• Archives of Pharmacal Research
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• 제7권1호
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• pp.41-45
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• 1984

The effect of Red ginseng saponin on plasma lipid levels in Wistar rats fed on a diet high in cholesterol and triglyceride was determined. A dose of Red ginseng-crude saponin (150 mg/kg/day) was administered orally for 4 weeks to Wistar rats fed on a diet containing 2% cholesterol and 10% olive oil. Plasma levels of total cholesterol, HDL-cholesterol and triglyceride were measured and lipoproteins were analyzed by using electrophoretic technique. Red ginseng saponin showed no significant changes of HDL-cholesterol level but it lowered plasma levels of total cholesterol and elevate those of triglyceride intensively.

• 혜화의학회지
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• 제15권1호
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• pp.19-31
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• 2006

KJST is the oriental herbal medicine of hyperlipemia which consisted of a herb of 17. We induced hyperlipemia to Spontaneous Hypertensive Rat(SHR) and studied the treatment effect by KJST. Hyperlipidemia was induced by hyper-lipidemic diet fed for 4weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, Triglyceride, Total bilirubin, Lactic dehydrogenase(LDH), Glucose and Total protein were measured on the serum after an oral administration of KJST. Total cholesterol, LDL-cholesterol, Glucose and LDH was significantly lower in the KJST treated animals, and HDL was significantly raised in the KJST treated animals. These results suggest that KJST is effective for the treatment of hyperlipidemia.

• 한국식품위생안전성학회지
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• 제12권1호
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• pp.83-95
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• 1997

This study showed the effect of fermented milk on the cholesterol level of Korean. 130 persons among the teachers of elementary, middle and high schools, professors and graduate school students were divided into two groups according to their cholesterol level and provided with fermented milk 300 $m\ell$ dairly from Sep.25 to No. V3. They were given blood test at 20 days and 40 days after drinking fermented milk, and surveyed about their ordinary life style and the change of fecal condition. Cholesterol, LDL and the ratio of LDL and HDL in blood were significantly decreased in both high cholesterol group and normal group while HDL cholesterol was notably increased. TG showed slightly tendency of decrease in normal group while no changed in high group. There is no significant change in cholesterol level after drinking fermented milk among groups which are divided by factors of dringking, smoking, caffeine, B.M.I. and family history. The research also showed that drinking fermented milk improved the fecal frequency and fecal condition.

• 대한임상검사과학회지
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• 제42권3호
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• pp.129-135
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• 2010

This study was performed to determine the risk factors associated with increased body mass index (BMI) in 672 heavy industry men workers. Subjects were examined in March, 2010 to September, 2010 in Gyeongnam province. Height, weight, systolic blood pressure, and diastolic blood pressure were measured. And fasting blood glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride levels were measured by Olympus AU 680, and their BMIs calculated. Age, smoking statue, and alcohol drinking of the workers were surveyed by questionnairs. The mean total cholesterol levels were $190.06{\pm}36.62mg/dL$, HDL-cholesterol $53.65{\pm}11.92mg/dL$, LDL-cholesterol $104.28{\pm}30.31mg/dL$, triglyceride $151.11{\pm}99.53mg/dL$, and fasting blood glucose $96.92{\pm}19.53mg/dL$. Mean systolic blood pressure was $126.08{\pm}13.78mmHg$, and diastolic blood pressure $71.88{\pm}10.45mmHg$. Subjects were categorized into two BMI groups, BMI ${\geq}23$ and BMI ${\leq}22.9$. The subjects with BMI of 23 or above had significantly higher levels of LDL-cholesterol, systolic blood pressure, and triglyceride, with lower levels of HDL-cholesterol. BMI showed the highest level at the age of thirties, increasing with age. BMI of smokers was higher than BMI of non-smokers, not showing a link between alcoholics and non alcoholics. In conclusion, age, systolic blood pressure, and HDL-cholesterol are mostly relevant to the increase of BMI in this study.

