• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.269-278
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• 2019

We fabricated glucose oxidase (GOx)-modified biosensor for detection of glucose by physical immobilization of GOx after electrochemical polymerization of the conductive mixture monomers of the 3-thiophenecarboxylic acid (TCA) and thiophene (Th) onto ITO electrode in this study. We confirmed the successfully fabrication of GOx-modified biosensor via FT-IR spectroscopy, SEM, contact angle, and cyclic voltammetry. The fabricated biosensor has the detection limit of $0.1{\mu}M$, the linearity of 0.001-27 mM, and sensitivity of $38.75mAM^{-1}cm^{-2}$, respectively. The fabricated biosensor exhibits high interference effects to dopamine, ascorbic acid, and L-cysteine, respectively. From these results, the fabricated GOx-modified biosensor with long linearity and high sensitivity could be used as glucose sensor in human blood sample.

• Publications of The Korean Astronomical Society
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• v.38 no.2
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• pp.59-73
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• 2023

Since the farside of the moon is a place to avoid artificial radio frequency interference (RFI) created by human civilization, it is a most suitable place for searching technosignature, which are signs of technological civilization in the universe, in the radio band. The RFI is a factor that makes the study of searching technosignature quite complicated because it is difficult to distinguish between technological signals produced by human and extraterrestrial civilizations. In this paper, we review why the farside of the moon is the best place to detect technosignature and also introduce radio observatories on the farside of the moon that have been proposed in radio astronomy. The SETI (Search for Extraterrestrial Intelligence) project on the farside of the moon is expected to be one of the main candidates for international collaboration research topics on lunar surface observatory.

• Annual Conference on Human and Language Technology
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• 2019.10a
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• pp.496-499
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• 2019

스마트폰의 쿼티 자판 소프트 키보드의 버튼과 버튼 사이 좁은 간격으로 인해 사용자가 의도치 않은 간섭 오타가 발생하는 것에 주목하였다. 그리고 오타 교정의 성능은 사용자의 관점에서 얼마나 잘 오타를 교정하느냐도 중요한 부분이지만, 또한 오타가 아닌 어절을 그대로 유지하는 것이 더 중요하게 판단될 수 있다. 왜냐하면 현실적으로 오타인 어절 보다 오타가 아닌 어절이 거의 대부분을 차지하기 때문이다. 따라서 해당 관점에서 교정 방법을 바라보고 연구할 필요가 있다. 이에 맞춰 본 논문에서는 대용량 한국어 말뭉치 데이터를 가지고 확률에 기반한 한국어 간섭 오타 수정 방법에 대해 제안한다. 제안하는 방법은 목표 어절의 좌우 어절 N-gram과 어절 내 좌우 음절 N-gram 정보를 바탕으로 발생할 수 있는 간섭 오타 교정 후보들 중 가운데서 가장 적합한 후보 어절을 선택하는 방법이다.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1067-1072
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• 2013

Hiwi, a human homologue of the Piwi family, plays an important role in stem cell self-renewal and is overexpressed in various human tumors. This study aimed to determine whether an RNA interference-based strategy to suppress Hiwi expression could inhibit tumor growth in a xenograft mouse model. A rare population of $SSC^{lo}\;Alde^{br}$ cells was isolated and identified as lung cancer stem cells in our previous study. Plasmids containing U6 promoter-driven shRNAs against Hiwi or control plasmids were successfully established. The xenograft tumor model was generated by subcutaneously inoculating with lung cancer stem cell $SSC^{lo}\;Alde^{br}$ cells. After the tumor size reached about 8 mm in diameter, shRNA plasmids were injected into the mice via the tail vein three times a week for two weeks, then xenograft tumor growth was assessed. In nude mice, intravenously delivery of Hiwi shRNA plasmids significantly inhibited tumor growth compared to treatment with control scrambled shRNA plasmids or the vehicle PBS. No mice died during the experiment and no adverse events were observed in mice administered the plasmids. Moreover, delivery of Hiwi shRNA plasmids resulted in a significant suppressed expression of Hiwi and ALDH-1 in xenograft tumor samples, based on immunohistochemical analysis. Thus, shRNA-mediated Hiwi gene silencing in lung cancer stem cells by an effective in vivo gene delivery strategy appeared to be an effective therapeutic approach for lung cancer, and may provide some useful clues for RNAi gene therapy in solid cancers.

• Korean Journal of Food Science and Technology
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• v.53 no.5
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• pp.509-513
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• 2021

Curcumin is known to possess diverse beneficial physiological effects including antioxidant, anti-inflammatory, anti-depressant, anti-microbial, and anti-neoplastic activities, as well as immune-modulating, metabolism-regulating, and neuroprotective effects. However, despite more than 13,000 research papers published during the last ten years regarding the health benefits of curcumin, curcumin has not been introduced in the market as a pharmaceutical agent in any country. Despite the abundance of positive findings, most investigations that tout its health benefits are based on in vitro and in vivo studies that fail to consider the protean chemical behaviors of curcumin, which is known to be a pan-assay interference compound and an invalid metabolic panacea. Therefore, human clinical trials, despite rigorous study design, have been unable to prove specific benefits. This article reviews the pleiotropic properties of curcumin so that they can be balanced against its beneficial effects and suggests potential research avenues to better understand its health benefits.

