• Title/Summary/Keyword: Guidance and control

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Guideline for Extended Release Oral Dosage Forms : Development, Evaluation, and Application of In Vitro/In Vivo Correlations (서방성 경구제형의 개발과 평가 및 생체내.외 상관성 연구를 위한 가이드라인)

  • Choi, Sun-Ok;Jeong, Sung-Hee;Um, So-Young;Jung, Seo-Jeong;Kim, Joo-Il;Kim, Ok-Hee
    • Journal of Pharmaceutical Investigation
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    • v.35 no.6
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    • pp.471-481
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    • 2005
  • In Korea, generic drug and bioequivalence test are the hot issues since a new medical system of separation of dispensary from medical practice was started in 2000. The KFDA(Korea FDA) had revised several times ${\ulcorner}Guidance\;for\;bioequivalence\;test{\lrcorner}$. In vitro dissolution test has been extensively used as a quality control tool for solid oral dosage forms. In an effort to minimize unnecessary human testing, in vitro/in vivo correlations (IVIVC) between in vitro dissolution and in vivo bioavailability are increasingly becoming an integral part on extended release drug product development. The recently published US guidance, ${\ulcorner}Extended\;release\;oral\;dosage\;forms\;:\;development,\;evaluation,\;and\;application\;of\;in\;vitro/in\;vivo\;correlations{\lrcorner}$ will be helpful for us to make our own guideline.

Monitoring of Heavy Metal Contents in Commercial Herbal Medicines in Korea: Cultivated Herbal Medicines in the Seoul and Daegu Areas (국내 유통 한약재의 중금속 함량 모니터링 -서울과 대구지역 한약재 중심으로 -)

  • Jang, Seol;Lee, Ah-Reum;Lee, A-Eong;Choi, Go-Ya;Kim, Ho-Kyoung
    • Journal of Environmental Health Sciences
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    • v.41 no.1
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    • pp.30-39
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    • 2015
  • Objectives: This study was conducted to determine the heavy metal contents in commercial herbal medicines in Korea. Methods: Monitoring of lead, arsenic, cadmium and mercury was carried out on 116 samples of eleven types of herbal medicines. Among the total samples, 71 samples were domestic and 45 were imported. The samples were digested using the microwave method. The heavy metal contents were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES) and a mercury analyzer. ICP-AES was used to analyze lead, arsenic cadmium. Mercury was analyzed by the amalgamation method. Results: The mean values of the heavy metal contents in the herbal medicines were Pb 0.64mg/kg, As 0.26mg/kg, Cd 0.07mg/kg and Hg 0.004mg/kg. Of the total samples, one violated the MFDS (Ministry of Food and Drug Safety) regulatory guidance on heavy metals in herbal medicines. Lead was detected at more than 5mg/kg in one sample. The measured values of arsenic, cadmium and mercury in the herbal medicines showed levels lower than the recommended levels for herbal medicines in MFDS regulatory guidance. In the comparison of domestic samples with imported herbal medicines, it was found that one domestic sample surpassed the maximum residue limits for lead. Conclusion: These results will be used to establish the regulation and control of heavy metal contents in herbal medicines. In addition, continuous monitoring is needed to ensure confidence in and the safety of these herbal medicines.

Performance Analysis of Navigation System for Guidance and Control of High Speed Underwater Vehicle System (고속 수중운동체 정밀 유도제어를 위한 항법성능 분석)

  • Hong, Sung-Pyo;Han, Yong-Su
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.9
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    • pp.2227-2232
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    • 2013
  • To obtain the system requirement specification in the beginning of the precision guidance system development, the effectiveness and reliability analysis for the system are necessary. The main purpose of this research is to obtain the system requirement specification for the high speed unmanned underwater vehicles by carrying out the effectiveness analysis using the modeling and simulation scheme. The effectiveness is position error for target position. Reaching accuracy is expected to be affected by the navigation sensor parameter. Assume that the navigation sensors that is consist of inertial navigation system(INS) and doppler velocity log(DVL) is the parameter. To analyze the effectiveness of each parameter, Monte-Carlo numerical simulation is performed in this research. The effectiveness analysis is carried out using circular error probability(CEP) and variance analyze scheme. Considering the cost function, the specification of the navigation sensor is provided. The cost function is consist of the INS and DVL specification and the price of those sensors.

