• Journal of computational fluids engineering
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• v.20 no.4
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• pp.63-69
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• 2015

The thermal balance test in vacuum chamber for satellite structures is an essential step in the process of satellite development. However, it is technically and economically difficult to fully replicate the space environment by using the vacuum chamber. To overcome these limitations, the thermal analysis through a computer simulation technique has been conducted. The CFRP composite material has attracted attention as satellite structures since it has advantages of excellent mechanical properties and light weight. However, the nonuniform nature of the thermal conductivity of the CFRP structure should be noted at the step of thermal analysis of the satellite. Two different approaches are studied for the thermal analyses; a detailed numerical modeling and a simplified model expressed by an effective thermal conductivity. In this paper, the effective thermal conductivities of the CFRP composite structures are extracted from the detailed numerical results to provide a practical thermal design data for the satellite fabricated with the CFRP composite structure. Calculation results of the surface temperature and the thermal conductivities along x, y, z directions show fairly good agreements between the detailed modeling and the simplified model for all the cases studied here.

• International Journal of Oral Biology
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• v.34 no.3
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• pp.157-164
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• 2009

We recently described a novel animal model of trigeminal neuropathic pain following compression of the trigeminal ganglion (Ahn et al., 2009). In our present study, we adapted this model using male Sprague-Dawley rats weighing between 250-260 g and then analyzed the behavioral responses of these animals following modified chronic compression of the trigeminal ganglion. Under anesthesia, the rats were mounted onto a stereotaxic frame and a 4% agar solution ($10{\mu}L$) was injected in each case on the dorsal surface of the trigeminal ganglion to achieve compression without causing injury. In the control group, the rats received a sham operation without agar injection. Air-puff, acetone, and heat tests were performed at 3 days before and at 3, 7, 10, 14, 17, 21, 24, 30, 40, 55, and 70 days after surgery. Compression of the trigeminal ganglion produced nociceptive behavior in the trigeminal territory. Mechanical allodynia was established within 3 days and recovered to preoperative levels at approximately 60 days following compression. Mechanical hyperalgesia was also observed at 7 days after compression and persisted until the postoperative day 40. Cold hypersensitivity was established within 3 days after compression and lasted beyond postoperative day 55. In contrast, compression of the trigeminal ganglion did not produce any significant thermal hypersensitivity when compared with the sham operated group. These findings suggest that compression of the trigeminal ganglion without any injury produces prolonged nociceptive behavior and that our rat model is a useful system for further analysis of trigeminal neuralgia.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.10a
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• pp.91-93
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• 2003

It has been estimated that the equivalent of approximately $US 50 billion has been spent on research on the behavior and fate of pesticides in the environment since Rachel Carson published “Silent Spring” in 1962. Much of the resulting knowledge has been summarized explicitly in computer algorithms in a variety of empirical, deterministic, and probabilistic simulation models. These models describe and predict the transport, degradation and resultant concentrations of pesticides in various compartments of the environment during and after application. In many cases the known errors of model predictions are large. For this reason they are typically designed to be “conservative”, i.e., err on the side of over-prediction of concentrations in order to err on the side of safety. These predictions are then compared with toxicity data, from tests of the pesticide on a series of standard representative biota, including terrestrial and aquatic indicator species and higher animals (e.g., wildlife and humans). The models' predictions are good enough in some cases to provide screening of those compounds which are very unlikely to do harm, and to indicate those compounds which must be investigated further. If further investigation is indicated a more detailed (and therefore more complicated) model may be employed to give a better estimate, or field experiments may be required. A model may be used to explore “what if” questions leading to possible alternative pesticide usage patterns which give lower potential environmental concentrations and allowable exposures. We are currently at a maturing stage in this research where the knowledge base of pesticide behavior in the environmental is growing more slowly than in the past. However, innovative uses are being made of the explosion in available computer technology to use models to take ever more advantage of the knowledge we have. In this presentation, current developments in the state of the art as practiced in North America and Europe will be presented. Specifically, we will look at the efforts of the ‘Focus’ consortium in the European Union, and the ‘EMWG’ consortium in North America. These groups have been innovative in developing a process and mechanisms for discussion amongst academic, agriculture, industry and regulatory scientists, for consensus adoption of research advances into risk management methodology.

• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.483-489
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• 2004

Fexofenadine HCl is non-sedating histamine H1 receptor antagonist that can be used for the treatment of seasonal allergic rhinitis. The objective of this study was to investigate whether the carriers of deformable liposomes can enhance the transepithelial permeability of fexofenadine HCl across the in vitro ALI human nasal monolayer model. Characterization of this model was achieved by bioelectric measurements and morphological studies. The passage 2 and 3 of cell monolayers exhibited the TEER value of $2852\;{\pm}\;482\;ohm\;{\times}\;cm^2$ on 11 days of seeding and maintained high TEER value for 5 days. The deformable liposome of fexofenadine HCl was prepared with phosphatidylcholine (PC) and cholic acid using extruder method. The mean particle size was about 200 nm and the maximum entrapment efficiency of 33.0% was obtained in the formulation of 1% PC and $100\;{\mu}g/ml$ fexofenadine HCl. The toxicity of the deformable liposome to human nasal monolayers was evaluated by MTT assay and TEER value change. MTT assay showed that it has no toxic effect on the nasal epithelial cells in 2-hour incubation when the PC concentration was below 1%. However, deformable liposome could not enhance the transepithelial permeability $(P_{app})$ and cellular uptake of fexofenadine HCl. In conclusion, the in vitro model could be used in nasal drug transport studies and evaluation of transepithelial permeability of formulations.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.31 no.4
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• pp.477-482
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• 1998

In the aquaculture industry, a photobioreactor (Pbr) with high productivity is a prerequisite for mass production of Chlorella sp., a feeding fry for Rotifer (Brachinous plicatilis). To enhance the productivity of Chlorella sp., model Pbrs such as Cylinder type, Spherical surface type, Half-spherical surface type, Plate type, Raceway pond type and Water-wheel type Pbr with different values of surface area exposed to light/culture volume (S/V) were manufactured, and the maximum specific growth rate (${\mu}_{max}$) and productivity of Chlorella vulgaris 211-11b at $25^{\circ}C$, pH 7.0 and 12,000 lux were compared each other. The ${\mu}_{max}$ and productivity were not proportional to S/V. Among the 6 model Pbrs, Half-spherical surface type Pbr showed the highest ${\mu}_{max}$ and productivity as 2.206 ($day^{-1}$) and 0.247($g^{{\ell}-1}day^{-1}$).

• Nuclear Engineering and Technology
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• v.53 no.2
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• pp.446-454
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• 2021

Critical heat flux (CHF) has traditionally been evaluated using look-up tables or empirical correlations for nuclear power plants. However, under complex moving condition, it is necessary to reconsider the CHF characteristics since the conventional CHF prediction methods would no longer be applicable. In this paper, the additional forces caused by motions have been added to the annular film dryout (AFD) mechanistic model to investigate the effect of moving condition on CHF. Moreover, a theoretical model of the natural circulation loop with additional forces is established to reflect the natural circulation characteristics of the loop system. By coupling the system loop with the AFD mechanistic model, a CHF prediction program called NACOM for natural circulation loop under moving condition is developed. The effects of three operating conditions, namely stationary, inclination and rolling, on the CHF of the loop are then analyzed. It can be clearly seen that the moving condition has an adverse effect on the CHF in the natural circulation system. For the calculation parameters in this paper, the CHF can be reduced by 25% compared with the static value, which indicates that it is important to consider the effects of moving condition to retain adequate safety margin in subsequent thermal-hydraulic designs.

• The Journal of Internal Korean Medicine
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• v.40 no.4
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• pp.567-581
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• 2019

Objective: This study aimed to evaluate the inhibitory effects of SGX01 on the lung injuries of COPD mice model. Materials and Methods: This study was carried out in two ways: in vitro and in vivo. In vitro, L929 cells were challenged with LPS, and then treated with six concentrations of SGX01 (10, 30, 50, 100, 300, and $500{\mu}g/ml$) and analyzed by ELISA. In vivo, C57BL/6 mice were challenged with LPS and cigarette smoking solution (CSS), and then treated with a vehicle only (control group), dexamethasone 3 mg/kg (dexa group), or a SGX01 200 mg/kg (SGX01 group). After sacrifice, the BALF or lung tissue was analyzed with Cytospin, FACS, ELISA, real-time PCR and H&E, and Masson's trichrome staining. Results: SGX01 significantly decreased NO, $TNF-{\alpha}$, and IL-6 on L929 cells challenged with LPS. In the COPD model, SGX01 significantly inhibited the increase of neutrophils, $TNF-{\alpha}$, IL-17A, CXCL-1, MIP2, CD8+ cells in BALF, and $TNF-{\alpha}$, $IL-1{\beta}$ mRNA expression in lung tissue. It also decreased the severity of the histological lung injury. Conclusion: This study suggests the usability of SGX01 for COPD patients by controlling lung tissue injury.

