• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.84-88
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• 2015

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and can result in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenous immunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalence in recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KD remains unclear, there has been increasing evidence for the role of genetic susceptibility to the disease since it was discovered in 1967. We retrospectively reviewed previous genetic research for known susceptibility genes in the pathogenesis of KD, IVIG resistance, and the development of CAL. This review revealed numerous potential susceptibility genes including genetic polymorphisms of ITPKC, CASP3, the transforming growth factor-${\beta}$ signaling pathway, B lymphoid tyrosine kinase, FCGR2A, KCNN2, and other genes, an imbalance of Th17/Treg, and a range of suggested future treatment options. The results of genetic research may improve our understanding of the pathogenesis of KD, and aid in the discovery of new treatment modalities for high-risk patients with KD.

• 한국CDE학회논문집
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• 제5권3호
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• pp.224-231
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• 2000

In order to satisfy customers'various needs in the market, manufacturing companies tend to add similar variants to an existing product model. This variety causes immense growth of product configuration and makes data management uncontrollable. In order to resolve this problem, we propose a method to efficiently represent the variants in a single schema of product structure and configuration and manage the product configuration. First of all, the product structure which adopts the concept of features and options is suggested. Second, the method to represent option specifications which restricts option configurations is proposed. Finally, the prototype module, which inspects if a product configuration violates the option specifications, is introduced.

• Asian Journal of Innovation and Policy
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• 제7권3호
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• pp.625-645
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• 2018

This paper's objective is to draw a decision guideline to continue research and development (R&D) investments in biotech start-ups facing the "Valley of Death" syndrome - a long negative profit period during a financial crisis. The data include financial indices as Net income, Revenues, Total stockholders' equity, Cash & equivalents, and R&D expenses of 18 major biotech companies (nine in negative profit and nine positive, in FY2008) and 15 major pharmaceutical corporations as benchmarks both in FY2008 and in FY2016 derived from the US SEC Database, EDGAR. A first methodology dealing with real options analysis assumes Total stockholders' equity as a growth option. And a second methodology, Bayesian Markov chain Monte Carlo (MCMC) analysis, is applied to test the probability relationship between the Total stockholders' equity and the R&D expenses in these three groups. This study confirms that Total stockholders' equity can play the role of a call option to support continuing R&D investments even in negative profits.

• Tuberculosis and Respiratory Diseases
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• 제87권1호
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• pp.31-39
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• 2024

After the successful development of targeted therapy and immunotherapy for the treatment of advanced-stage non-small cell lung cancer (NSCLC), these innovative treatment options are rapidly being applied in the adjuvant setting for early-stage NSCLC. Some adjuvants that have recently been approved include osimertinib for epidermal growth factor receptor-mutated tumors and atezolizumab and pembrolizumab for selected patients with resectable NSCLC. Numerous studies on various targeted therapies and immunotherapy with or without chemotherapy are currently ongoing in the adjuvant setting. However, several questions regarding optimal strategies for adjuvant treatment remain unanswered. The present review summarizes the available literature, focusing on recent advances and ongoing trials with targeted therapy and immunotherapy in the adjuvant treatment of early-stage NSCLC.

• 대한예방한의학회지
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• 제9권2호
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• pp.43-58
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• 2005

