• Korean Journal of Plant Resources
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• v.28 no.5
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• pp.635-640
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• 2015

Nonalcoholic fatty liver disease (NAFLD) is a kind of liver inflammation caused by an accumulation of fat in the liver. Patients with NAFLD have an increased risk to develop liver fibrosis, which leads to cirrhosis. To investigate hepatoprotective effects of Agrimonia eupatoria L (A. eupatoria), oleic acid-induced NAFLD in HepG2 cells was used and A. eupatoria was fractionated with ethanol (EtOH), n-hexane, dichloromethane (CH₂Cl₂), ethyl acetate (EtOAc), n-butanol (BuOH), and H₂O. Cells treated with the EtOAc fraction showed the highest lipid accumulation inhibiting effect. A. eupatoria also suppressed triglyceride accumulation and inhibited expression of lipid marker gene, such as a peroxisome proliferator activated receptor γ (PPAR-γ). Moreover, another marker, mRNA expression level of peroxisome proliferator activated receptor α (PPAR-α) was significantly increased by in a dose-dependent manner. These results suggest that A. eupatoria is a potent agent for the treatment of NAFLD.

• Journal of Institute of Control, Robotics and Systems
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• v.21 no.6
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• pp.518-523
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• 2015

This paper proposes a gait phase classifier using a Recurrent Neural Network (RNN). Walking is a type of dynamic system, and as such it seems that the classifier made by using a general feed forward neural network structure is not appropriate. It is known that an RNN is suitable to model a dynamic system. Because the proposed RNN is simple, we use a back propagation algorithm to train the weights of the network. The input data of the RNN is the lower body's joint angles and angular velocities which are acquired by using the lower limb exoskeleton robot, ROBIN-H1. The classifier categorizes a gait cycle as two phases, swing and stance. In the experiment for performance verification, we compared the proposed method and general feed forward neural network based method and showed that the proposed method is superior.

• International Journal of Automotive Technology
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• v.8 no.6
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• pp.745-752
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• 2007

In this study, the effects of flexible bodies in vehicle suspension components were investigated to enhance the accuracy of multibody dynamic simulation results. Front and rear suspension components were investigated. Subframes, a stabilizer bar, a tie rod, a front lower control arm, a front knuckle, and front struts were selected. Reverse engineering techniques were used to construct a virtual vehicle model. Hard points and inertia data of the components were measured with surface scanning equipment. The mechanical characteristics of bushings and dampers were obtained from experiments. Reaction forces calculated from the multibody dynamics simulations were compared with test results at the ball joint of the lower control arm in both time-history and range-pair counting plots. Simulation results showed that the flexibility of the strut component had considerable influence on the lateral reaction force. Among the suspension components, the flexibility of the sub-frame, steering knuckle and upper strut resulted in better correlations with test results while the other flexible bodies could be neglected.

• 제어로봇시스템학회:학술대회논문집
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• 1999.10a
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• pp.92-95
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• 1999

The design problem of the control system is the ability to synthesize controller that achieve robust stability and robust performance. The paper explains the Finite Inclusions Theorem (FIT) by the procedure namely FIT synthesis. It is developed for synthesizing robustly stabilizing controller for parametrically uncertain system. The fundamental problem in the study of parametrically uncertain system is to determine whether or not all the polynomials in a given family of characteristic polynomials is Hurwitz i.e., all their roots lie in the open left-half plane. By FIT it can prove a polynomial is Hurwitz from only approximate knowledge of the polynomial's phase at finitely many points along the imaginary axis. An example shows the simplicity of using the FIT synthesis to directly search for robust controller of parametrically uncertain system by way of solving a sequence of systems of linear inequalities. The systems of inequalities are solved via the projection method which is an elegantly simple technique fur solving (finite or infinite) systems of convex inequalities in an arbitrary Hilbert space. Results from example show that the controller synthesized by FIT synthesis is better than by H$\sub$$\infty$/ synthesis with parametrically uncertain system as well as satisfied the objectives for a considerably larger range of uncertainty.

• Korean Journal of Environmental Agriculture
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• v.26 no.4
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• pp.294-299
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• 2007

Natural gypsum has been used as a soil amendment in the United States. However, flue gas desulfurization (FGD)-gypsum has not traditionally been used for agricultural purpose although it has potential benefit as a soil amendment. To expand use of FGD-gypsum for agricultural purpose, the effect of FGD-gypsum on soil chemical properties was investigated in the field scales. Application rates for this study were 0 (control), 1.1, and 2.2 Mg ha-1 of FGD-gypsum. After two year application, the soil samples were taken to 110 cm depth and sub-sampled at 10 cm intervals. The heavy metal contents in FGD-gypsum were lower than ceiling levels allowed by regulations for land-applied biosolids. Soil pH was not largely affected by FGD-gypsum application. Although degree of calcium (Ca) saturation in surface horizons increases only slightly with respect to the control, there is a clear decrease in exchangeable aluminum (Al). FGD-gypsum clearly increases the soil electrical conductivity (EC) with increasing application rate. Water-soluble Ca and sulfate is increased with FGD-gypsum application and these ions moved to a depth of at least 80 cm after only 2 years. We conclude that surface application of FGD-gypsum can mitigate toxicity of Al and deficiency of Ca in subsoil of acid soil.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.1
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• pp.111-119
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• 2015