• Advances in nano research
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• v.10 no.1
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• pp.77-90
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• 2021

In the present study, novel chitosan coated magnetic magnetite (Fe3O4) nanoparticles were successfully biosynthesized from mushroom, Agaricus campestris, extract. The obtained bio-nanocomposite material was used to investigate ultra-fast and highly efficient for removal of Ni2+ ions in a fixed-bed column. Chitosan was treated as polyelectrolyte complex with Fe3O4 nanoparticles and a Fungal Bio-Nanocomposite Material (FBNM) was derived. The FBNM was characterized by using X-Ray Diffractometer (XRD), Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy (SEM-EDS), Fourier Transform Infrared spectra (FTIR) and Thermogravimetric Analysis (TGA) techniques and under varied experimental conditions. The influence of some important operating conditions including pH, flow rate and initial Ni2+ concentration on the uptake of Ni2+ solution was also optimized using a synthetic water sample. A Central Composite Design (CCD) combined with Response Surface Modeling (RSM) was carried out to maximize Ni2+ removal using FBNM for adsorption process. A regression model was derived using CCD to predict the responses and analysis of variance (ANOVA) and lack of fit test was used to check model adequacy. It was observed that the quadratic model, which was controlled and proposed, was originated from experimental design data. The FBNM maximum adsorption capacity was determined as 59.8 mg g-1. Finally, developed method was applied to soft drinks to determine Ni2+ levels. Reusability of FBNM was tested, and the adsorption and desorption capacities were not affected after eight cycles. The paper suggests that the FBNM is a promising recyclable nanoadsorbent for the removal of Ni2+ from various soft drinks.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.579-588
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• 2022

In order to meet the needs of domestic reactor severe accident analysis program, a MIDAC (Module Invessel Degraded severe accident Analysis Code) is developed and maintained by Xi'an Jiaotong University. As the accuracy of the calculation results of the analysis program is of great significance for the formulation of severe accident mitigation measures, the article select three experiments to evaluate the updated severe accident models of MIDAC. Among them, QUENCH-06 is the international standard No.45, QUENCH-16 is a test for the analysis of air oxidation, and FROMA is an out-of-pile fuel rod melting experiment recently carried out by Xi'an Jiaotong University. The heating and melting model with lumped parameter method and the steam oxidation model with Cathcart-Pawel and Volchek-Zvonarev correlations combination in MIDAC could better meet the needs of severe accident analysis. Although the influence of nitrogen still need to be further improved, the air oxidation model with NUREG still has the ability to provide guiding significance for engineering practice.

• Atmosphere
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• v.26 no.3
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• pp.387-400
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• 2016

In this study, the atmospheric $CO_2$ concentrations estimated by CT2013B, a recent version of CarbonTracker, are compared with $CO_2$ measurements from the Comprehensive Observation Network for Trace gases by Airliner (CONTRAIL) project during 2010-2011. CarbonTracker is an inversion system that estimates surface $CO_2$ fluxes using atmospheric $CO_2$ concentrations. Overall, the model results represented the atmospheric $CO_2$ concentrations well with a slight overestimation compared to observations. In the case of horizontal distribution, variations in the model and observation difference were large in northern Eurasia because most of the model and data mismatch were located in the stratosphere where the model could not represent $CO_2$ variations well enough due to low model resolution at high altitude and existing phase shift from the troposphere. In addition, the model and observation difference became larger in boreal summer. Despite relatively large differences at high latitudes and in boreal summer, overall, the modeled $CO_2$ concentrations fitted well to observations. Vertical profiles of modeled and observed $CO_2$ concentrations showed that the model overestimates the observations at all altitudes, showing nearly constant differences, which implies that the surface $CO_2$ concentration is transported well vertically in the transport model. At Narita, overall differences were small, although the correlation between modeled and observed $CO_2$ concentrations decreased at higher altitude, showing relatively large differences above 225 hPa. The vertical profiles at Moscow and Delhi located on land and at Hawaii on the ocean showed that the model is less accurate on land than on the ocean due to various effects (e.g., biospheric effect) on land compared to the homogeneous ocean surface.