• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5811-5816
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• 2013

Background: Breast cancer is the most common cancer among women. Molecular subtypes are important in determining prognosis. This study evaluated five-year disease-free survival among four molecular subtypes in patients with early stages of breast cancer. Materials and Methods: In this retrospective descriptive-analytical study, information on patients with breast cancer between 2001-2010 was evaluated. Five hundred ninety two patients in the early stages of breast cancer (stages 1 and 2) were selected to undergo anthracycline-based chemotherapy. Relapse, death or absence (censor) were considered as the end of the study. Patients based on ER, PR and HER-2 expression were divided into four subtypes (luminal A, luminal B, HER-2 enriched and triple negative). Information based upon questionnaire was analysed. To show the patients survival rate, life table and Kaplan-Meyer methods were used, and for comparing mean survival among different groups, the Log-Rank test was utilized. Results: Mean age at diagnosis was $47.9{\pm}9.6$. Out of the 592 patients, 586 were female (99%) and 6 were male (1%). Considering breast cancer molecular subtypes, 361 patients were in the luminal A group (61%), 49 patients in the luminal B group (8.3%), 48 patients in the HER-2 enriched group (8.1%) and 134 in the triple negative group (22.6%). Mean disease-free survival was 53.7 months overall, 55.4 months for the luminal A group, 48.3 months for the luminal B group, 43 months for the HER-2enriched group and 54.6 months for the triple negatives. Disease free survival differed significantly among the molecular subtypes (p value=0.0001). Conclusions: The best disease-free survival rate was among the luminal A subgroup and the worst disease-free survival rate was among the HER-2 enriched subgroup. Disease free survival rate in the HER-2 positive groups (luminal B and HER-2 enriched) was worse than the HER-2 negative groups (luminal A and triple negative).

• 한국의상디자인학회지
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• 제7권2호
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• pp.101-110
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• 2005

Vivienne Westwood could be placed in a unique position in the contemporary fashion design. She has never belonged in a core group of mainstream fashion designer but not been always in an outsider position. She got from mainstream fashion designer circles enormous appreciation, even established fashion industry was influenced by her fashion design. She began her fashion design with rebellious T-shirts like 'destroy' T-shirt, chicken-bone T-shirt, and nipple-zipper T-shirt, all of which revealed her disgust against establishment. All these T-shirts testify her total negation tendency in her youth. However, she did not continue to keep such a kind of total negation attitude against establishment In 1980s she changed her political attitude towards establishment, and this change also found a reflection in her fashion design. In her pirate-collection the dark image of her fashion in the 1970s changed into a totally different bright image with full of gold colour. Although this collection had radiated brightness, it contained still outsider character from mainstream fashion design. The following fashion design in 1980s and 1990s evolved further on the line of Pirate-collection, but they continued to contain certain outsider characteristics. Vivienne Westwood kept some kind of anti-establishment attitude, and this attitude more or little came to the surface of her design. She was always political and critical to the establishment. In 2005, in her 64, she designed a liberty T-shirt, which showed her political attitude and her engagement in social issues. Also it showed the change from the early total negation to the constructive critical affirmation. In this paper the relation between the fashion design of Vivienne Westwood and her political attitude and the influence of her political attitude to her fashion design is analyzed.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.335-339
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• 2016

Background: The aim of this work was to investigate if serum and salivary auto-antibodies, isotypes IgG and IgM, against HER2 and MUC1 tandem repeat fragments could play a role in breast cancer screening. Materials and Methods: Our case-control study was conducted in breast cancer patients, in early stages (n=29), at the gynecology service, Maternity Souissi Hospital, Rabat, Morocco and healthy woman (n=31). Salivary and serum auto-antibodies against HER2 and MUC1 (tandem repeat) were assessed by enzyme-linked immunosorbent assay (ELISA) and compared between patients and healthy women using the Mann-Whitney U test. A P-value <0.05 was considered to be statistically significant. Results: Our data showed higher expression of all serum and salivary autoantibodies in patients as compared to healthy women p<0.05. However, serum IgM anti-MUC1 expression did not show a significant difference between cases and controls (p=0.79). Similarly, salivary IgG anti-HER2 expression did not differ (p=0.15). The correlation between the different isotypes of antibodies revealed that the highest correlation was between salivary IgG anti-HER2 and salivary IgG anti-MUC1(r=0.65). In fact, we have found in saliva the correlation between autoantibodies anti-MUC1 and anti-HER2 more important than in serum (r=0.59 and r=0. 55). However, the correlation between serum and saliva values for all antibodies was weak. Conclusions: Autoantibodies against HER2 and MUC1 may provide a useful approach in breast cancer screening when using both serum and saliva values.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2591-2600
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• 2015

