• 생약학회지
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• 제44권1호
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• pp.22-29
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• 2013

This study was to investigate the quality of commercial Hwangryunhaedok-tang (Hwanglianjiedu-tang, HHT) extractive granules by comparing with HHT decoction. The contents of index components and the anti-inflammatory and antioxidative abilities of two different commercial HHT granules (HHT-2 and HHT-3) were compared with those of the HHT decoction (HHT-1). The contents were analyzed with HPLC. The anti-inflammatory effects were determined by measuring NO, $PGE_2$ and IL-6 in RAW 264.7 cell. We compared the anti-oxidative effects through ABTS radical scavenging activities. The range of contents of 7 ingredients was 0.42-36.54 mg/g in HHT-1, not detected-12.30 mg/g in HHT-2, not detected-18.79 mg/g in HHT-3. Although HHT-1, HHT-2, HHT-3 had the inhibitory effects on the production of NO, $PGE_2$ and the scavenging activities on ABTS, HHT-1 showed stronger effects than HHT-2, HHT-3 (HHT-1 > HHT-3 > HHT-2). HHT-1 inhibited the production of IL-6, while HHT-2, HHT-3 showed no inhibitory effects. It is necessary to find appropriate methods for extracting HHT and to establish standardized processes, in order to improve the quality of commercial traditional herbal formula.

• 한국자원식물학회지
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• 제23권2호
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• pp.172-178
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• 2010

천연집단에 서식하는 개비자나무 개체들을 이용해 무생물 및 생물적 환경인자가homoharringtonine(HHT) 함량에 미치는 영향을 조사하여 향후 항암제 가능성이 있는 HHT의 고부가가치 산업적인 생산이 기대되는 연구에 기초자료를 제공하고자 본 연구를 수행하였다. 무생물적 환경인자(토양습도, 토양pH, 서식밀도, 기온)와 HHT 함량과의 상관관계에 있어 HHT 는 토양습도(0.77)와 토양pH(-0.68)에서 높은 상관을 보였다. 고도에 따른 무생물적 환경인자 (토양습도, 토양pH)와 HHT 의 함량 관계에 관해 다중회귀 분석을 실시한 결과, 토양 습도의 회귀계수($26.48^{***}$) 만 유의하여 토양 습도가 상대적으로 HHT 함량에 높은 영향을 미치는 것으로 나타났다. 생물적 환경인자(damage index)에 따른 HHT 함량에 미치는 영향을 살펴 본 결과, HHT는 2차곡선회귀적으로 증가하다 감소하는($H=278.23+1242D-398.87D^2$) 경향을 보였고 damage index는 HHT 함량에 높은 영향을 미치는 것으로 분석되었다. 마지막으로 HHT 의 함량에 영향을 미치는 최적환경인자를 분석한 결과, damage index와 토양 습도 모두가 2차다항회귀식으로 가장 적합하였고 결정계수는 각각 0.73와 0.67로 damage index가 상대적으로 HHT 함량에 높은 영향을 미치는 것으로 나타났다. 이는 섭식자 또는 균류와 같은 스트레스로 인한 방어기작이 HHT 의 생성에 높은 영향을 미치는 것으로 판단된다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2012년도 제38회 춘계학술대회논문집
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• pp.555-561
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• 2012

Empirical Mode Decomposition(EMD)을 통한 Hilbert Huang Transform(HHT)은 시간-주파수 영역분석 방법 중 하나로 기존의 다른 분석 방법에 비해 비선형, 비정상 신호를 해석 가능하다는 등 여러가지 이점이 있다. 그러나 인접한 주파수를 분별하기 힘들고 잡음에 취약하다는 결점이 있다고 알려져 있다. 본 논문에서는 HHT와 정상신호 분석에 효과적인 Short-Time Fourier Transform(STFT)을 비교하여 각 방법의 장 단점을 분석하고 Rijke 튜브 실험에서 얻은 열음향학적 불안정 데이터에 적용하여 잡음에 취약한 점을 보완한 Improved HHT와 비교한다. 그 결과, EMD를 이용한 Original HHT보다 EEMD를 이용한 Improved HHT가 잡음의 영향을 적게 받아 보다 정확한 신호분석이 가능하다는 것을 알 수 있었다.

• 대한한의학방제학회지
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• 제21권1호
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• pp.80-90
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• 2013

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

• Structural Engineering and Mechanics
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• 제14권4호
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• pp.417-434
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• 2002

This paper explores the possibility of using a combination of the empirical mode decomposition (EMD) and the Hilbert transform (HT), termed the Hilbert-Huang transform (HHT) method, to identify the modal damping ratios of the structure with closely spaced modal frequencies. The principle of the HHT method and the procedure of using the HHT method for modal damping ratio identification are briefly introduced first. The dynamic response of a two-degrees-of-freedom (2DOF) system under an impact load is then computed for a wide range of dynamic properties from well-separated modal frequencies to very closely spaced modal frequencies. The natural frequencies and modal damping ratios identified by the HHT method are compared with the theoretical values and those identified using the fast Fourier transform (FFT) method. The results show that the HHT method is superior to the FFT method in the identification of modal damping ratios of the structure with closely spaced modes of vibration. Finally, a 36-storey shear building with a 4-storey light appendage, having closely spaced modal frequencies and subjected to an ambient ground motion, is analyzed. The modal damping ratios identified by the HHT method in conjunction with the random decrement technique (RDT) are much better than those obtained by the FFT method. The HHT method performing in the frequency-time domain seems to be a promising tool for system identification of civil engineering structures.

