• Journal of Yeungnam Medical Science
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• 제22권1호
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• pp.1-12
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• 2005

Normal growth and development is of prime concern during childhood. The treatment of children with growth hormone deficiency has been revolutionized by growth hormone therapy. An improved height outcome with a final height within the target height range has been achieved. However, close follow-up with regular clinical and laboratory monitoring is essential for achieving the desirable height outcome. The theoretical unlimited supply of growth hormone has led to its wide spread use in a variety of disorders other than a growth hormone deficiency. Initially used in children with Turner syndrome, growth hormone is now used to treat chronic renal failure, an idiopathic short stature and intrauterine growth restrictions in addition to a wide array of newly emerging indications. This review summarizes the basics for a proper growth assessment, the differentiation of normal and abnormal growth causes of a short stature, and the indications for growth hormone treatment.

• 보건교육건강증진학회지
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• 제23권5호
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• pp.13-27
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• 2006

This study was performed to formulate the most recent traits of physical growth of youth, and to identify the need of youth for health promotion planning in modern Korea. Study participants were 171 boys and 400 girls in two senior high schools in Seoul, Korea. Health records were collected from the individual students in May 2005. Longitudinal data on stature and body weight from 6 to 16 years old were analysed. Significance tests on some measures were performed by t-test and ANOVA. Major conclusions were as follows: 1. Girls were taller than boys during the specific time of adolescence. However, this phenomenon was not found in the growth process investigated by peak age and in over-all mean growth process of body weight. 2. Peak age came later in boys than in girls in both stature and body weight. This meant that boys matured later in stature and body weight than girls. However, boys were larger in peak velocity than girls. 3. Peak ages distributed more widely in girls than in boys both for stature and body weight. 4. Even in such short growth process from 6 through 16 years old, growth spurt tended to appear in several times. 5. Growth spurt tended to appear more often in boys than in girls.

• 대한한방소아과학회지
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• 제18권1호
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• pp.77-91
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• 2004

Objective: The purpose of this study were to examine the growth pattern of weak children by measurement according to the five weak symptoms (respiratory, digestive, psycho-neurological, neuromotor, urogenital symptom). Five weak symptoms are common etiology of short stature in childhood and oriental medicine therapy is used as a treatment in short stature but the effects on height are not conclusive. Methods: This clinical study had been carried out with the 166 case (male 74, female 92) of the children aged 3 to 18 years old who visited in growth clinic of Pediatrics, Dongguk university Bundang Oriental Hospital. They were divided into 3 groups by age (3-10, 11-14, 15-18 years group) Five weak symptoms were studied to determine the association with growth stature among children by comparison with the growth stature of weak children group and normal group Results: The distribution of age showed the highest in 11-14 years(58.4%), followed by I 3-10 years (26.5%), over 15years(15%) in order. In case of male, the distribution of five weak symptoms showed the highest respiratory weak symptom(68.9%), followed by digestive(52.7%), psycho-neurological(43.2%), neuromotor(24.3%), urogenital weak symptom (143.5%) and digestive weak children's Height SDS were lower than normal children in all age groups and respiratory weak children's Height SDS were lower than normal children in age group of 3-10. In case of female, the distribution of five weak symptoms showed the highest digestive weak symptom(59.8%), followed by respiratory(52.5%), psycho-neurological(51.5%), neuromotor (35.9%), urogenital weak symptom (25%) and digestive weak children's Height SDS were lower than normal children in age group of 3-14. Other weak children Height SDS were no significant difference from normal group. Conclusions: From the above result, it was suggested that weak symptoms is cause in short stature. These data indicate that the height was correlated with respiratory, digestive weak symptom and a way to improve the weakness increased significantly height in children growth stature. Growth stature should be investigated as a new field of oriental medical treatment and more controlled, long term studies are required to classify benefits of Oriental medicine therapy in short stature.

