• Journal of Yeungnam Medical Science
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• 제37권1호
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• pp.59-62
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• 2020

Hemoptysis is a major reason for emergency department (ED) visits. Catamenial hemoptysis (CH), a rare condition of thoracic endometriosis, can cause recurrent hemoptysis but is difficult to diagnose in the ED due to the scarcity of cases and nonspecific clinical findings. We report a case of a 26-year-old woman who presented to the ED with recurrent hemoptysis since 2 years without a definite cause. Her vital signs and blood test findings were unremarkable. Chest computed tomography (CT) did not show any specific lesions other than a non-specific ground-glass opacity pattern in her right lung. She was on day 4 of her menstrual cycle and her hemoptysis frequently occurred during menstruation. Although there was no histological confirmation, based on her history of hemoptysis during menstruation and no other cause of the hemoptysis, the patient was tentatively diagnosed with CH and was administered gonadotropin-releasing hormone. She had no recurrence of hemoptysis for 3 months. While CH is difficult to diagnose in the ED, the patient's recurrent hemoptysis related to menstruation was a clue to the presence of CH. Therefore, physicians should determine the relationship between hemoptysis and menstruation for women of childbearing age presenting with repeated hemoptysis without a definite cause.

• 대한가정학회지
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• 제31권1호
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• pp.13-24
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• 1993

The reformed family law was enforced from Jan.1,1991 and the claim to division of matrimonial property in case of divorce, a newly enacted right in the law, is expected to increase the economic position of married women. By this system, married woman can claim her share in the matrimonial property in case of divorce if she verifies her contribution to it. But actually, household work of housewives has not been evaluated properly as compared with their husbands' work in deciding of property division rate, because there is no economic base about the value of household work. So, this study verified wives' role of contribution to matrimonial property and compared their work hours with their husbands. As the result, following suggestions can be presented. 1. The contribution rates of husband and wife to the matrimonial property have to be acknowledged equally and, in case of employed wife, her rate has to be evaluated higher than her husband. 2. Because the property division is not a solatium but a transfer of wife's share, responsibility which marriage has dissolved should not be taken more to women than men. 3. Decision of division rate has to be made regardless the amount fo property unless there are special reasons. 4. The donation tax and inheritance tax should not be imposed on matrimonoal property which was returned to wife from her husband.

• 가정과삶의질연구
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• 제3권1호
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• pp.77-91
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• 1985

This study was carried out to learn about the contents of communication between mother and her adolescents in this country, and possible differences in the contents of communication with demographic variables. In particular, I wanted to find out the following; 1)contents of communication between mother and her adolescents. 2)Contents of communication between parents with adolescents. 3)Possible differences in the contents of communication with differences in the level of education, employment status, and age of mother, family income level, and sex, and birth order of children. To test these hypotheses, I distributed questionnaires to 600 mothers of selected high school juniors(11th grade) in Seoul. Four hundred and fourty-eight questionnaires were returned, and the results were analyzed using frequency distribution, percentage, and x2-test. The results were as following; 1) In general, mothers communicated well with their adolescents, especially in topics related to studying, friends, school, parents and family, and future career. Communication on sex-education or sex-role, however, was rather limited in contents. ool, parents and family. Communication on sex-education or sex-role of adolescent was almost never attempted. This result showed similarity with 1 above. 3) (1) contents of communication and educational level of mother; contents of communication between mother and her adolescents differed significantly with educational level on all topics except parents and family, indicating that the educational level of mother, the more diverse was contents of communication between mother and her adolescents. (2) Contents of communication and employment status of mother: On all topics except sex-education, communication between mother and her adolescents differed significantly between employed and unemployed mothers, indicating that unemployed mothers communicate on greater number of topics with their adolescents than employed mothers do. (3) contents of communication and family income level; Family income level did not affect contents of communication between mother and her adolescents significantly. (4) contents of communication and age of mother; Age of mother did not affect a contents of communication between mother and her adolescents significantly. (5) contents of communication and sex of adolescent; Thee were significant differences in contents of communication on certain topics; On virginity, sex, marriage, and dating, mother communicate more diversely with daughters than with sons. This result certainly reflects the deep-rooted traditional value system among koreans, with permissive attitude toward males, and far more strict attitude toward females, on sex-related matters. (6) Contents of communication and birth order of adolescents; The birth order of adolescents did not affect contents of communication between mother and her adolescents significantly.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4127-4131
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• 2015

Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.

