• Title/Summary/Keyword: H1*-H2* measure

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Pharmacodynamic Interactions of Diazepam and Flumazenil on Cortical Eeg in Rats (흰쥐 대뇌피질의 뇌파에 대한 diazepam 및 flumazenil의 약력학적 상호작용)

  • 이만기
    • Biomolecules & Therapeutics
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    • v.7 no.3
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    • pp.242-248
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    • 1999
  • Diazepam, a benzodiazepine (BDZ) agonist, produces sedation and flumazenil, a BDZ antagonist, blocks these actions. The aim of this study was to examine the effects of BDZs on cortical electroencephalogram (EEG) in rats. The recording electrodes were implanted over the frontal and parietal cortices bilaterally, and the reference and ground electrodes over cerebellum under ketamine anesthesia. To assess the effects of diazepam and flumazenil, rats were injected with diazepam (1 mgHg, i.p.) and/or flumazenil ( 1 mg/kg, i.p.), and the EEG was recorded before and after drugs. Normal awake had theta peak in the spectrum and low amplitude waves, while normal sleep showed large amplitude of slow waves. The powers of delta, theta and alpha bands were increased during sleep compared with during awake. Diazepam reduced the mobility of the rat and induced sleep with intermittent fast spindles and large amplitude of slow activity, and it produced broad peak over betaL band and increased the power of gamma band, which were different from EEG patterns in normal sleep. Saline injection awakened rats and abolished fast spindles for a short period about 2-5 min from EEG pattern during diazepam-induced sleep. Flumazenil blocked both diazepam-induced sleep and decreased the slow activities of delta, theta, alpha and betaL, but not of gamma activity for about 10 min or more. This study may indicate that decrease in power of betaL and betaH bands can be used as the measure of central action of benzodiazepines, and that the EEG parameters of benzodiazepines have to be measured without control over the behavioral state by experimenter.

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Simulation and assessment of 99mTc absorbed dose into internal organs from cardiac perfusion scan

  • Saghar Salari;Abdollah Khorshidi;Jamshid Soltani-Nabipour
    • Nuclear Engineering and Technology
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    • v.55 no.1
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    • pp.248-253
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    • 2023
  • Directly, it is not possible to measure the absorbed dose of radiopharmaceuticals in the organs of the human body. Therefore, simulation methods are utilized to estimate the dose in distinct organs. In this study, individual organs were separately considered as the source organ or target organ to calculate the mean absorption dose, which SAF and S factors were then calculated according to the target uptake via MIRD method. Here, 99mTc activity distribution within the target was analyzed using the definition and simulation of ideal organs by summing the fraction of cumulative activities of the heart as source organ. Thus, GATE code was utilized to simulate the Zubal humanoid phantom. To validate the outcomes in comparison to the similar results reported, the accumulation of activity in the main organs of the body was calculated at the moment of injection and cardiac rest condition after 60 min of injection. The results showed the highest dose absorbed into pancreas was about 21%, then gallbladder 18%, kidney 16%, spleen 15%, heart 8%, liver 8%, thyroid 7%, lungs 5% and brain 2%, respectively, after 1 h of injection. This distinct simulation model may also be used for different periods after injection and modifying the prescribed dose.

Effects of Camping Recreation on Natural Environment in Mt. Chiak National Park (치악산도립공원에서의 양영행위가 자연환경에 미치는 영향)

  • 권영선;이경재
    • Journal of the Korean Institute of Landscape Architecture
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    • v.15 no.2
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    • pp.67-78
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    • 1987
  • This study was executed to measure the user\`s impact natural environment in National Park Campsite. Therefore, we choose Mt. Chiak National Park and the campsite in the district of Temple Ku-Ryong as a model of analysis, which is made by ecological approach, the number of the user has influence on the environment near the campsite. The result are as follows : 1. The more the number of users becomes, the more Na, Ca, Mg ion concentration and pH in the soil increase and the less K ion becomes. 2. Litter and humus depth, litter coverage, herb coverage, soil hardness, the surface of the ground layer and tree species numbers, density and coverage of lower layer shows a sensitive reaction to the number of the users. 3. The research shows that the tolerant trees against campsite impact are Lespedeza maximowiczii, Zanthoxylum schinifolium Staphylea bumalda, Smilax sieboldii, Quercus aliena, Euonymus oxyphyllus, Weigela subsessilis and Securinega suffruticosa, and the sensitive trees are Stephanandra incisa, Rubus trichocarpa, Rubus crataegifolius, Rhododendron mucronulatum, Styrax obassia, Acer palmatum, Lindera obtusiloba, Rhododendron suhlippenbachii, Rhus japonica and Callicarpa japonica. 4. The high density of the users made the simplication of a vegetation structure. So, as the number of the user increase the species showed severe heterogeniety between the heavy-use and nonuse site. 5. As considering the landscape management about campsite and surrounding area on the way of analysis of national landscape aspect and succession sere according to ecological aspect, it may be desirable that Pinus densiflora forest be conserved as Pinus densiflora landscape and mixed forest produce natural scenery with succession sere.