Design of Auto Race-Track and Figure-8 Flight Mode for UAV (무인기의 자동 장주비행 및 8자 비행모드 설계)

  • Lee, Sangjong
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.42 no.10
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    • pp.851-857
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    • 2014
  • This paper addresses the design of the auto race-track and figure-8 flight mode which can be applied to expand the loitering flight mode and increase the safety of UAV. To implement these flight modes, necessary waypoints and entry points can be calculated automatically from several information of the ground control system. The flight logic is proposed to pass the desired waypoints as well as entry points and transfer to the desired flight path by combining the light-of-sight and loitering guidance controller. The proposed algorithm and logic is verified using the 6-DOF UAV model and nonlinear simulation under the several flight conditions.

AGV Distance Learning Model Based on Virtual Simulation (가상 시뮬레이션 기반의 AGV 원격 교육 모델)

  • Jin, Go-Whan
    • Journal of the Korea Convergence Society
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    • v.11 no.11
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    • pp.41-46
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    • 2020
  • The start of the Fourth Industrial Revolution has brought about various changes in the domestic industry in general, and smart factories have spread to companies in the fields of production, manufacturing and logistics, and they are using automation equipment. Especially in the field of logistics automation, AGVs are widely used, and most of them use the line guidance system, which is the traditional AGV drive system. In addition, the demand for AGV system developers, system operators and managers, and maintenance personnel is increasing, and the installation of systems for education is expensive and requires a large space to utilize. It is a situation where systematic education is difficult. In this paper, we propose a virtual simulation-based AGV distance education model for smooth practice of trainees. The proposed model consisted of a model that can drive the AGV by analyzing video information, instead of the line guidance method that is the conventional technology. As a result of self-diagnosis evaluation, it was confirmed that the experimental group through online education had an average satisfaction level of 0.65 higher than the control group using existing equipment, and that it could be used in an online education environment.

Control Law Design for a Tilt-Duct Unmanned Aerial Vehicle using Sigma-Pi Neural Networks (Sigma-Pi 신경망을 이용한 틸트덕트 무인기의 제어기 설계연구)

  • Kang, Youngshin;Park, Bumjin;Cho, Am;Yoo, Changsun
    • Journal of Aerospace System Engineering
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    • v.11 no.1
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    • pp.14-21
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    • 2017
  • A Linear parameterized Sigma-Pi neural network (SPNN) is applied to a tilt-duct unmanned aerial vehicle (UAV) which has a very large longitudinal stability ($C_{L{\alpha}}$). It is uncontrollable by a proportional, integral, derivative (PID) controller due to heavy stability. It is shown that the combined inner loop and outer loop of SPNN controllers could overcome the sluggish longitudinal dynamics using a method of dynamic inversion and pseudo-control to compensate for reference model error. The simulation results of the way point guidance are presented to evaluate the performance of SPNN in comparison to a PID controller.

I3A Framework of Defense Network Centric Based C2 Facilities (국방 NC 기반 C2 시설 I3A Framework)

  • Kim, Young-Dong;Lee, Tae-Gong;Park, Bum-Shik
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.39C no.8
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    • pp.615-625
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    • 2014
  • Ministry of National Defense, MND, established a "Master Plan of Military Facility" in 2010 based on the defense reform to prepare for future war. It was a plan for consolidating small military facilities into battalion units, reflecting on and preparing for the needs of various changes in defense environment as well as balanced growth of ROK Army, Navy, and Air Force. However, to move forward with "Military Facility Master Plan," current design criteria for military facilities need to be revised to be enacted due to numerous calculation errors in facility footprints because of the absence of a sound facility criteria. Because the future war environment will be changed from Platform basis to Network Centric Warfare basis, Command & Control capability of C4I systems is getting more important. Therefore, Successful mission accomplishment can be secured by convergence of facility and military Information Technology(IT). So, MND should quickly prepare for the operational guidance, design criteria and policy that are suitable for Network Centric Warfare accomplishment, and implement infrastructure of IT and installation of C2 facility in conjunction with consolidation movement of military facilities. In this paper, we propose the defense I3A framework in order to solve this problem.

3-Dimensional Path Planning and Guidance using the Dubins Curve for an 3-DOF Point-mass Aircraft Model (Dubins 곡선을 이용한 항공기 3자유도 질점 모델의 3차원 경로계획 및 유도)

  • O, Su-Hun;Ha, Chul-Su;Kang, Seung-Eun;Mok, Ji-hyun;Ko, Sangho;Lee, Yong-Won
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.24 no.1
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    • pp.1-9
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    • 2016
  • In this paper, we integrate three degree of freedom(3DOF) point-mass model for aircraft and three-dimensional path generation algorithms using dubins curve and nonlinear path tracking law. Through this integration, we apply the path generation algorithm to the path planning, and verify tracking performance and feasibility of using the aircraft 3DOF point-mass model for air traffic management. The accuracy of modeling 6DOF aircraft is more accurate than that of 3DOF model, but the complexity of the calculation would be raised, in turn the rate of computation is more likely to be slow due to the increase of degree of freedom. These obstacles make the 6DOF model difficult to be applied to simulation requiring real-time path planning. Therefore, the 3DOF point-mass model is also sufficient for simulation, and real-time path planning is possible because complexity can be reduced, compared to those of the 6DOF. Dubins curve used for generating the optimal path has advantage of being directly available to apply path planning. However, we use the algorithm which extends 2D path to 3D path since dubins curve handles the two dimensional path problems. Control law for the path tracking uses the nonlinear path tracking laws. Then we present these concomitant simulation results.

