• 한국임상약학회:학술대회논문집
• /
• 2007.12a
• /
• pp.185-186
• /
• 2007

• The Journal of Pediatrics of Korean Medicine
• /
• v.24 no.1
• /
• pp.36-45
• /
• 2010

Objectives The purpose of this study is to evaluate the effect of herbal medicine in children's growth and to report the children's expectation. Methods 171 children visited the department of Pediatrics, Kyung-Hee Oriental Medical Hospital from June 2009 to December 2009 were studied. They were treated more than 6 months and they visited our clinic more than 3 times. Every time when patients visited our hospital, their height, body weight and obesity degree was examined using DS-102(dszenix, Seoul). Also, height percentile of first and the last visit was measured, and those were compared by the Growth Statistics Curve made by the Korean Association of Pediatrics, 2007. Results and Conclusions The mean growth of total children increased by 4.42 percent; the increased percent for boys was 4.17 and that of girls was 5.00. Herbal medical treatment helped growth in children who took medicine for growth retardation problem. Plus, majority of parents who visited the department of Pediatrics, Oriental Medical Hospital satisfied with the service and their children's height. Although thinking genetic factor is important for their height, but they think that herbal medical treatment help the growth with changing eating habit.

• The Journal of Pediatrics of Korean Medicine
• /
• v.18 no.2
• /
• pp.119-126
• /
• 2004

Objective : We used herbal medicine to treat various disease and also to keep good general condition of children. We aimed to evaluate the effect of herbal medicine on the growth of children treated with herbal medicine. Method: We studied 187 children who visited the department of Pediatrics, KyungHee Oriental Medical Hospital from March 2004 to August 2004. They meet condition as follows; they were treated for more than 6 months and they visited our clinic more than 3 times. Whenever patients visited our hospital, we measured their height, body weight and obesity degree using DS-102(dszenix, Seoul). We measured height percentile of first time visit, and that of last time visit. And we compared them using the Growth Statistics Curve made by the Korean Association of Pediatrics, 1998. Results : The mean growth of total children showed 4.04 percentile upwardly; the growth- up percentile of boys was 4.52 and that of girls was 3.26. Analysis according to disease resulted as follows; children with respiratory disease showed 10.29 percentile growth-up, digestive disease 4.21percentile, urinary disease 4 percentile, allergic disease 2.65 percentile, weak children 2.52 percentile and other disease 3.19 percentile. Conclusion : Herbal medical treatment helped growth not only in children who took medicine for growth retardation problem but children with various disease. Moreover herbal medical treatment applied to keep good general condition of children also gave positive effect on the growth of children.

• Journal of Oriental Neuropsychiatry
• /
• v.16 no.2
• /
• pp.25-34
• /
• 2005

Background and Objectives There was no clinical data except literary study on mutual correlation with autistic disorder in Western medical diagnosis and five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) in Oriental medical diagnosis. This study was performed to investigate the correlation of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) to the children with autistic disorder and to set the time table for clinical diagnosis of developmental retardation by making a comparative study of normal developmental children so we can treat the children with autistic disorder in good time. Method We made the comparative study of interview sheets recorded by parents of total 163 children who were diagnosed as autistic disorder who visited HaeMa Oriental Medical Clinic with interview sheets recorded by parents of generally accepted normal developmental children(263) and then we took statistics. Results : 1. There was significant correlation with speech and walking among five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) in autistic disorder statistically and clinically in comparison with normal children. 2. There wasn't significant correlation with growth time of tooth among five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) on diagnosis of autistic disorder in comparison with normal children. 3. There was significant correlation with retardation of times going to toilet by oneself (it does not consist in five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲).) in both of autistic disorder. Conclusion Autistic disorder was significantly correlated with the faculty of speech(語遲), retardation in walking out(行遲) of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲). We need to concrete the index of diagnosis, because it is so difficult to measure times and register retardation in tooth eruption(齒遲), retardation in hair-growing(髮遲), debility of neck and nape(頭項軟), flaccidity of extremities(手軟) and flaccidity of muscle(肌肉軟). And we can also use times going to toilet by oneself as one of diagnostic criteria because of its significant correlation. It is required to make early diagnosis of five kinds of flaccidity in infants(五軟), five kinds of retardation(五遲) using these criteria, and to treat them early by oriental medicine.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.17 no.2
• /
• pp.63-68
• /
• 2017

Gaucher disease (GD) is caused by the deficiency of glucocerebrosidase. In pediatric patients with GD, especially Type I GD, enzyme replacement therapy (ERT) can reduce the hepatosplenomegaly and improve the hematologic finding and growth velocity. Herein, we report a 2-year-old girl with Type I GD presented with hepatosplenomegaly, bone pain and growth retardation. A 2 year-old-girl was referred to our hospital due to severe hepatosplenomegaly and growth retardation. She suffered from both leg pain and chronic fatigue. Simple x-ray showed widened distal long bones like that of an 'Erlenmeyer flask' which is associated with GD. The laboratory test showed anemia and thrombocytopenia. The enzyme activity was markedly reduced and the direct sequencing of the GBA gene showed the compound heterozygous mutations, p.G46E and p.L444P. As the G46E have been considered as the protective gene against neuronopathic genotype, we could assess the Type I GD in this patient. After one year of ERT, the growth velocity became 11 cm per year. Bone pain and fatigue disappeared. The volume of liver and spleen was reduced from $683cm^3$ and $703cm^3$ to $590cm^3$ and $235cm^3$, respectively. Although GD is an extremely rare disease in Korea, growth retardation and bone pain in children are the important signs which lead to early detection of GD and a simple radiologic finding is helpful to assess the GD at outpatient clinic. We highlight that the early diagnosis and early ERT is important for good growth and outcome for pediatric patients with GD.

