• International Journal of Concrete Structures and Materials
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• v.8 no.1
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• pp.69-81
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• 2014

In this study, portland cement (PC) has been partially replaced with a Class F fly ash (FA) at level of 70 % to produce high-volume FA (HVFA) concrete (F70). F70 was modified by replacing FA at levels of 10 and 20 % with silica fume (SF) and ground granulated blast-furnace slag (GGBS) and their equally combinations. All HVFA concrete types were compared to PC concrete. After curing for 7, 28, 90 and 180 days the specimens were tested in compression and abrasion. The various decomposition phases formed were identified using X-ray diffraction. The morphology of the formed hydrates was studied using scanning electron microscopy. The results indicated higher abrasion resistance of HVFA concrete blended with either SF or equally combinations of SF and GGBS, whilst lower abrasion resistance was noted in HVFA blended with GGBS.

• Proceedings of the KIEE Conference
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• 2008.10b
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• pp.476-477
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• 2008

본 연구에서는 가속도 센서를 이용하여 보행패턴을 검출하고 가속도 센서의 출력 값을 무선으로 PC에 실시간으로 전달할 수 있는 휴대용 모듈을 개발하였다. PC에서는 휴대장치로부터 전송되는 데이터를 수집하여 운동패턴을 화면에 실시간으로 출력할 수 있게 하였다. 휴대 장치의 전력 소모를 최대한 줄이기 위해 무선 전송 부분은 zigbee 통신을 사용하였다. 착용자의 걸음걸이 패턴을 분석하기 위해 2축 가속도 센서를 사용하였으며 기본적인 보행수는 임계치를 사용하는 moving average 알고리즘을 이용하여 마이크로 콘트롤러에서 처리하였다.

• Proceedings of the KIEE Conference
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• 1988.07a
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• pp.971-974
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• 1988

In this study, we designed a model of NC controller with IBM-PC as a host CPU and intelligent servo controller for 2 axes that can be expaned to 4 axes. OS software was developed with C language at the base of mode selection technic for 9 NC operating modes. Servo controller design was based on the application of interpolator IC(3701) and position controller IC(3702) that permits low cost and high performance. For connection of two systems, parallel I/O communication was implemented. Finally, auto interpolation program test was executed for linear and circular paths resulting 1 LSB accuracy.

• Proceedings of the KIPE Conference
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• 2012.07a
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• pp.373-374
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• 2012

본 논문에서는 전력변환장치의 고효율화 시대에 맞추어 AC-DC단에는 브릿지리스 PFC, DC-DC단에는 Full-Bridge LLC 공진형 컨버터를 적용하여 전부하 ZVS 동작영역 확보를 통한 고효율의 저전압, 대전류 AC-DC 정류기를 제안하였다. 제안된 AC-DC 정류기는 그린 PC용 전력변환 장치로써 단말형 중앙 집중식 PC rack 시스템에 사용된다. 따라서 19 [V], 105 [A] (2KW) Full-bridge LLC 공진형 컨버터를 설계 및 제작하여 실험을 통해 제안된 토폴로지의 타당성을 검증하였다.

• Polymer(Korea)
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• v.25 no.6
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• pp.893-901
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• 2001

We developed the nerve growth factor (NGF) loaded poly (L - lactide) (PLA) scaffolds by means of emulsion freeze drying method to the possibility for the application of the nerve regeneration of spinal cord disease and the degeneration in Alzheimer's disease. The release amount of NGF from NGF loaded PLA scaffold were analyzed over a 4 week period in vitro at phosphate buffered saline (PBS), pH 7.4, at $37^{\circ}C$. It can be observed the open cell pore structure of porous scaffolds and can be easily controlled the pore structure by the controlling of formulation factors resulting in the controlling of the release rate and the release period. The stability of NGF during the preparation of PLA scaffold was evaluated by comparing the released amounts of total NGF, assayed NGF enzyme - linked immunosorbent assay (ELISA). Released NGF has been found to enhance the neurite sprouting and outgrowth from pheochromocytoma (PC-12) cells. These results suggest that the released NGF from NGF loaded PLA scaffold such as conduit type can be very useful for the nerve regeneration in the neural tissue engineering area.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.572-577
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• 2001

