• Journal of Acupuncture Research
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• v.33 no.2
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• pp.135-150
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• 2016

Objectives : The aim of this study is to review the combination effects and adverse effects of Yerba Mate (Ilex paraguariensis) on the treatment of obesity. Methods : Four databases were searched, including Pubmed, National assembly library, RISS4u, and NDSL, for studies published before March 31, 2016 using the keywords 'yerba mate', 'Ilex paraguariensis', and those related to 'obesity'. Clinical trials, and both in vivo and in vitro studies were classified according to the following categories: publication year, nationality, types and composition of test compounds, combination effects, adverse effects, and safety. Results : A total of 16 articles (14 clinical trials, one in vivo, one in vitro) were included in the analysis. Combination effects were reported from six YGD (Yerba Mate, Guarana, Damiana, Zotrim), five Meltdown, one Shred-matrix, one DBX (DymaBurn Xtreme), one XSIII research study, and adverse effects were reported from two YGD (Zotrim), four Meltdown, one Shred-matrix and one MetEF research study. YGD and Shred-matrix increased satiety while YGD and MetEF had adverse gastrointestinal effects potentially due to guarana. Meltdown and Shred-matrix increased energy expenditure and fat oxidation and had the adverse effects of increased heart rate and blood pressure due to the thermogenic effect of caffeine and yohimbine. DBX increased resting energy expenditure but no difference was observed in respiratory exchange ratio. XSIII reduced body weight gain and food intake more than each of the extracts did on their own. Conclusion : Taken together, the combination effects and adverse effects differed according to the composition of test compounds and the ratio of ingredients. Multicomponent approaches should be used for treating multifactorial diseases such as obesity. As a general conclusion, there is a place for a combination of herbal components including yerba mate, based on the principle of Kun-Shin-Choa-Sa for the treatment of obesity.

• Journal of Acupuncture Research
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• v.29 no.2
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• pp.43-57
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• 2012

Objectives : The purpose of this study is to observe the effects of $Sa-Am$ lung sedating acupuncture (LS) on wrist pulse changes in healthy participants. Method : Forty healthy subjects participated in this study, and were divided into an acupuncture group and controlled group. Using a three-dimensional pulse imaging system (DMP-3000), wrist pulse was measured before, immediately after, 30 minutes after and 60 minutes after acupuncture in the acupuncture group, with the rest in controlled group. Sixteen parameters between the acupuncture group and the controlled group were analyzed at Cun, Guan and Chi in each time. Result : After LS acupuncture, wrist pulse sixteen parameters were changed significantly according to the time at each measuring region. 1. Heart rate significantly decreased in immediately after, 30 minutes after and 60 minutes after, Pulse period significantly increased in 30 minutes after and 60 minutes after. 2. T4 didn't significantly changed, T-T4 significantly increased in immediately after, 30 minutes after and 60 minutes after. T4/T, T4/(T-T4), T1/T, T5/T significantly decreased in immediately after, 30 minutes after and 60 minutes after. (T-T4)/T significantly decreased in immediately after, 30 minutes after and 60 minutes after. T5 significantly increased in 30 minutes after and 60 minutes after. 3. Modulus of elasticity significantly decreased in left Cun 60 minutes after, significantly increased in left Chi 30 minutes after. 4. Variance of Amplitude significantly increased in right Guan 60 minutes after. 5. Area of pulse significantly increased in left Cun 60 minutes after, left Chi 30 minutes after and right Cun 60 minutes after. Systolic pulse area significantly decreased left Chi 30 minutes after, right Cun immediately after, 30 minutes after and 60 minutes after, right Guan in immediately after. 6. Energy/min significantly decreased in left Chi 60 minutes after and right Cun immediately after. EIx significantly decreased in right Cun immediately after. 7. In both sides Cun, Guan, Chi wrist pulse, a lot of significant changes in right Cun and left Chi appeared, and then followed by the left Cun, right Guan. Conclusion : This study analyzed that the correlation between LS acupuncture and radial pulse(cun, guan, chi) is considered to be meaningful, hereafter clinical studies on this are needed.

• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.415-419
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• 2019

Fipronil is an insecticide that belongs to the N-phenylpytazole and has been used mainly for an insect pest control. However, it is known that acute poisoning of the human body causes various symptoms such as dizziness, muscle weakness, dyspnea, skin irritation, and increased heart rate. Lately, eggs containing fipronil have been distributed and toxic problems are spreading around the world. In this study, we tried to develop analytical methods to evaluate the exposure of fipronil and fipronil sulfone in animal serum samples. The differences according to mobile phase and the results of liquid - liquid extraction and solid phase extraction pretreatment method were compared. Distilled water (A) and acetonitrile (B) were selected for the mobile phase, and the pretreatment method was determined by solid phase extraction. As a result of the method validation, the intra-day / inter-day accuracies were 82.2~114.1% and the precisions were less than 20%. The detection limit was 0.027 ng/ml for fipronil and 0.087 ng/ml for fipronil sulfone. The linearity obtained was satisfying, with a coefficient of determination (r²) higher than 0.99. The concentrations in some animal sera were determined using the methods of analysis for fipronil and fipronil sulfone in animal sera developed in this study. Using the method developed in this study, it could be used as an analytical method for human bio-monitoring of fipronil and fipronil sulfone as well as animal serum.

• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.31-35
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• 2020

Objective: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are frequently prescribed medications worldwide for the treatment of hypercholesterolemia. Statins are considered to be well tolerated; however, they have a potential for myotoxicity. Concomitant drugs that inhibit cytochrome P450 3A4 can increase the concentration of statins and thus the risk of developing myotoxicity. The purpose of this study was to evaluate risk factors associated with potential drug-drug interactions in patients receiving statins. Methods: The subjects of this study were patients aged more than 18 years who received at least one prescription of statins in a general hospital located in Chuncheon-si, Korea, between January 1, 2018, and March 31, 2018. Data regarding statin use and baseline characteristics was collected from the computerized hospital database. Logistic regression analysis was used to identify risk factors associated with potential drug-drug interactions. Results: A total of 1061 patients were finally included in the study. The incidence of potential drug-drug interactions was 45% in all subjects. According to the results of the multivariate logistic regression analysis, myocardial infarction as the indication of statin, arrhythmia or heart failure as a comorbidity, and aspartate aminotransferase levels higher than 40 IU/L were significant risk factors for potential drug-drug interactions in study subjects. Diltiazem was the most commonly co-prescribed drug that caused potential drug-drug interactions with statins. Conclusion: There was a considerable rate of potential drug-drug interactions in patients receiving statins. Health care professionals should attempt to reduce potential drug-drug interactions during statin administration.

• Science of Emotion and Sensibility
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• v.20 no.3
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• pp.97-108
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• 2017

The purpose of this study was to propose a product planning and design direction for smart fitness wear that will improve the impact of personal training based on researching the requirements of smart fitness wear and its acceptance level, as well as the functional demand. The study conducted in-depth interviews with professional fitness trainers and derived five categories and thirteen keywords by analyzing the categorical data analysis using the interview data. In addition, we surveyed general consumers to measure the acceptance level of smart fitness wear and the functional demand for product development. The results revealed that the difference in the acceptance level of smart fitness wear generally depended on the characteristics related to exercise involvement and exercise-related culture rather than on the demographic characteristics. With regard to the difference in the functional demand of smart fitness wear, the results showed that professional trainers focused on the scientific improvement of the effect of exercise while general consumers focused on the function that considers the sustainability of exercise. Based on the results, we proposed product planning and design directions such as 'mounting of heart rate sensing, muscle activity sensing, motion angle or posture sensing, and motion sensing', 'development of concepts and contents for expert line, ordinary line', 'compression wear design', and 'differentiation of product development according to exercise areas'.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4450-4458
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• 2015

