• Journal of Veterinary Clinics
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• v.20 no.2
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• pp.233-236
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• 2003

A 10 year old, intact female Yorkshire terrier was referred to the Veterinary Teaching Hospital of Konkuk University. Upon admission, the patient had severe necrotic skin disease on face and abdominal wall, and also showed polyuria, polydipsia (PUPD), and polyphagia. A tentatative diagnosis of hyperadrenocorticism was made on the basis of history takings, physical examination, and results of CBC and serum biochemistry. Hyperadrencorticism was confirmed by ACTH stimulation test and pituitary-dependent hyperadrenocorticism (PDH) was diagnosed according to the results of high dose dexamethasone suppression test (HDDST). After initiating mitotane therapy, severe skin problem and clinical signs including PUPD were improved. And we determined whether or not mitotane therapy well controlled serum cortisol level with ACTH stimulation test. This case was presented to show that the patient misdiagnosed and treated for more than 1 year as other dermatologic problem in 3 local animal clinics was treated and managed sucessfully with mitotane administration.

• Journal of Veterinary Clinics
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• v.26 no.1
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• pp.95-100
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• 2009

A 15-year-old, spayed female maltese dog was presented with polydipsia, polyuria, polyphagia, abdominal distention, alopecia and hyperpigmentation. The complete blood counts were in normal range, and the serum biochemistry revealed elevated level of glucose and globulin. Mild hepatomegaly was seen on radiography of abdomen. Abdominal ultrasonography revealed the uniformly enlarged left adrenal gland measured 2.4 cm in diameter. ACTH stimulation test and LDDST revealed hyperadrenocorticism. HDDST revealed pituitary dependent hyperadrenocorticism. On CT images, isodense mass with contrast enhancing was seen in left adrenal gland. Cytologic result is consistent with benign tumor. Adrenal mass was surgically removed and evaluated. Histopathologic examination revealed adenocortical adenoma.