Internationally, many countries are facing the demand for reshaping health care systems to cope with rapid changing circumstances in health care sector. The recent growth of oriental medicine and complementary and alternative medicine (CAM) in the many countries is, to a large extent, due to the growth of the number of oriental medical doctors and physicians who have taken up alternative therapies alongside conventional medicine. To cope with the changing environments, many countries consider to develop integrative health care which is now used widely in health care sector. In both biomedical and CAM sectors(including oriental medicine), attention appears to have shifted away from separating therapeutic modalities into categories such as biomedical or CAM, towards a focus on merging diverse modalities into a 'new' integrative health system. In Korea, one of peculiar characteristics of health care system is that as health care provider, Hanbang medicine (traditional Korean medicine) and (western) medicine coexist since 19 century. Recently, the government of Korea has given many efforts to enhance the role and function of traditional Korean medicine in health care sector. However, the strategies and measures for integrative health care settings combining traditional Korean medicine and western medicine on health sector have not been developed yet. The research question of this study is In Korea, what are the trends and problems in interface of traditional Korean medical sector and Western medical sector; what are the causes of or associated factors to the problems; how to cope with the problems and how to resolve the causes?; what are the health policy directions and its strategies that the government should take to cope with the future demand and the burden on health care sector? In order to do this, this study explores the current situations and issues on the interface between traditional Korean medicine and (western) medicine in various ways using contents analysis of existing data and documents related to traditional Korean medicine and health policy. Finally, we discussed stakeholders' views on the interface in the health care sector. Then, health policy options to have shifted away from separating therapeutic modalities into categories such as 'traditional Korean medicine' or 'western medicine', towards a focus on merging diverse modalities into a 'new' integrative health system.

• Journal of Yeungnam Medical Science
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• 제31권1호
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• pp.61-64
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• 2014

Craniopharyngiomas are rare primary intracranial tumors. Despite their benign histological appearance, they are often associated with an unfavorable prognosis. The typical manifestations upon diagnosis are headache, visual impairment, polyuria/polydypsia, growth retardation, disturbance of pubertal development, and significant weight gain. The treatment options include radical surgery or radiotherapy, or a combination of these modalities. Slipped capital femoral epiphysis (SCFE) is the most common adolescent hip disorder. SCFE occurs when the capital femoral epiphysis displaces posteriorly on the femoral neck at the level of the physis. The etiology of SCFE is thought to be multifactorial and may include obesity, growth surges, and less common endocrine disorders. The related endocrine disorders include hypothyroidism, growth hormone supplementation, hypogonadism, and panhypopituitarism. Reported herein is a case of panhypopituitarism caused by craniopharyngioma combined with SCFE.

• 통상정보연구
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• 제10권3호
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• pp.265-290
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• 2008

Domestic industries are facing the open era as a result of signing the Korea-U.S. FTA with no exception to the financial industry. The FFA between two countries is expected to produce pros and cons for domestic financial industry. Therefore, it is very important to minimize the shock caused by opening our financial market and to adopt the advanced financial tools actively. Signing the Korea-U.S. FTA and enforcing the Integration Law of Capital Market are leading a big crisis to the Savings Banks which have been shrinking under the dramatically changing domestic financial environment since the financial crisis. To cope with financial globalization, Korean Savings Banks are demanded to build up their concrete identity and reposition their status. This is related to shaping the long-term position of domestic financial industry. Therefore, the Savings Banks must take the growth strategy for their survival, and it is an inescapable choice. Several options are available: big scale operation and diversification of business functions, reinforcement of local-focused mediating function of funds, establishment of strategic alliance with other financial firms, reinforcement of risk management system and core competence, nourishment and employment of professional manpower, and active deregulation and policy support. When the Savings Banks are refurbished as an independent local bank performing the central role of local finance, the bright future can be their destiny under the enormously changing global financial environment. Also, two more conditions need to be satisfied: to establish horizontal networks among local banks directed by cooperative Korea Federation of Savings Banks to reverse the weak scale position, and to satisfy their own peculiar niche market with internal countermeasure to face global financial networks.