• 대한본초학회지
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• 제22권1호
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• pp.7-12
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• 2007

Objectives : In Alzheimer's disease(AD), free radical oxidative stress caused by amyloid beta-peptide may lead to DNA damage, neuronal dysfunction, neurotoxicity and cell death, Hwangryunhaedok-tang(HHT) is traditionally used for the treatment of pyrogenetic diseases. To develop a new anti-AD drug from natural herb, HHT was selected and extracted in this study. Methods : The antioxidant activities of HHT water extract powder were examined by hydroxyl radical-induced DNA strand nicking assay, and antioxidative enzymes expression assay in H4IIE cell. In addition, HHT was examined for the inhibitory effect on the acetylcholinesterase(AChE) using by Ellman's coupled assay. Results: The HHT exhibit DNA protective effect in the hydroxyl radical-induced DNA Strand nicking assay, mRNA expression of superoxide dismutase and glutathione peroxidase were recovered at a normal level by HHT treatment in H4IIE cell. Furthermore, water extract of HHT showed inhibitory effect on AChE activity. Conclusion : These results suggest that HHT may be effective in delaying and preventing AD progression related to the free radical-induced DNA damage and AChE activity.

• 한방재활의학과학회지
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• 제29권2호
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• pp.171-188
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• 2019

Objectives The purpose of this thesis is to compare and analyze outcomes of case studies and controlled studies about Hwangryunhaedok-tang (HHT) pharmacopuncture in clinical studies. Based on these studies reporting clinical effects by using HHT pharmacopuncture, we object to deduct the comparative review in applying clinical disorders limitedly. And conclusionally, by using this comparative review, we aim to make the fine evidence in treating clinical specific diseases. Methods We searched 106 studies about HHT pharmacopuncture from 6 Korean web databases by using in Korean word 'Hwangryunhaedok-tang pharmacopuncture'. This search had been progressed throughout 1 month (January, 2019). There was 106 thesis and we excluded studies that are not related to HHT pharmacopuncture, experimental research, not the case report or randomized controlled trials, non-randomized controlled trials, not using HHT pharmacopuncture, not using only one pharmacopuncture, and not using HHT pharmacopuncture for major treating method. As a result, 39 thesis are selected as a population. Results We analyzed 34 case reports and 5 controlled studies. As the final outcome, HHT pharmacopuncture was used in musculoskeletal diseases, dermatopathy, and 32 specific diseases. Conclusions After analyzing 39 studies, effective symptom changes clinically and statistically by using HHT pharmacopuncture herbal acupuncture were identified. However, these thesis designs were reported deficiently in many parts such as not excluding other confounding variables. After modifying defects of thesis design and conduct study, it can play a role as the evidence using HHT pharmacopuncture more precisely.

• 대한한의학방제학회지
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• 제20권2호
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• pp.83-92
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• 2012

본 연구를 통해서, 한(寒) 처방의 대표 처방인 황련해독탕(黃連解毒湯)과 열(熱) 처방의 대표 처방인 건강부자탕(乾薑附子湯) 모두 항염 효능을 확인할 수 있었으나, 그 작용 기전에 있어 뚜렷한 차이를 나타내었다. 이러한 차이는 한의학의 기본 이론인 한열에 대한 개념에 대한 연구의 초석이 될 수 있기를 바라며, 각 개별 약물의 효능 및 다른 처방들과 다른 기전적 실험이 추가적으로 필요할 것을 보인다.

• 한국전자파학회논문지
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• 제23권9호
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• pp.1100-1106
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• 2012

본 논문에서는 시간-주파수 동시 해석 기법 중 하나인 수정된 HHT 기법을 이용하여 회전하는 프로펠러의 날개에서 산란되는 마이크로 도플러 신호를 분석하였다. 프로펠러의 날개 모서리에 산란되는 산란파는 등가전류법(ECM)을 이용하여 구했다. 산란파의 시간 데이터를 얻은 후, 수정된 HHT 기법을 마이크로 도플러 신호의 해석에 적용하였다. 해석 결과는 실제 날개의 동특성에 잘 부합하였으며, 회전체로부터 발생하는 마이크로 도플러의 정편파적인 특성을 보였다. 수정된 HHT를 이용한 시간-주파수 동시 해석은 작은 레이더 단면적 값을 갖는 소형 비행체를 식별하기 위한 명확한 특성을 제공하였다.

• 한방안이비인후피부과학회지
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• 제35권1호
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• pp.48-57
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• 2022

Objectives : The purpose of this review study is to identify clinical indications of Hwangryunhaedok-tang(HHT) external application and to suggest directions for future research and treatment by analyzing domestic cases applying HHT external treatment except for pharmacopuncture research. Methods : We searched 235 studies published in Korean since 2000 from four domestic databases: Oriental Medicine Advanced Searching Integrated System(OASIS), Research Information Sharing Service(RISS), Korean Traditional Knowledge Portal(KTKP), and Korean studies Information Service Systems(KISS) using keywords such as 'HTT and external use', 'HHT and external agent' 'HHT and wet dressing', or 'HHT and case'. We excluded duplicate papers, papers related to acupuncture including pharmacopuncture, or papers not related to the topic. Results : We selected and analyzed seven case reports. HHT external agent was used alone in one case, as main treatment in two cases, and as adjuvant treatment in four cases. HHT external application was applied to various skin diseases accompanied by inflammation mainly in the form of wet dressings. Conclusion : HHT external agent may be effective on various skin diseases accompanied by inflammation when applied alone or in combination with other agents according to the treatment stage. Based on this results, further studies will be needed to establish the primary clinical indication of HHT external agent.