• Bulletin of the Korean Chemical Society
• /
• 제32권5호
• /
• pp.1692-1696
• /
• 2011

The reactions of 1H-1,2,4-triazole (Htr) with $MX_2$ ($ZnCl_2$ for 1; $CdBr_2$ for 2) resulted in two coordination polymers, [Zn(tr)Cl]$_n$ (1) and $[Cd(Htr)_2Br_2]_n$ (2). The structural analyses indicate that 1 and 2 feature a 2D layer and 1D triple chain, respectively. In 1, neighouring Zn atoms are connected by ${\mu}_3-1$ ${\kappa}N$: 2 ${\kappa}N$: $4{\kappa}N-tr^-$ anionic ligand into 6- and 16-membered rings, further grow into a 2D sheet. Cd atoms in 2 are bonded by two ${\mu}_2-Br^-$ bridges and neutral ${\mu}_2$-1 ${\kappa}N$: 2 ${\kappa}N$-Htr to form a 1D triple chain. The fluorescent characterizations of 1, 2 and the free Htr ligand feature simlilar emission peakes at 444, 446 and 423 nm respectively, which can be assigned to intra-ligand ${\pi}-{\pi}^*$ transition of (H)tr. The energy gaps of 5.90 eV for 1, 5.16 eV for 2, and 5.93 eV for Htr suggest that the compounds behave as insulators.

• Journal of Microbiology and Biotechnology
• /
• 제32권6호
• /
• pp.792-799
• /
• 2022

As a vital problem in reproductive health, recurrent spontaneous abortion (RSA) affects about 1% of women. We performed this study with an aim to explore the molecular mechanism of interleukin-23 (IL-23) and find optimal or effective methods to improve RSA. First, ELISA was applied to evaluate the expressions of IL-23 and its receptor in HTR-8/SVneo cells after IL-23 treatment. CCK-8, TUNEL, wound healing and transwell assays were employed to assess the proliferation, apoptosis, migration and invasion of HTR-8/SVneo cells, respectively. Additionally, the expressions of apoptosis-, migration-, epithelial-mesenchymal transition- (EMT-) and p38 MAPK signaling pathway-related proteins were measured by western blotting. To further investigate the relationship between IL-23 and p38 MAPK signaling pathway, HTR-8/SVneo cells were treated for 1 h with p38 MAPK inhibitor SB239063, followed by a series of cellular experiments on proliferation, apoptosis, migration and invasion, as aforementioned. The results showed that IL-23 and its receptors were greatly elevated in IL-23-treated HTR-8/SVneo cells. Additionally, IL-23 demonstrated suppressive effects on the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells. More importantly, the molecular mechanism of IL-23 was revealed in this study; that is to say, IL-23 inhibited the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells via activating p38 MAPK signaling pathway. In conclusion, IL-23 inhibits trophoblast proliferation, migration, and EMT via activating p38 MAPK signaling pathway, suggesting that IL-23 might be a novel target for the improvement of RSA.

• 대한의생명과학회지
• /
• 제21권4호
• /
• pp.181-187
• /
• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• 대한치과보철학회지
• /
• 제27권1호
• /
• pp.181-192
• /
• 1989

Loss of teeth causes the inevitable reduction of residual ridge. Among the various methods solving this problem, hydroxyapatite proved to be useful for correction of ridge defect and irregularity. The purpose of this study is to evaluate the tissue responses of two types Of hydroxyapatites and resin polymer. Calcitite 2040 (Calcitek Inc.), Interpore 200 (Interpore Int.), and HTR polymer (HTR Sciences) were implanted into the jaw of an adult dog. The procedure was designed to obtain the results of 1 week, 2 week, 4 week, and 12 week-intervals. And after 12 weeks from the first operation day, the dog was sacrificed and evaluated histologically by light microscope. The results were as follows : 1. The mucosa was healed after two weeks. 2. After 1 week, there were acute inflammatory cells, but diminished after 2 weeks and were not seen after 12 weeks. 3. The hydroxyapatites implanted in soft tissues were surrounded by fibrous connective tissue. And some foreign body giant cells were found. 4. Calcitite and Interpore particles implanted subperiosteally were surrounded by newly formed bone after 12 months. And direct contact between bone and particles was noted. 5. The HTR particles implanted in soft tissues were encapsulated by fibrous connective tissues. The sample where the particles contacted directly to bone could not obtained by some probable insufficiencies of surgical technique or care of the animal. And the residue of HTR particles was digested by macrophage.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제29권1호
• /
• pp.63-71
• /
• 2024

