• Journal of the Korea Society for Simulation
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• v.26 no.1
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• pp.1-11
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• 2017

During the past several years the ROK military has made an effort to build LVC synthetic battlefield that reflects the real world environment. In spite of its efforts, little has been accomplished. The disappointing achievement is mainly due to the lack of operational requirements and concepts, and policies or systematic approaches on the architecture and technology. Furthermore, there is insufficient understanding on the basic concepts and principles, and conflicting interests between organizations. In this study, I propose to construct an LVC based on the HLA that focuses on the system view and technical standard view, rather than the operational view. The proposed approach employs the information centric integration, focuses on an architecture convergence efforts based on the HLA/RTI, emphasizes the HLA compliance test and federation test, adapts to DSEEP, DMAO, and FEAT, and finally invents and implements an LVC Compliance Test System.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.79-87
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• 1994

For the purpose of evaluating the human leukocyte antigen(HLA) disease-association with bipolar disorder, HLA class I and class II allelic frequencies were assessed in 37 bipolar patients and were compared to the data from normal population. HLA class 1 typing was performed with microlymphocytotoxicity method while class II(DRB1) genotyping with reverse dot blot hybridization and sandwich method. Statistical analysis consisted of relative risk, Haldane's modified relative risk, Fisher's exact test and Bonferoni's corrected P. The results were as follows : 1) Bipolar patients showed increased allelic frequency of HLA A3 which has statistical significance. 2) Allelic frequencies of HLA B7, B14 and B54 were higher, while those of B51 and B55 were lower in bipolar patients, but they were not statistically significant. 3) Both of increased frequencies of DR2 in bipolar patients and DR15 in normal controls had statistical significance. The results of the present study suggested that some of HLA allelic types might be associated with bipolar disorder. To clarify the genetic influence of HLA to bipolar disorder, we should do consecutive study of bipolar disorder with new information about HLA system including alleles.

• Journal of the military operations research society of Korea
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• v.35 no.1
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• pp.95-103
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• 2009

HLA is the IEEE 1516 standard for the interoperation among heterogeneous simulations and RTI is a technology which provides a lower infrastructure service to interoperation. In this paper, we propose a Object-Oriented federate model architecture to enhance code reusability. It improves an efficiency of the system development process, and results in development time reduction and cost saving. It also is verified its practical effect through acting HLA certification on an software developed proposed architecture.

• Journal of the Korea Society for Simulation
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• v.22 no.2
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• pp.73-83
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• 2013

This paper presents design and implementation of the monitoring system for the distributed simulation of underwater warfare. As importance of defense modeling and simulation(M&S) has raised, Simulation-Based Acquisition(SBA) was authorized for an obligatory process in the development process of weapon systems. Yet, it requires tremendous resources to develop a large-scale simulation system that describes complex and broad battlefields. Therefore, an approach of the distributed system was devised to develop a new simulation system combining legacy simulators that were developed for confined purpose and sole operations. High-Level Architecture(HLA) of distributed systems is a standardized protocol by IEEE for the distributed simulation system and Run-Time Infrastructure(RTI) is an implementation of HLA to structure efficient distributed systems. The main objective of this paper is to derive appropriate monitoring factors for underwater warfare simulation, design and implementation of the monitoring system to analyze the factors based on HLA/RTI.

• IE interfaces
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• v.17 no.1
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• pp.128-141
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• 2004

Although a number of container terminal simulators have been developed for various purposes, none of the existing simulators allow the system structure to reuse the system structure depending on application. Our goal is to develop highly reusable, highly inter-operable and flexible container terminal simulation system. The High Level Architecture(HLA) is an architecture for reuse and inter-operation of simulation. It is based on premise that no simulation can satisfy all use and users. An individual simulation or set of simulations developed for one purpose can be applied to another application under the HLA concept of the federation : a composable set of interacting simulations. The intent of the HLA is a structure which will support reuse of capabilities available in different simulations, ultimately reducing the cost and time required to create a synthetic environment for a new purpose, and the possibility of distributed collaborative development of complex simulation applications. In this paper, we discuss the design of a HLA-based port container terminal simulation system. Furthermore, we describe various technical motivations for HLA, the key elements of the architecture and how they are minimum and essential to the goal of reuse and interoperability.

• IMMUNE NETWORK
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• v.23 no.6
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• pp.44.1-44.16
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• 2023

Mesenchymal stem cells (MSCs) are effective in treating autoimmune diseases and managing various conditions, such as engraftment of allogeneic islets. Additionally, autologous and HLA-matched allogeneic MSCs can aid in the engraftment of human allogeneic kidneys with or without low doses of tacrolimus, respectively. However, HLA alloantigens are problematic because cell therapy uses more HLA-mismatched allogeneic cells than autologous for convenience and standardization. In particular, HLA-mismatched MSCs showed increased Ag-specific T/B cells and reduced viability faster than HLA-matched MSCs. In CRISPR/Cas9-based cell therapy, Cas9 induce T cell activation in the recipient's immune system. Interestingly, despite their immunogenicity being limited to the cells with foreign Ags, the accumulation of HLA alloantigen-sensitized T/B cells may lead to allograft rejection, suggesting that alloantigens may have a greater scope of adverse effects than foreign Ags. To avoid alloantigen recognition, the β2-microglobulin knockout (B2MKO) system, eliminating class-I MHC, was able to avoid rejection by alloreactive CD8 T cells compared to controls. Moreover, universal donor cells in which both B2M and Class II MHC transactivator (CIITA) were knocked out was more effective in avoiding immune rejection than single KO. However, B2MKO and CIITA KO system remain to be controlled and validated for adverse effects such as the development of tumorigenicity due to deficient Ag recognition by CD8 T and CD4 T cells, respectively. Overall, better HLA-matching or depletion of HLA alloantigens prior to cell therapy can reduce repetitive transplantation through the long-term survival of allogeneic cell therapy, which may be especially important for patients seeking allogeneic transplantation.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.324-335
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• 2011

