• Clinical and Experimental Reproductive Medicine
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• 제46권3호
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• pp.132-139
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• 2019

Objective: Vitamin D-binding protein (VDBP) mediates various biological processes in humans. The goal of this study was to investigate whether VDBP gene polymorphisms could predispose Korean women to endometriosis. Methods: We prospectively enrolled women with endometriosis (n = 16) and healthy controls (n = 16). Total serum 25-hydroxyl vitamin D (25(OH)D) concentrations were measured using an Elecsys vitamin D total kit. Levels of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using a vitamin D BP Quantikine ELISA kit. DNA was extracted using a DNeasy blood & tissue kit. Two single-nucleotide polymorphisms (SNPs; rs4588 and rs7041) in GC, the gene that codes for VDBP, were analyzed using a TaqMan SNP genotyping assay kit. The functional variant of VDBP was determined based on the results of the two SNPs. Results: Gravidity and parity were significantly lower in the endometriosis patients than in the control group, but serum CA-125 levels and the erythrocyte sedimentation rate were significantly higher. Total serum 25(OH)D levels in the endometriosis patients were significantly lower than in the control group. However, serum bioavailable 25(OH)D, free 25(OH)D, and VDBP levels did not differ significantly between the endometriosis and control groups. The genotypes and allele frequencies of GC were similar in both groups. Conclusion: Korean women with endometriosis had lower total serum 25(OH)D concentrations than controls. Neither serum VDBP concentrations nor polymorphisms in the gene coding for VDBP were associated with endometriosis. Further studies are needed to investigate the pathophysiology and clinical implications of 25(OH)D and VDBP in endometriosis.

• 한국강구조학회 논문집
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• 제19권3호
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• pp.303-312
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• 2007

경간 40m~100m 정도 경간에 대해 일반적으로 강 박스 거더교에 대한 설계가 이루어지고 있다. 상부구조의 자중을 줄이기 위해서 복합트러스 교량에서 복부의 콘크리트 웹 대신에 강 사재가 사용되고 있다. 이러한 복합트러스 교량의 설계 시 가장 중요한 부분 중의 하나가 콘크리트 상 하부를 연결하는 연결부의 형태이다. 이러한 접합부는 외부에서 작용하는 조합하중을 분담해야하는데, 아직 이러한 접합구조에 대한 명확한 설계기준이 없는 실정이다. 한계상태에서 격점부의 하중전달에 대한 명확한 연구와 설계방법에 대한 조사가 필요하다. 콘크리트 상 하부를 연결하는 격점부 사재는 다양한 연결형태가 있다. 이번 논문에서는 거셋 플레이트에 용접되어진 그룹 스터드 연결재에 관한 연구가 수행되었다. 25mm 절곡 스터드를 사용하여 수행된 전단실험을 통하여 현재의 스터드 간 최소기준 간격을 만족하는 상태에서는 현재의 설계 규정을 사용할 수 있음을 밝혔다. 휨-전단 실험을 통해서는 조합하중이 작용하는 격점부의 상세를 개선하였다. 격점부의 인발강도를 증진시키기 위해서 절곡 스터드가 제안되었고 그룹 스터드의 최 외측 스터드에 적용되었다. 이러한 결과들을 바탕으로 복합 트러스 교량의 개선된 격점부 상세가 개선되고 설계 방안이 제안되었다.

• 대한치과보철학회지
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• 제44권4호
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• pp.455-465
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• 2006

