• Herbal Formula Science
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• v.18 no.2
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• pp.227-239
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• 2010

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

• Korean Journal of Health Education and Promotion
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• v.19 no.4
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• pp.77-97
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• 2002

Since growth promotion was defined by Koch(1935), many researches like Benholdt and Thomsen(1942) have conducted studies for understanding problem of puberty growth. Growth promotion means that growth is developed in puberty, and several researchers have reported that the more becomes economic growth, the more becomes growth promotion. Thereupon, this study was attempted to find Maximum Growth Age(M.G.A.), as an index of height growth promotion in Korea, which was obtained by longitudinal observations of the same group. Thus, this study can explain the earlier tendency of growth. To investigate domestic changes in M.G.A., M.G.A. was calculated with the results of cross-sectional researchs using 25 representative papers between 1940-1953 including measurements by Lee(1940) and data by Kim(1953) in this study. Based on the research data published between 1940 and 2000, height and M.G.A. of males and females who were born between 1925 and 1983 were gotten by years, and a trend of growth promotion for height in Koreans was suggested by examining study subjects. Findings of this study are as follows; 1. M.G.A. for height decreased both in males and females; for males, 14.28 years in 1940, 14.24 in 1953, 13.86 in 1967, 12.74 in 1985, and 11.71 in 2000; for females, 12.0 in 1940, 11.52 in 1965, 10.00 in 1978 and 9.77 in 2000. 2. Regression equations and standard errors of estimate concerning M.G.A. for height by years were obtained; for males, Y$_1$(M.G.A.) = 17.21 - 0.059X$_1$, S$_{Y1X1}$(standard error of estimate about the regression line) = ${\pm}$0.62; for females, Y$_2$(M.G.A.) = 13.81-0.042X$_2$, S$_{Y2X2}$(standard error of estimate about the regression line) = ${\pm}$0.64 3. As a result of finding correlation between year and M.G.A. r=-0.763 (p<0.001) for male and r=-0.699(p<0.001) for female were obtained 4. From a view that the growth promotion has been continued before 2000, M.G.A. decreased 0.6 years for male and 0.4 for female per 10 years. 5. M.G.A. for height is as shown in Table 2. 6. It is thought that the future trend of growth promotion for height will follow the progress from 1940s to now. It shall be reviewed again after development of coming several years is investigated.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.2 s.117
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• pp.126-135
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• 2007

This paper proposes a new miniaturization method for a parallel coupled line filter with enhanced bandwidth characteristics. A previous method incorporated several advantages, such as size reduction through the use of only a small number of capacitors, in addition to grounding, suppression of harmonic characteristics, and improved skirt characteristics for the parallel coupled line filter, which is conventional in the field of RE filters due to its design and fabrication simplicity. However, the previous method also has disadvantages related to the bandwidth shrinkage of the miniaturized filters. In this paper, the amount of bandwidth shrinkage is analyzed in terms of the relationship between the loaded Q(quality factor) and the group delay of a resonator. Moreover, the reduction in the bandwidth is solved by a design with new design equations. To show the validity of the proposed method, a hairpin filter with a center frequency of 5.2 GHz and an fractional bandwidth(FBW) of 10% was scaled down to half its original dimension by the proposed method with the enhanced bandwidth characteristics. The measured result shows a high level of agreement with theoretical results.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.10
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• pp.933-940
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• 2009

To evaluate characteristics in spray flame, laminar counterflow is investigated on the effects of equivalence ratio and fuel by a two-dimensional DNS (direct numerical simulation). For the gaseous phase, Eulerian mass, momentum, energy, and species conservation equations are solved. For the disperse phase, all individual droplets are calculated by the Lagrangian method without the parcel model. n-Decane ($C_{10}H_{22}$) and n-heptane ($C_7H_{16}$) is used as a liquid spray fuel, and a one-step global reaction is employed for the combustion reaction model. As equivalence ratio increases, the fuel ignites early and the high temperature region spreads wider. The peak value of temperature, however, tends to once increase and then decreases with increasing equivalence ratio. The decrease in the peak value of temperature for the higher equivalence ratio condition is caused by the cooling effect associated with droplet group combustion. Since the evaporation of n-heptane is early, the high temperature region spreads wider than ndecane, but the peak values of temperature for both n-heptane and n-decane is almost same.

• Journal of KIISE:Computing Practices and Letters
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• v.11 no.5
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• pp.427-435
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• 2005

With the accumulation of protein and its related data on the Internet, many domain based computational techniques to predict protein interactions have been developed. However, most of the techniques still have many limitations to be used in real fields. They usually suffer from a low accuracy problem in prediction and do not provide any interaction possibility ranking method for multiple protein pairs. In this paper, we reevaluate a domain combination based protein interaction prediction method and develop an interaction possibility ranking method for multiple protein pairs. Probability equations are devised and proposed in the framework of domain combination based protein interaction prediction method. Using the ranking method, one can discern which protein pair is more probable to interact with each other than other protein pairs in multiple protein pairs. In the validation of the ranking method, we revealed that there exist some correlations between the interacting probability and the precision of the prediction in case of the protein pair group having the matching PIP(Primary Interaction Probability) values in the interacting or non interacting PIP distributions.