The purpose of this study was to examine the influence of the exercise performance of yoga and pilates on the autonomic nervous system in an effort to provide some clinical information on exercise prescription. The subjects were 20 selected college students who majored in P.E. A yoga group and a pilates group were organized with 10 students respectively, the autonomic nervous system of the students was measured before the exercise, immediately after that and 30 minutes after recovery. The findings of the study were as follows: First, there were significant differences in the yoga group's stress index and average pulse according to the main effect of the time and interaction effect between the time and group. Second, there were significant differences in the yoga group's sympathetic nervous system activity and autonomic nerve balance according to all the main effect of the time, interaction effect between the time and group and the main effect of group. Third, there were significant differences in HRV(Heart Rate Variability), parasympathetic nervous system activity, SDNN, and RMSSD according to the main effect of the time, and interaction effect between the time and group and the main effect of group produced no statistically significant differences. In conclusion, yoga seemed to be effective at lowering stress index and average pulse. Specifically, yoga exercise seemed to exert a more positive influence on the decrease of sympathetic nervous system activity and autonomic nerve balance than pilates exercise.

• Journal of Yeungnam Medical Science
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• v.33 no.2
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• pp.90-97
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• 2016

Background: We have previously found that intra-peritoneal lidocaine instillation before pneumoperitoneum attenuates pneumoperitoneum-induced hypertension. Whether this procedure alters patient's hemodynamic status during operation should be determined for clinical application. This study elucidated the possible mechanism of the attenuation of the pneumoperitoneum-induced hypertension by intra-peritoneal lidocaine before pneumoperitoneum. Methods: Thirty-four patients underwent laparoscopic cholecystectomy (LC) were randomly allocated into two groups. After induction of general anesthesia, 200 mL of 0.2% lidocaine (lidocaine group, n=17), or normal saline (control group, n=17) were sub-diaphragmatically instilled 10 minutes before pneumoperitoneum. The changes in systolic blood pressure, heart rate, central venous pressure, stroke volume, cardiac output, and systemic vascular resistance were compared between the groups. The number of analgesics used during post-operative 24 h was compared. Results: Systolic blood pressure was elevated during pneumoperitoneum in both groups (p<0.01), but the degree of elevation was significantly reduced in the lidocaine group than in the control (p<0.01). However, stroke volume and cardiac output were decreased and systemic vascular resistance was increased after induction of pneumoperitoneum (p<0.05) without statistical difference between two groups. The number of analgesics used was significantly reduced in the lidocaine group (p<0.01). Conclusion: These data suggest that intra-peritoneal lidocaine before pneumoperitoneum does not alter patient's hemodynamics, and attenuation of pneumoperitoneum-induced hypertension may be the consequence of reduced intra-abdominal pain rather than the decrease of cardiac output during pneumoperitoneum. Therefore, intra-peritoneal lidocaine instillation before pneumoperitoneum is a useful method to manage an intraoperative pneumoperitoneum-induced hypertension and to control postoperative pain without severe detrimental hemodynamic effects.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.5
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• pp.1-12
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• 2015

This study analyzes the physiological healing effects on users according to forest types. Forest types are classified into Chamaecyparis obtusa, Quercus serrata and Pinus densiflora and the subjects of this study, 64 hypertensives, 59 diabetics and 59 ordinary people, were tested to observe their physiological effects. The index of physiological reaction comprises electroencephalogram(EEG), heart rate variability(HRV), blood pressure and cortisol level. An analysis of the stress-buffering effect from the physiological reactions of the overall subjects indicates that Quercus serrata forests have a higher stress-buffering effect than others in terms of central nervous, endocrine and autonomic nervous systems. Chamaecyparis obtusa forests are contributory to soothing stress in the central nervous and endocrine systems. Pinus densiflora forests contribute in some indexes of the endocrine and autonomic nervous systems. In contrast, Pinus densiflora forests are less influential on a stress-buffering effect than the other two. In the level of the effect for lowering blood pressure, Chamaecyparis obtusa and Quercus serrata forests are more effective than Pinus densiflora forests. Therefore, staying in the first two forests can heighten the healing effect of the lowering of blood pressure for hypertensive patients. Every forest is efficacious to lowering diabetic blood glucose levels. Spending time in Quercus serrata forests is more effective for hypoglycemic.