Statement of problem: Many factors influence shade determination in clinical practice and shade matching is highly affected by the viewing conditions. Purpose : This study investigated the differences in shade perception among distinct groups of dental personnel (10 prosthodontists, 10 general practitioners, 10 last-year dental students and 10 dental technicians) Material and method: Four groups of dental personnel were investigated. They were tested to eliminate color blindness. To compare shade selection ability, they were asked to match four test tabs of shades A3, B2, C2 and D4 (VITAPAN$^{(R)}$ Classical shade guide. The identification codes of the shade tabs were masked to prevent shade memory. ) against another full set of VITA$^{(R)}$ PAN$^{(R)}$ Classical shade guide under similar lighting conditions. Shade selections were randomly repeated five times every week and then the repeatability between dental personnel was evaluated. To compare value perception ability, they were asked to arrange randomly selected five test tabs (Bl, A2, D2, C3, A4) in descending order from the brightest to the darkest. To compare hue determination ability, they were asked to divide selected eight test tabs (n, A3, B2, B3, C2, C3, D2, D3) into four groups by manufacturer as follows : Group A-Reddish brown, Group B-Reddish yellow. Group C-Grey. Group D-Reddish grey. Results and conclusion : The obtained results were as follows : 1. For the value perception ability and hue determination ability. there was no significant difference among 4 groups: prosthodontists, general practitioners, dental students, dental technicians (P>.05). 2. For shade selection ability, the prosthodontists and dental technicians were significantly higher than dental students(P<.05). 3. The repeatability of selected shade in the dental technicians was significantly higher than that of general practitioners and dental students(P<.05). 4. The prosthodontists and dental technicians had significantly higher selection ability than dental students for shade B2 (P<.05).

• The Korean Journal of Pain
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• 제35권4호
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• pp.423-432
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• 2022

Background: The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) which codes MOR directly. So, the authors hypothesized that miR-339-5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP. Methods: To simulate perioperative short-term stress, a perioperative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception rat model was built. A pmiR-RB-REPORT^TM dual luciferase assay was taken to verify whether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid level of rats was test. Differential expressions of MOR, GFAP, and pERK1/2 in each group of the rats' amygdala were tested, and the expressions of miR-339-5p in each group of rats' amygdalas were also measured. Results: Perioperative stress prolonged the recovery time of incision pain. The expression of MOR was down-regulated in the amygdala of rats in stress + incision (S + IN) group significantly compared with other groups (P < 0.050). miR-339-5p was up-regulated in the amygdala of rats in group S + IN significantly compared with other groups (P < 0.050). miR-339-5p acts on oprm1 3'UTR and take MOR mRNA as a target. Conclusions: Perioperative stress could increase the expression of miR-339-5p, and miR-339-5p could cause the expression of MOR to decrease via targeting oprm1. This regulatory pathway maybe an important molecular mechanism of CPSP.

• 패션비즈니스
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• 제12권4호
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• pp.56-72
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• 2008

The purpose of this study was to provide with the useful fundamental data by developing the appearl sizing system according to body types for the Women's Wear Specifications(GB/T 1335.2-1997), National Standards of People's Republic of China. Thus, it was to improve of the garment fit and coverage rate for the apparel production assortment and stock of exporting domestic clothing to China. For this study, 581 female women aged in their twenties who lived in Beijing and Shanghai were selected for the development of the apparel sizing system who resident in Beijing and Shanghai in China. As for the method of this study was made three primary items(length, bust girth, waist girth) and seven secondary items. Data analysis were processed by SPSS WIN 10.0 Program was used. The research selected 3 major body measurements, such as stature, bust girth, waist girth and 7 secondary measurements to investigate the body features of the Chinese adult women. The data throughout the study were analyzed by using SPSS WIN version 10.0 S/W. The result were as follows: The clothes dimensions for upper and lower body and the coverage rate of body size that had the highest appearance ratio from the selected age group in 20's were: Y-type 160-84 155-64(5.9%) and the section 160cm 22.6%, A-type 160-80 160-62(39%) and the section 160cm 27.9%, B-type 155-80 155-66(6.2%) and the section 160cm 24.7%. The representative size codes of the Chinese adult women aged in their 20's were set for representing certain body dimensions such as 150-76A 150-60A(0.0%), 155-80A 155-64A(2.4%), 160-84A 160-68A(3.9%), 165-88A 165-72A(0.3%), 170-92A 170-76A(0.0%). The production coverage rates for the each representative size codes were S size the section 150cm 1.5%, M size the section 155cm 15.3%, L size the section 160cm 36.0%, XL size the section 165cm 29.7%, XXL size the section 170cm 11.4% that covered 93.9%.