A growth trial was conducted to determine the optimal incorporation level of dietary magnesium hydrogen phosphate (MHP, $MgHPO_4$), which was manufactured from swine manure and phosphorus (P), required by juvenile far eastern catfish (Silurus asotus). Graded MHP of 0.5%, 1.0%, 1.5%, and 2.0%, and 2.0% monocalcium phosphate (MCP) each was added to the basal diet (control) in lieu of cellulose to become the range of available P (AP) from 0.4% to 0.8% of which diets were designated as control, MHP0.5, MHP1.0, MHP1.5, MHP2.0, and MCP, respectively. Control diet contained fish meal (20%), soybean meal (40%), wheat flour (27%), corn gluten meal (5%), fish oil (2%) and soy oil (2%) as main ingredients. Following a 24 h fasting, 540 fish with a mean body weight of 11.8 g were randomly allotted to 6 groups in triplicate, whereby 18 tanks ($0.4{\times}0.6{\times}0.36cm$, water volume of 66 L) were prepared. The feeding experiment lasted for 8 weeks. Fish group fed the control diet showed the lowest weight gain (WG) and feed efficiency (FE) among treatments. The WG was, however, not significantly different (p>0.05) from that of fish group fed MHP0.5. Fish group fed MHP2.0 showed the highest WG and FE of which values were not significantly different from those of fish groups fed diets MHP1.0 and MHP1.5 as well as MCP (p>0.05) except fish groups fed control and MHP0.5. Aspartate aminotransferase was significantly decreased with an increase in available P, while alanine aminotransferase did not show a significant difference among treatment. The highest inorganic P in plasma was observed in fish fed MHP2.0. From the present results, a second-order regression analysis revealed that the optimal dietary MHP level and the AP requirement were found to be 1.62% and 0.7%, respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.5
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• pp.690-699
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• 2017

Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.1
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• pp.91-99
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• 2020

Objective: This study investigated the effects of oral administration of rumen-protected L-tryptophan (RPL-T) on duodenal starch digestion and gastrointestinal hormones (GIH) secretions using Hanwoo beef steers as the animal models. Methods: Four steers (423±24 kg) fitted with ruminal and duodenal cannulas were employed in a crossover design replicated twice. Treatments were control (basal diet) and RPL-T (basal diet+191.1 mg/kg body weight [BW]) group. Blood and duodenal samples were collected to measure serum GIH levels and pancreatic α-amylase activity at day 0, 1, 3, and 5 (-30, 30, 90, 150, and 210 min) of the study. Samples from each segment of the gastrointestinal tract were collected via ruminal and duodenal cannulas and were used to determine soluble protein and the starch digestion rate at days 6 (-30, 180, 360, and 540 min) and 8 (-30, 90, 270, and 450 min) of the experiment. Results: No significant difference in ruminal pH, NH₃-N, and total volatile fatty acid including the levels of acetate, propionate, butyrate, isobutyrate, valerate, isovalerate, and the acetate-to-propionate ratio was observed between groups (p>0.05). Crude protein uptake was higher and feces starch content was lower in RPL-T group than the control group (p<0.05). The D-glucose contents of feces in RPL-T group decreased at day 5 compared to those in the control group (p<0.05), however, no change was found at day 0, 1, or 3 compared to the control group (p>0.05). Serum cholecystokinin (CCK), melatonin, duodenal pancreatic α-amylase activity, and starch digestion were significantly higher in RPL-T group than the control group (p<0.05). Conclusion: Taken together, oral administration of RPL-T at the rate of 191.1 mg/kg BW consistently increased CCK concentration, pancreatic α-amylase activity in duodenal fluids, and starch digestion rate in the small intestine and thus found to be beneficial.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.33 no.1
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• pp.46-58
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• 1997

The energy saving is one of the most important factors for profit in marine transportation. In order to reduce the fuel oil consumtion the ship's propulsion efficiency must be increased as possible. The propulsion efficiency depends upon a combination of an engine and a propeller. The propeller has better efficiency as lower rotational speed. This situation led the engine manufacturers to design the engine that has low speed, long stroke and a small number of cylinders. Consequently, the variation of rotational torque became larger than before because of the longer delay-time in fuel oil injection process and an increased output per cylinder. As this new trends the conventional mechanical-hydrualic governors for engine speed control have been replaced by digital speed controllers which adopted the PID control or the optimal control algorithm. But these control algorithms have not enough robustness to suppress the variation of the delay-time and the parameter perturbation. In this paper we consider the delay-time and the perturbation of engine parameters as the modeling uncetainties. Next we design the robust servo controller which has zero offset in steady state engine speed, based on H sub($\infty$) control theory. The validity of the controller was investigated through the response simulation. We used a personal computer and an analog computer as the digital controller and the engine (plant) part respectively. And, we could certify that the designed controller maintains its robust servo performance even though the engine parameters may vary.

• Korean Journal of Adult Nursing
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• v.12 no.3
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• pp.407-417
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• 2000

The purpose of this study was to examine the effect of preoperative teaching as a nursing intervention on the emotional status of the patients prior to surgery. The method of this study was Nonequivalent Control Group Non-Synchronize Design. The data were selected from H universuty hospital in Seoul, and they consisted of an experimental group-30patients, and a control group-30 patients. The questionnaire consisted of 28 Preoperative Stress Inventory(Kang, 1998), and 16 State- Trait Anxiety Inventory(Spielberger, 1972). The collected data were analized by means of frequency, percentage, $X^2$ test, t-test and paired t-test with SPSS WIN. The results of this study were as follows : 1. The level of stress prior to surgery was significantly lower for the preoperative teaching group than for the control group(t=2.61, p< .01). 2. The level of anxiety prior to surgery was not significantly lower for the preoperative teaching group than for the control group. 3. The difference level of the anxiety level the prior to surgery was significantly higher for the preoperative teaching group than for the control group(t=2.82, p< .01). In conclusion, preoperative teaching is a beneficial nursing intervention that has a positive effect on the stress and anxiety of patients prior to surgery. Therefore it is recommended to use the preoperative teaching program as a nursing intervention for patients prior to surgery.