• 한국정보통신학회논문지
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• 제18권1호
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• pp.1-10
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• 2014

인터넷 트래픽의 성격은 최근에 극적으로 변화했으며 특히 인터넷 트래픽에서 동영상 트래픽이 차지하는 비중이 크게 증가했다. 동영상 트래픽은 트래픽의 패턴을 전통적인 쌍방향 통신에서 일방향 콘텐츠 전송으로 변화시키기 때문에 현행 정액제 중심의 인터넷망 요금구조는 이를 수용하기에 적절하지 않을 수 있다. 이러한 문제가 발생하는 가장 큰 이유는 트래픽(비용발생의 주요동인)과 수입간의 불연속이 있기 때문이다. 트래픽은 급격하게 성장할 것이라고 다 예측하고 있지만 트래픽을 전송하는 망 제공자의 수입은 그만큼 증가할 것이라 예측하기 힘들다. 본 논문에서는 예상되는 트래픽 성장을 감당하고 현행 수익모델을 개선하기 위한 다양한 대안들을 검토한다. 구체적으로 가용 네트워크 용량을 보다 효율적으로 사용하고 인터넷 서비스의 제공에 있어 보다 큰 혁신을 촉발시키기 위한 유인제도와 가격신호를 반영하는 대안을 평가기준에 따라 검토하고 바람직한 망이용대가 산정방안을 제시한다.

• Archives of Plastic Surgery
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• 제46권6호
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• pp.580-588
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• 2019

Background There are various reconstructive options for nail bed defects. However, it is challenging not to leave a deformity. In this study, we investigated differences in outcomes depending on the reconstruction method, attempted to determine which method was better, and analyzed other factors that may affect outcomes. Methods The long-term outcomes of nail bed reconstruction were reviewed retrospectively. We performed three types of reconstruction depending on the defect type: composite grafts of severed segments, nail bed grafts from the big toe, and two-stage surgery (flap coverage first, followed by a nail bed graft). Subsequent nail growth was evaluated during follow-up, and each outcome was graded based on Zook's criteria. The reconstruction methods were statistically analyzed. Other factors that could contribute to the outcomes, including age, the timing of surgery, germinal matrix involvement, defect size, and the presence of bone injuries, were also compared. Results Twenty-one patients (22 digits) who underwent nail bed reconstruction were evaluated. The type of reconstruction method did not show a significant relationship with the outcomes. However, patients who sustained injuries in the germinal matrix and patients with a defect larger than half the size of the nail bed had significantly worse outcomes than the comparison groups. Conclusions The results suggest that no operative method was superior to another in terms of the outcomes of nail bed reconstruction. Nevertheless, involvement of the germinal matrix and defect size affected the outcomes.

• 한국항만경제학회지
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• 제31권4호
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• pp.227-240
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• 2015

아시아를 중심으로 한 크루즈산업은 매년 관광객의 지속적인 증가로 인하여 급성장하고 있다. 이러한 이유로 아시아의 대표 항만 도시들 간에는 크루즈 관광객 및 크루즈선사를 유치하기 위하여 심한 경쟁을 하고 있는 실정이다. 한국도 예외는 아니며 부산을 중심으로 크루즈산업을 성장시키기 위하여 많은 노력들이 이루어지고 있다. 따라서 본 논문의 목적은 부산을 Hybrid항만 도시로서의 발전 가능성을 분석하였고 이를 위하여 크루즈 이용객을 국적별로 분류하여 부산에 대한 기대치와 만족도를 통하여 새로운 전략을 모색하였다. 위의 분석을 위하여 탐색적 요인분석과 IPA가 사용되었다. 부산이 크루즈 중심지로 발전하기 위해 우선적으로 개선이 필요한 요인은 다양한 관광옵션, 독특한 경험, 직접 서비스 인프라, 관광매력도, 타 교통수단과의 연계성, 관광명소와의 연계성으로 분석되었다. 부산이 동북아 경쟁 항만들을 뛰어넘는 세계적인 크루즈 중심지로 발전시키기 위해서는 지속적으로 다양한 관광상품 개발 및 차별화된 체험형 상품 개발이 시급하며 국제공항의 활성화 및 다양한 항공노선 확장을 통하여 Fly & Cruise 연계상품 개발에 주력해야한다. 또한 부산을 대표할 수 있는 국제적인 페스티벌을 유치하여 잠재적 승객 유치가 필요한 것으로 분석되었으며 크루즈 터미널의 재개발을 통한 상업적 문화공간 확충이 절실한 것으로 분석되었다.