Hydrothermal Reaction (HTR) was applied for the stabilization of contaminated soil with heavy metals, and then the test determined the optimal conditions for HTR. After HTR, the concentration of heavy metals in the contaminated soil increased. However, it was observed that the leachability potential significantly decreased as determined by TCLP and SPLP tests. This decrease was attributed to a decline in fractions 1-2 and an increase in fractions 3-4 as revealed by sequential extraction procedure. Due to the mineralogical characteristics of the dredged soil, distinct changes were not evident in the five-stage fraction. Therefore, it is deemed necessary to understand the chemical and mineralogical characteristics of the target soil for HTR application in order to selectively address contaminants. Comparison among operating conditions determined the optimal condition to be at 240℃ for one hour.

• Nuclear Engineering and Technology
• /
• 제41권3호
• /
• pp.307-318
• /
• 2009

KAERI (Korea Atomic Energy Research Institute) has developed the GAMMA+ code for a thermo-fluid and safety analysis of a VHTR (Very High Temperature Gas-Cooled Reactor). A key safety issue of the VHTR design is to demonstrate its inherent safety features for an automatic reactor power trip and power stabilization during an anticipated transient without scram (ATWS) accident such as a loss of forced cooling by a trip of the helium circulator (LOFC) or a reactivity insertion by a control rod withdrawal (CRW). This paper intends to show the ATWS assessment capability of the GAMMA+ code which can simulate the reactor power response by solving the point-kinetic equations with six-group delayed neutrons, by considering the reactivity changes due to the effects of a core temperature variation, xenon transients, and reactivity insertions. The present benchmark calculations are performed by using the safety demonstration experiments of the 10 MW high temperature gas cooled-test module (HTR-10) in China. The calculation results of the power response transients and the solid core temperature behavior are compared with the experimental data of a LOFC ATWS test and two CRW ATWS tests by using a 1mk-control rod and a 5mk-control rod, respectively. The GAMMA+ code predicts the power response transients very well for the LOFC and CRW ATWS tests in HTR-10.

• 한국작물학회지
• /
• 제38권3호
• /
• pp.219-227
• /
• 1993

본 시험은 벼 담수표면직파재배 (이하는 담수직파)에서 가장 문제가 되는 도복발생의 원인을 손이양재배와 비교, 구명하기 위하여 작물시험장 답물포장에서 1991～1992년에 수행되었다. 공시품종은 자포니카인 화정벼를 이용하였고, 벼 재배방법은 침수작파와 손이양으로 하였으며, 질소시비량은 4수준(50,100, 150,200kg/ha)으로 처리하였다. 1. 벼의 지상부생중은 출수후 20일경에 가장 무거웠으며, 그 후 계속 감소되었고, 중심고비율은 성숙기까지 점진적으로 증가되었다. 또 좌절중은 출수후 40일 까지 계속 감소되었으며, 도복지수는 출하후 30～40일 경에 가장 컸다. 2. 손이앙에서는 간장, 지상부 생중, 도복지수는 침수직파에서 보다 현저히 크고, 좌절종은 서로 비슷하였으나 실제 포장도복은 침수직파에서 더 심하였는데 이는 두 재배양식 간에 도복원인이 서로 다르다는 것을 나타낸다. 3. 손이양은 질소 200kg/ha에서 반복형 도복이 있었으나, 침수직파는 질소 150kg/ha 이상에서 뿌리도복이 심하게 발생되었다. 4. 침수직파에서 뿌리도복이 심했던 주된 요인은 벼 뿌리의 천근화 현상 때문인데, 토층표면(0～5cm)의 뿌리분포는 침수직파(65.2%)가 손이앙(51.6%)보다 현저히 많았으나 상층 5～10cm에서는 침수직파(18.5%)가 손이앙(28.0%)보다 적었다. 또 간기부의 매몰깊이가 손이앙은 4.0cm로 깊었으나 침수직파는 1.2cm로 얕기 때문에 등숙의 진전과 더불어 지상부의 무게중심이 높아질 때 침수직파의 경우 뿌리의 식물체 지지력이 양화되어 도복이 쉽게 발생되었다. 5. 침수직파는 손이양에 비하여 단위면적당 수수는 많았으나 수당입수가 적고 도복으로 인하여 등숙비율이 낮았다. 벼 수량은 평균적으로 침수직파는 손이앙의 약 82% 정도였으며, 침수직파의 수량제한요인은 도복으로 인한 낮은 등숙비율이었다.