• 수산해양기술연구
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• 제25권2호
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• pp.70-74
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• 1989

실험선 제주 402호의 조종성능을 전속전진중 최대타각으로 전타한 때의 선회권측정과 $10^{\circ}$, 20$^{\circ}$, 30$^{\circ}$Z시험에서 산출된 조종성지수를 분석, 검토한 결과를 요약하면 다음과 같다. 1. 선회종거는 우현선회시가 79.1m로 배의 길이의 약 2.6배였으며, 좌현선회시는 81.4m로서 배의 길이의 약 2.7배였다. 또, 선회경은 배의 길이의 약 2.6배로서 우현선회시가 78.3m로서 좌현선회시 80.4m보다 작았다. 2. 선회권시험시 속력저감율은 0.49였으며, 평균선회각속도는 우현선회시가 4.3$^{\circ}$/sec, 좌현선회시는 4$^{\circ}$/sec이었다. 3. Z시험 결과 over shot angle은 우현전타시가 좌현전타시보다 더 컸으며, 좌우타전타시의 평균값은 $10^{\circ}$Z시험시가 10.5$^{\circ}$, 20$^{\circ}$Z시험시가 20.5$^{\circ}$, 30$^{\circ}$Z시험시가 29.5$^{\circ}$로 다소 큰 편이었다. 4. $10^{\circ}$, 20$^{\circ}$, 30$^{\circ}$Z시험에서 K' 및 T'의 값은 각각 0.755, 0.566, 0.481 및 3.468, 1.621, 1.547로서 대체적으로 선회성은 대각도 전타 일수록 나쁘거나, 추종성은 대각도 전타 일 수 록 좋았다.

• 한국초등과학교육학회지:초등과학교육
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• 제37권4호
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• pp.402-415
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• 2018

This study aims to inquire into the U. S. elementary school teachers' storylines for science teaching methods, scientific knowledge and interactions with students. As research subjects, two American elementary school teachers, named Christina and Melissa, were selected. As test tools, this study adopted Storyline Test and semi-structured interviews. Firstly, in regard to the science teaching method, Christina evaluated that she gradually improved her science teaching skills up to positive 6 points, starting from 2 points in the first year of teaching career, while Melissa sustained a stable state with 5 points in the 9th year of teaching career, starting from 1 point in the first year of teaching career. It was found that both the teachers had more confidence in their science teaching methods by participating in various training programs. Secondly, Christina evaluated her scientific knowledge in the first year of teaching career as 4 points, but evaluated her present scientific knowledge as stable as 6 points since she started studying teaching materials actively, discussing with other teachers and having more ability of application through science class integrated with other school subjects, in the 7th year of her teaching career. On the other hand, Melissa evaluated her scientific knowledge in the first year of teaching career as 1 point since she did not exactly know what to teach elementary school students, but in the 6th year of teaching career, she sustained a stable state with points through joint-activities with other teachers. It was found that chances to research with other teachers had important effect on both the teachers' confidence in scientific knowledge. Thirdly, in regard to interactions with students in science class, Christina said that she did not have any interaction with students when instructing inquiry activities in the first year of teaching career, but since the 10th year of her teaching career, she had sustained a stable state with 6 points through active interaction with students, by leading learning projects and science competitive exhibitions, etc. On the other hand, Melissa evaluated her interaction with students in the first year of teaching career as 1 point because her class was reading-oriented, but since the 9th year of teaching career, she had sustained a stable state with 6 points so far, by developing inquiry activity strategies to improve interaction with students. Overall, it was found that inquiry activities played a central role in improving both the teachers' interaction with students.

• Radiation Oncology Journal
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• 제22권4호
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• pp.307-315
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• 2004

목적: 한국인은 젊은 여성 유방암의 비율이 높으며 저자들의 선행 연구에서 HER-2/neu 과발현이 백인에 비해 높았으며 나쁜 예후 인자였다. 이 환자들을 대상으로 COX-2 발현의 비교와 HER-2/neu 과발현의 관계를 비교하고 한국인에서 COX-2의 예후인자로서의 역할을 알아보기 위해 이 연구를 시행하였다. 대상 및 방법: 45세 이하의 한국인 여성 유방암 환자와 같은 나이의 백인 여성 환자 60명의 파라핀 포매조직을 이용하여 COX-2 염색을 시행하였다. COX-2 발현을 판독하고 한국인과 백인의 발현 비율을 비교하였다 그리고 한국인 환자의 추적 검사 결과와 COX-2를 관계를 조사하여 예후인자로서의 역할을 연구하였다. 결과: 판독이 가능한 전체 환자의 COX-2 발현 비율은 $27.6\%$이었으며 한국인은 $37.9\%$37.9%, 백인은 $20.8\%$로 한국인 젊은 여성의 비율이 다소 높았으나 통계적인 유의성은 없었다(p=0.090). 전체 환자의 COX-2 발현과 HER-2/neu 과발현의 상관 관계는 발견하지 못하였지만 에스트로겐 수용체 음성과 COX-2 발현은 통계적으로 유의한 관계가 있었다. (p=0.046) COX-2 양성의 5년 무병 생존율은 $67.9\%$로 COX-2 음성의 $81.6\%$에 비해 낮았으나 통계적인 유의성이 없었다(p=0.3607). 결론: 젊은 여성 유방암 환자에서 한국인과 백인간의 COX-2 발현 비율의 차이는 통계적으로 유의하지 않았으며 HER-2/neu 과발현과의 관련성도 없었으며 예후와의 관련성도 통계적으로 유의하지 않았고 에스트로겐 수용체 음성과의 관련성은 있었다. COX-2 발현과 다른 임상적 병리적 인자와의 관계나 예후인자로서의 역할을 찾기 위해 보다 많은 환자를 대상으로 한 연구가 필요하며 COX-2 발현에 따라 방사선치료가 예후에 미치는 영향에 관한 연구도 필요하다.

