• 복식문화연구
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• 제4권2호
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• pp.219-245
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• 1996

Throughout her life time, Edith Head produced cinema costumes for over one thousand movies. She was the leading cinema costume designer in Hollywood. Since the Academy Awards added the area of costume design to be recognized [during 33 years of her work(1948∼1981)], she was nominated 35 times an awarded eight times. However, there were no significant studies done on her work or accomplishments although she was acknowledged as an ingenue and creative designer who elicited artistic effects by reflect character's images through their costumes. The purpose of the study was focused on revealing Edith Head's life and work as her creations had a great impact in he field of cinema costumes. It was also to emphasize the forceful affect of cinema costumes on fashion and to disclose the powerful influence of cinema costume designers. The method of the study includes reviews of literature, movies for which she created costumes, her own possessions, and fashion magazines as well as her works that were nominated and chosen for the Academy Awards. Edith head's emphasis in costume design was based on a blend of both simplicity and sophistication avoiding excessive exaggeration and transformation in her work. Her work was also realistic and contemporary. She developed a dramatic ambience through an innovative design while preserving the actor's individual character and uniqueness. Through this accept her her work was highly renowned as an art form as it was gaining popularity. She was also a dominant figure who influenced trends in the areas of fashion magazines, uniforms, and public clothing. In the review of her cinema costumes, it was revealed that the styles of cinema costumes can be as quickly adapted by the public as movies are viewed because the cinema costumes are highly projected through a visual channel. Subsequently, a follow up study on the affect of cinema costumes on fashion would be beneficial.

• Journal of Gastric Cancer
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• 제21권2호
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• pp.191-202
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• 2021

Purpose: A near-infrared (NIR) fluorescence imaging is a promising tool for cancer-specific image guided surgery. Human epidermal receptor 2 (HER2) is one of the candidate markers for gastric cancer. In this study, we aimed to synthesize HER2-specific NIR fluorescence probes and evaluate their applicability in cancer-specific image-guided surgeries using an animal model. Materials and Methods: An NIR dye emitting light at 800 nm (IRDye800CW; Li-COR) was conjugated to trastuzumab and an HER2-specific affibody using a click mechanism. HER2 affinity was assessed using surface plasmon resonance. Gastric cancer cell lines (NCI-N87 and SNU-601) were subcutaneously implanted into female BALB/c nu (6-8 weeks old) mice. After intravenous injection of the probes, biodistribution and fluorescence signal intensity were measured using Lumina II (Perkin Elmer) and a laparoscopic NIR camera (InTheSmart). Results: Trastuzumab-IRDye800CW exhibited high affinity for HER2 (K_D=2.093(3) pM). Fluorescence signals in the liver and spleen were the highest at 24 hours post injection, while the signal in HER2-positive tumor cells increased until 72 hours, as assessed using the Lumina II system. The signal corresponding to the tumor was visually identified and clearly differentiated from the liver after 72 hours using a laparoscopic NIR camera. Affibody-IRDye800CW also exhibited high affinity for HER2 (K_D=4.71 nM); however, the signal was not identified in the tumor, probably owing to rapid renal clearance. Conclusions: Trastuzumab-IRDye800CW may be used as a potential NIR probe that can be injected 2-3 days before surgery to obtain high HER2-specific signal and contrast. Affibody-based NIR probes may require modifications to enhance mobilization to the tumor site.

• 대한한방소아과학회지
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• 제15권2호
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• pp.201-208
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• 2001

The somatoform disorder are distinguished by physical symptoms suggesting a medical condition, yet the symptoms are not fully explained by the medical condition, by substance use, or by another mental disorder. This is that an unconscious intrapsychic conflict, wish, or need is converted to a somatic symptom and clinically express various symptoms such as headache, dizziness, nausea, vomiting dyspepsia, diarrhea and constipation, etc. We report a case of somatoform disorder patient, who was 9 years old female and complained of nausea, vomiting and dysdipsia. She had her case diagnosed as somatoform disorder in Yong-dong severance hospital and took anti-depressant (chlomipramine) with counseling for 2 months. After treatment, her emotional instability and depression were improved, yet the somatic symptoms remain same. We diagnosed her case as vomiting induced by deficiency of the stomach(胃虛嘔吐) and administered Bihe-yin(比和飮) to her. After administration of Bihe-yin(比和飮) for one month, her somatic symptoms of nausea, vomiting and dysdipsia were almost disappeared and she got acquired her confidence in school life.