• 대한조현병학회지
• /
• 제23권2호
• /
• pp.71-77
• /
• 2020

Objectives: Tardive dyskinesia (TD) is a movement disorder that is characterized by hyperkinetic movements. Previous studies have suggested that the serotonergic systems are correlated with TD vulnerability. In this study, the association between a single-nucleotide polymorphism (SNP) of the serotonin 1A receptor gene (HTR1A) rs6295 and TD was investigated. Methods: We investigated whether HTR1A rs6295 SNP is associated with antipsychotic-induced TD in 280 Korean patients with schizophrenia. Patients with schizophrenia having TD (n=105) and those without TD (n=175) were matched for their antipsychotic exposures and other relevant variables. The HTR1A rs6295 SNP was analyzed using polymerase chain reaction (PCR)-based methods. Results: There was no significant difference in the distribution of genotypic (χ²=2.70, p=0.26) and allelic (χ²=1.87, p=0.17) frequencies between the patient groups with TD and without TD. There was no significant difference in total abnormal involuntary movement scale score (F=0.39, p=0.68) among the genotype group either. Conclusion: Although there were no differences in genotypic and allelic frequency between patient groups with and without TD, further studies on association of TD with other SNPs of HTRA1 are needed to understand the pathophysiological mechanism of TD.

• 한국통신학회논문지
• /
• 제30권4A호
• /
• pp.241-249
• /
• 2005

ATM based MPLS(Multiprotocol Label Switching) is discussed for its provisioning QOS commitment capabilities, Traffic engineering and smooth migration for BcN in Korea. At this time, due to the comprehensive nature of ATM protocol, ATM has been adapted as the backbone system for carrying Internet traffic[1,2,3,4]. This paper presents preventive congestion control mechanisms for detecting HTR(Hard-To-Reach) LSP(Label Switched Path) in ATM based MPLS systems. In particular, we have introduced a HTR LSP detection method using network signaling information in an ATM layer. MPLS related studies can cover LSP failures in a physical layer fault, it can not impact network congestion status. Here we will present the research results for introducing HTR LSP detection methods and control mechanisms and this mechanism can be implementing as SOC for high speed processing a packet header. We concluded that it showed faster congestion avoidance abilities with a more reduced system load and maximized the efficiency of network resources by restricting ineffective machine attempts.

• Parasites, Hosts and Diseases
• /
• 제58권4호
• /
• pp.393-402
• /
• 2020

Toxoplasma gondii is an intracellular parasite that causes severe disease when the infection occurs during pregnancy. Adenosine is a purine nucleoside involved in numerous physiological processes; however, the role of adenosine receptors in T. gondii-induced trophoblast cell function has not been investigated until now. The goal of the present study was to evaluate the intracellular signaling pathways regulated by adenosine receptors using a HTR-8/SVneo trophoblast cell model of T. gondii infection. HTR8/SVneo human extravillous trophoblast cells were infected with or without T. gondii and then evaluated for cell morphology, intracellular proliferation of the parasite, adenosine receptor expression, TNF-α production and mitogen-activated protein (MAP) kinase signaling pathways triggered by adenosine A₃ receptor (A₃AR). HTR8/SVneo cells infected with T. gondii exhibited an altered cytoskeletal changes, an increased infection rate and reduced viability in an infection time-dependent manner. T. gondii significantly promoted increased TNF-α production, A₃AR protein levels and p38, ERK1/2 and JNK phosphorylation compared to those observed in uninfected control cells. Moreover, the inhibition of A₃AR by A₃AR siRNA transfection apparently suppressed the T. gondii infection-mediated upregulation of TNF-α, A₃AR production and MAPK activation. In addition, T. gondii-promoted TNF-α secretion was dramatically attenuated by pretreatment with PD098059 or SP600125. These results indicate that A₃AR-mediated activation of ERK1/2 and JNK positively regulates TNF-α secretion in T. gondii-infected HTR8/SVneo cells.