• Journal of Navigation and Port Research
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• v.43 no.3
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• pp.143-152
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• 2019

In this paper, the towing stability of the LNG bunker barge was estimated. Currently, LNG bunkering barge is being developed for the bunkering of LNG (Liquefied Natural Gas), an eco-friendly energy source. Since the LNG bunkering barge assumes the form of a towed ship connected to the tow line, the towing stability of the LNG bunker barge is crucial f not only for the safety of the LNG bunker barge but also the neighboring sailing vessels. In the initial stages, a numerical code for towing simulation was developed to estimate the towing stability of the LNG bunkering barge. The MMG (Maneuvering Mathematical modeling Group) model was applied to the equations of motion while the empirical formula was applied to the maneuvering coefficients for use in the initial design stage. To validate the developed numerical code, it was compared with published calculation and model test results. Towing simulations were done based on the changing skeg area and the towing position of the LNG bunkering barge using the developed numerical codes. As a result, the suitability of the designed stern skeg area was confirmed.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2019.05a
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• pp.185-188
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• 2019

In this paper, the towing stability of the LNG bunker barge is estimated. Currently, LNG bunkering barge is being developed as an infrastructure for the bunkering of LNG (Liquefied Natural Gas), an eco-friendly energy source. Since the LNG bunker barge are in the form of towed ship connected to the tow line, the towing stability of the LNG bunker barge is very important for the safety of not only the LNG bunker barge but also the surrounding sailing vessels. The numerical code for towing simulation was developed to estimate the towing stability of the LNG bunker barge at the initial design stage. The MMG(Manoeuvring Mathematical Group) model was applied to the equations of motion and the empirical formula was applied to the maneuvering coefficients so that they could be used in the initial design stage. To validity of the developed numerical code, it was compared with published calculation and model test results. Towing simulations were carried out according to with and without stern skeg of the LNG bunker barge using the developed numerical code. Through the results of the simulations, the appropriateness of the stern skeg area designed was confirmed.

• Journal of Convergence for Information Technology
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• v.9 no.6
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• pp.153-163
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• 2019

The purpose of this study is to research the effect of life satisfaction on young people at an early age and the impact of media on behavioral aggressiveness during this process. To this end, a group of primary schools located in Jiangnan and Jiangbei in the Seoul area and the Nanjing Road in the city were selected and 290 early youths from grades 4-6 of elementary school were chosen as specimens of structural equations. The results indicate that firstly, the personal causes of early youth have a positive (+) effect on the self-esteem life satisfaction and negative (-) impact on liquidity aggressiveness. Secondly, depression has a negative impact on life satisfaction, while action aggressiveness has no effect. Thirdly, the mobility aggression of early youth has a negative impact on life satisfaction (-), and there is a partial media relationship between self-esteem and life satisfaction. However, there is no media relationship between depression and life satisfaction. Based on the above research results, the project of improving youth early life satisfaction and reducing mobile aggression was proposed.

• Geomechanics and Engineering
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• v.24 no.2
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• pp.115-127
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• 2021

This paper investigates the effects of soaking on a lime stabilized high plasticity clay and evaluates the implications for pavement design. In this context, the soil was stabilized by 4%, 6% and 9% hydrated lime. The soil was pulverized in two different gradations so that representative field gradations could be simulated. Both soil pulverization levels passed the relevant field gradation criteria. Curing durations were chosen as 7 days, 28 days and 56 days. Two groups of samples were prepared and were tested in unconfined compression test apparatus to measure the strength and secant modulus at failure values. One of the groups was tested immediately after curing. The other group of samples were first cured and then subjected to soaking for ten days before testing. Visual observations were made on the samples during the soaking period. The results showed the superiority of fine soil pulverization over coarse soil pulverization for unsoaked conditions in terms of strength and modulus values. Soaking of the samples affected the unconfined compressive strength and modulus values based on lime content, curing duration and soil pulverization level. In soaked samples, fine soil pulverization resulted in higher strength and modulus values compared to coarse soil pulverization. However, even with fine soil pulverization, effects of soaking on modulus values were more significant. A new term named as "Soaking Influence Factor (SIF)" was defined to compare the reduction in strength and modulus due to soaking. The data was compared with the relevant design guidelines and an attempt was made to include Soaking Influence Factors for strength and modulus (SIFS and SIFM) into pavement design processes. Two equations which correlated secant modulus at failure to unconfined compressive strength were proposed based on the samples subjected to soaking. The results of this study showed that in order to decrease the diverse effects of soaking for lime stabilized soils, soil pulverization level should be kept as fine as possible in the field. Importance of proper drainage precautions in the pavements is highlighted for better performance of the pavements.

• Communications of Mathematical Education
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• v.36 no.1
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• pp.139-170
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• 2022

In relation to differentiated mathematics education, Russia has a longer experience in research and practice than Korea. The mathematics curriculum for 10-11 grades currently in use in Russia is a level-specific curriculum and consists of a basic level and an advanced level. And in Russia mathematics textbooks for 10-11 grades are also textbooks for each level. In this study, we analyzed basic level textbook and advanced level textbook written by the same author group among the textbooks 'Algebra and Introduction of Mathematical Analysis' of the 10th grade in Russia. To analyze the main learning contents and textbook descriptions that were added in advanced level the 'real numbers' and 'complex numbers' sections were studied. The main contents of basic and advanced level textbooks for 'functions', 'trigonometric functions', 'trigonometric equations', 'conversions of trigonometric expressions', and 'derivatives', which are included in both basic and advanced textbooks were compared and analyzed, and the descriptive characteristics of the definitions and theorems presented in the two levels of textbooks were also compared and analyzed. From the results of this study, it is expected that various information on the contents of various level textbooks of mathematics, the differences between textbooks for each level, and strategies for the composition of textbooks for various level can be accumulated.