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Velocity Profiles and Entrance Length of Transitional Oscillatory Flows in the Entrance Region of a Square Duct (정(正)4각(角)덕트 입구영역(入口領域)에서 천이(遷移) 진동유동(振動流動)의 입구(入口)길이와 속도분포(速度分布))

  • Choi, J.H.;Choi, B.M.;Yoo, Y.T.
    • Journal of Biosystems Engineering
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    • v.18 no.3
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    • pp.275-287
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    • 1993
  • The flow characteristics of the transitional oscillatory flows are investigated analytically and experimentally in the entrance region of a square duct. The systems of conservation equations are analytically solved by linearizing the non-linear convective terms for the developing transitional oscillatory flows in a square duct. The analytical solutions are obtained in the form of infinite series for the velocity profiles. The experimental study for the air flow in a square duct is carried out to measure the velocity profiles and waveforms by using a hot-wire anemometer with the data acquisition and processing systems. The theoretical and experimental results provide the major characteristics of the developing transitional oscillatory flows, such as velocity profiles, velocity waveforms, and entrance length. The velocity profiles in the decelerating phase are larger than those in the accelerating phase for the developing transitional oscillatory flows. The correlations of the entrance length of the transitional oscillatory flows in a square duct are found to be $Le/Dh=K{\cdot}Re_{os}/2({\omega}^+)^2$, where K is 1.23 of an experimental constant.

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Analysis of the Operational Characteristic of a High-Tc Superconducting Power Supply for Charging of the Superconducting Magnet (초전도자석 충전용 고온초전도전원장치의 특성해석)

  • Yun, Yong-Su;Kim, Ho-Min;An, Min-Cheol;Bae, Deok-Gwon;Go, Tae-Guk
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.51 no.4
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    • pp.159-164
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    • 2002
  • This paper presents the design and fabrication of a high-Tc superconducting (HTS) power supply for charging of the HTS magnet load, and its characteristics have been analyzed through experiments. HTS power supply consists of two heaters, an electromagnet, a Bi-2223 solenoid and a Bi-2223 pancake magnet load. In this experiment, 331 mH electromagnet and 0.8 A dc heater current were used, and 8.5 sec and 17 sec were used for pumping period. Mechanism of the superconducting switch is used for heater-trigger. In order to measure the pumping-current with respect to the magnet flux changes, hall sensor was installed at the center of the Bi-2223 pancake load. The experimental observations have been compared with the theoretical predictions. In this experiment, the pumping-current has reached about 1.2 A. In computer simulation, the maximum pumping-current of the system has been predicted to be about 2.7 A.

Noise Levels in Intensive Care Units and Patient's Perception (중환자실 소음도와 소음에 대한 환자의 인지)

  • Kim, Min Young;Park, Ui-Jun
    • Journal of Korean Critical Care Nursing
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    • v.8 no.1
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    • pp.41-49
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    • 2015
  • Purpose: The purpose of this study was to measure the noise levels in intensive care units (ICUs) and to analyze the causes of the noise and patient perceptions of the noise. Methods: Noise levels were recorded in adult ICUs for 24 h over a week from the patients' bedside with a sound level meter. Noise sources were categorized into three groups: medical equipment, health care providers, and the environment. Noises from the environment were recorded in an empty ICUs side room. Perceptions of the noise of 125 patients admitted to the ICUs were recorded using a questionnaire. Results: The mean level of noise in the ICUs was 58.5 dBA (range: 34.2-80.2 dBA). The causes of noise higher than 70 dBA were nebulizers and infusion/syringe pumps among medical equipment, and drawer slamming, phone ringing, and stripping packages of medical fluids among environmental noises. According to the questionnaire, 64.0% of the patients responded that the ICUs were noisy and that they suffered from sleep disturbance because of the noise. Conclusion: Noise is considerably high in ICUs and is an annoying factor for the patients. Most noise sources are adjustable, and we should try to reduce noise whenever possible to make the ICUs environment more pleasant.

