• 한방비만학회지
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• 제20권1호
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• pp.31-39
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• 2020

Objectives: Obesity is becoming more popular disease worldwide. Because of the side effects of conventional obesity treatment modality, herbal medicine treatment is becoming more preferred. Gambihwan which including Ephedra sinica Staph is widely used in traditional Korean Medicine practice for obesity treatment. Garcinia cambogia is a kind of health functional food that has body fat reducing effect. Nowadays, ephedra and Garcinia cambogia are often used simultaneously in clinical practice of Korean Medicine. However, the effectiveness and safety of combination therapy in obesity treatment is not well established. Methods: We conducted retrospective observational study to explore effectiveness and safety of combination therapy. We evaluated effect of combined treatment of Gambihwan and Garcinia cambogia on body weight, body mass index, body fat mass, and waist hip ratio reduction. We also assessed safety via liver function test and adverse event. Results: Finally, 23 patients were included. In paired t-test, body weight significantly decreased from 64.50±14.50 kg to 62.94±13.85 kg (P<0.001) and body mass index were also significantly decreased from 24.43±3.79 kg/㎡ to 23.83±3.59 kg/㎡ (P<0.001). Body fat mass was also reduced. Aspartate transaminase and alanine aminotransferase were not significantly increased. There were no drug-induced liver injury and no severe adverse event. Conclusions: In our retrospective review, we found combination therapy of Gambihwan and Garcinia cambogia reduce body weight, body mass index and body fat mass. There were no severe adverse event and drug induced liver injury which indicated safety of combination therapy in obesity treatment.

• 사상체질의학회지
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• 제13권1호
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• pp.35-44
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• 2001

The Clinical Study on the Body Weight Loss of Taeumin Inpatients in Stroke by Sasang Constitutional Medicinal Treatment. Purpose: It has been frequently noted that overweight and obesity have a stronger relationship to hypertension and diabetes mellitus than to the risk of stroke. The purpose of this study is to find out whether Sasang Constitutional Medicinal treatment in the stroke patients of Tae-um-in has an effect on local or general weight loss. Methods: Case-control study was applied. The experiment group is the 24 Taeumin stroke inpatients who were in hospital in Kyung-Hee Oriental Hospital from July 1, 2000 to October 1 and received Sasang Constitutional Medicinal treatment. The control group is the 13 Taeumin stroke inpatients who were in the hospital during the same period but didn't receive Sasang Constitutional Medicinal treatment. In the two groups, body weight, BMI, the skin fold(cm) of triceps, suprailiac, abdominal portion, and thigh and the circumference(cm) of wrist, biceps, triceps, and W/H ratio were compared and studied for three weeks. Results: 1. In the experiment group, there were 8 women and 15 men, 23 in total and in the control group, there were 5 women and 9 men, 14 in total. 2. From two weeks later, there was a significant decrease in the experiment group in weight loss, the ratio of loss, and BMI(p<0.05). 3. Concerned with the change in the skin fold of suprailiac portion, there was a significant decrease in each group(p<0.05). 4. Concerned with the change in the skin fold of Chunchu-Hyel portion(天樞穴), thigh and in the circumference of hip, W/H ratio, there was a significant decrease in the experiment group(p<0.05). 5. Concerned with the change in the value of Lipid Profile, GOT, and GPT, only Glucose(GLU) showed a significant decrease(p<0.05) in the experiment group(p<0.05). As Conclusion, Sasang Constitutional Medicinal treatment in the stroke patients of Tae-um-in has an effect on local or general weight loss.

• 대한의용생체공학회:의공학회지
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• 제24권5호
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• pp.401-410
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• 2003

본 연구에서는 유한요소법을 이용하여 대퇴골 전자간 골절 치료에 대한 다양한 수술기법을 골밀도 변화에 따라 생체역학적으로 분석하여 이를 평가하고자 한다. 이에 구현된 모델들은 압박 고관절 나사만을 이용하여 시술한 모델 (Type I), 삽입된 압박 고관절 나사 주위에 시멘트 영역을 확보한 뒤 골 시멘트로 보강하는 시술을 구현한 모델 (Type II),대학교추가의 골소실이 없이 시멘트를 가압하여 주입하는 시술을 구현한 모델 (TypeIII)의 3가지 형태로 구현하였다. 시술 상황에 따라 골절부위와 삽입물의 경계면 주위에 접촉요소를 사용하기 위해 적절한 마찰계수를 설정하였으며, 골다공증 정도 (Singh Indices, II∼V)에 따라 대퇴골의 물성치를 적절하게 적용시켰다. 각 모델에 있어 골밀도 변화에 따른 수술기법의 차이를 분석하기 위하여 다음과 같은 인자를 분석하였다 : (a) 대퇴골두 내에서의 von Mises 응력 부피비, (b) 대퇴골두 망상골과 인공 삽입물내에서의 최대 von Mises 응력 (PVMS), (c) 대퇴골두 내에서의 최대 von Mises 변형률 (MVMS), (d) 골절 부위와 인공 삽입물 주위에서의 미세운동량. 수술기법 중 Type III가 대퇴골두 내에서 골밀도 변화에 상관없이 가장 낮은 PVMS, MVMS 수치를 보여 가장 효율적인 결과를 나타내었다. 이는 기존 시술법 (Type I,II)에 비해 내고정 실패 가능성이 가장 적을 것으로 예측되었다. 특히, 골밀도가 낮을 때에는 Type III의 수술 효과가 더욱 커지는 것으로 나타났다. 또한, 삽입물 주위에서 미세운동량을 분석한 결과, Type III의 수치가 다른 시술법들의 15∼20%로 나타나 시멘트를 가 압하여 보강하는 시술법이 삽입물 주위의 미세운동을 억제하는데 있어 가장 효과적이다는 것을 증명하는 것이다. 이러한 결과로부터, 압박 고관절 나사를 이용한 대퇴골두 전자간 골절 치료에 있어 골 시멘트를 가압하여 보강하는 방법이 골밀도가 낮은 환자에 있어 인공삽입물의 내고정 및 골유합에 가장 큰 효과를 보일 것으로 사료된다.

