• Clinical and Experimental Reproductive Medicine
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• 제44권1호
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• pp.28-32
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• 2017

Objective: Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility. Methods: Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed. Results: TG, TC, LDL, and hs-CRP levels were higher and HDL levels were lower in patients with unexplained infertility than in fertile controls (p<0.05 for all). Positive associations were found between unexplained infertility and TG, TC, LDL, and hs-CRP levels, and a negative correlation was found for HDL (p<0.05 for all). Multivariate logistic regression analysis showed that TG, HDL, and hs-CRP were independent variables associated with unexplained infertility. Conclusion: Our study showed that women with unexplained infertility had an atherogenic lipid profile and elevated hs-CRP levels, suggesting a higher risk of developing CVD in the future. Further studies with larger groups are needed to investigate the nature of this link.

• 대한간호학회지
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• 제41권2호
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• pp.182-190
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• 2011

Purpose: This study was done to identify correlates and variables predicting daily activity among elders with Diabetes Mellitus (DM). Methods: Seventy-six elders registered in the Department of Endocrine Medicine at C university hospital participated in data collection. Data on daily activity and biochemical variables were collected via actigraph accelerator (Actical) and blood tests between September 2009 and July 2010. Data analysis was done using SPSS WIN 15.0 program and included one-way ANOVA, independent t-test, Pearson correlation coefficients, and stepwise multiple regression. Results: This study showed a positive correlation between daily activity and High Density Lipoprotein Cholesterol (HDL-C) and a negative correlation among Total Cholesterol (TC), Triglyceride (TG), and Low Density Lipoprotein Cholesterol (LDL-C). The variables predicting daily activity were frequency of exercise, HDL-C, and TC. These factors accounted for 40.0% of the variance of daily activity in elders with DM. Conclusion: The results indicate that it is necessary to improve daily activity to reduce Fasting Blood Glucose (FBG), TC, and TG in elders with DM.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -3
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• pp.1744-1747
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• 2002

In late years, the tendency to shift the design language of electronic circuits from HDL to C-based languages of C/C)1 and so on is strengthened. The current of adopting these software languages thrives by necessity to solve the problem peculiar to HDL that verification of design is difficult. When we use C-based languages, we can describe the design by higher abstraction degree, mount the design as both hardware and software finally and so that express the design part which is not made clear at early stage the same one language. Therefore, the flexibility of design very improves, the design work in environment the range of applying the whole systems become possible. This paper introduces example at having applied C-based languages in image processing LSI design and describes that the design technique of C-based languages is effective for the system design.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.411-413
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• 2003

본 논문에서는 ARM922T Core와 주변장치를 설계할 수 있는 100만 게이트의 FPGA를 내장한 알데라(Altera)사의 엑스칼리버(Excalibur)를 이용하여 DC모터 제어용 SoC를 설계하였다. SoC란 System on Chip의 약자로 하나의 칩 안에 프로세서와 다양한 목적의 주변장치들을 집적하는 것을 말한다. 모터를 구동하기 위한 PWM신호 생성기를 하드웨어 설계언어(Hardware Description Language)로 구현하고 시뮬레이션을 통해 설계모듈을 검증하였다. 이렇게 검증한 PWM 생성기 모듈과 ARM922T Core를 합성하여 SoC를 설계하였다. PWM 생성기 모들을 구성하는 내부의 각 분분을 VerilogHDL로 코딩하여 심볼로 만들어 통합하는 방식으로 설계를 하였으며 실제 모터를 구동하기 위해서 프로세서가 동작할 수 있도록 C언어로 프로그램하여 함께 칩에 다운로드하여 테스트를 하였다. SoC를 기반으로한 시스템 설계의 장점은 시스템이 간단해지고 고속의 동작이 가능하며 회로의 검증 및 다양한 시뮬레이션이 용이하다는데 있다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2012년도 추계학술발표대회
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• pp.649-651
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• 2012

본 논문에서는 Core-A를 이용한 실시간 영상 신호 처리 SoC 설계와 검증에 대해 기술한다. 영상 신호 처리를 위한 방식으로 SoC를 사용하였으며 영상 처리를 위한 ISP를 설계하였다. 영상 처리를 위한 마이크로프로세서는 코드밀도를 높이고 Verilog HDL을 사용하여 기술되어 여러 응용분야에서 최적화할 수 있는 국내에서 개발된 Core-A를 사용하였다. 본 논문에서 제안한 SoC는 Verilog HDL언어로 설계 되었고, 기본 SoC의 구조는 Core-A, AMBA Bus, ISP, Memory controller, Uart로 구성하였다. 구현된 SoC는 다양한 영상 신호 처리를 지원하여 향후 영상압축 인코더의 실시간 이미지 처리용 소스로 사용할 수 있고 신호 처리 알고리즘 검증용에도 유용하게 사용될 수 있을 것으로 보인다. 설계 검증을 위해 먼저 FPGA를 이용하여 검증하였으며 TSMC $0.18{\mu}m$ CMOS공정으로 합성한 결과 동작주파수는 50MHz, 전체 게이트 수 86.1k로 확인되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3385-3388
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• 2012

