• Journal of Nutrition and Health
• /
• 제23권4호
• /
• pp.237-247
• /
• 1990

This study was to investigate the effect of zinc supplementation on serum cholesterol concentration of young women. Thirty healthy students were divided into Zn and placebo groups, and were orally given with zinc(50mg/day, 220mg as ZnSO4·7H2O) or placebo for 2 month (June 9-August 7, 1988). Changes of plasma zinc, serum total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol(LDL-C) and total lipid were analyzed from the initiation to 1 month after the end of zinc supplementation at monthly interval. Plasma zinc, serum LDL-C content and LDL-C/HDL-C were significantly increased by zinc supplementation. Serum total cholesterol content tended to be increased by zinc supplementation but was not significantly different between the two groups. Serum HDL-C content was significantly decreased by zinc supplementation. Serum total lipid content was not different between the two groups during experimental period. Thus, in this study considering the effect of zinc supplementation on serum cholesterol concentration, we conclude that the effect of zinc supplementation on coronary heart disease may be negative.

• Asian-Australasian Journal of Animal Sciences
• /
• 제15권11호
• /
• pp.1564-1567
• /
• 2002

Influence of dietary sesame meal on plasma glucose, non-esterified fatty acid (NEFA), triglyceride, total cholesterol, high-density lipoprotein (HDL)-cholesterol and urea concentrations in goats was examined. Goats were fed a control diet (50% timothy hay and 50% concentrates) (CD) or a sesame meal diet (50% timothy hay, 25% concentrates and 25% sesame meal) (SMD) during 12 days. Blood samples were taken after overnight fasting and afternoon every day. Body weight was not changed by feeding either CD or SMD. The concentrations of plasma triglyceride and urea were higher (p<0.05) in goats fed SMD than those fed CD. Plasma NEFA concentration was higher in plasma samples after overnight fasting. Plasma glucose concentration in plasma samples collected afternoon was higher than those after overnight fasting. Plasma total cholesterol concentration was significantly increased by feeding SMD but not by feeding CD, which was due to the remarkable increase of plasma HDL-cholesterol concentration. In conclusion, dietary sesame meal brought about an increase in plasma total cholesterol concentration accompanied with an increment in plasma HDL-cholesterol consentration in goats.

• 보험의학회지
• /
• 제2권1호
• /
• pp.101-115
• /
• 1985

In Med Dept. Daehan Education Insurance, Total 690 cases(male 376 cases, female 314 cases) were inspected to study the change of serum lipid value. The objects of investigation were total cholesterol, HDL cholesterol, triglyceride, phospholipid and total lipid value. The results are as follows: 1) In the normal subjects, with the relation of serum lipid value and the age. triglyceride, phospholipid and total lipid value showed the increasing tendency by 70 age, but total cholesterol value and HDL cholesterol value showed the increasing tendency by 59 age and the decreasing tendency after 59 age. 2) In the normal subject the difference of serum lipid value between sexes did not make the significant difference of level statistically in all items which can be inspected. 3) The weight change and serum lipid value are very significantly related. Total cholesterol, HDL cholesterol and total lipid value are high in female if the weight is light. But they are high in male the weight is heavy phospholipid value is opposite to the above result. Triglyceride value is high in male regardless the weight, but the significant difference happened in the high weight group. 4) As serum lipid value of hypertension patients is compared with that of the normal subjects, HDL cholesterol, triglyceride, phospholipid and total lipid value are significantly high. 5) The doubtful group of the fatty infittration of liver among the hypertension pafients have very significant difference in serum lipid value compared with not only the value of the normal subject but also that of the obesity group. 6) The doubtless group of the fatty infitration of liver among the hypertension patients have the significant difference in all serum lipid value compared with that of the normal subject, but compared with the obesity group males had the significant difference of HDL cholesterol value and both sexes had the significant difference in total lipid value, but had no significant difference in total cholesterol, triglyceride and phosprolipid value. 7) The ratio of total cholesterol per HDL cholesterol had the significant difference in the doubtful hypertension patients of the fatty infittration of liver and the relative weight, but it had no significant difference compared with the normal subject in the doubtless hypertension patients.