• 구강회복응용과학지
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• 제33권2호
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• pp.143-153
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• 2017

치아 외상에 따른 흔한 합병증 중 하나는 치아 유착이다. 성인과 달리 성장기 아동에서 유착이 나타날 경우 유착치가 인접 치조골의 성장을 방해하여 치조골의 발육 부전과 이에 따른 개방 교합을 야기한다. 그러나 저위된 유착치를 단순 발치할 경우, 성장 완료 시까지 치조제의 상당한 소실을 유발하여 향후 심미적인 보철물을 수복하기가 어려워진다. 본 증례에서는 성장기에 상악 전치의 유착이 발생한 환자에서 단일 치아 골절단술 후 치조골 신장술과 치관 절제술을 시행하여 상악 전치부의 유착치를 심미적으로 결과를 얻었으므로 소개하고자 한다.

• Archives of Plastic Surgery
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• 제39권2호
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• pp.126-129
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• 2012

Background : Facial capillary malformations (CMs) rarely recede; they often become darker and raised in proportion to their growth. These malformations may hypertrophy in adulthood, resulting in increased disfigurement and dysfunction. Laser treatment is considered a first-line therapy for focal CMs, but thick wide lesions, which are accompanied by hypertrophy and have a well-circumscribed nodularity, may be treated with surgical excision and reconstruction. Methods : We retrospectively reviewed the records of 25 consecutive patients who had undergone complete or partial excisions of facial capillary malformations in our unit. After the excisions, the defects that encompassed their facial aesthetic units were subsequently covered by various methods, including primary closures, local flaps, expanded flaps, split-thickness skin grafts, and full thickness skin grafts. Results : The data demonstrated satisfactory results and reliability. Our patients were treated without significant complications, and all of the patients were moderately or fully satisfied with the outcome of their surgeries. Conclusions : Among the many reconstructive options for adult patients with facial capillary malformations, thick split-thickness skin grafts can be a good choice for the coverage of widely excised wounds.

• 대한암한의학회지
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• 제25권1호
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• pp.11-24
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• 2020

Objective : Radiodermatitis is a common sequelae in 95% of patients receiving radiation therapy, which is important to be well managed as it can affect the patient's quality of life as well as the cancer treatment schedule. The aim of this study is to review and summarize the interventions available for the treatment of acute radiodermatitis, including traditional Korean medicine, and to propose treatment algorithms for clinicians. Methods : To collect studies about managements for radiodermatitis, domestic and foreign database were used such as Korean journal of traditional knowledge portal (KTKP), Korean studies information service system (KISS), national discovery or science leaders (NDSL), and oriental medicine advance searching integrated system (OASIS), Pubmed, Google scholar and Scopus. Results : Thirty-two studies were selected. There were nine studies on usual care and dressing, eleven studies on chemical agents, two studies on biological preparations, and ten studies on herbal medicines. Conclusion : Hygienic options and dressings have proved to be useful in the management of radiodermatitis. Chemical agents such as corticosteroid, statin, and topical antibiotic agent have proved to alleviate symptoms and severity, regenerate damaged skin, and prevent secondary infection. In biological preparations, EGF (epidermal growth factor) and GM-CSF (granulocyte-macrophage colony-stimulating factor) could be used to protect skin and prevent radiodermatitis. For herbal medicines, Calendula, catechin, β-sitosterol, and Jaungo (紫雲膏) may be effective for symptoms including pain, itching, and burning sensation induced by radiation therapy. Because of some research with conflicting results, further studies are needed to propose an algorithm for more optimal treatments.

• Journal of Microbiology and Biotechnology
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• 제24권9호
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• pp.1216-1225
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• 2014

Biofilm-related infections of Candida albicans are a frequent cause of morbidity and mortality in hospitalized patients, especially those with immunocompromised status. Options of the antifungal drugs available for successful treatment of drug-resistant biofilms are very few, and as such, new strategies need to be explored against them. The aim of this study was to evaluate the efficacy of phenylpropanoids of plant origin against planktonic cells, important virulence factors, and biofilm forms of C. albicans. Standard susceptibility testing protocol was used to evaluate the activities of 13 phenylpropanoids against planktonic growth. Their effects on adhesion and yeast-to-hyphae morphogenesis were studied in microplate-based methodologies. An in vitro biofilm model analyzed the phenylpropanoid-mediated prevention of biofilm development and mature biofilms using XTT-metabolic assay, crystal violet assay, and light microscopy. Six molecules exhibited fungistatic activity at ${\leq}0.5mg/ml$, of which four were fungicidal at low concentrations. Seven phenylpropanoids inhibited yeast-to-hyphae transition at low concentrations (0.031-0.5 mg/ml), whereas adhesion to the solid substrate was prevented in the range of 0.5-2 mg/ml. Treatment with ${\leq}0.5mg/ml$ concentrations of at least six small molecules resulted in significant (p < 0.05) inhibition of biofilm formation by C. albicans. Mature biofilms that are highly resistant to antifungal drugs were susceptible to low concentrations of 4 of the 13 molecules. This study revealed phenylpropanoids of plant origin as promising candidates to devise preventive strategies against drug-resistant biofilms of C. albicans.

