• Journal of Yeungnam Medical Science
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• 제22권1호
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• pp.1-12
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• 2005

Normal growth and development is of prime concern during childhood. The treatment of children with growth hormone deficiency has been revolutionized by growth hormone therapy. An improved height outcome with a final height within the target height range has been achieved. However, close follow-up with regular clinical and laboratory monitoring is essential for achieving the desirable height outcome. The theoretical unlimited supply of growth hormone has led to its wide spread use in a variety of disorders other than a growth hormone deficiency. Initially used in children with Turner syndrome, growth hormone is now used to treat chronic renal failure, an idiopathic short stature and intrauterine growth restrictions in addition to a wide array of newly emerging indications. This review summarizes the basics for a proper growth assessment, the differentiation of normal and abnormal growth causes of a short stature, and the indications for growth hormone treatment.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2079-2086
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• 2012

창업에 대한 기대가 성장의도에 미치는 영향을 살필 본 연구목적은, 현재 중국 및 한국에서 기업경영하고 있는 기업가들을 대상으로 창업 초기에 가졌던 기대감과 창업 이후 성장의도에 어떤 영향이 있었는지를 확인하고자 양국 간의 차이를 발견하기 위한 것이다. 본 연구에서 기업가의 기대는 창업에 대한 기대로, 창업창출 및 성장의도는 기업가의 주도적 생각으로 정의되었다. 총 489 개 표본 연구결과에 따르면 제시된 상위가설은 모두 채택되었다. 즉 양국 기업가의 창업에 대한 기대는 창업 창출, 그리고 성장의도에 모두 유의한 정(+)의 영향을 미치는 것으로 나타났다. 또한 양국 기업가의 특성 간에 서로 차이가 비교했으므로, 창업에 대한 기대는 창업창출에 미치는 영향에서 한국 기업가들이 중국 기업가들보다 강하게 영향을 미치는 것으로 나타났으면서 창업창출은 성장의도에 미치는 영향에서 양국 기업가들 간에 차이가 없는 것으로 나타났다.

• Journal of Interdisciplinary Genomics
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• 제4권2호
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• pp.35-38
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• 2022

Background: Prader-Willi syndrome (PWS) is a complex genetic disease associated with growth impairment, severe obesity and metabolic dysfunctions. High proportion of PWS patients are born small for gestational age (SGA) than normal children, which also increase the risk of growth impairment and metabolic dysfunction in PWS. We aimed to compare growth outcome and metabolic profiles between SGA and appropriate for gestational age (AGA) PWS patients. Methods: Data of 55 PWS children and adults aged more than 2 years old (32 male and 23 female, age 2-18.8 years) from single center were studied. Only patients who were treated with GH were included. The clinical characteristics and laboratory findings were reviewed retrospectively. Results: Among 55 subjects, 39 had 15q11-13 deletion and 16 had uniparental disomy (UPD). Twenty (36.3%) were born SGA. All patients received GH treatment, and 11 (20%) discontinued GH treatment. Mean age at GH treatment initiation was 2.5 (range 0.3-12.4) years, and mean duration of treatment was 6.3 (range 1.0-11.3) years. Current height-SDS (-0.36 vs -0.16) and BMI-SDS (1.44 vs 1.33) did not differ between AGA and SGA group. Two patients in SGA group, but none in AGA group had diabetes mellitus. Mean glucose level was also higher in SGA group (100.1 vs 114.4 mg/dL). Conclusion: Our report gives an overview of growth profile and metabolic dysfunctions recorded in GH treated PWS patients. Growth profile did not differ between AGA and SGA group. Glucose level was higher in SGA group, so more careful monitoring and prevention for DM will be required in SGA group.

• Tuberculosis and Respiratory Diseases
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• 제77권6호
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• pp.243-250
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• 2014