• Journal of Preventive Medicine and Public Health
• /
• 제25권1호
• /
• pp.44-52
• /
• 1992

This study was conducted to evaluate the relations between alcohol intake and blood lipid level in a group of 1,138 Korean adult men, ages 20 to 69 years. Total number of each of a variety of drinks in the previous two weeks was obtained by questionnaire and converted into grams of alcohol consumed in a week. The levels of blood lipid such as Cholesterol, HDL-Cholesterol, Triglyceride and LDL-Cholesterol were examined by enzyme method. We also observed the effects of various variables such as age, body mass index, smoking, exercise and blood pressure on blood lipid level. The results obtained were as follows : 1. Average weekly alcohol intake was $129.0{\pm}167.4gm$ and that of 30-39 age group was the highest as $149.3{\pm}170.4gm$. 2. Levels of Cholesterol Triglyceride and LDL-Cholesterol tended to increase with increasing age, but level of HDL-Cholesterol showed no significant relationship with age. 3. The positive linear regressions of alcohol intake on HDL-Cholesterol and Triglyceride were noted statistically significant. 4. Multiple regression analysis demonstrated that the effect of alcohol on HDL-Cholesterol and Triglyceride was statistically significant and the contribution rates were 5.0% and 0.8%, respectively. And, in the case of HDL-Cholesterol, the alcohol intake was the most significant independent variable.

• 동의생리병리학회지
• /
• 제24권1호
• /
• pp.102-110
• /
• 2010

This study was designed to investigate the hyperlipidemia-healing effect of aqueous extract from Mahwangimun-tang(麻黃二門湯) and it was performed on the hyperlipidemia of rats induced by high cholesterol diet and Triton WR-1339. We prepared two types of hyperlipidemia model in rats induced by high cholesterol diet and Triton WR-1339. The amount of total cholesterol, HDL-cholesterol, LDL -cholesterol, triglyceride, phospholipid, free fatty acid, the activity of superoxide dismutase and glutathione were measured. The aqueous extract from Mahwangimun-tang showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride in the both model. And it showed significant increasing effects on HDL-cholesterol, the activity of SOD in both model. These results suggest that aqueous extract from Mahwangimun-tang has healing efficacy on hyperlipidemia induced by high cholesterol diet and Triton WR-1339.

• 대한간호학회지
• /
• 제28권1호
• /
• pp.184-192
• /
• 1998

This study was done to examine the correlations between weight, BMI and risk factors of coronary heart disease in men and women in their forties and fifties. The subjects were 412 adults. who had regular health examinations between January and December of 1996 at S-Hospital in Seoul. The data were analyzed using ANOVA, Scheffe test, and Pearson correlation coefficient. The results are as follows : 1. The men between 50 and 59 years of age had higher levels for BMI, weight, systolic blood pressure, diastolic blood pressure, total cholesterol. LDL-cholesterol, triglyceride, fasting blood sugar, plasminogen activator-1, and hemoglobin A,C than the group of women in their forties. Yet. HDL-cholesterol was lower than in the former group. 2. In the group of men in their forties, weight was significantly correlated to diastolic blood pressure(r=.22), LDL-cholesterol(r=.20), plasminogen activator-inhibitor-1(r=.35) HDL-cholesterol(r=-.19). Their BMI was significantly correlted to systolic blood pressure(r=.27), diastolic blood pressure (r=.33), total cholesterol(r=.23), LDL-cholesterol (r=.26), plasminogen activator-1(r=.36) and HDL-cholesterol(r=-.25). 3. As for the group of women in their forties weight was significantly correlated to systolic blood pressure(r=.20), diastolic blood pressure(r=.22), triglyceride(r=.32) , plasminogen activator inhibitor-1 (r=.30) and HDL-cholesterol(r= -.37). Their BMI was significantly correlated to diastolic blood pressure (r=.25) triglyceride(r=.47), plasminogen activator-1 (r=.35), fibrinogen(r=.27) and HDL-cholesterol(r=-.47). 4. In the group of men in their fifties. weight was significantly correlated to total cholesterol (r=32), LDL-cholesterol(r=.29). plasminogen activator inhibitor-1(r=.26). Their BMI was significantly correlated to systolic blood pressure(r=.24), diastolic blood pressure (r=.22), total cholesterol (r=.34), LDL-cholesterol (r=.32), and plasminogen activator-1(r=.25). 5. In the group of women in their fifties, weight was significantly correlated to diastolic blood pressure(r=.33), total cholesterol(r=.21), LDL-cholesterol(r=.20), plasminogen activator inhibitor-1 (r=.43) and HDL-cholesterol(r=-.21). Their BMI was significantly correlated to systolic blood pressure(r=.25), diastolic blood pressure(r=.40), total cholesterol(r=.24), LDL-cholesterol(r=.24), triglyceride(r=22), and HDL-cholesterol (r=-.30). The above findings indicate that the BMI was more predictive than weight as a risk factor for coronary artery disease for men and women in their forties and fifties.