• 시스템엔지니어링학술지
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• 제12권1호
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• pp.73-87
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• 2016

Combining power generation and water production by desalination is economically advantageous. Most desalination projects use fossil fuels as an energy source, and thus contribute to increased levels of greenhouse gases. Environmental concerns have spurred researchers to find new sources of energy for desalination plants. The coupling of nuclear power production with desalination is one of the best options to achieve growth with lower environmental impact. In this paper, we will per-form a sensitivity study of coupling nuclear power to various combinations of desalination technology: {1} thermal (MSF [Multi-Stage Flashing], MED [Multi-Effect Distillation], and MED-TVC [Multi-Effect Distillation with Thermal Vapour Compression]); {2} membrane RO [Reverse Osmosis]; and {3} hybrid (MSF-RO [Multi-Stage Flashing & Reverse Osmosis] and MED-RO [Multi-Effect Distillation & Reverse Osmosis]). The Korean designed reactor plant, the APR1400 will be modeled as the energy production facility. The economical evaluation will then be executed using the computer program DEEP (Desalination Economic Evaluation Program) as developed by the IAEA. The program has capabilities to model several types of nuclear and fossil power plants, nuclear and fossil heat sources, and thermal distillation and membrane desalination technologies. The output of DEEP includes levelized water and power costs, breakdowns of cost components, energy consumption, and net saleable power for any selected option. In this study, we will examine the APR1400 coupled with a desalination power plant in the Kingdom of Saudi Arabia (KSA) as a prototypical example. The KSA currently has approximately 20% of the installed worldwide capacity for seawater desalination. Utilities such as power and water are constructed and run by the government. Per state practice, economic evaluation for these utilities do not consider or apply interest or carrying cost. Therefore, in this paper the evaluation results will be based on two scenarios. The first one assumes the water utility is under direct government control and in this case the interest and discount rate will be set to zero. The second scenario will assume that the water utility is controlled by a private enterprise and in this case we will consider different values of interest and discount rates (4%, 8%, & 12%).

• 무역상무연구
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• 제77권
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• pp.215-237
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• 2018

This study closely examines domestic supplementary measures implemented for Free Trade Agreements (FTA) concerning the agriculture and livestock industry and finds out their problems and put forward improvement measures in terms of their system and contents. The systematic problems with previously established supplementary measures are as follows. First, the existing short and long term measures does not comply with each FTA's special and unique economical, political and legislative purpose. Secondly, they focus on improvements for individual FTAs. They must be holistic and integrative considering all FTAs, thus producing synergy to reach better policy overall. Lastly, FTA policies and the measures must reflect the expanding size and scope of regional economic integration. Problems or concerns in existing supplementary measures include first, flexible financing. The government hands out loans to players in the industry based on assets but these loans must be flexible to market interest changes and must include reduced mortgage rate options. Secondly, rigid standards that trigger direct loss prevention, establishing maximum and minimum loan limits, and developing a comprehensive standard for identifying crops to support are all problems that need to be addressed. Thirdly, education of next and future agricultural generation is paramount in building a competitive workforce. Fourthly, the government must identify industries lacking in performance or short in supply to cease or reducing funding. Last but not least, the government should actively search for new markets for export and produce long term road maps for export growth.

• Biomolecules & Therapeutics
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• 제26권3호
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• pp.328-334
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• 2018

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dose-dependent inhibition of cell growth with an $IC_{50}$ of $15{\mu}M$ and no to little effect on normal human MCF-10A breast cells. To define the mechanism of these anti-proliferative effects of PA, we determined its effect critical molecular events known to regulate the cell cycle and apoptotic machinery. Immunofluorescence and flow cytometric analysis of Annexin V-FITC staining provided evidence for the induction of apoptosis. PA treatment of BC cells resulted in increased activity/expression of mitochondrial cytochrome C, caspases 7, 8 and 9 with a significant increase in the Bax:Bcl-2 ratio, suggesting the involvement of a mitochondrial-dependent apoptotic pathway. Furthermore, cell cycle analysis using flow cytometry showed that PA treatment of cells resulted in G0/G1 arrest in a dose-dependent manner. Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dose-dependent (i) induction of $p21^{WAF1/Cip1}$ and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1. These findings suggest that PA may be an effective therapeutic agent against BC.