• 한국융합학회논문지
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• 제12권6호
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• pp.39-47
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• 2021

이 연구는 치아발육단계에서 성장호르몬 결핍의 영향을 알아보기 위해서 성장호르몬 결핍이나 특발성 저신장 소아와 정상 소아 간의 차이를 분석하는 것을 목적으로 한다. 영남대학교 의과대학 부속병원 소아청소년과에서 저신장으로 진단받은 소아들을 성장호르몬 결핍인 대상자와 특발성 저신장 소아로 분류하였다. 구강 파노라마와 신체지수를 계측하여 치아발육과의 관계를 분석하였다. 성장호르몬 결핍성 저신장 소아와 특발성 저신장 소아 간의 유의한 차이는 측절치에서만 나타났다. 성장호르몬 결핍성 저신장 소아와 정상 소아 간에는 모든 치아에서 성장호르몬 결핍성 저신장 소아의 발육이 유의하게 늦은 것으로 나타났다. 결론적으로 저신장 소아에서 성장호르몬 결핍성 저신장 소아나 특발성 저신장 소아 모두 신장뿐만 아니라 치아 발육 역시 영향을 받은 것으로 나타났다. 이 연구는 향후 저신장 소아의 교정치료 프로토콜의 기초자료를 제시할 수 있을 것으로 기대한다.

• 대한치과교정학회지
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• 제37권1호통권120호
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• pp.16-28
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• 2007

본 연구는 청소년의 교정 치료 시 중요한 교정 환자의 성장 평가 및 잔여 성장량 예측 방법을 개발하기 위하여 시행되었다. 이를 위하여 한국인의 전국적 표본 자료 중에서 $2\;{\sim}\;20$세 남자 4,893명, 여자 4,987명의 키 자료를 이용하여 성별 연령별 키에 대한 성장 곡선을 3차 스플라인 함수(NCSF)로 구현하였다. 이후 성장 예측 알고리즘을 개발하고 이를 임의로 선택된 200명의 종단 성장 자료를 이용하여 검증하였다. 검증에는 최종 키 예측 정확성과 검증 표본의 모든 연령에 대한 키 예측 오차 분석 및 NCSF 성장 곡선의 적합성 검사가 포함되었다. 그 결과 NCSF 성장 곡선은 기준 성장 곡선을 표현하는데 매우 적합한 것으로 나타났으며 최종 키 예측 정확성도 높았다. 또한 예측 정확성은 남자 보다 여자가 유의하게 높았다. 이러한 결과에도 불구하고 검증 표본의 모든 연령에 대한 키 예측 오차의 양상이 독립성과 정규성이 부족한 단점도 나타났다. 결론적으로 본 연구 결과 도출된 NCSF 성장 곡선을 이용한 성장 예측 방법의 높은 정확성에도 불구하고 개인의 종단 성장에 좀 더 적합한 성장 모형의 개발이 필요할 것으로 생각되었다.

• Journal of Interdisciplinary Genomics
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• 제5권2호
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• pp.18-23
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• 2023

Conventional evaluation method for identifying the organic cause of short stature has a low detection rate. If an infant who is small for gestational age manifests postnatal growth deterioration, triangular face, relative macrocephaly, and protruding forehead, a genetic testing of IGF2, H19, GRB10, MEST, CDKN1, CUL7, OBSL1, and CCDC9 should be considered to determine the presence of Silver-Russell syndrome and 3-M syndrome. If a short patient with prenatal growth failure also exhibits postnatal growth failure, microcephaly, low IGF-1 levels, sensorineural deafness, or impaired intellectual development, genetic testing of IGF1 and IGFALS should be conducted. Furthermore, genetic testing of GH1, GHRHR, HESX1, SOX3, PROP1, POU1F1, and LHX3 should be considered if patients with isolated growth hormone deficiency have short stature below -3 standard deviation score, barely detectable serum growth hormone concentration, and other deficiencies of anterior pituitary hormone. In short patients with height SDS <-3 and high growth hormone levels, genetic testing should be considered to identify GHR mutations. Lastly, when severe short patients (height z score <-3) exhibit high levels of prolactin and recurrent pulmonary infection, genetic testing should be conducted to identify STAT5B mutations.