Background: Information regarding prognostic value of growth differentiation factor 15 (GDF-15) and heart-type fatty acid-binding protein (H-FABP) in patients with chronic obstructive pulmonary disease (COPD) exacerbation is limited. The aim of this study was to investigate whether serum levels of GDF-15 and H-FABP predict an adverse outcome for COPD exacerbation. Methods: Clinical variables, including serum GDF-15 and H-FABP levels were compared in prospectively enrolled patients with COPD exacerbation that did or did not experience an adverse outcome. An adverse outcome included 30-day mortality and need for endotracheal intubation or inotropic support. Results: Ninety-seven patients were included and allocated into an adverse outcome (n=10) or a control (n=87) group. Frequencies of mental change and $PaCO_2$>37 mm Hg were significantly higher in the adverse outcome group (mental change: 30% vs. 6%, p=0.034 and $PaCO_2$>37 mm Hg: 80% vs. 22%, p<0.001, respectively). Serum GDF-15 elevation (>1,600 pg/mL) was more common in the adverse outcome group (80% vs. 43%, p=0.041). However, serum H-FABP level and frequency of serum H-FABP elevation (>755 pg/mL) did not differ between the two groups. Multivariate analysis showed that an elevated serum GDF-15 and $PaCO_2$>37 mm Hg were significant predictors of an adverse outcome (odds ratio [OR], 25.8; 95% confidence interval [CI], 2.7-243.8; p=0.005 and OR, 11.8; 95% CI, 1.2-115.3; p=0.034, respectively). Conclusion: Elevated serum GDF-15 level and $PaCO_2$>37 mm Hg were found to predict an adverse outcome independently in patients with COPD exacerbation, suggesting the possibility that serum GDF-15 could be used as a prognostic biomarker of COPD exacerbation.

• The Journal of Asian Finance, Economics and Business
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• 제8권4호
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• pp.625-633
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• 2021

Bangladesh's growing foreign aid has sparked controversy over whether it affects the country's economic performance. This review assesses foreign aid's influence on the country's economic growth with annual data covering the 1989-2018 period. The Autoregressive Distributed Lag (ARDL) model is applied to achieve the research objective, and the empirical results indicate a substantial and robust impact of foreign assistance on economic growth. The outcome further reveal that domestic investment also contributes significantly to the country's economic evolution. However, trade openness plays a substantial positive role in the short run, although the impact is immaterial in the long run. The empirical findings indicate that the association between aid, domestic investment, and growth has a confident meaningful effect at 1 per cent level in the long run, whereas aid influences more than domestic investment. However, in the short run, aid, domestic investment, trade openness, and growth show positive and noteworthy response also at 1 percent level. This review undertakes a detailed analysis about the country's economic growth, and grounded on its outcome, this work suggests that focus should be placed more on creating domestic investment, promoting more export, and allocation of aid should be determined by the relative needs of the country.

• 동아시아경상학회지
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• 제10권2호
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• pp.1-17
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• 2022

Purpose - This exploratory study analyzes the performance of the business from the HRM point of view. Analyzed the influence of HRM and organization effectiveness on business performance. Also moderating effect of the strategy is analyzed. Research design, data, and methodology - Two outcome variables are measured, non-financial performance and financial performance. Two organizational effectiveness variables are measured, job satisfaction and organizational commitment. And two HRM areas are measured, HRM practice and organizational culture. Finally, two strategies are measured as moderators, market strategy and product/service strategy. This study analyzed employees of 554 from the 7th HCCP. This study used SEM and MCFA. Result - The results of turnover intention, growth rate, and profit rate verified the influence of HRM and organizational effectiveness. Overall results showed a contrary effect of education & training system implement and participation on job satisfaction and organizational commitment. Among organizational culture, innovation and relation positively affect job satisfaction and organizational commitment. However, antecedents influencing turnover intention, growth rate, and profit rate bear no resemblance. And the MCFA result shows that strategy's group differentiation analysis is meaningful in turnover intention not in financial performance. Conclusion - Based on this study result, management suggestions for turnover intention, growth rate, profit rate, and organizational effectiveness are made. Especially, due to the company's strategy.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제20권1호
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• pp.41-46
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• 2017