The Effectiveness of a Career Design Program for Medical Students (의학전문대학원생을 대상으로 한 진로설계프로그램 효과분석)

  • Yoo, Hyo Hyun;Park, Kwi Hwa;Kim, Seong Yong;Im, Sun Ju
    • Korean Medical Education Review
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    • v.17 no.3
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    • pp.131-139
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    • 2015
  • The purpose of this study was to develop a career planning program for medical students and to examine its effectiveness with regard to career choice motivation and career maturity. A total of 89 medical students participated in the study. Forty-four were in the experimental group and 45 were in the control group. The collected data were analyzed with the t-test, analysis of covariance, descriptive statistics, and analysis of frequency by PASW SPSS ver. 18.0 (SPSS Inc.). A career planning program was developed using the ADDIE (analysis, design, development, implementation, and evaluation) model. The contents of self-understanding and career exploration were included in this program. The program was conducted as a seminar with preferred major professors. There was a significant difference in the intrinsic motivation score between the control and experimental groups (p<0.05). The score of the experimental group (M=4.59) was higher than that of the control group (M=4.40). Significant differences in decisiveness (p<0.01) and realistic choice (p<0.05), the sub-factors of the career maturity test, were found between the control and experimental groups. The score of decisiveness of the experimental group (M=2.94) was higher than that of the control group (M=2.79). The score of realistic choice in the experimental group (M=3.17) was lower than that in the control group (M=3.37). Most medical students were satisfied with the career planning program. It is hoped that these results provide useful information for designing career guidance programs for students in medical schools.

An Analysis of Consumers' Problematic Complaining Behaviors and Firms' Reactions (소비자의 악성불평행동 분석 및 기업의 대처행동 조사 연구)

  • Huh, Kyung-Ok
    • Journal of Families and Better Life
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    • v.30 no.6
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    • pp.167-181
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    • 2012
  • This study analyzed consumer's harsh complaining behaviors and firm's reactions toward consumers' harsh complaining behavior, and investigated the differences in the firms' reactions according to the characteristics of counselors and customer service centers. In addition, this study attempted to find a strategy and provide guidance regarding consumer's harsh complaining behaviors. The results of this study are discussed below. First, consumer's harsh complaining attitudes were expressed by crude language, violent language, threats, personal attacks, and claims of a high-ranking social position. Consumer's directive, complaining behaviors were repeated on the telephone, and threats of prosecution or disclosure to the public, exposure of habitual product returns, and requests for interviews with superiorsat the representative firm were made. Second, a firm typologies according to its reaction style toward a consumer's harsh complaining behaviors were as follows: Group 1, having a neutral attitude toward consumers and preparation thoroughly regarding their demands; Group 2, having a negative attitude toward consumers and some degree of preparation toward consumers' demands; and finally, Group 3, having a positive attitude toward consumers but offering insufficient reparation regarding consumers' demands. Third, female counselors, counselors having a certified counselor's license, and those much experience working in labor work were more likely to be in Group 3. Male counselors, part-time counselors, and those having experience of many years were more likely to be in Group 2. Group 1 were more likely to have large number of workers at customer service centers, male counselors, and to have large numbers of educational training programs related to the reactions of consumers in the form of dissatisfaction, complaints, how to offer compensation for injuries to consumers, and issues related to PL(product liability). In addition, Group 1 also had more firm level welfare policies related to hight stress levels of consumer counselors and extra types of support regarding harsh consumers. However, Group 2 members were more likely to provide excessive compensation and rewards to harsh consumers. Finally, to react to consumer's harsh complaint efficiently, it was suggested that firms should not treat consumers as harsh consumers, should react to consumers' complaints sincerely, and should take precautionary management efforts as regards consumer dissatisfaction based on better quality control of products. In addition, it was deemed necessary to formulate a management strategy to train competent consumer counselors with a high quality of counselor skill, having standardized and consistent reaction guidance toward consumer complaints and thorough knowledge of compensation rules for consumer injuries and subsequent guidance.