• 한국식품영양과학회지
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• 제24권4호
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• pp.510-516
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• 1995

체지방이 30% 이상으로 비만이라 판정되는 20~62세의 지원자들에게 저열량 균형식, 무리하지 않은 유산소 운동 및 개인별 비만의 원인을 교정하고 평생체중을 조절하기 위한 영양상담과 교육을 포함한 행동수정을 통해 5주 동안 비만을 치료하고 성인병과 관련된 위험 요인들의 변화를 살펴보았다. 활동량, 식습관, 식이섭취조사를 실시하여 개인별 비만의 원인을 진단한 후 잘못된 식생활을 교정할 수 있도록 주 3회의 영양상담과 매주 1회의 영양교육을 실시하였다. 식이요법은 1일 1끼의식사와 3회의 조제식이를 통해 열량이 1200kcal 정도가 되고, 양질의 단백질, 비타민, 무기질은 성인 권장량의 100~150% 이상이 되도록 하였다. 식전에 식이섬유와 물을 복용하고 식사 기간은 20분 이상으로 천천히 섭취하도록 하였으며, 투긴음식, 가공식품, 패스트 푸두, 술, 청량음료, 달고 기름진 음식, 짜고 자극적인 음식 등은 제한하였다. 주당 3~5일간 1시간 정도의 가벼운 유산소 체조를 실험대상자 저원이 모여서 실시하였다. 먹은 식품, 활동, 운동, 감정상태, 피로여부 등을 일지로서 기록하게 하여 삼담을 통해 교정하고 관찰하여 긍정적인 내적동기를 갖도록 교육하였다. 비만치료 기간 중 탈락한 수는 총 16명 중 5명 (31.3%)이었으며, 비만도는 대상자의 대부분이 경증이고, 불규칙적인 식사, 빨리 먹는 습관, 과식, 짜게 먹는 습관, 야식, 음주 등의 비만의 원인이 되는 습관들을 가지고 있어 식습관 점수는 개선이 요구된다고 진단되었다. 5주동안의 비만치료로 체중은 평균 4.8kg(주당 0.96kg)이 감량 되었으며, 체지방, body mass index, 허리, 팔, 둔부의 둘레가 유의적으로 감소되었다. 혈압, 공복시의 혈당, 혈액증의 중성지방, 총콜레스테롤, HDL-콜레스테롤은 변화가 없었으나, LDL-콜레스테롤은 유의적으로 감소하였다.

• 대한방사선기술학회지:방사선기술과학
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• 제33권4호
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• pp.369-378
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• 2010

고밀도 물질의 존재에 따른 킬로볼트 및 메가볼트 에너지 전산화 단층촬영(kilovoltage & megavoltagecomputed tomography, KVCT & MVCT) 영상의 아티팩트 차이를 비교하기 위하여 Cheese 팬텀을 사용하여 KVCT와 MVCT로 얻은 영상자료를 통해 밀도변화에 따른 HU값의 변화를 비교하였다. 또한 각 영상의 sinogram 자료를 치료계획 장비에 입력 후 시행하여 치료선량에 변화 여부와 조사면내 계산값과 실측값간의 차이를 r값으로 비교분석하였으며 이에 대한 실제 환자에 적용하여 임상적용에 관한 유용성을 검정하였다. KVCT와 MVCT간에 HU값 차이는 KVCT의 밀도 3.0에서 역치를 보여 변화가 없었으나 MVCT에서는 밀도 5.0 이상도 구별하는 것을 관찰할 수 있었다. 각 방법의 Sinogram 정보를 통해 일반팬텀으로 계산한 결과 r 값이 허용오차인 1보다 낮은 비율은 KVCT와 MVCT에서 각각 94.92%, 93.87%로 큰 차이를 보이지 않았으나 고밀도팬텀을 이용해 아티팩트가 존재하는 자료를 이용한 선량계산의 결과는 KVCT와 MVCT에서 각각 88.25%와 93.77%로 다소 차이를 보였다. MVCT 이용 시에는 아티팩트가 거의 나타나지 않았고 고밀도 물질의 윤곽을 정확히 알 수 있었으며 상대적으로 선량계산의 정확성이 향상되어 척추궁 절제술 후 인공보형물이 삽입된 척추종양과 같이 결정장기와 종양이 인접한 환자에 있어서도 MVCT영상자료를 이용하여 선량 계산 시 보다 정확한 치료계획이 가능하리라 사료된다.