• 전자공학회논문지 IE
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• v.43 no.1
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• pp.5-15
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• 2006

In this paper, we measured the biosignal using hot-water system(STYX ford202) on foot. The biosignal transition data is observed from hot-water thermotherapy on foot. pre and post demonstration conditions under 43$^{\circ}C$ and 45$^{\circ}C$ are checked about 9 physiological factors for 10 persons and 10 days. (Checking Time: pre-test, post-test(5, 10, 15, 20 minutes)). The biosignal transition of demonstration's results showed as belows; Forehead Temperature($^{\circ}C$): -0.69 $\pm$ 0.01 dec, Leg Temperature($^{\circ}C$): 1.51 $\pm$ 0.22 inc, Blood Flow($m\ell/min$): 1.18 $\pm$ 0.50 inc, Blood Pressure(mmHg): (max) -1.49$\pm$ 2.81, (min) -0.06 $\pm$ 0.13 dec, Heart Rate(bpm): 6.97 $\pm$ 0.72 inc, Blood Sugar($mg/d\ell$) : -2.41 $\pm$ 1.55 dec, Oxygen Saturation(%): 1.34 $\pm$ 0.28 inc, Body Fat(%) -1.75 $\pm$ 0.15 dec, Weight(kg): -0.10 $\pm$ 0.04 dec. (dec: decrease, inc: increase)

• Journal of Korean Neurosurgical Society
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• v.47 no.5
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• pp.345-351
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• 2010

Objective : In this study, the Mindfulness Based Stress Reduction (MBSR) program was applied to patients presenting with depression and anxiety after surgery from spontaneous subarachnoid hemorrhage (SAH) and the effects were assessed. Methods : The subjects were patients admitted for cerebral aneurysm rupture and treated by means of surgery from March to December, 2007. More than 6 months had passed after surgery, without any special lesions showing up on computed tomography (CT), and the Glasgow outcome scale (GOS) was 5 points. Among patients with anxiety and depression symptoms, 11 patients completed the program. The MBSR program was conducted once a week, 2.5 hours each, for 8 weeks. The evaluation criteria were : 1) the Beck Depression Inventory (BDI): it measures the type and level of depression, 2) the State-Trait Anxiety Inventory : the anxiety state of normal adults without mental disorder, and 3) Heart Rate Variability (HRV) : the influence of the autonomous nervous system on the sinoarterial node varies continuously in response to the change of the internal/external environment. Results : The BDI value was decreased from 18.5 ${\pm}$ 10.9 to 9.5 ${\pm}$ 7.1 (p = 0.013) : it was statistically significant, and the depression level of patients was lowered. The state anxiety was decreased from 51.3 ${\pm}$ 13.9 to 42.3 ${\pm}$ 15.2; the trait anxiety was reduced from 50.9 ${\pm}$ 12.3 to 41.3 ${\pm}$ 12.8, and a borderline significant difference was shown (p = 0.091, p = 0.056). In other words, after the treatment, although it was not statistically significant, a decreased tendency in anxiety was shown. In the HRV measurement, standard deviation normal to normal (SDNN), square root of the square root of the mean sum of squared differences between adjacent normal to normal intervals (RMSSD), and total power (TP) showed significant increase, Physical Stress Index (PSI) showed a significant reduction, and thus an improvement in the homeostatic control mechanism of the autonomic nervous system was ween. Conclusion : The MBSR program was applied to the patients showing anxiety and depression reaction after SAH treatment, and a reduction in depression symptoms and physiological reactions were observed. The application of the MBSR program may be considered as a new tool in improving the quality of life for patients after surgery.