• Journal of Preventive Medicine and Public Health
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• 제12권1호
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• pp.38-42
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• 1979

The objectives of this study were to identify the determinants of the 1. Home visiting activities by FHWs 2. Utilization of village Family Health Workers(FHWs) 3. Attitudes towards FHWs 4. Knowledge about FHW's activities] among housewives in the Kang Wha Community Health Project area This study was analysed by using path analysis Exogenous variables were 1. Distance between the housewives' houses and that of their local FHW 2. Duration of work of each FHW as FHW in her village 3. Number of preschool children in the households Endogenous variables were 1. Home visiting frequency to each household by FHW 2. Knowledge about FHW's activities 3. Attitude towards FHWs 4. Utilization of FHW] by the housewives The results were as follows: The shorter the distance between client's and FHW's house, the higher the number of preschool children in the household, and the longer the duration of work of FHW as FHW, the higher is the number of her household visits in a given time span. The more frequently the FHW visits a household and the higher the knowledge about FHW's activities in the household, the more positive is the attitude of the housewives to the FHW and the more frequently she visits and utilizes the FHW on her own initiative.

• 동의신경정신과학회지
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• 제33권4호
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• pp.485-495
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• 2022

The purpose of this study is to report a case of a patient with pattern identification of liver fire flaming upward and metabolic syndrome improved by Korean medicine. The patient felt completely lost. She was treated for headache, insomnia, and metabolic syndrome with Korean medicine and psychotherapy. Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Pattern Identification Tool for Insomnia (PIT-Insomnia), Minnesota multiphasic personality inventory-2 (MMPI-2), and bioelectrical impedance analysis (BIA) were used for assessment. During treatment for six months, the patient stopped taking headache pills. Her blood pressure was stabilized. Her body weight, body fat, body mass index (BMI), and visceral fat decreased significantly. The sum of ISI, PSQI, PIT-insomnia also decreased significantly. Her Ego strength increased in the MMPI-2 supplementary scale. We assume that Korean medicine treatment through acupuncture, herbal medicine, and psychotherapy is effective in treating pattern identification of liver fire flaming upward and metabolic syndrome.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2645-2651
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• 2015

Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2-overexpressing breast cancer, but data about whether activation of PI3K/Akt is associated with poor prognosis and resistance to trastuzumab therapy is controversial. In this study we investigated predictive and prognostic significance of expression of p27, Akt, PTEN and PI3K, which are components of the PI3K/Akt signaling pathway, in HER2-positive metastatic breast cancer (MBC), retrospectively. Materials and Methods: Fifty-four HER2-positive MBC patients who had received first-line trastuzumab-based therapy were recruited for the study group. All of the patient's breast tissue samples were examined for p27 and Akt expression. In addition, twenty-five patients with sufficient amount of tumor tissue were also examined for PTEN and PI3K expression. p27, Akt, PTEN and PI3K were evaluated by immunohistochemistry and their relationship with patient demographic features, tumor characteristics, response to trastuzumab-based treatment and survival outcomes were analyzed. Results: p27, Akt, PTEN and PI3K were positive in 25.9%, 70.4%, 24% and 96% of the cases, respectively. Nomne were significantly associated with response to trastuzumab and time to progression (TTP). A trend toward statistical significance for longer overall survival (OS) was found for PTEN-positive patients (p=0.058); there was no significant relationship between the other immunohistochemical variables and OS. When we analyzed groups regarding co-expression, the PTEN-negative/Akt-negative group had a significantly lower objective response rate (ORR) (20% vs 80%, p=0.023) and the PTEN-negative/p27-negative and PTEN-negative/Akt-negative groups had significantly lower median OS compared to other patients (26.4 months vs 76.1 months, p=0.005 and 25.6 months vs 52.0 months, p=0.007, respectively). Conclusions: p27, Akt, PTEN and PI3K expression is not statistically significantly associated with ORR, TTP and OS, individually. However, the combined evaluation of p27, Akt and PTEN could be helpful to predict the response to trastuzumab-based therapy and prognosis in HER2-positive MBC.