• 한국정밀공학회지
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• 제31권11호
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• pp.1051-1058
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• 2014

In this study, we investigated the improvement effect of obesity by treatment with a developed low frequency electrical stimulation system. Thirty female in their 20's as an experiment subjects divided 3 groups(control, commercialized device, developed device) were treated with electrical stimulation on abdomen for 4 weeks. The body weight, body mass index(BMI), waist-hip ratio(WHR), muscle strength, muscle(transverse abdominis(TrA), internal obliquus abdominis(IO), external obliquus abdominis(EO)), fat thickness and abdominal surface temperature were measured by electromyogram(EMG), ultrasound and digital infrared thermal image(DITI). In the result, the body weight and BMI were decreased. Subcutaneous abdominal fat were significantly reduced after 4 weeks. The muscle strength and TrA muscle thickness was increased 13.2%(p<0.05), and 35.5%, respectively. The fat thickness showed decrease in abdomen (p<0.05). Infrared measurement on abdominal surface temperature as a parameter of improvement in blood circulation was significantly increased(p<0.05). Therefore, the low frequency stimulation showed positive effects on parameters of the obesity improvement.

• 한국임상수의학회지
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• 제24권4호
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• pp.631-635
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• 2007

Luxation of the hip is the most common luxation seen in small animals. Luxations are classified by the direction in which the femoral head lies in relation to the acetabulum and craniodorsal luxations are the most common type. Recommendations for treatment are based on the presence of preexisting disease, the type and duration of luxation and severity of concurrent injuries. In this study modified external skeletal fixation was used for craniodorsal coxofemoral luxation in 5 dogs. Luxated head Joint was reduced and fixator pins were applied into the greater trochanter, the middle point of iliac body and the lateral surface of sacroiliac joint in a closed fashion. Reduction was successful in 4 of the 5 operated limbs. Complications noted in this study included pin tract drainage, pin loosening and secondary fracture at the pin insertion site.

• 한국전문물리치료학회지
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• 제3권1호
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• pp.65-72
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• 1996

The purpose of this study was to introduce rotation-plasty procedure and prosthetic ambulation training. The recent development of chemotherapy and diagnostic facility have permitted the orthopaedic surgeons to try limb saving procedures rather than amputations for the treatment of the malignant bone tumors. If the tumors around the knee joint were treated by mid-thigh amputation or hip disarticulation, it would impose the client with a great handicap for rehabilitation. Rotation-plasty procedure was first done by Borggreve, in 1930 for the congenital short femur. Recently this procedure was used a malignant bone tumor at the distal femur by Kotz and Salzer in 1982. In spite of its cosmetic problem of the distal stump, this procedure has the great functional advantage of converting the above-knee amputation to the below-knee amputation. The inverted foot was also good to control the prosthesis as a below-knee stump and heel functioned as a patella to support the body weight. This 15 years old girl case was had rotation-plasty due to osteosarcoma of the distal femur with 3rd postoperative chemotherapy, and admitted to Yonsei rehabilitation hospital for prosthetic ambulation training. Then, the case had excellent functional results of prosthetic ambulation training with rotaion-plasty after 3 months.

• Biomolecules & Therapeutics
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• 제13권4호
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• pp.227-231
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• 2005

The estrogen receptor (ER) is activated and degraded by estrogen. We have examined ER downregulation and activation under hypoxia mimetic conditions. Cobalt chloride induced ER downregulation at 24 h of treatment. This degradation involved hypoxia-inducible factor-1$\alpha$ (HIF-1$\alpha$) as examined by using a constitutively active form of HIF-1$\alpha$, HIF-1$\alpha$/VP16, constructed by replacing the transactivation domain of HIF-1$\alpha$ with that of VP16. Western blot analysis revealed that E2-induced ER downregulation was observed within ${\~}6h$, whereas HIF-1$\alpha$/VP16-induced ER degradation was observed within 12${\~}$20h. HIF-1$\alpha$/VP16 activated the transcription of estrogen-responsive reporter gene in the absence of estrogen. These results suggest that ER downregulation and activation under hypoxia maybe mediated in part by a HIP-1$\alpha$ expression.

• Journal of Trauma and Injury
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• 제24권2호
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• pp.159-163
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• 2011

Massive bleeding due to traumatic pelvic bone fracture is a leading cause of death. Thus, several methods to control bleeding have been attempted, but none of these has yet been clearly established. After an automobile accident, a 34-year-old motorist was admitted to the Emergency Department for right hip,leg and abdominal pain. Because the patient's pressure remained consistently low and pelvic bone fracture and abdominal bleeding were found on radiologic examination, an explorative laparotomy was performed. After pelvic packing and bleeding control, bleeding still continued, so Angiography was performed, and arterial embolization for bleeding was performed.