Objective: The study was conducted to assess biochemical profiles in premenopausal and postmenopausal women having breast cancer. Materials and Methods: A hospital based case control study was carried out at Manipal Teaching Hospital (MTH), Pokhara, Nepal. The analysed variables were age, metabolic profile including total cholesterol, triglycerides, HDL-C, LDL-C, blood sugar, insulin concentration, C-peptide, HbA1c and selenium. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software. Results: In premenopausal women, significant differences were noted for total cholesterol (P value <0.001), triglycerides (P value 0.002), HbA1c level (P value <0.001), insulin concentration (P value 0.030), C-peptide concentration (P value 0.001), and selenium (P value <0.001) between cases and controls. Insignificant results were found for HDL-C (P value 0.749), LDL-C (P value 0.933), blood sugar (P value 0.59) and BMI (P value 0.746). Similarly, significant difference in total cholesterol (P value <0.001), triglycerides (P value 0.001), LDL-C (P value <0.001), HDL-C (P value 0.025), blood sugar (P value <0.001), insulin concentration (P value <0.001), c-peptide concentration (P value <0.001), HbA1c level (P value <0.001) and selenium (P value <0.001) were observed for postmenopausal patients and controls. Conclusions: Assessing metabolic changes and their management may be important for control of breast cancer and increased survival.

• 한국항공우주학회지
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• 제49권4호
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• pp.335-342
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• 2021

통신 시스템 FPGA 개발 시 HLS를 이용하면 성능 검증용 C/C++ 소스 코드를 일부 수정하여 자동으로 HDL 코드를 생성할 수 있으므로 개발 기간을 단축할 수 있는 장점이 있다. 본 논문에서는 텔레메트리 표준 106-17 LDPC 복호기를 Xilinx사의 Vivado HLS를 이용하여 C언어로 설계하는 방법을 제시하였고, Spartan-7와 Kintex-7 디바이스를 타겟으로 합성하여 throughput과 FPGA 이용률을 비교하였다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 춘계학술대회
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• pp.779-782
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• 2013

오늘날 우리 생활에 영상이나 이미지는 우리 실생활에 아주 밀접하게 연관되어 있다. 카메라, 휴대폰, TV, 영상 및 이미지 관련 기기들이 증가하고 이로 인해 영상이나 이미지 관련 서비스의 기술적인 요소들이 중요시되고 있다. 이러한 영상에서 기본적으로 사용하는 압축방식인 DCT는 직교 변환 방식의 국제 표준으로써, 정지 이미지나 동영상의 압축 파일등에서 사용된다. DCT(Discrete Cosine Transform) 알고리즘은 음성 및 영상 압축 등 많은 디지털 신호처리 분야에서 사용되고 있다. 본 논문에서는 WMV의 $4{\times}4$, $4{\times}8$,$8{\times}4$, $8{\times}8$ 4가지 모드에 대해 DCT를 지원할 수 있도록 C언어를 통해 상위 수준의 검증을 수행하고, 이를 HDL을 사용하여 코딩하고, Modelsim SE6.1을 사용해 회로 검증하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.852-855
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• 2003

This paper reports the RFC(Recursive Flow Classification) algorithm that is available on multiple fields. It is easy to be implemented by both software and hardware. For high speed classification of packets, the implementation of RFC is essential by hardware. Hence, in this paper, RFC algorithm is simulated by Verilog-HDL, and it verify the efficiency of the algorithm. The result shows that the algorithm can perform a packet classification within several cycles. It is not only much faster than software implementation but also enough to support OC192c.

• Nutrition Research and Practice
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• 제16권6호
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• pp.716-728
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• 2022

BACKGROUND/OBJECTIVES: An imbalanced adipokine profile in obesity increases the susceptibility to obesity-related cardiometabolic alterations, including type 2 diabetes, hypertension, dyslipidemia, and non-alcoholic fatty liver disease. The mulberry plant has been reported to have health benefits, such as hypolipidemic and hepatoprotective effects. This study examined the effects of a mulberry (Morus alba L.) fruit ethanol extract (MBEE) on dyslipidemia, liver steatosis, and adipokine imbalance in response to a high-fat diet. MATERIALS/METHODS: Male Sprague-Dawley rats were assigned to one of 4 groups containing 6 rats each and fed either a control diet (CON), a high-fat diet (HFD), or a high-fat diet with MBEE of 150 mg/kg/day (LMB) or 300 mg/kg/day (HMB). The triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were measured spectrophotometrically. The leptin, adiponectin, and plasminogen activator inhibitor-1 (PAI-1) levels were determined by an enzyme-linked immunosorbent assay. RESULTS: The plasma TG levels were similar in the 4 groups. Plasma cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and TC/HDL-C ratio increased in the HFD group compared with the CON group, whereas those values decreased in the LMB group (P < 0.05), indicating that MBEE had a plasma lipid-lowering effect. HDL-C decreased in the HFD group, but MBEE did not affect the HDL-C level. The HFD rats significantly increased hepatic TG and cholesterol levels and plasma ALT and AST activities compared to the CON group. The hepatic TG level and ALT and AST activities were reduced markedly by the MBEE treatment. The HFD group showed a higher PAI-1 level, whereas MBEE treatment, especially in the HMB group, significantly reduced leptin level, and leptin/adiponectin and PAI-1/ adiponectin ratios. These findings suggest that MBEE altered the imbalance between the pro-and anti-inflammatory adipokines to a more anti-inflammatory state. CONCLUSIONS: MBEE could protect against abnormal lipid metabolism and hepatic steatosis induced by a high-fat diet, lowering plasma cholesterol, LDL-C and TC/HDL-C, and hepatic TG. These findings are associated with the regulating effect of MBEE on the leptin/adiponectin and PAI-1/adiponectin ratios.