• 생약학회지
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• 제34권2호통권133호
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• pp.132-137
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• 2003

The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated local anaphylaxis. When IJAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. IJAE dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when IJAE was added, significantly was increased, compared with that of normal control. These results indicate that IJAE will beneficial in the treatment of immediate-type allergic reaction.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.142.2-143
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• 2003

We studied the effect of methanol extract of Carpopeltis affinis (CA) on atopic allergic reaction. CA dose-dependently inhibited interleukin (IL)-8 and tumor necrosis factor (TNF)-$\alpha$ secretion from the PMA- plus A23187- stimulated HMC-1. CA also dose-dependently inhibited the histamine and $\beta$-hexosaminidase release from mast cells. CA had no cytotoxic effect. (omitted)

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 하계종합학술대회논문집
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• pp.405-408
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• 1998

Due to the large conduction band discontinuity between emitter base, OmGaAs HBT has an advantge to enable the hot electrons to inject into the base. In this paper, InAlGaAs/InGaAs HBT with the various emitter junction gradings and the modified collectors are simulated and analyzed by HMC(hybrid monte carlo) simulator in order to find a optimal structure for the shortest transit time. A minium base transit time (.tau.$_{b}$ ) of 0.21 ps was obtained for HBT with the grading layer, which is parabolically graded from x=1.0 to x=0.5. The minimum collector transit time (.tau.$_{c}$ ) of 0.31ps was found when the collector was modified by inserting p$^{[-10]}$ and p$^{+}$ layers. Thus HBT in combination with the emitter grading and the modified collector layer showed the cut-off frequency (f$_{T}$) of 183GHz.z.z.

• 생약학회지
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• 제43권2호
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• pp.163-166
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• 2012

In the present study, we investigated the effect of the water extract of Perilla frutescens var. acuta (Labiatae; WEPF) on the mast cell-mediated allergic reactions. WEPF was anally administered to mice for high and fast absorption. WEPF inhibited compound 48/80-induced systemic allergic reaction. WEPF attenuated immunoglobulin E (IgE)-mediated local allergic reaction. In addition, WEPF decreased the gene expression of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. These results indicate that WEPF inhibits mast cell-mediated allergic reactions in vivo and in vitro.

• International Journal of Automotive Technology
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• 제7권2호
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• pp.139-143
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• 2006

As an automobile tends to be high grade, the needs for more luxurious interior and comfortable HVAC system are emerged. The defrosting ability is another major factor of the performances of HVAC system. The present work is to simulate the flow and the temperature field of cabin interior during the defrost mode. The three-dimensional incompressible Navier-Stokes equations and energy equation were solved on the multi blocked grid system by the iterative time marching method and AF scheme, respectively. The present computations were validated by the comparison of the temperature field of a driven cavity and velocity field of 1/5 model scale of an automobile. Generally good agreements were obtained. By the present computation, the complicated features of flow and temperature within the automotive cabin interior could be well understood.

• 한국분무공학회지
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• 제3권1호
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• pp.27-33
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• 1998

Correlations of drop size and velocity in a spray from the disintegration of liquid jet and liquid film from an internal mixing twin-fluid atomizer, were determined by phase Doppler method. The distribution pattern of Sauter mean diameter(SMD) in a spray was changed by a behavior of liquid flow. As smaller droplets became faster and slower easily by the surrounding conditions, the correlation between drop size and mean velocity was found to be varied as next 3 steps; firstly smaller droplets have a higher mean velocity at the area near atomizer, droplets have almost the same mean velocity and finally larger droplets have a higher mean velocity at the area far from an atomizer.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (3)
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• pp.238-240
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• 2004

인간과 컴퓨터와 사물이 유기적으로 연계되어 다양하고 편리한 새로운 서비스를 제공해 주는 유비쿼터스 컴퓨팅 환경에서, 외부 환경의 감지와 제어 기능을 수행하는 센서 네트워크 기술이 최근 활발히 연구가 되고 있다. 이러한 센서 네트워크 기술은 저전력 저가격의 무선 통신 기술, 초소형 마이크로 프로세서 기술, 자동구성 이 가능한 ad-hoc 네트워크 기술, MEMS기술, 다양한 종류의 센서들과 이들의 표준화 노력, 그리고 임베디드 시스템 기술등의 발전으로 실현이 가능한 기술로서 평가되고 있다. 본 논문에서는 무선 센서 노드인 MICA2[1]와 자기장센서 HMC1002[2]를 이용하여 자기장의 변동을 감지하여 자성체의 위치를 파악하는 시스템의 설계 및 구현을 다룬다.

• Natural Product Sciences
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• 제23권1호
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• pp.1-4
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• 2017

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism remain unknown. To explore the mediator and cellular inflammatory response of sinensetin, we examined its influence on phorbol 12-myristate 13-acetate (PMA) plus A23187 induced inflammatory mediator production in a human mast cell line. In this study, interleukin (IL)-6 production was measured using the enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. Sinensetin inhibited PMA plus A23187 induced IL-6 production in a dose-dependent manner as well as IL-4, IL-5 and IL-8 mRNA expression. Furthermore, sinensetin inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation, suggesting that sinensetin inhibits the production of inflammatory mediators by blocking STAT3 phosphorylation. Moreover, sinensetin was found to inhibit nuclear factor kappa B activation. These findings suggest that sinensetin may be involved in the regulation of mast cell-mediated inflammatory responses.

• 대한약침학회지
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• 제11권4호
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• pp.5-14
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• 2008

Objective This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-1). Results The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in $200{\sim}300%$ range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in $0{\sim}33%$ range. Conclusion These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.

• Bulletin of the Korean Chemical Society
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• 제30권8호
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• pp.1811-1816
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• 2009

An extensive phytochemical investigation of the polar fractions of a methanolic extract of Egyptian medicinal food, black cumin (seeds of Nigella sativa L.) led to the isolation of two new triterpene saponins, named sativosides A and B (1-2), along with four known saponins (3-6). Sativoside A (1) is the first example of saponins containing 18-ene triterpene aglycon not only in this Nigella genus but also in the family Ranunculaceae. The structure of the new saponins was elucidated mainly by a combination of 1D and 2D NMR data, together with HRFABMS and acid hydrolysis. Three compounds (1-3) showed the significant inhibition effect of phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced production of IL-6 in a human mast cell (HMC-1) line.