• International Journal of Computer Science & Network Security
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• v.22 no.6
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• pp.275-287
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• 2022

As a result, for the increasing expansion by the university faculties in the field of postgraduate studies, The Deanship of Graduate Studies at the university has been established in 1430 AH/2009 CE to specifically address the needs of the current and prospective graduate population to supervise postgraduate studies programs in coordination with the concerned faculties. This comes as a result for the university being certain of the importance of providing postgraduate studies opportunities that follow the bachelor's degree to qualify our ambitious youth appropriately. The University offers 72 different Graduate programs, awarding doctoral and master's degrees along with fellowships and diplomas in various disciplines like health, engineering, science, literary, and educational. Currently, the financial model for admission and students' payment is manual and paper based. This paper proposes to provide a user interface for Financial Management in Deanship of Graduate studies The basic purpose of the system was to minimize human interference and reduce mistakes placed by human interference, also to have efficient and a fast performance, and perform Electronic Data Interchange (EDI) for various tasks such as billing and scheduling details.

• The Korean Journal of Ecology
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• v.24 no.6
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• pp.385-394
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• 2001

An attempt to clarify the landscape structure of urban areas was carried out in the greenbelt around Seoul, Korea's metropolis. By means of aerial photographs and a field survey, a vegetation map including land-use pattern was made. Landscape structure was described by analyzing this vegetation map and the results of phytosociological survey. Landscape element types identified were (1) secondary forest, (2) plantation, (3) cultivated field, (4) urbanized area, (5) graveyard, and (6) bare rock. Vegetation units, resulting from the phytosociological analysis, included Quercus mongolica, Q. variabilis, Q. acutissima, Pinus densiflora, Q. aliena, and Alnus japonica communities. Plantations were composed of Robinia pseudoacacia, Populus tomentiglandulosa, P. rigida, Larix leptolepis, P. koraiensis, and Castanea crenata stands. Patches near to human settlements in the lower zones of the mountains were fragmented and small but they became larger towards the higher mountain zones. On the other hand, the number of patches was fewer and their size was larger in Mt. Cheonggye more distant from the principal residential area, larger in size, and higher in elevation compared with the other 2 mountains, Mt. Daemo and Mt. Acha. Floristic composition of Mongolian oak(Q. mongolica) stand distributing in the upper part of each mountain, in which artificial interference is rare, showed a difference among those study areas different in parent rock and disturbance regime. But that of black locust(R. pseudoacacia) stand located in lowland of mountainous area, in which artificial interference is frequent was similar to each other. As the results of analyses on the frequency distribution of diameter classes of major species, dominant landscape elements, Mongolian oak forest showed different responses depending on artificial interference as continuous maintenance and retrogressive succession in the sites far from and near to the residential areas, respectively. On the other hand, black locust stands showed a probability to be restore to the native oak forest through progressive succession.

• Human Ecology Research
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• v.59 no.3
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• pp.369-386
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• 2021

The purpose of this study was to examine which aspects of coresident intergenerational relationships were associated with the life satisfaction of unmarried children in established adulthood and of their parents. In this study, the coresident relationship characteristics included support exchange, emotion, interference-conflict, and perceptions of coresidence. Data were collected from (a) 250 never-married adults who were 35+ years old and lived in Seoul with at least one parent aged 75 years or younger and (b) 250 older adults who were 75 years old or younger and had at least one unmarried child aged 35+ years living in the same household. Our multiple regression analysis of unmarried children showed that the adult child's financial support, the adult child's psychological reliance on parents, the parent's psychological reliance on the child, and relationship quality were significantly related to higher levels of life satisfaction. In contrast, the parent's daily interference, daily conflicts, and anticipation of future care of parents were related to lower levels of life satisfaction. Second, the characteristics that were positively associated with the parent's life satisfaction were the parent's instrumental support, relationship quality, the coresident child's daily interference, positive perceptions of intergenerational coresidence, and expectation of future care of parents. In contrast, the parent's financial support, daily conflicts with the child, and taking intergenerational coresidence for granted were negatively related to the parent's life satisfaction. This study advances our understanding of coresidence between unmarried children in established adulthood and their older parents by focusing on the multiple aspects of intergenerational coresidence.

• Analytical Science and Technology
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• v.5 no.1
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• pp.51-56
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• 1992

A method to determine the trace level of arsenic in scalp hair by the hydride generation(HG)-inductively coupled plasma(ICP) spectrometry is described. The optimum conditions for the generation of arsine($AsH_3$), and the interference effects from the concomitant ions were studied. Severe interference effect from Ni(II) is circumvented by the coprecipitation of arsenic with $La(OH)_3$. The detection limit of arsenic is 0.3ppm and the arsenic contents in scalp hair ranged 10~20ppb.

• BMB Reports
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• v.41 no.4
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• pp.294-299
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• 2008

Elevated expression of SMYD3 is a frequent genetic abnormality in several malignancies. Few studies knocking down SMYD3 expression in cervical carcinoma cells have been performed to date. In this paper, we established an inducible short hairpin RNA expression system to examine its role in maintaining the malignant phenotype of HeLa cells. After being induced by doxycycline, SMYD3 mRNA and protein expression were both reduced, and significant reductions in cell proliferation, colony formation and migration/invasion activity were observed in the SMYD3-silenced HeLa cells. The percentage of cells in sub-G1 was elevated and DNA ladder formation could be detected, indicating potent induction of apoptosis by SMYD3 knockdown. These findings imply that SMYD3 plays crucial roles in HeLa cell proliferation and migration/invasion, and that it may be a useful therapeutic target in human cervical carcinomas.