The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and disease associations have been widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. Because recently developed molecular based HLA typing has several advantages like improved specimen stability and increased resolution of HLA types, the association between HLA alleles and a given disease could be more accurately quantified. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, drug responsiveness and other diseases with unknown etiology in Koreans and attempt to summarize some remarkable HLA alleles related with specific diseases.

• Journal of the military operations research society of Korea
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• v.26 no.2
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• pp.101-119
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• 2000

US DoD designated the High LEvel Architecture (HLA) as the standard technical architecture for all military simulation since 1996. HLA will supercede the current Distributed Interactive Simulation(DIS) and Aggregated LEvel Simulation Protocol(ALSP) methods by no funds for developing/modifying non-HLA compliant simulations. The new architecture specifies Rules which define relationships among federation components, an Objects Model Template which species the form which simulation elements are described, and an Interface Specification which describes the way simulations interact during operations. HLA is named as standard architecture in NATO, Australia and many other militaries. Also, it will be IEEE standard in the near future. It goes without saying that ROK military whose simulation models are almost from US must be prepared in areas such as ROK-US combined exercise, training, weapon system acquisition, interface models with C4I system, OPLAN analysis, operations, and os on. In this paper, we propose several effective alternatives and issues for ROK Defense Modeling and Simulation under the transition of new HLA architecture. Those include secure the kernel of new simulation technology and develop our own conceptual model, RTI software, prototype federation for each service and aggregated one. In order to challenge the new simulation architecture effectively, we should innovate our current defense modeling and simulation infrastructure such s manpower, organization, budget, research environment, relationships among academia and industry, and many others.

• Korean Journal of Head & Neck Oncology
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• v.13 no.1
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• pp.16-23
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• 1997

Although normal thyroid epithelial cells do not constitutively express HLA-DR antigen, their expression in wide spread within thyroid glands obtained from the human with autoimmune thyroid disease and with many neoplastic thyroids. We have, therefore, studied immunohistochemically with regard to the expression of HLA-DR antigen of thyroidectomy specimens from 50 patients of various thyroid diseases with use of paraffin-embedded tissue. One or two sections from each case were stained with commercially available mouse monoclonal antibody for class II HLA-DR antigen(HLA-DR/Alpha, DAKO) and examined by semiquantitative counting system for thyrocytes, neoplastic thyrocytes and other cells expressing HLA-DR antigen. All patients with lymphocytic thyroiditis(2/2) and diffuse hyperplasia(Graves' disease)(5/5), most patients with Hashimoto's disease(9/ll) expressed HLA-DR antigens in thyrocyte with abundant HLA-DR expressing lymphocytic infiltrates with lymph follicle formation in its vicinity or adjacent to the lesion. Most patients with papillary carcinoma(9/1l) had HLA-DR antigen detected in malignant thyrocytes ; while follicular carcinoma(0/3) and follicular adenoma(0/5) did not have detactable HLA-DR immunoreactivity. Adenomatous goiter(3/7) had HLA-DR antigen detected focally in lesser than half cases. Conversely, in four papillary carcinomas and three adenomatous goiters, HLA-DR expression of thyrocytes was found in the absence of HLA-DR expressing lymphoid infiltrates. In such cases therefore other factors more than thyroid autoimmunity must be causative for HLA-DR immunoreactivity. The results of this study indicate as follows. 1) The expression of HLA-DR on thyrocytes involved in autoimmune reactions appeared to be secondary to cytokine release from associated lymphocytic infiltrates. 2) Thyrocytes in thyroid lesions with equal degrees of lymphocytic infiltration without HLA­DR expression exhibited no HLA-DR immunoreactivity. 3) In neoplastic thyrocytes, most papillary carcinoma(9/11) exhibited detactable HLA-DR expression, while follicular carcinoma/adenoma(0/3/0/5) exhibited no detactable HLA-DR immunoreactivity which suggest the existence of divergent mechanisms inducing and modulating HLA-DR expression of different types of neoplastic thyrocytes.

• IEMEK Journal of Embedded Systems and Applications
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• v.10 no.6
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• pp.345-352
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• 2015

Recently, by developing many training systems in battle field, the demand for interconnecting and internetworking between Live, Virtual, Constructive training systems has been increased to support efficient data distribution and system control. But, there are lots of problems for them to interwork, because the existing researches only support L-L, V-V, C-C Interoperability. Therefore, we propose L-V-C gateway to provide interoperable simulation environment based on HLA and DDS between them. First, we illustrate FOM Management that parses RPR-FOM XML file to acquire Data information to be shared between them, and generates common data structure and source code used for L-V-C Gateway. L-V-C Gateway created from FOM Management supports Data Conversion and Quality of Service between HLA and DDS. HLA Federate and DDS Domainparticipant in L-V-C Gateway play a role of logical communication channel and relay data from HLA Federation to DDS Domain and vice versa.