• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6783-6787
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• 2015

Background: Despite consistent pharmacogenetic effects of CYP2D6 on tamoxifen exposure, there is considerable controversy regarding the validity of CYP2D6 as a predictor of tamoxifen outcome. Understanding the current state of evidence in this area and its limitations is important for the care of patients who require endocrine therapy for breast cancer. Materials and Methods: A total of 101 patients with breast cancer who received tamoxifen therapy for at least 3 years, were genotyped for common alleles of the CYP2D6 gene by nested-PCR and restriction fragment length polymorphism PCR. Patients were classified as extensive or poor metabolizers (PM) based on CYP2D6*4 alleles in 3 different groups according to the menopause, Her2-neu status, and stage 3. Results: The mean age of the patients with the disease recurrence was $50.8{\pm}6.4$ and in non recurrent patients was $48.2{\pm}6.8$. In this study 63.3% (n=64) patients were extensive metabolizers and 36.6% (n=37) were poor metabolizers. Sixty four of the 101 patients (63.3%) were Her2-neu positive. For tamoxifen-treated patients, no statistically significant difference in rate of recurrence observed between CYP2D6 metabolic variants in stage 3 and post-menopausal patients. However, there was a significant association between CYP2D6 genotype and recurrence in tamoxifen-treated Her2-neu positive patients. Compared with other women with breast cancer, those with Her2-neu positive breast cancer and extensive metabolizer alleles had a decreased likelihood of recurrence. Conclusions: This study for the first time demonstrated significant effects of CYP2D6 extensive metabolizer alleles on risk of recurrence in Her2-neu positive breast cancer patients receiving adjuvant tamoxifen therapy. Therefore, CYP2D6 metabolism, as measured by genetic variation, can be a predictor of breast cancer outcome in Her2-neu positive women receiving tamoxifen.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9739-9745
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• 2014

Purpose: We aimed to evaluate the effects of hormone receptor, HER2, and epidermal growth factor receptor (EGFR) expression on epithelial ovarian cancer (EOC) prognosis and investigate whether or not phenotypic subtypes might exist. Materials and Methods: The medical records of 82 patients who were diagnosed with EOC between 2003 and 2012 and treated by platinum-based chemotherapy were retrospectively evaluated. Expression of EGFR, oestrogen (ER), progesterone (PR), and cerbB2 (HER2) receptors were assessed immunohistochemically on paraffin-embedded tissues of these patients. Three phenotypic subtypes were defined according to ER, PR, and HER2 expression and associations of these with EGFR expression, clinicopathologic features, platinum sensitivity, and survival were investigated. Results: When we classified EOC patients into three subtypes, 63.4% had hormone receptor positive (HR(+)) (considering breast cancer subtypes, luminal A), 18.3% had triple negative, and 18.3% had HER2(+) disease. EGFR positivity was observed in 37 patients (45.1%) and was significantly more frequent with advanced disease (p=0.013). However, no significant association with other clinicopathologic features and platinum sensitivity was observed. HER2(+) patients had significantly poorer outcomes than HER2(-) counterparts (triple negative and HR positive patients) (p=0.019). Multivariate analysis demonstrated that the strongest risk factor for death was residual disease after primary surgery. Conclusions: Triple negative EOC may not be an aggressive phenotype as in breast cancer. The HER2 positive EOC has more aggressive behaviour compared to triple negative and HR(+) phenotypes. EGFR expression is more frequent in advanced tumours, but is not related with poorer outcome. Additional ovarian cancer molecular subtyping using gene expression analysis may provide more reliable data.

• 수산해양기술연구
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• 제25권3호
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• pp.133-133
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• 1989

부산수산대학 실습선 부산404호(GT: 150ton)의 조종성능을 연구하기 위해 Z 조종시험을 한 결과를 요약하면 다음과 같다. 1. 타각 10°, 20°, 30°Z 시험에서 선회성지수 K'는 각각 0.9359, 0.9781, 0.9108이고, 추종성지수T'는 0.1955, 0.5802, 0.7090으로서 선회성은 타각 20°일때가 추종성은 타각 10°일때가 좋은 것으로 나타나서 대체적으로 대타각을 사용할 때보다도 소타각을 사용하는 것이 조종성이 좋음을 알 수 있었다. 2. Over shoot angle은 타각 10°, 20°, 30°일 때 우현전타했을때는 각각 4.5°, 12°, 21°이었고 좌현전타했을 때는 각각 5.5°, 15°, 23°로서 우현전타했을 때가 좌현전타했을 때보다도 조종성이 조금 양호했다. 3. 타각 10°Z 시험에서 일조작간 항주거리는 배 길이의 8.7배가되어 종성표준거리인 5~11배 이내가 되므로 대체적으로 조종성능이 양호하다고 볼 수 있다.