Performance Test and Flue Gas Characteristics of a 350 kW Wood Pellet Boiler (350 kW(300,000 kcal/h)급 우드 펠렛 보일러 운전 특성 및 성능 평가)

  • Kim, Jong-Jin;Kang, Sae-Byul
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.167-171
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    • 2009
  • We conducted performance test of a 350 kW class wood pellet boiler installed at a dormitory whose total area is $1,354\;m^2$. The maximum heating capacity of the boiler is 350 kW(300,000 kcal/kg). The wood pellet boiler consists of 3 parts; boiler, hot water storage tank and wood pellet storage tank. In testing the boiler, we shut off hot water utility supply and open up floor heating water system in order to measure exact value of the heating output of the wood pellet boiler. To determine the efficiency and heating output of the wood pellet boiler, we measured mass flow rate of wood pellet, the lower heating value(LHV) of the wood pellet, mass flow rate and temperature of water for floor heating and so on. We measured the mass flow rate of fuel, wood pellet with respect to rotational speed of auger, wood pellet feeding screw. We also measured the flue gas concentration of the wood pellet boiler by using a gas analyser. The result shows that the efficiency of the wood pellet boiler is 80.6% based on lower heating value at 124 kW of heating output. At this condition, O2 concentration of the flue gas is 6.0%, CO and NOx concentrations are 85 and 102 ppm.

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A Fundamental Study on the Antiwashout Underwater Concrete for the Underwater Work of Ocean (수중불분리성 콘크리트의 해양공사 적용에 관한 기초적 연구)

  • 김명식;윤재범;박세인
    • Journal of the Korea Concrete Institute
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    • v.12 no.5
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    • pp.25-34
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    • 2000
  • When concrete is placed underwater, it is diluted with separating cementitious material and as a result the quality of concrete becomes poor. To solve this problem, antiwashout underwater concrete is increasingly used for the construction and repair of the concrete structure underwater. The objective of this study is to investigate the characteristics of antiwashout underwater concrete as to the mix proportion, casting and curing water through experimental researches. The unit weight of water and cement, water-cement ratio, fine aggregate ratio, unit weight of antiwashout underwater agent and superplasticizer, and casting and curing water were chosen to measure the suspended solids, pH, air contents, slump flow, unit weight of hardened concrete, and compressive strength. From this study, the incremental modulus at mix proportion design and unit weight of antiwashout underwater agent were increased more than fresh water, and it is a optimum mix proportion that the unit weight of water(and cement) is 230kg/$\textrm{m}^3$(460kg/$\textrm{m}^3$), waterOcement ratio is 50%, fine aggregate ratio is 40%, unit weight of antiwashout underwater agent is 1.2% of water contents per unit weight of concrete, and unit weight of supeplasticizer is 2.5% of cement contents per unit weight of concrete when the antiwashout underwater concrete is used for the underwater work of ocean.

Natural wind impact analysis of transiting test method to measure wind pressure coefficients

  • Liu, Lulu;Li, Shengli;Guo, Pan;Wang, Xidong
    • Wind and Structures
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    • v.30 no.2
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    • pp.199-210
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    • 2020
  • Building wind pressure coefficient transiting test is a new method to test the building wind pressure coefficient by using the wind generated by a moving vehicle, which is susceptible to natural wind and other factors. In this paper, the Commonwealth Advisory Aeronautical Research Council standard model with a scale ratio of 1:300 is used as the test object, and the wind pressure coefficient transiting test is repeated under different natural wind conditions to study the influence of natural wind. Natural wind is measured by an ultrasonic anemometer at a fixed location. All building wind pressure coefficient transiting tests meet the test conditions, and the vehicle's driving speed is 72 km/h. The mean wind pressure coefficient, the fluctuating wind pressure coefficient, and the correlation coefficient of wind pressure are used to describe the influence of natural wind on the building wind pressure coefficient transiting test qualitatively and quantitatively. Some rules, which can also help subsequent transiting tests, are also summarized.

Development of Continuous Monitoring System of Acidic Pollutants for The Studies of Their Diffusion in The Atmosphere (대기오염의 확산 연구를 위한 산성 오염물질의 연속 측정법의 개발)

  • Chung, Hyung-Keun;Dasgupta, Purnendu K.;Lee, Dai Woon
    • Analytical Science and Technology
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    • v.5 no.3
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    • pp.269-276
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    • 1992
  • An ion-exchange/conductometric method is applied for the determination of total acidity in simulated atmospheric samples. Non-$H^+$ cations and strong acid anions are enriched by the preconcentrator columns in series and eluted through the corresponding parallel suppressor units. The conductivities from each channel correspond to the concentrations of the resulting ionized species in equivalents per unit volume. The difference is the measure of acidity due to strong acids. With 5-min sampling at a flow rate of 0.3 mL/min, the detection limits for ${NH_4}^+$ and ${SO_4}^{2-}$ are 0.3 and $0.1{\mu}equiv/L$, respectively. The acidity for samples composed of various ions can be determined without significant error, usually less than 5%. The proposed method discriminates against the artifact from the $CO_2$ dissolution. Principles of acidity measurements are also presented.

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