경우, 단말기 이동시 경로 최적화가 이루어지지 않는 단점에도 불구하고. 멀티캐스트 트리 수정에 대한 오버헤드가 존재하지 않은 장점이 있다. 이러한 장점은 망의 안정성을 놓일 수 있기 때문에 많은 연구에서 HA 기반 라우팅을 채택하고 있다. 하지만, 기존의 HA 기반 라우팅 방법에서 가장 큰 장애 요소는 터널링 집중화 현상이며, 이를 해결하기 위해 Mobile Multicast (MOM) 등에서 정성적인 방법을 제안하고 있지만, 구체적인 프로토콜이 없으며 모든 HA들이 관여하는 복잡도로 인해 실제로 망에 배치되는 데 한계성을 가진다. 본 논문에서는 현재의 Mobile IP 메시지의 간단한 확장과 FA메 멀티캐스팅을 위한 기능을 첨가하여. 터널링 집중화 현상을 해결하는 프로토콜을 제안하고자 한다. 제안되는 프로토콜은 현재의 모든 IP 멀티캐스트를 수용하고, Mobile IP와의 호환성을 유지한다.