Breast cancer is the most common cancer worldwide among women and the second most common cancer. Approximately 15-23% of breast cancers over-express human epidermal growth factor receptor2 (HER2), a 185-kDa transmembrane tyrosine kinase, which is mainly found at the cell surface of tumor cells. HER2-positive breast cancer, featuring amplification of HER2/neu and negative expression of ER and PR, has the three following characteristics: rapid tumor growth, lower survival rate, and better response to adjuvant therapies. Clinically, it is notable for its role in a pathogenesis that is associated with increased disease recurrence and acts as a worse prognosis. At the same time, it represents a good target for anti-cancer immunotherapy despite the prevalence of drug resistance. New treatments are a major topic of research, and a brighter future can be expected. This review discusses the role of HER2 in breast cancer, therapeutic modalities available and prognostic factors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8121-8125
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• 2014

Background: Ovarian mucinous carcinoma has a poor prognosis in advanced stages and a poor response to conventional chemotherapy. An efficient treatment is not yet available. We heere investigated HER2 expression and the potential for trastuzumab therapy in ovarian mucinous tumors. Materials and Methods: Immunohistochemistry was performed in formalin-fixed, paraffin-embedded tissue from 27 ovarian mucinous tumors including 14 carcinomas and 13 borderline tumors diagnosed in the Pathology Department, Farhet Hached Hospital, Sousse, between 1993 and 2013. The HercepTest (DAKO) was used for immunohistochemistry. Results: HER2 expression was observed in only one borderline tumor (7.7%) and in 14.3% of mucinous carcinomas of the ovary. Conclusions: Our results suggest that trastuzumab therapy would be an option for patients with mucinous carcinoma when the tumor has HER2 overexpression.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6131-6134
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• 2013

Background: The two basic methods that are currently accepted to identify the HER2 status are immunohistochemistry and flyorescence in situ hybridization (FISH). The aim of this study was to perform the dual-color silver in situ hybridization (dc-SISH) technique as an alternative to FISH. Materials and Methods: A total of 40 invasive breast carcinoma cases were assessed for HER2 gene amplification by FISH and dual-color SISH. Results: Significant correlation was found in the HER2 expression results obtained with the two approaches (p=0.001, p<0.05). The concordance rate was 92.3%. Conclusions: Foutine practical use of the dc-SISH method, which is much easier to apply, score, and evaluate, has many advantages. HER2 and CEN17 status can be evaluated simultaneously with the newly developed "Dual-Color Probe". All these specifications and the reliable results obtained support the widespread use of SISH technique in clinical practice.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3363-3367
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• 2016

Background: Breast cancer (BC) is a major health issue worldwide as well as in Pakistan. All women belonging to any race, ethnicity or lineage are in danger of developing breast cancer. Significant factors influencing the development of breast malignancies are the genetic background, environmental conditions, reproductive parameters, the consequences of female hormones both intrinsic and extrinsic, alteration of immune status, and biologic determinants. Materials and Methods: Overall 150 biopsy proven patients were included in the study. Samples were submitted for histopathology and determination of estrogen and progesterone receptor expression and HER-2/neu status. Associations with other characteristics like age, tumor stage, node involvement, histological grade were also studied. Results: Mean age at presentation was 46.7 years. The majority had invasive ductal carcinoma, 100 (84.7%), and were in stage pT3, 54 (45.7%). Important relationships (P<0.05) were found among ER, PR positivity, and Her 2 neu overexpression. However, no noteworthy link was identified amongst ER, PR, Her 2 neu and tumor grade, stage, age, lymph node involvement except for the menopausal status. Conclusions: In summary, breast cancer patients featured an advanced stage of disease, more lymph node involvement, and moderately high grade tumors and with more estrogen, progesterone receptor and HER-2 positive tumors.

