• BMB Reports
• /
• 제43권12호
• /
• pp.795-800
• /
• 2010

Huntingtin-interacting protein 1-related (HIP1r) is known to function in clathrin-mediated endocytosis and regulation of the actin cytoskeleton, which occurs continuously in non-dividing cells. This study reports a new function for HIP1r in mitosis. Green fluorescent protein-fused HIP1r localizes to the mitotic spindles. Depletion of HIP1r by RNA interference induces misalignment of chromosomes and prolonged mitosis, which is associated with decreased proliferation of HIP1r-deficeint cells. Chromosome misalignment leads to missegregation and ultimately production of multinucleated cells. Depletion of HIP1r causes persistent activation of the spindle checkpoint in misaligned chromosomes. These findings suggest that HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes. This finding may provide new insights that improve the understanding of various human diseases involving HIP1r as well as its fusion genes.

• Mycobiology
• /
• 제44권2호
• /
• pp.67-78
• /
• 2016

Rice contaminated with fungal species during storage is not only of poor quality and low economic value, but may also have harmful effects on human and animal health. The predominant fungal species isolated from rice grains during storage belong to the genera Aspergillus and Penicillium. Some of these fungal species produce mycotoxins; they are responsible for adverse health effects in humans and animals, particularly Aspergillus flavus, which produces the extremely carcinogenic aflatoxins. Not surprisingly, there have been numerous attempts to devise safety procedure for the control of such harmful fungi and production of mycotoxins, including aflatoxins. This review provides information about fungal and mycotoxin contamination of stored rice grains, and microbe-based (biological) strategies to control grain fungi and mycotoxins. The latter will include information regarding attempts undertaken for mycotoxin (especially aflatoxin) bio-detoxification and microbial interference with the aflatoxin-biosynthetic pathway in the toxin-producing fungi.

• Archives of Pharmacal Research
• /
• 제22권4호
• /
• pp.348-353
• /
• 1999

Possible antiinflammatory effect of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-$\alpha$ production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. the compound significantly inhibited TNF-$\alpha$, production by lipopolysaccaride (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-$\alpha$ production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.

• 대한산업공학회지
• /
• 제19권4호
• /
• pp.23-40
• /
• 1993

In this paper, we developed a prototype part recognition system for FMS (Flexible Manufacturing System) by comparing the features extracted from CAD data and the features obtained from the image through a single camera, Good or distinct features with high recognition efficiency for a specific part are obtained automatically and intelligently according to the rules from CAD data. Since the selection of distinct features are done automatically without any human interference, the developed system seems to be quite robust. Fourther, since it uses only a few distinct features on-line among many features and all the time-consuming calculations are done off-line, it is possible to recognize each part quickly and accurately. In order to evaluate the performance and the effectiveness of the developed system, two example(L and T shaped parts) are tested and the results are reported.

• Genomics & Informatics
• /
• 제12권4호
• /
• pp.261-267
• /
• 2014

MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.

• 한국위성정보통신학회논문지
• /
• 제8권2호
• /
• pp.44-49
• /
• 2013

LED 통신은 LED(Light Emitting Diode)에서 나오는 가시광선을 이용해 정보를 전송하는 무선통신기술로 RF(Radio Frequency) 통신의 문제점인 주파수 할당, 인체 내 유해성, 보안의 취약성, 전자기기 간 간섭 등을 극복할 수 있는 기술이다. LED를 이용하여 조명과 통신을 동시에 사용할 수 있는 융합 기술로 유비쿼터스 환경에 적합하다. 본 논문에서는 LED, PD(Photodiode) 및 MCU(Micro Controller Unit)를 이용한 LED 통신 시스템의 데이터 전송 알고리즘을 개발하였고 구현하는 과정을 소개한다.

• 한국소음진동공학회논문집
• /
• 제21권7호
• /
• pp.650-656
• /
• 2011

The noise inside a naval vessel is very important in considering the need for hearing protection, improving the working environment and maintaining good communications for crews living on board a naval vessel. The indoor noise of a ship usually is specified by the A-weighted sound pressure level, but other evaluating parameters are required to reflect human senses more effectively. This paper uses additional noise indices related to room acoustics, such as NR(noise rating), NC(noise criterion), RC(room criterion), PSIL(preferred speech interference level) and loudness level to evaluate the noise inside cabins on a naval vessel. Using these psychological noise indices, allowable limit of noise level in cabins is suggested through psycho-acoustic evaluation for the noise in cabins.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2001년도 추계학술대회논문집 II
• /
• pp.1335-1340
• /
• 2001

The information technology brought us many kinds of conveniences to our life, but it also caused social problems such as privacy interference, unexpected personal information leaks, and nose generation by telephonic talks, etc. In this paper, the microphone system of the cellular phone is developed to prevent these problems caused by progress of information technology. The developed system was designed to detect only acoustic signals from a human being in the presence of various kinds of background noises. A windscreen was designed by use of micro-channels to eliminate the popping noise by the wind from the mouth of a speaker and four microphone array and signal processing techniques are applied to reduce background noise. The impact of the developed system was evaluated by experimental tests. The results show that the system can improve the required functions considerably.

• 한국멀티미디어학회논문지
• /
• 제10권9호
• /
• pp.1135-1142
• /
• 2007

전방투사형 인터랙티브 디스플레이에서는 프로젝터의 빔이 사용자의 손이나 몸에도 투사되는 특성으로 인해 보편적 칼라 추져 기법을 통한 맨 손 영역의 검출이 어렵다. 본 논문에서는 원본 영상의 칼라가 카메라 영상으로 포착되기까지 칼라의 변환 관계를 분석하여 결과를 추정함으로써, 기대치와의 차이 영역 계산을 통해 손 영역을 검출하였다. 이 때, 기존 논문의 부정확한 칼라 추정을 보완하기 위해, 프로젝터와 카메라 반응 값의 칼라 채널별 간섭현상 및 투사된 프레임 내부의 밝기 오차를 룩업테이블로 모델링 하고 맨 손 영역에 대해 유동적인 밝기 차 임계치를 적용하여 정확도를 개선하였다.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.424.2-424.2
• /
• 2002

The in vivo release characteristics of rhGH-loaded PLGA microsphere prepared using a double emulsion process from hydrophilic 50:50 poly(D.L-lactide-co-glycolide) (PLGA) polymers were analyzed. This formulation showed particle size of ca 53.1$\mu\textrm{m}$ with high drug incorporation efficiency. To investigate in vivo release kinetics without the interference of formation of antibodies to rhGH in the experimental animals, the animals were immunosuppressed by treatment with Cyclosporin. (omitted)