• 보건행정학회지
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• 제3권2호
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• pp.100-129
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• 1993

This study is designed to find out some intra-clinic factors affecting the content of practice provided by primary care physicians in Korea, and proposed factors in this study are characteristcs of each private clinc --- physician-related variables(age, sex, specialty), bfed-related variables for inpatient care, laboratory-related variables for precise diagnosis. We have tried to estimate the difference of disease entities cared by each primary care physician according to above factors by analyzin gdisease data claimed during one month(April, 1992) to National Federation of Medical Insurance. The diagnosis codes by ICD-9 in the research disease data were reclassified to 'diagnosis clusters' by virtue of clinical similarities for effective analyses. We have converted frequent-tsing ICD-9 codes to 86 diagnosis clusters, which incorporated 97.4 percents of all ambulatory visits to private clinics. This result means proposed diagnosis-cluster method is effective tool for analysis of the content of ambulatory medical care carried out by primary care physicians. Comparisons and analyses of multiple diagnosis-clusters made on the basis of presented factors were done and the results were as follows; - Major factors affecting the difference between diagnosis-cluster pattern by each variables were phyusician's age, sex, specialty and bed counts of each private clinic for inpatient care and the size of laboratories of each clinic. - Middle aged(30th to 40th) group physicians are providing more comprehensive care than 20th or above 50th aged groups. Male physicians are more adequate for comprehensive care than female physicians, because woman-doctors are providing narrow-spectrum care. The content of practice of obstetricians and gynecologists shows much difference from primary medical practice, and they cannot be included in primary care physician, this study suggested. Pediatricians are also providing short-spectum acre, and nearly all visits to pediatricians were incorporated only 2-3 diagnosis-clusters. General surgeons' practices are very similar to general practioners' or family physicians' practices, the means they are providing primary care rather than special surgical care. And small number of beds(under 5 beds) and only basic(2-3 sorts of)diagnostic apparatuses are sufficient for primary physicians' clinic to carry out primary care. In conclusion, to reinforce primary care department in Korea, there must be support with health policy to expand office-based primary care practice-- with small number of beds for inpatient care and only basic laboratories-- provided by general practitioner of family physician.

• Journal of Trauma and Injury
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• 제25권4호
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• pp.152-158
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• 2012

Purpose: To understand the epidemiology of head trauma and the utilization of brain CT in Korea, we analyzed a national sampling data set, the National Patient Sample obtained from the Health Insurance Review and Assessment Service. Methods: We retrospectively collected and analyzed demographic and clinical data on enrolled patients from the National Patient Sample based on medical claims data for 2009. The data included patient's age, sex, treatment date, diagnosis codes, procedure codes related with CT, holiday or night consultation fee, and fee for emergency management services. Results: In 2009, the estimated population with head trauma was 819,059(1.8%), and the rate of brain CT utilization was 22.4%. Children ages 5 to 15 were the most commonly injured group(22.8%), but had the lowest brain CT utilization(16.5%). The mean age of the estimated population with head trauma was $34.9{\pm}0.5years$ old, and male patients accounted for 60.5% of that population. Intracranial injury was found in 8.6% of all head traumas, and the rate of intracranial injury in children was lower than it was in adults(4.1% vs. 10.9%, p<0.001). Twenty- three percent of patients with head trauma visited the emergency department (ED). More patients with head trauma visited medical facilities in the daytime on weekdays(66.5% vs. 33.5%, p<0.001), but head CT was performed more frequently at night or on weekends/holidays(16.1% vs. 34.7%, p<0.001) There is low incidence of head trauma in the winter in children (p<0.001). In the multivariate logistic regression analysis, patients who were adults, female, or ED visitors were more likely to undergo brain CT (odds ratio (OR): 1.65, 95% confidence interval (CI): 1.47-1.84; OR: 1.40, 95% CI: 1.27-1.54; OR: 7.80, 95% CI: 6.91-8.80, respectively). Conclusion: In this study, we analyzed the national epidemiologic trend for head trauma, and the pattern of utilization of brain CT.

• 지능정보연구
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• 제28권4호
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• pp.135-155
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• 2022