• Journal of Astronomy and Space Sciences
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• 제16권1호
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• pp.21-30
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• 1999

소백산 천문대에서 1997년 2월부터 1998년 3월까지 총 3일 밤 동안 VRI 필터를 가지고 AK Her에 대한 CCD 측광관측을 수행하여 얻은 관측점의 수는 V는 236점, R은 198점, I는 197점이다. 관측 기간 동안 주극심과 부극심 시각을 각각 1개씩 관측하였으며, 우리의 관측자료를 가지고 VRI 광도곡선과 (O-C)도를 만들었다. Wilson-Devinney 방법으로 우리의 광도곡선을 분석한 결과 AK Her는 접촉형 (모드 3)의 경우는 해를 구할 수 없었고, 나머지(모드2, 4, 5)에 대해서는 접촉형에 가까운 분리형 또는 반분리형이라고 할 수 있었다. 우리의 최근자료를 가지고 만든 (O-C)도에서 AK Her 공전주기는 Borkovits & Hegedus의 예상과는 다르게 1990년도 이후 증가하는 변화가 나타났다.

• 한국표면공학회지
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• 제54권4호
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• pp.164-170
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• 2021

Vanadium redox flow batteries (VRFB) have emerged as large-scale energy storage systems (ESS) due to their advantages such as low cross-contamination, long life, and flexible design. However, Hydrogen evolution reaction (HER) in the negative half-cell causes a harmful influence on the performance of the VRFB by consuming current. Moreover, HER hinders V²⁺/V³⁺ redox reaction between electrode and electrolyte by forming a bubble. To address the HER problem, carbon nanotube/graphite felt electrode (CNT/GF) with oxygen functional groups was synthesized through the hydrothermal method in the H₂SO₄ + HNO₃ (3:1) mixed acid solution. These oxygen functional groups on the CNT/GF succeed in suppressing the HER and improving charge transfer for V²⁺/V³⁺ redox reaction. As a result, the oxygen functional group applied electrode exhibited a low overpotential of 0.395 V for V²⁺/V³⁺ redox reaction. Hence, this work could offer a new strategy to design and synthesize effective electrodes for HER suppression and improving the energy density of VRFB.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1973-1978
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• 2016

Background: Breast cancer is a heterogeneous disease that represents a major public health problem. The immunohistochemical determination of breast cancer subtypes with regard to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2) status can contribute to improved selection of therapy and patientcare. The purpose of this study was to determine the prevalence of the molecular breast cancer subtypes and to assess their associations with classical clinicopathologic parameters for better therapeutic decisions in women with breast cancer in the Ivory Coast. Materials and Methods: Formalin-fixed and paraffin-embedded blocks of patients diagnosed with primary breast carcinoma were subjected to immunohistochemical assay for the assessment of ER/RP and HER2 expression. The one-way analysis of variance evaluated the difference between breast cancer subtypes and mean age of patients. The Chi-square Test was used to compare standard clinicopathologic prognostic parameters with tumor subtypes. Results. Among 302 patients, 57% were premenopausal and 43% were postmenopausal. The invasive ductal carcinoma not otherwise specified (IDC NOS) (82.8%) was the most frequent histological type, and the tumor grade 2 (56%) was predominant followed by grade 3 (20.9%). The proportion of positivity of ER, PR, and HER2 was 56%, 49%, and 15.6%, respectively. Half of patients of this study (51.6%) had luminal A breast tumor type followed by TN (32.1%). Other subtypes were luminal B (10.1% ) and non-luminal HER2+ (6.3%). Conclusions. The findings of the present study are in line with the literature and should assist in management of breast cancer in our country.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1643-1649
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• 2015