• Journal of Korea Trade
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• 제26권8호
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• pp.21-36
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• 2022

Purpose - Carbon emission standards are based on the "production-based carbon emissions" generated by the production of goods in the relevant country which were the existing measurement methods. However, can such carbon emissions measurement standards be established international? For example, some of the goods produced in developing countries are produced for the demand of developed countries. The method of measuring carbon emission based on the final demand of a certain country is called "consumption-based carbon emissions." This study compares productionand consumption-based CO₂ emissions according to economic growth in ninety-three countries categorized by income level. Design/methodology - Our empirical model considers the difference between production- and consumption-based CO₂ emissions according to economic growth. Also, our model investigated whether the EKC hypothesis in most of the previous studies that had been based on production-based emissions was also established in the consumption-based emission model. Considering the continuous characteristics of CO₂, we utilized the generalized method of moments (GMM), specifically a system GMM econometric technique because CO₂ in the previous period can affect CO₂ in the present period. Findings - Our main findings can be summarized as follows: The results show that for the consumption-based CO₂ emissions model, CO₂ continuously increases as economic growth increases in the upper-middle income countries. The inverted U-shaped result was found in the case of the production-based model. However, in the lower-income countries, an inverted-U shape in which CO₂ emissions decrease at some point as the economy grows in the production-based model does not appear. On the other hand, in the consumption-based model, an inverted U-shaped result was obtained when estimating with system-GMM. Additionally, the proportion of manufacturing, energy imports, and energy consumption had an effect on both the production- and the consumption-based model regardless of the group's CO₂ emissions. On the basis of such assessments, policymakers need to consider not only production- but also consumption-based options. Originality/value - Previous studies have mainly focused on production-based CO₂ emissions, with most of them revolving around economic growth or the effect of various social and economic factors on CO₂ emissions. However, this study considers the relationship with economic growth using consumption-based emissions as a dependent variable by classifying ninety-three countries by income level.

• 공업화학
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• 제28권3호
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• pp.306-312
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• 2017

해양 미세조류 Dunaliella tertiolecta에서 바이오디젤 원료인 지질생산을 위하여 철 함량 변화 및 빛 공급과 $CO_2$ 공급에 의한 다중스트레스 인자의 조합이 세포성장 및 지질함량의 변화에 미치는 영향을 조사하였다. 1차 스트레스 인자로 정상보다 높거나 부족한 철 함량 조건이 지질 합성을 유도할 수 있음을 확인하였다. 2차 스트레스 인자로 빛 또는$CO_2$ 공급이 제한될 때 지질함량이 증가하였지만 오랜 시간 배양할 때 세포성장이 감소하는 단점이 있었다. 이와 같이 스트레스 조건에서 세포의 성장과 지질생산이 서로 다른 경향을 보이면 단일 배양기에서 지질생산성을 높이기 어려우므로, 세포성장과 지질생산을 분리한 2단계 배양 전략을 적용하였다. 1단계 배양에서는 성장 위주의 조건으로 고농도배양을 얻은 후, 2단계에서 지질생산을 유도하는 스트레스 조건을 부여하는 것이다. 암소 조건이 다른 조건에 비해 세포농도 감소폭이 작고 지질함량이 높아졌기 때문에, 세포 2 g/L의 고농도로 접종한 2단계에서 5X 철 농도(3.25 mg/L as Fe) 및 암소 조건을 사용하여 12 h의 짧은 배양을 통하여 1.44 g/L/d의 높은 지질생산성을 얻을 수 있었다.

• 한국시스템다이내믹스연구
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• 제12권2호
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• pp.37-67
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• 2011

This study first attempted to point out fundamental reasons behind the failure to have WiBro services off the saddle, investigating the previous studies, and second to screen the WiBro promotion policies after reviewing the major steps conducted thus far by the government. In order to put the screened policies in order by the importance, an AHP analysis was conducted targeting WiBro professionals in various fields such as government offices, universities, research institutes, and industry. One step further, causal loop diagramming on the system dynamics methodology was conducted to examine the dynamic structure of the WiBro market in holistic standpoint of view. Finally, a simulation model was developed based on the causal loop diagrams and the results of the AHP analysis in order to examine how various policy scenarios influence the growth of the WiBro market over time, and to compare the mix of policy options. Finally, the study attempted to draw some implications for WiBro vitalization.