• Korean Journal of Community Nutrition
• /
• v.17 no.3
• /
• pp.271-279
• /
• 2012

The prevalence of atopic dermatitis (AD) has increased recently all over the world. Several studies worldwide reported growth retardation associated with AD, but few studies were reported in Korea. Therefore, the objective of this study was to identity the differences in growth and nutrient intakes between Korean children with and without AD. The participants were 71 AD children and age, gender-matched 81 control children aged 10 to 36 months. Demographic information was gathered by questionnaires. Height and weight were measured at clinic and health centers. Height and weight for age, and weight for height were converted as deviation in Z scores using World Health Organization Standard. A 24 hour dietary recall method was performed to estimate nutrient intakes. A higher percentage of AD children had insufficient energy and intakes of calcium, phosphorus, iron, zinc and vitamin B2, defined as intakes lower than 75% of the Dietary Reference Intakes for Korean, compared to the control group (P < 0.001, P < 0.001, P = 0.003, P = 0.001, P = 0.014, P = 0.001, respectively). The percentages of children with height and weight for age Z score below than-1 (stunted) were significantly higher in the AD group (P < 0.001 and P < 0.001, respectively). Multiple food restriction, defined as ${\geq}$ 3 food elimination, was associated with insufficient energy and intakes of calcium, phosphorus, iron, zinc, vitamins A and B2. In conclusion, children with AD need regular nutrient assessment and education about alternative food choices to avoid r food elimination in order to prevent growth retardation or inadequate nutrient intakes. Further longitudinal studies for growth and nutrient intakes should be performed to understand the patterns of growth in children with AD.

• Child Health Nursing Research
• /
• v.13 no.1
• /
• pp.51-57
• /
• 2007

Purpose: The purpose of this study was to look for physical growth and developmental retardation of the disabled children in registered educational institutions. Method: The participants in this study were 103 children. The data was collected from January to September 2006. Body weight, height and head circumference were measured and the Denver II developmental screening tool was used to measure personal-social development. Results: For 40.8% of the children body weight was less than the average for Korean children of the same age, for 49.5% height was lower than average and for 44.7% head circumference was lower. For 84.5% of the children there was a delay in personal-social development, for 87.4% a delay in fine motor-adaptive development, for 80.6% a delay in speech development and for 81.6% a delay in gross motor development. Conclusion: Based on the findings of this study, it is necessary to develop an individual developmental programs for these children based on their growth and development status.

• Clinical and Experimental Pediatrics
• /
• v.61 no.7
• /
• pp.226-230
• /
• 2018

Purpose: This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period. Methods: The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months. In addition, the diameter, thickness, and volume of the femoral and tibial growth plates were measured using magnetic resonance imaging. Results: The mean bone age in boys and girls was 11.7 and 10.7 years, respectively. In boys, height (z score) (-0.2 vs. 0.0), weight (z score) (0.8 vs. 1.1), body mass index (BMI) (z score) (1.27 vs. 1.5), IGF-1 (ng/mL) (343.6 vs. 501.8), and IGF-BP3 (ng/mL) (5,088.5 vs. 5,620.0) were significantly higher after 6 months. In girls, height (z score) (-1.0 vs. -0.7), weight (z score) (-0.5 vs. 0.1), BMI (z score) (-0.02 vs. 0.3), IGF-1 (ng/mL) (329.3 vs. 524.6), and IGF-BP3 (ng/mL) (4,644.4 vs. 5,593.6) were also significantly higher after 6 months. In both sexes, the mean diameter and volume of the femoral and tibial growth plates were significantly increased 6 months later. Conclusion: No significant correlation was found between changes in the growth plate and clinical parameters in children with growth retardation in this study, other than correlations of change in femoral diameter with weight and BMI. A larger, long-term study is needed to precisely evaluate the correlation between change in the growth plate and growth.

• Child Health Nursing Research
• /
• v.17 no.4
• /
• pp.281-287
• /
• 2011

Purpose: The study was done to explore growth variation in head circumference (HC) in extremely premature infants (EPI) with brain injury. Methods: A retrospective cohort study was conducted with 79 cohort samples from the archives of the catch-up growth project. Mean age of the infants was 29.2 weeks of gestation and mean HC, 27.1 cm at birth. Their HC measurements were retrieved from the archives up to 6 month of corrected age (CA) and analyzed against history of brain injury during hospitalization. Results: Overall growth retardation in HC was observed in the cohort sample compared to longer gestation premature infants. EPI with brain injury showed decreased HC compared to infants without brain injury, and resulting growth variation across 6 month of CA. Highest retardation in HC growth was observed in male infants with brain injury. Conclusion: Extreme preterm birth itself may function as a major obstacle against HC growth toward term age in EPI. Sustainability of brain injury could be observed with higher HC growth retardation after term. Evolutionary favor to female infants may exist in HC growth of EPI. Intensive education on HC monitoring is highly suggested for parents of EPI, particularly with children with brain injury.

• The Journal of Pediatrics of Korean Medicine
• /
• v.27 no.4
• /
• pp.50-56
• /
• 2013

Objectives The purpose of this study is to evaluate the effect of the herbal medicine in treating digestive system problem on children's growth. Methods We studied 135 children who visited ${\bigcirc}{\bigcirc}$ oriental medical hospital to treat digestive system problem from March 2010 to February 2012. We measured their height and body weight on their first time visit and a year later. We compared them using the Growth Statistics Curve made by the Korean Association of Pediatrics, 2007. Results Generally, total children's average height and weight were significantly increased after the herbal medicine. The difference between the height and weight of treated children and the average height and weight was significant. Conclusions Herbal medicine to treat disorder of digestive system helped growth of children.