• 대한가정학회지
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• 제34권2호
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• pp.31-42
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• 1996

The purpose of this study was to examine the mother's perception on the concrete pattern of such behavior problems as noncompliance, jealousy, dependency, hyperactivity and stealing, by analyzing the difference between two cases of her own child and another mother's child relating to her attribution to the behavior problem of the child and the relationship between her attribution and behavioral reaction. This study was carried out by using 515 questionnaires answered by 1000 mothers of children of 7 kindergartens in Ulsan and Taegu, using Melissa Sweitzer's method (1986). The data was subjected to t-test, Pearson's correlation coefficient. T-test was applied to test the difference between two cases of her own child and another mother's child relating to her attribution to the behavior problem of the child and Person's correlation coefficient was estimated to test the relationship between her attribution and behavioral reaction. The result of this study is sumarized as follows : 1. It was shown that the mother's attribution to the behavior problem of the child is less serious when her child showed the behavior problem than when another child dose the problem while her attribution has an affective reaction to the behavior problem of the child. 2. The relationship between the mother's attribution and behavior reaction to the behavior problem of the child appeared variously in accordance with the attribution factor and behavior problem. Then the mother showed more attribution to stability while frequently ignoring the child.

• 영어영문학
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• 제64권2호
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• pp.273-298
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• 2018

This paper, postulating that Lowell's Imagism is not some "Amygism" that wobbles with "emotional slither," "mushy technique" and "general floppiness" as Pound once mocked, but another kind of poetic discourse that deserves the fullest re-consideration, goes back to the very scene where Pound left for Vorticism, condescendingly allowing Lowell and her supporters to use the name "Imagism" for three years. There, it tries to illuminate how Lowell, making the most of the opportunity given to her, picked up what Pound had left behind, grafted it on the soil of America, and finally fulfilled her literary passion to awaken the common reading public to the taste for poetry reading. For the purpose, it looks into her critical reviews in Tendencies in Modern American Poetry, and stresses her creative critical efforts to re-address Pound's principles of "Imagisme." In particular, given the limit of space, it focuses only on the second principle of her Imagism and examines the modernity of her concepts of "a cadence," "suggestion," and "the real poem beyond." Then it reads "Patterns" in the context of Japanese poetry and Noh drama and analyzes the poetic patterns that Lowell made through a creative adaptation of Japanese aesthetics for Imagist poetics. In doing so, this paper aims to provide reasonable evidences to evaluate the modernity of Lowell's Imagist ars poetica and to consider her a truly serious Imagist poet worthy of a place in the history of American poetic modernism.

• 비교문화연구
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• 제37권
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• pp.131-156
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• 2014

This article attempts to explore the literature of Catherine the second, focusing on her comedies in the light of anti-freemasonry in the late 18th-centuryof Russia. Her main idea towards social morals was consistently expressed from in her early comedies during 1770s, such as 'Oh! times!'(1772), to her late counterparts during 1880s, such as so called 'anti-freemason trilogy,' which includes 'the deceiver'(1785), 'the deceived one'(1785) and 'Siberian shaman'(1786). By depicting antagonists-freemasons in her own trilogy, only as alchemists, shamans, fallacious chemists, hypocritical medical doctors, and so on, Caterine the second intended to undermine the mason influence against Russian Empire, which had ideationally attracted Russian nobles and intellectuals and furthermore to reinforce her political control over the intellectuals as well as the public. The above literacy attempts by Catherine can be said to aim to found morals of her own era through the utilization of social discourse, rather than through the political or governmental control.