• 수산해양기술연구
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• 제25권3호
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• pp.125-128
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• 1989

부산수산대학 실습선 부산404호(GT: 150ton)의 조종성능을 연구하기 위해 Z 조종시험을 한 결과를 요약하면 다음과 같다. 1. 타각 $10^{\circ}$, 20$^{\circ}$, 30$^{\circ}$Z 시험에서 선회성지수 K'는 각각 0.9359, 0.9781, 0.9108이고, 추종성지수T'는 0.1955, 0.5802, 0.7090으로서 선회성은 타각 20$^{\circ}$일때가 추종성은 타각 $10^{\circ}$일때가 좋은 것으로 나타나서 대체적으로 대타각을 사용할 때보다도 소타각을 사용하는 것이 조종성이 좋음을 알 수 있었다. 2. Over shoot angle은 타각 $10^{\circ}$, 20$^{\circ}$, 30$^{\circ}$일 때 우현전타했을때는 각각 4.5$^{\circ}$, 12$^{\circ}$, 21$^{\circ}$이었고 좌현전타했을 때는 각각 5.5$^{\circ}$, 15$^{\circ}$, 23$^{\circ}$로서 우현전타했을 때가 좌현전타했을 때보다도 조종성이 조금 양호했다. 3. 타각 $10^{\circ}$Z 시험에서 일조작간 항주거리는 배 길이의 8.7배가되어 종성표준거리인 5~11배 이내가 되므로 대체적으로 조종성능이 양호하다고 볼 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5343-5348
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• 2014

Background: A meta-analysis was performed to examine the benefit/risk ratio for the addition of anti- HER MoAbs to chemotherapy in patients with advanced gastric and gastroesophageal cancer from six randomized phase II/III trials. Materials and Methods: We searched relative trials from Pubmed, EMBASE, Cochrane library databases, China National Knowledge Infrastructure databases, Google Scholar and the NIH ClinicalTrials. Primary outcomes were overall response rate (ORR), progression-free survival (PFS), overall survival (OS). Secondary outcomes were toxicities. All analyses were performed using STATA 12.0. Results: This meta-analysis included six randomized controlled trials (RCTs) with 2, 297 patients and we demonstrated that the anti-HER MoAbs arm did have a positive effect on ORR in the anti-HER MoAbs arm (OR 1.28, 95% CI 1.00-1.64, p=0.01). There was an increasing benefit regarding OS (HR 0.74, 95% CI 0.60-0.88, p<0.05) and PFS (HR 0.72, 95% CI 0.60-0.84, p<0.05) in the anti-HER2 subgroup, but a reduction of OS (HR 1.11, 95% CI 0.87-1.36, p<0.05) and PFS (HR 1.13, 95% CI 0.98 -1.28, P<0.05) in anti-EGFR subgroup. Some grade 3-4 toxicity had a significantly higher incidence in the anti-HER MoAbs arm. There was no significant publication bias for all endpoints. Conclusions: The addition of trstuzumab MoAb to chemotherapy for gastric and gastroesophageal cancer significantly improved outcome of OS and PFS endpoints, while other MoAbs led to no improvement in results. Some adverse events were increased in anti-HER MoAbs arm compared with the control.

• 심성연구
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• 제26권1호
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• pp.1-35
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• 2011

프리다칼로는 그녀의 생애에서 143개의 작품을 남겼는데 그 중 55개가 자화상이다. 그녀는 자신의 삶에서 많은 시간을 그림을 그리는 것에 몰두하였고, 자신을 그림에 넣어서 표현하였다. 작가의 예술과 창조적 작품은 작가의 무의식의 표현 과정이다. 일련의 작품들은 그의 개인 무의식적 내용을 표현하지만, 어떤것들은 집단적 그리고 원형적 무의식이 표출된다. 이러한 작품들은 그들의 마음에 일련의 인상적인 이미지를 주며, 아직 알지 못한 정동에 충격적으로 자극한다. 예술가는 이러한 과정에서 자신의 작품과 스스로 대화할 수 있다. 이렇게 산출된 상징적 이미지는 예술가의 의식과 조화를 추구한다. 이 연구는 분석심리학적 관점에서 프리다 칼로의 사실적인 자화상 네 개를 해석함으로서 그녀의 심리적 변화과정을 검토하였다. 이 네 개의 작품은 그녀의 삶에서 가장 절박한 순간에 표출된 것들이다. 우리는 이 작품들이 어떠한 목적을 가지고 있는지를 알아보고자 하였다. 본 연구를 통하여 다음과 같은 결론을 내릴 수 있었다. 1) 그녀의 자화상은 그녀의 개인적인 삶과 개인무의식 뿐만 아니라 집단적 무의식의 요소들이 포함되어있다. 2) 그녀는 자신의 충격적인 변환의 사건들을 자화상에 표현함으로서 심리적치유를 경험하였다. 3) 그녀의 자화상들은 그녀가 격은 창조적 변환과정의 표현이다.