• Childhood Kidney Diseases
• /
• 제5권2호
• /
• pp.136-146
• /
• 2001

목 적 : 신증후군 환아의 궁극적인 예후는 양호하지만 치료시의 어려움은 빈번한 재발이다. 스테로이드에 반응을 보였던 신증후군 환아의 재발 가능성의 예측인자에 대한 여러 보고가 있었는데 최근에는 스테로이드에 반응을 보이는 신증후군 환아에서 관해기까지의 기간이 짧을수록 재발의 빈도가 의미 있게 적음이 보고되었다. 본 연구에서는 신증후군으로 처음 진단 후 스테로이드에 반응을 보였던 환아들을 대상으로 스테로이드를 사용하기 전의 고지혈증의 정도와 환아의 신기능 및 관해 유도기간과의 연관성을 검증하여, 고지혈증이 관해유도의 지연 혹은 빈발 재발 환자를 조기에 선별하여 예측지표로 사용될 수 있는지 알아보고자 시행하였다. 대상 및 방법 : 1994년 10월부터 2000넌 8월까지 본원 소아과에서 입원했던 환아들 중 처음으로 신증후군으로 진단된 후 스테로이드 치료에 반응을 보였던 33명을 대상으로 이들의 입원 및 외래 기록지를 중심으로 후향적으로 분석하였다. 결 과 : 모든 대상 환아에서 고지혈증 소견이 관찰되었으며 이중 triglyceride, total cholesterol, LDL cholesterol, apoB, Lp(a), total cholesterol/HDL cholesterol은 증가하였으나 HDL cholesteol은 증가하지 않았다. 스테로이드를 사용하기 전의 혈청 알부민은 $1.7{\pm}0.8\;g/dL$의 감소되었고 단백뇨는 $3.8{\pm}3.2\;g/24hr$로 증가보이나 크레아티닌 청소율은 $121.7{\pm}47.7\;mL/min/1.73m^2$로 감소되지 않았으며 스테로이드 사용 후 관해 유도기간은 $15.6{\pm}11.0일$이 필요했다. 혈청 알부민은 total cholesterol (r = -0.5157, P<0.005), LDL cholesterol (r = -0.5543, P<0.005), total cholesterol/HDL cholesterol (r = -0.4506, P<0.01), Lp(a) (r = -0.4570, P<0.025), apoB (r = -0.5297, P<0.025), apoB/apoAl (r = -0.5851, P<0.01), apoB/HDL cholesterol (r = -0.4961, P<0.05)등과 음의 상관관계가 있었다. 단백뇨와 크레아티닌 청소율은 스테로이드를 사용하기 전 혈청지질, 지단백과 상관관계를 보이지 않았다. 관해 유도기간은 스테로이드를 사용하기 전 HDL cholesterol (r = +0.4511, P<0.05), apoB (r = +0.5190, P<0.05), apoB/HDL cholesterol (r = +0.7169, P<0.005)과 양의 상관관계가 있었다. 결 론 : 본 연구를 통해 신증후군의 특징인 고지혈증은 서로 다른 경과의 신증후군, 서로 다른 병리조직학적 소견과 지질대사 과정에 다양한 영향을 끼치는 요인에 의해 각각의 지질 및 지단백의 상승에 차이가 있을 수 있고 이런 지질 및 지단백의 상승은 주로 간에서 생성의 증가의 발생함을 알 수 있었다. 또한 지단백중 스테로이드를 사용하기전의 HDL cholesterol, apoB, apoB/HDL cholesterol등은 관해 유도기간과 의미 있는 양의 상관관계를 보여서 신증후군 환아의 재발을 예측 할 수 있는 지표로서 임상적인 의미를 부여할 수 있을 것이다.