Background: The aim of the present study was to evaluate clinicopathological characteristics of our early stage breast cancer patients who are epidermal growth factor receptor 2 (HER2) overexpressed/amplified (HER2+), the efficacy of trastuzumab treatment and survival results. Materials and Methods: Patients with HER2-positive early stage breast cancer receiving adjuvant trastuzumab were investigated retrospectively. Clinicopathological features of 210 patients and treatment outcome were analysed. To evaluate survival rates, the Kaplan-Meier method was used. Univariate and multivariate analyses were conducted with the Cox regression model. Results: Mean age of the patients was 51.8, 71.9% being postmenopausal. Some 37.6% of patients were node negative, and 31% had T1 tumor size and 52.4% were positive for estrogen receptor. Of 210 patients, 89.5% completed planned 52 weeks adjuvant trastuzumab treatment. The median follow up was 27.5 months (6.0-86.0). Relapse free survival (RFS) was 68.0 months (95% CI: 62.1-74.0) and overall survival (OS) was 74.8 months (95% CI: 69.5-80.1). The 3 year OS for all patients was 92.0% and RFS was 79.6%. During follow up, relapse was detected at the rate of 14.3%. Trastuzumab associated cardiotoxicity was found at the rate of 3.3%. In univariate analyses, larger tumor size and grade III were significantly associated (p<0.05) with RFS. Multivariate analyses of covariates displaying p<0.05 identified grade III as an independent prognostic factor. Conclusions: In the present study, it was established that trastuzumab had a satisfactory safety profile and treatment efficacy as in other clinical studies and that among clinicopathological factors evaluated, only being grade 3 had a significant effect on RFS. The occurrence of relapse with adjuvant trastuzumab makes it necessary to identify molecular predictors, which will define this group better and help explain resistance to anti HER2 based therapies.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility
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• pp.167.1-167.1
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• 2006

• 비교문화연구
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• 제52권
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• pp.31-52
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• 2018

이 논문은 19세기 프랑스 소설가인 조르주 상드의 공상적 사회주의를 재조명하기 위한 것이다. 한 마디로 그녀의 사회주의는 기독교적 사회주의라고 할 수 있다. 그녀는 당시 기독교적 사회주의를 부르짖은 르루와 라므네에게서 지대한 영향을 받았다. 이것은 당시의 공상적 사회주의자들인 생시몽과 푸리에등과도 다른 사회주의였다. 또한 상드의 사회주의는 당시 유행하였던 코뮤니즘과도 닮아있었다. 우리는 많은 저술에서 상드를 코뮤니스트로 묘사하는 것을 볼 수 있다. 그녀의 소설도 그녀의 코뮤니즘적 사상을 전파하기 위해 쓰여진 것이다. 하지만 그녀의 코뮤니즘은 마르크스식의 코뮤니즘과는 또 다른 사상을 보여준다. 이 논문에서는 그녀의 소설과 편지 그리고 그녀가 쓴 정치적 격문들 속에 나타난 그녀의 코뮤니즘 사상을 마르크스 주의와의 비교를 통해 다음 세 가지로 분석할 것이다. 1.마르크스의 공산주의가 폭력을 정당화하였다면 상드의 코뮤니즘 사상은 비폭력주의를 바탕으로 한다 2. 상드의 코뮤니즘은 노동자뿐 아니라 노동자와 자본가 모두를 위한 평등을 주장한다. 그녀는 "모두를 위한 평등이 아니라면 우리는 논할 자격도 없다"고 말한다. 3. 마지막으로는 그녀의 코뮤니즘은 철저하게 기독교적 가치관 즉 사랑과 연대에 바탕을 둔 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9643-9647
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• 2014

Background: Several studies have been performed to investigate the association of the HER2 Ile655Val polymorphism and breast cancer risk. However, the results were inconsistent. To understand the precise relationship, a meta-analysis was here conducted. Materials and Methods: A search of PubMed conducted to investigate links between the HER2 Ile655Val polymorphism and breast cancer, identified a total of 32 studies, of which 29, including 14,926 cases and 15,768 controls, with odds ratios (ORs) with 95% confidence intervals were used to assess any association. Results: In the overall analysis, the HER2 Ile655Val polymorphism was associated with breast cancer in an additive genetic model (OR=1.136, 95% CI 1.043-1.239, p=0.004) and in a dominant genetic (OR=1.118, 95% CI 1.020-1.227, p=0.018), while no association was found in a recessive genetic model. On subgroup analysis, an association with breast cancer was noted in the additive genetic model (OR=1.111, 95% CI: 1.004-1.230, p=0.042) for the Caucasian subgroup. No significant associations were observed in Asians and Africans in any of the genetic models. Conclusions: In summary, our meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model.