• 가족자원경영과 정책
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• 제1권2호
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• pp.1-15
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• 1997

The purpose of this study is to investigate (1)the level of the urban housewives’behavior and satisfaction of wedding, (2)the influential factors related to the two dependent variables above mentioned. So that provides some fundamental materials to improve the level of sound wedding culture and the whole home living. The subjects were 356 housewives, in April, 1997, Seoul. The data obtained were analyzed by Mean, Pearson’s correlation, Stepwise Multiple Regression and Path Analysis. The major findings were as follows: 1) The general tendency of the housewives’wedding behavior and satisfaction was reasonable. 2) According to the background variables(ie: marital form, the existence of job, the recognition degree of her husband’s family’s living standards, the recognition degree of her parents’home’s living standards, the perception of marital transactions), the housewives’wedding behavior was significantly different. 3) According to (1)the background variables(ie: communication frequency in household, self-acceptance, the adequacy of household income, educational level), (2)intermediated variable(ie: articles essential to a marriage), the housewives’wedding satisfaction was significantly different. 4) The indirect variable of the positive influence for housewives’satisfaction of wedding was marital form, the existence of job. the indirect variable of the negative influence for housewives’satisfaction of wedding was the recognition degree of her husband’s family’s living standards, the recognition degree of her parents’home’s living standards, the perception of marital transfactions.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10505-10508
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• 2015

Background: Breast cancer is an important cause of death among women. One way of classifying different forms of breast cancer is by molecular features, usually in terms of the four subtypes: luminal A, luminal B, HER2-enriched, and triple negative. Objectives: This study aimed to investigate the association between molecular subtypes and survival among breast cancer patients treated with radiotherapy. Materials and Methods: A retrospective cohort study was conducted. The subjects were 272 breast cancer patients who had received treatment in the radiotherapy unit at Srinagarind Hospital, Thailand, between 1 January, 1999, and 31 May, 2009. The end of the study was 1 June, 2014. Overall survival was defined as the time elapsing between initial registration at the radiotherapy unit and death or the end of the study. Survival curves were estimated by the Kaplan-Meier method, and a multivariate analysis was performed using Cox's proportional hazard regression model. Results: The patient mean age was $47.5{\pm}10.4$ at the time of diagnosis. Of the 272 patients, 146 (53.7%) were classified as luminal A, 12 (4.4%) as luminal B, 30 (11.0%) as HER2-enriched, and 84 (30.9%) as triple negative. The overall survival rates at 1, 3 and 5 years were 87.1%, 68.4% and 59.2%, respectively. According to molecular subtypes, HER2-enriched patients had the lowest 5-year survival rate (30.0 %, 95%CI: 15.02-46.55). The median follow-up time was 8.37 years. In the Cox model analysis a higher risk of death was found for patients with HER2-enriched ($HR_{adj}=3.34$, 95%CI:1.96-5.67), triple negative ($HR_{adj}=2.17$, 95%CI: 1.44-3.27), and stage IIlB ($HR_{adj}=2.20$, 95%CI: 1.16-4.17) cancers. Conclusions: The worst survival rates were among patients classified as HER2-enriched, triple negative and at stage IIIB. Early detection and an advanced treatment modality are needed to help these patients.

• 가정과삶의질연구
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• 제15권1호
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• pp.111-128
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• 1997

This study mainly deals with the housewife's value orientation home management strategy and home management satisfaction,. The major results are as follows; 1) The degree of communication and communication frequency in household prove the predictable variables to influence the housewife's value orientation home management strategy and home management satisfaction. 2) Among the value orientation fate control orientation predicts home management strategy. 3) Material orientation shows the negative influence on her home management satisfaction. 4) Among home management strategy the fact that household financial management strategy and housework organization strategy are the important variables in the home management satisfaction suggest that household financial management and everyday repeated housework management cause the deep influence on her life satisfaction. 5) The higher her material orientation and gender equilibrium orientation are the higher housework socialization stra egy frequency is the lower her home management satisfaction is.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4353-4358
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• 2013

Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.