The feasibility of skin penetration was studied for aspalatone (AM, acetylsalicylic acid maltol ester), a novel antithrombotic agent. In this studys hairless mouse dorsal skins were used as a model to select composition of vehicle and AM. Based on measurements of solubility and partition coefficient, the concentration of PC that showed the highest flux for AM across the hairless mouse skin was found to be 40%. The cumulative amount permeated at 48 h, however, appear inadequate, even when the PC concentration was employed. To identify a suitable absorption enhancer and its optimal concentration for AM, a number of absorption enhancers and a variety of concentration were screened for the increase in transdermal flux of AM. Amongst these, linoleic acid (LOA) at the concentration of 5% was found to have the largest enhancement factor (i.e., 132). However, a further increase in AM flux was not found in the fatty acid concentration greater than 5%, indicating the enhancement effect is in a bell-shaped currie. In a study of the effect of AM concentration on the permeation, there was no difference in the permeation rate between 0.5 and 1% for AM, below its saturated concentration. At the donor concentration of 2%, over the saturated condition, the flux of AM was markedly increased. A considerable degradation of AM was found during permeation studies, and the extent was correlated with protein concentrations in the epidermal and serosal extracts, and skin homogenates. In rat dorsal skins, the protein concentration decreased in the rank order of skin homogenate > serosal extract > epidermal extract. Estimated first order degradation rate constants were $6.15{\pm}0.14,{\;}0.57{\pm}0.02{\;}and{\;}0.011{\pm}{\;}0.004{\;}h^{-1}$ for skin homogenate, serosal extract and epidermal extract, respectively. Therefore, it appeared that AM was hydrolyzed to some extent into salicylmaltol by esterases in the dermal and subcutaneous tissues of skin. taken together, our data indicated that transdermal delivery of AM is feasible when the combination of PC and LOA is used as a vehicle. However, since AM is not metabolically stable, acceptable degradation inhibitors may be nervessary to fully realize the transdermal delivery of the drug.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.81.2-81.2
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• 2014

We have analyzed the archival data of far ultraviolet (FUV) observations made for the region of GSH 006-15+7, a large shell-like structure discovered by Moss et al. (2012) from the H I velocity maps. FUV emission is seen enhanced in the lower supershell region and is believed to originate from dust scattering of interstellar photons. A corresponding Monte Carlo simulation indicates that the supershell is located at a distance of $1250^{+750}{_{-500}}$ pc, similar to the previous estimation of 1.5{\pm}0.5 kpc based on kinematic considerations. The spectrum obtained for the lower supershell exhibits molecular hydrogen fluorescence lines: a simulation model for this candidate photodissociation region (PDR) yields a rather high total hydrogen density of $n_H{\sim}30cm^{-3}$ with H2 column density of $N(H_2){=}^{1017.5-20.0}cm^{-2}$. It is argued that the region is in a transition stage from a warm to a cool neutral phase. Strong C IV emission is also seen in the spectrum, but it is not believed to be associated with the supershell as the corresponding spectral map shows a broad region of enhancement both inside and outside the supershell.

• The Korea Journal of Herbology
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• v.34 no.5
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• pp.29-37
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• 2019

Objectives : Bang-poong (Saposhnikovia divaricata; SD) was traditionally used to treat inflammatory disorders. In this study, we aimed to investigate whether Bang-poong and related species including SD, Glehnia littoralis (GL), and Peucedanum japonicum (PJ) possess neuroprotective effects and acetylcholinesterase (AChE) inhibitory activities. Methods : Roots of SD, GL and PJ were extracted with distilled water (DW) or 70% ethanol (EtOH). We assessed 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activities of the extracts. To examine neuroprotective effects, we measured cell viability in PC12 or HT22 cells after treatment of the extracts with $H_2O_2$ or amyloid-beta ($A{\beta}$). To assess anti-neuroinflammatory effects, we measured the nitric oxide (NO) levels after treatment with the extracts and lipopolysaccharide (LPS) in BV2 microglial cells. In addition, we performed AChE inhibition assay to explore effects of the extracts on the cholinergic system. Results : DW and EtOH extracts of SD, GL and PJ showed mild DPPH free radical scavenging activities. Also, DW extracts of GL and PJ showed protective effects against $H_2O_2$-induced toxicity in PC12 cells. In LPS-activated BV2 cells, EtOH extracts of SD, GL and PJ exerted inhibitory effects on NO production. Meanwhile, DW extracts of SD, GL and PJ inhibited the $A{\beta}$-induced cell death in HT22 cells. In addition, DW and EtOH extracts of GL exhibited remarkable inhibitory activities on AChE. Conclusions : We demonstrated that SD, GL and PJ exert anti-oxidative, anti-neuroinflammatory and AChE inhibitory activities. These results indicate that SD, GL and PJ could be potential candidates for neurological disorders.

• Proceedings of the Korean Vacuum Society Conference
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• 2009.02a
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• pp.212.2-212.2
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• 2009

• Molecules and Cells
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• v.21 no.2
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• pp.237-243
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• 2006

Brain-derived neurotrophic factor (BDNF) is a neuromodulator of nociceptive responses in the dorsal root ganglia (DRG) and spinal cord. BDNF synthesis increases in response to nerve growth factor (NGF) in trkA-expressing small and medium-sized DRG neurons after inflammation. Previously we demonstrated differential activation of multiple BDNF promoters in the DRG following peripheral nerve injury and inflammation. Using reporter constructs containing individual promoter regions, we investigated the effect of NGF on the multiple BDNF promoters, and the signaling pathway by which NGF activates these promoters in PC12 cells. Although all the promoters were activated 2.4-7.1-fold by NGF treatment, promoter IV gave the greatest induction. The p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C (PKC) inhibitor, chelerythrine, had no effect on activation of promoter IV by NGF. However, activation was completely abolished by the MAPK kinase (MEK) inhibitors, U0126 and PD98059. In addition, these inhibitors blocked NGF-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 1/2. Taken together, these results suggest that the ERK1/2 pathway activates BDNF promoter IV in response to NGF independently of NGF-activated signaling pathways involving PKA and PKC.