• Journal of Genetic Medicine
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• 제15권2호
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• pp.102-106
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• 2018

Aggrecan is a proteoglycan in the extracellular matrix of growth plate and cartilaginous tissues. Aggrecanopathy has been reported as a genetic cause not only for severe skeletal dysplasia but also for autosomal dominant short stature with normal to advanced bone age. We report a novel heterozygous mutation of ACAN in a Korean family with proportionate short stature identified through targeted exome sequencing. We present a girl of 4 years and 9 months with a family history of short stature over three generations. The paternal grandmother is 143 cm tall (-3.8 as a Korean standard deviation score [SDS]), the father 155 cm (-3.4 SDS), and the index case 96.2 cm (-2.9 SDS). Evaluation for short stature showed normal growth hormone (GH) peaks in the GH provocation test and a mild delayed bone age for chronological age. This subject had clinical characteristics including a triangular face, flat nasal bridge, prognathia, blue sclerae, and brittle teeth. The targeted exome sequencing was applied to detect autosomal dominant growth palate disorder. The novel variant c.910G>A (p.Asp304Asn) in ACAN was identified and this variant was found in the subject's father using Sanger sequencing. This is the first case of Korean familial short stature due to ACAN mutation. ACAN should be considered for proportionate idiopathic short stature, especially in cases of familial short stature.

• 대한치과교정학회지
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• 제16권1호
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• pp.145-154
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• 1986

The purpose of the present study was to investigate the coordination and correlation of growth pattern between craniomaxillary complex and mandible, and among the craniofacial region, body-weight and stature. 14 boys and 16 girls between 6 and 12 years of age were used in this study. The result were as follows; 1. Total increments and maximum increment in mandible is higher than in oraniomaxillary complex during given period and no significant sexual difference existed. 2. The annual growth of craniofacial region did not assume an aspect of constant growth, periodically. 3. Craniofacial growth pattern was interrelated with stature more than with body-weight. 4. The growth behavior of body-weight and stature coincided with the growth of craniofacial region or preceded it in time.

• 대한예방한의학회지
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• 제26권1호
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• pp.1-10
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• 2022

Objectives : The aim of this study was to introduce the development process of Korean medicine health promotion program for short stature children that is suitable for applied at public health center. Methods : The draft of health promotion program was developed through literature search of previous similar programs and advice of several experts. A small conference targeted public health Korean medicine doctors was also held to introduce the developed program and discuss for improvements. Results : The details of 12-week of Korean medicine health promotion program for children growth are as follows: 4-week of taking herbal medicines (Yukmijihwang-tang or Yukgunja-tang), contactless counseling with Korean medicine doctor, self-care home kit consisting of Sogeonjung-tang tea leaf, Sogeonjung-tang with Cervi Parvum Cornu extract, ear acupressure stick, finger chuna manual, growth diary, and jump rope. Conclusions : This health promotion program can help to increase the height of children and self-esteem of children with short stature as well as decrease the stress of parents.

• 대한치과교정학회지
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• 제19권3호
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• pp.123-133
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• 1989

To predict the pubertal growth peak in stature and study the skeletal maturity degree using hand-wrist radiograph, the author used the 70 malocclusions (male 24, female 46). After longitudinal measurement of stature and skeletal maturity indicators of hand-wrist radiographs were taken during 4 years, the rsults were as follows. 1) The pubertal growth peak in stature occurred mainly at SMI 6-7 (56.5%) in female, SMI 5-6 (37.5%), 6-7 (37.5%) in male (Table 5). 2) It was suggested that the pubertal growth peak in stature was already passed, if SMI 8 occurred. 3) Ages of SMI in female were about 2 years earlier than those of SMI in male, and the sexual difference was gradually decreased in puberty. 4) Duration of SMI was longest at SMI 6-7 in both sex and the mean was 8.5 months. After this stage, the velocity of skeletal maturity in female was decreased than in male. 5) The correlation coefficient between each SMI and pubertal growth peak was very high (Table 8).