Purpose: Vitamin D deficiency is common in Crohn disease (CD). The aim of the study was to examine the prevalence of vitamin D deficiency and evaluate the association between vitamin D status and growth outcome in Korean pediatric CD patients. Methods: In this retrospective study, 17 children younger than 18 years old diagnosed with CD were enrolled and their serum 25-hydroxy vitamin D (25[OH]D) was checked between 2011 and 2015. We categorized the patients into two groups, Group 1 and Group 2. Group 1 included patients with serum 25(OH)D levels below 10 ng/mL, and Group 2 was for patients with a 25(OH)D serum levels between 10 ng/mL and 30 ng/mL. The z-scores for height (Htz), weight (Wtz), and body mass index (BMIz) were measured at baseline, 6 months, and 12 months. Results: The mean serum 25(OH)D levels of the total 65 CD patients and 17 enrolled patients were $15.64{\pm}6.9ng/mL$ and $13.1{\pm}5.1ng/mL$, respectively. There was no correlation at the beginning of the study between vitamin D level and growth parameters (Htz, Wtz, BMIz) or other variables including laboratory data and Pediatric Crohn Disease Activity Index. The Htz, Wtz, and BMIz in Group 1 showed no significant improvement at 6 months and 12 months follow-up. In Group 2, Wtz and BMIz showed significant improvements sustained until 12 months of follow-up. Htz showed no significant improvement at 6 months but there was significant improvement at 12 months. Conclusion: It seems that baseline vitamin D status affects growth outcome in pediatric CD.

• 한국IT서비스학회지
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• 제9권1호
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• pp.57-71
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• 2010

The purpose of this study is to verify the competence level of IT service companies in Korea from the view point of capability of creating customers value and outcome as an independent companies which have been growing in the captive customers(market) circumstance by performance data analysis and IT specialists survey. This study presents a growth model which emphasis on the importance of the correlation between IT service companies and captive customers. It proves that the captive customers have been being the growth power and motive of the IT service company, because IT service companies have been cumulating the competence for IT service through the service for the customers, and with this competence, IT service companies have been expanding its service out to non-captive market(customers) and got good outcomes as an independent companies. And this study proves that the captive customers who served by the IT service companies which have a higher level of service capabilities have better business outcome. IT service companies contribute to improve the IT level of the captive customers and to make the customers to increase sales by conducting IT projects.

• 의학교육논단
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• 제15권3호
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• pp.112-119
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• 2013

Most medical colleges in Korea have been shifting from traditional education to outcome-based education, which is the general trend in medical education. The purpose of this study was to make some suggestions in light of the reality and challenges of student assessment in medical education from the perspective of outcome- based education. First, those who are responsible for student assessment should be diversified to include faculty, residents, students, and evaluation committee members. They need separate roles in educational evaluation, so evaluation competencies are required for them. Second, various methods for evaluation and score interpretation can be used for effective evaluation. We can adopt diagnostic, formative, and summative evaluation functionally, and the norm-referenced, criterion-referenced, growth-referenced, and ability-referenced evaluation based on criteria for score interpretation. Finally, various evaluation domains and test forms can be administered together in the common lectures in the medical school. We can test not only knowledge but also skills and attitudes, with diverse test forms such as supply and performance types.

• 기술혁신연구
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• 제19권1호
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• pp.1-27
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• 2011

본 연구는 1984년부터 패널자료의 확보가 가능한 17개 OECD 국가를 표본으로 하여 R&D 생산성 및 효율성에 대한 실증분석을 통해 비교하고 우리나라의 수준과 특징을 살펴보고자 하였다. 이를 위해 그 성과를 산출(output) 측면과 성과(outcome) 측면으로 구분하고, 맘퀴스트 생산성지수와 자료포락분석방법을 활용하여 R&D경로단계별 생산성 및 효율성과 그 변화추이를 비교분석하였다. 우리나라는 R&D 투자 대비 산출 생산성은 매우 높은 반면, 평균효율성은 매우 낮게 나타났으며, 효율성의 시계열 변화추이를 보면 최초 지수 0.10에서 시작하여 최종 0.83까지 가파르게 상승하면서 주요 선진국들 수준에 도달하였다. R&D 산출 대비 생산성은 매우 낮으며, 통합 프런티어에 대한 효율성은 최초 지수 1.00에서 최종 0.057까지 주요 선진국들 수준으로 가파르게 하락하여 왔다. 그리고 상관분석을 통해 R&D 산출 대비 생산성이 곧 R&D 투자 대비 생산성을 가늠하는 지표가 될 수 있음을 보았다. 본 연구는 우리나라의 R&D 생산성 및 효율성 향상을 위해서는 R&D 투자 및 산출 증대의 노력이상으로 R&D 산출물의 활용 측면이 보다 강화되어야 하고 이를 위해 효과적인 기술확산 체계 구축, 기술금융시장환경 조성 및 사업화에 성공하기까지 실질적인 인큐베이팅 제공 등 전반적인 기술사업화 시스템의 혁신이 주요 과제임을 시사하고 있다.