• 한국식품영양학회지
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• 제14권2호
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• pp.113-119
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• 2001

1. 수축기 혈압은 운동을 하고 있는 군에서 약간 낮았으나 이완기 혈압은 유의성 있는 차이를 보이지 않았다. 운동을 하고 있는 여대생의 경우 체지방량이 낮게 나타난 반면 제지방량은 변화가 없어 운동 여부에 의한 차이가 거의 보이지 않았다. 또 혈중 포도당 함량은 규칙적인 운동을 하고 있는 여대생에서 다소 높은 수준이었다. 2. 체지방율은 지속적인 운동을 하고 있는 여대생에 서 유의성은 없었지만 약간 낮았으며 혈청 총 콜레스테롤과 중성지방의 농도 역시 유의성 있게 낮게 나타났다. HDL 콜레스테롤 농도는 두 군 모두 거의 비슷한 수준으로 군간에 뚜렷한 차이를 보이지 않았던 반면 LDL 콜레스테롤의 경우 운동에 의해서 유의성 있게 낮게 나타났다. 따라서 규칙적인 운동에 의해서 HDL-Chol/Total-Chol 비율은 증가되었으며 LDL-Chol/HDL-Chol의 비율은 낮았다. 3. 혈액중 지단백질의 상대적인 분포는 HDL(%)의 경우 지속적인 운동을 하고 있는 여대생의 경우 일반 여대생에 비해 거의 차이가 없었고 LDL(%)는 유의성 있게 낮았던 반면 VLDL( %)는 오히려 높게 나타났다. Plasma의 지방산 조성중 포화 지방산 함량은 운동을 하고 있는 여대생에서 약간 높았지만 다가 불포화 지방산 함량은 같은 수준으로 두 군간에 차이를 보이지 않았다.

• 대한임상검사과학회지
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• 제44권3호
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• pp.103-111
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• 2012

Low-Density Lipoprotein cholesterol (LDLC) is the most important marker for the treatment of hyperlipidemia in NCEP-ATP III(National Cholesterol Education Program-Adult Treatment Panel III) guideline. Therefore, LDL cholesterol is pathologically meaningful, accurate measurement should be a top priority. Currently, LDLC is directly measured in most cases, but, the estimate is still used in mass health examination or screening test. This study is about the comparison of LDL-Cholesterol direct measurement with the estimate using various formula (Friedewald: [LDL-F=TC-HDL-TG/5], Nakajima: [LDL-N=TC-HDL-TG/4], Hattori: [LDL-H =0.94TC-0.94HDL-0.19TG], Puavilai: [LDL-P=TC-HDL-TG/6], Carvalho: [LDL-C=3(TC-HDL)/4]) for calculating more accurate value. We analyzed total cholesterol (TC), try-glyceride (TG), high-density lipoprotein cholesterol (HDLC), and LDLC levels of 210 subjects between June and November in 2011. Until now, the Friedewald formula is the most commonly used estimate for the LDLC. When Friedewald formula was applied, the correlation coefficient (r) was 0.940, showing high correlation. But, the result of the direct method was significantly different, compared with those of the Friedewald formula in triglyceride levels ${\geq}400mg/dL$(p<0.05). There was the highest correlation when we used LDL-P formula(r=0.947) in triglyceride levels <400 mg/dl. Also there was the lowest mean difference regardless of triglyceride level. Therefore, the study showed that TG/6 is more precise means of calculation than TG/5. On the other hand, the calculation of LDL-Cholesterol was underestimated, compared with direct measurement. It is necessary to have more data and modified Friedewald formula should be used for the accurate calculation.

• Journal of Preventive Medicine and Public Health
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• 제31권1호
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• pp.59-71
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• 1998