• 한국지역사회생활과학회지
• /
• 제19권1호
• /
• pp.113-123
• /
• 2008

This study was performed to find and compare the characteristics of dietary factors and obesity indices on serum lipid profiles using 407 healthy adult males that had physical examinations conducted at the general hospital located in Suwon. The subjects were divided 56.3% for the normal group, 16.7% for TG, 14.5% for TC and 12.5% for TC TG group, respectively. When comparing the blood lipid profiles to normal group, TC group was high in both total cholesterol and LDL-cholesterol, TG group was high in triglyceride and low in HDL-cholesterol, TC TG group was high in triglyceride, total cholesterol, LDL-cholesterol and low in HDL-cholesterol. In comparison of blood lipid profiles with normal group, among anthropometric factors, body weigh, BMI (Body Mass Index) and WHR (Waist Hip Ratio) showed significant differences. TC group was high in both total cholesterol and LDL-cholesterol, and TG group was high in triglyceride and low in HDL-cholesterol. TC TG group was high in triglyceride, total cholesterol and LDL-cholesterol, and was low in HDL-cholesterol. Body weigh of TG group was significantly higher than that of normal group (p<0.05). BMI and WHR of TG group and TC TG group were significantly higher than those of normal group (p<0.05). Total cholesterol was mainly related to the intake of animal lipids and alcoholic beverage. Serum triglyceride levels were closely related with lipid intake and high BMI in this group. In TC TG group, BMI and WHR were high. As well, serum LDL-cholesterol was high and HDL-cholesterol was low which indicates TC TG group had the most undesirable blood lipid profiles. Therefore, it may be necessary to manage BMI and WHR to prevent hyperlipidemia and obesity for adult males in Suwon.

• 한국가금학회지
• /
• 제40권4호
• /
• pp.337-349
• /
• 2013

본 총설은 논란이 되고 있는 계란 콜레스테롤이 심장질환과 관련성이 없다는 것을 증명하기 위하여 지난 50여 년간의 연구 결과를 조사하였다. 그 결과, 식이로 섭취된 콜레스테롤은 혈액 콜레스테롤 농도에 큰 영향을 미치지 않는 것이 밝혀졌다. 더욱이 고콜레스테롤혈증이 있는 중년 남녀에게 1일 2개의 계란을 더 섭취한 실험에서도 혈액 콜레스테롤이 증가되지 않는 것으로 나타났다. 식이 콜레스테롤 섭취가 증가하면 LDL-콜레스테롤 뿐 아니라, HDL-콜레스테롤도 같이 증가하여 심장질환 위험의 중요 지표인 LDL : HDL 비율은 거의 변화가 없었다. 특히 노인에게서 더 좋은 지표로 밝혀진 HDL-콜레스테롤이 증가하므로, 콜레스테롤 섭취는 심장질환 예방에 좋은 것으로 나타났다. 따라서 계란의 섭취는 건강에 나쁘다고 알려진 인식은 사실이 아니며, 오히려 심장질환 예방에 효과적인 것으로 밝혀졌다. 또한, 계란 섭취량에 관한 공식적인 기준도 없는 것으로 나타났다. 따라서 이와 같은 증거들은 더 이상 계란에 대한 오해와 불신이 없기를 제안한다.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2003년도 생물공학의 동향(XIII)
• /
• pp.717-720
• /
• 2003

A chromogenic biosensor employing microfluidics on a chip has been developed for the determination of high-density lipoprotein (HDL) cholesterol (HDL-C) in human serum. We have investigated a plain and effective method to immobilize enzymes within the microchip without chemically modifying micro-channel or technically micro-fabricating column reactor and fluid channel network. In assessing risk factors of coronary heart disease, a micro-chip system would minimize requirements of instrument and reagent handling.