본 연구는 Organic Light-Emitting Diodes(OLEDs) 산업의 하위기술 분야를 도출하여 특허 동향을 분석하고 각 하위기술 분야별 기술 가치, 독창성, 다양성을 분석한다. 특허 자료 수집을 위해 OLED 기술과 관련된 국제 특허 분류(International Patent Classification) 집합을 정의하고, 이를 활용해 2005년부터 2017년까지 출원된 OLED 연관 특허를 수집하였다. 이어서 토픽모델을 이용하여 대량의 특허 문서를 12가지 주요 기술로 구분하고 각 기술에 대한 동향을 조사하였다. 그중 터치 센서, 모듈, 이미지 처리, 회로 구동 관련 특허는 증가 추세를 보였으나 가상 현실, 사용자 인터페이스 관련 특허는 최근 감소하였고, 박막 트랜지스터, 지문 인식, 광학필름 관련 특허는 지속적인 추세를 보였다. 이후 각 기술 그룹에 포함된 특허의 전방 인용 수, 독창성, 다양성을 조사하여 기술적 가치를 비교하였다. 결과로부터 전방 인용 수, 독창성, 다양성이 높은 이미지 처리기술, UI/UX, 모듈 기술, 점착 기술 분야가 상대적으로 높은 기술적 가치를 보여주었다. 본 연구를 통해 기업의 기술 전략 수립과정에서 활용 가치가 높은 정보를 제공한다.

• Safety and Health at Work
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• 제13권4호
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• pp.493-499
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• 2022

Background: The purpose of this study is to construct a job-exposure matrix for lead that accounts for industry and work processes within industries using a nationwide exposure database. Methods: We used the work environment measurement data (WEMD) of lead monitored nationwide from 2015 to 2016. Industrial hygienists standardized the work process codes in the database to 37 standard process and extracted key index words for each process. A total of 37 standardized process codes were allocated to each measurement based on an automated key word search based on the degree of agreement between the measurement information and the standard process index. Summary statistics, including the arithmetic mean, geometric mean, and 95th percentile level (X95), was calculated according to industry, process, and industry process. Using statistical parameters of contrast and precision, we compared the similarity of exposure groups by industry, process, and industry process. Results: The exposure intensity of lead was estimated for 583 exposure groups combined with 128 industry and 35 process. The X95 value of the "casting" process of the "manufacture of basic precious and non-ferrous metals" industry was 53.29 ㎍/m³, exceeding the occupational exposure limit of 50 ㎍/m³. Regardless of the limitation of the minimum number of samples in the exposure group, higher contrast was observed when the exposure groups were by industry process than by industry or process. Conclusion: We evaluated the exposure intensities of lead by combination of industry and process. The results will be helpful in determining more accurate information regarding exposure in lead-related epidemiological studies.

• 한국식품위생안전성학회지
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• 제37권6호
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• pp.418-428
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• 2022

본 연구는 코덱스 식품분류에 포함된 식물성 가공식품에 대해 그 원료식품에 대한 코덱스 식품원료 분류 정보(그룹 및 subgroup)와 국내 식품원료 분류 포함 여부를 파악하기 위해 수행되었다. 연구 결과를 간략히 요약하면 다음과 같다. 첫째 코덱스 주요 가공식품 그룹별로 코덱스 분류 내용을 가공식품 그룹(분류 코드의 수/원료식품이 포함되는 식품원료 그룹 수/식품원료 분류에 포함되지 않은 원료식품의 수)로 보면, 건조 과일류(46/8/0), 건조 채소류(76/11/1), 건조 허브류(54/4/12), 곡류 도정 가공품(36/1/0), 차(19개 코드, 가공식품으로만 분류), 식물성 조제유(17/4/3), 식물성 정제유(34/8/9), 과일 주스(20/8/0), 채소 주스(3/2/0)로 나타났다. 둘째 국내 식품원료 분류에 포함되어 있지 않은 원료식품의 수는 건조 과일류 9종, 건조 채소류 14종, 건조 허브류 35종, 곡류 도정 가공품 0종, 차 6종, 식물성 조제유 3종, 식물성 정제유 9종, 과일 주스 2종, 채소 주스 0종이었다. 셋째 코덱스와 국내 식품 분류에 차이를 보이는 코코넛(코덱스는 열대과일뿐만 아니라 견과로도 분류), 올리브(유지종실뿐만 아니라 열대과일로도 분류) 그리고 코덱스 분류에서 특이점을 보이는 건조 고추(향신료로 분류, 건조채소류로 분류하지 않음), 토마토 주스(원료식품은 채소류, 주스는 과일주스로 분류), 생강(잎은 식품원료 분류에 포함되어 있지 않으나 뿌리줄기는 향신료에 포함)과 같은 식품에 대해 코덱스 식품 분류를 활용하는 데 주의가 필요한 것으로 나타났다.