To examine the association of hypertension with cluster of obesity, abnormal glucose and dyslipidemia in Korean urban population, we conducted this cross-sectional study among 3027 men and 2127 women age 20-85 years who visited a prevention center between May 1991 and June 1995 for a multiphasic health check at St. Mary's Hospital, Seoul. By the self-administered questionnaire, the informations of educational attainments, monthly income, alcohol consumption, cigarette smoking, and physical excercise level were obtained. Height, weight, and blood pressure were measured by a trained nurse. The fasting blood sugar (FBS), total cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride were tested by enzyme method. Low density lipoprotein (LDL) cholesterol was calculated by 'total cholesterol - HDL cholesterol - triglyceride/5'. For testing the differences of cardiovascular risk factors between hypertension and normotension group, 1-test and $\chi^2$-test were performed. For the age adjusted odds ratios of hypertension in persons with obesity, abnormal glucose, and dyslipidemia compared with normal, logistic regression was performed by using SAS pakageprograme. The results obtained were as follows: 1. Age, weight, body mass index(BMI), blood glucose, total cholesterol, LDL cholesterol, and triglyceride of hypertension group in men and women were significantly higher than normotension group, but height and HDL cholesterol of hypertension group only in women significantly lower than normotension group. The frequency of obesity $(BMI\geq25kg/m^2)$, abnormal glucose $(\geq\;120mg/dl)$, hypercholesterolemia $(\geq\;240mg/dl)$, lower HDL cholesterol (<45 mg/dl in women only), higher LDL cholesterol $(\geq\;160mg/dl)$, and hyper hypertriglyceridemia $(\geq\;250mg/dl)$ in hypertension group of men and women were significantly higher than normotension group. 2. Systolic and diastolic blood pressure were negatively correlated with hight, but positively with age, weight, BMI, total cholesterol, LDL cholesterol, and triglyceride in men and women. BMI was positively correlated with fasting blood sugar, total cholesterol, LDL cholesterol and triglyceride but negatively with HDL cholesterol. 3. The age adjusted odds ratios of hypertension were as follows in men and women : among persons who were obese compared with those nonobese, 2.53 (95% Confidence Intervals [C.I.] 2.08-3.07) and 2.22 (95%C.I. 1.71-2.87): among persons who were abnormal glucose compared with those normoglycemic, 1.43 (95%C.I 1.13-1.82) and 2.01 (95%C.I 1.36-2.94): and among persons who were dyslipidemia (hypercholesterolemia or lower HDL cholesterol or higher LDL cholesterol or hypertriglyceridemia) compared with those normal lipid, 1.59 (95%C.I 1.30-1.95) and 1.51 (95%C.I 1.16-1.96). After combined more than one risk factor, the odds ratios were increased. Among persons with cluster of obesity, abnormal glucose, and dyslipidemia, the odds ratio of hypertension was 2.25 (95%C.I 1.47-3.37) in men and 3.02 (95%C.I 1.71-5.30) in women. In conclusion, it was suggested that hypertension was associated with cluster of obesity, abnormal glucose, dyslipidemia in this Korean urban population.

• BMB Reports
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• 제42권7호
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• pp.393-400
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• 2009

High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (<40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and structural changes of HDL have been recognized as factors pivotal to the evaluation of HDL-quality. In this review, I have elected to focus on the functional and structural correlations of HDL and the roles of HDL-associated apolipoproteins and enzymes. Recent clinical applications of HDL have also been reviewed, particularly the therapeutic targeting of HDL metabolism and reconstituted HDL; these techniques represent promising emerging strategies for the treatment of cardiovascular disease, for drug or gene therapy.

• Journal of Nutrition and Health
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• 제17권2호
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• pp.85-93
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• 1984

The present studies were designed to compare the effects of dietary fat sources and levels on plasma and tissue cholesterol. Changes in plasma total cholesterol and HDL-cholesterol, cholesterol concentration in aortas, liver and intestines were determined in young rats fed diets providing dietary fat as corn-oil or butter and levels as 10%, 20% or 30% of calories respectively 1) Plasma total cholesterol and HDL-cholesterol levels were little sensitive to the modification of dietary fat sources and levels. 2) Dietary cholesterol increased the levels of plasma total cholesterol and this effect was accentuated by feeding butter. But dietary cholesterol did not increase the levels of HDL-cholesterol in the butter-fed groups, but decreased in the corn-oil-fed groups. 3) Liver cholesterol concentrations were significantly higher in rats fed diets of corn-oil than those fed diets of butter. On the contrary, cholesterol concentrations of intestines were significantly higher in the butter-fed groups than the corn-oil-fed groups. However, in aortas, no significant differences were found.

• 동아시아식생활학회지
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• 제9권1호
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• pp.27-34
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• 1999

This study was carried out to investigate the effects of the kinds and the amounts of dietary fiber on serum lipid composition in rats. Seventy-two male Sprague-Dawley rats weighting 160$\pm$10g were fed diets containing 1.0%, 3.6%, 6.0% and 10.0% $\alpha$-cellulose, pectin and alginic acid fer 4 weeks. Daily food intake of experimental groups was significantly higher in the u-cellulose 10.0% group than in the other groups. Increasing the dietary fiber level decreased the food efficiency ratio of the $\alpha$-cellulose, pectin and alginic acid groups. Serum triglyceride concentration was significantly lower in the rats fed the alginic acid diet. Serum total cholesterol concentration showed no significant difference in the kind and the amount of three dietary fibers. Serum HDL-cholesterol concentration was higher in $\alpha$-cellulose and pectin diet. HDL-cholesterol/total cholesterol ratio was higher in u-cellulose and pectin diet than alginic acid diet. In conclusion, alginic acid is good for the serum triglyceride decrease, pectin is good for HDL-cholesterol increase, $\alpha$-cellulose and alginic acid are good for HDL-cholesterol/total cholesterol ratio increase. But the different effects according to the dietary fiber's contents did not show a significant trend.