• Title/Summary/Keyword: Group Normalization

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Hepatoprotective and antioxidant effects of Monochoria vaginalis against acetaminophen-induced hepatotoxicity in rats

  • Palani, S.;Raja, S.;Sakthivel, K.;Devi, K.;Kumar, B. Senthil
    • Advances in Traditional Medicine
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    • v.10 no.1
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    • pp.29-36
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    • 2010
  • The present study was aimed to investigate the hepatoprotective and antioxidant activities of ethanol extract from Monochoria vaginalis (250 mg/kg and 500 mg/kg B/W) on acetaminophen (APAP) induced rat hepatic injury. Monochoria vaginalis is a traditional medicinal plant that is commonly used to treat and improve liver conditions in India and other Asian countries. The development of hepatotoxicity induced by APAP is promoted by oxidative stress. APAP treated group significantly (P < 0.01) elevated the serum enzymatic levels like glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase (SALP), total bilirubin and malondialdehyde (MDA), which were restored towards normalization significantly (P < 0.01) thanol extract of yonochoria vagin is (EEMV). In addition, the EEMV significantly (P < 0.01) elevated the decreased level of total protein and antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase and reduced glutathione. Apart from these, histopathological changes also showed the protective nature of the EEMV against APAP induced hepatic damage in liver tissues. The activity of EEMV at 500 mg/kg B/W was comparable to the standard drug silymarin (25 mg/kg B/W). In conclusion, these data suggest that the EEMV possess hepatoprotective and antioxidant effects against APAP-induced hepatotoxicity and oxidative stress in rats.

Effectso fvitamin E Supplementation on the Lipid Perosides and Activities of Antioxidative Enzymes in the Pancreas of diabetic KK Mice (비타민 E 보강식이가 당뇨 KK 마우스의 췌장에서 지잘과 산화물의 항산화 효소 활성에 미치는 영향)

  • 장연수
    • Journal of Nutrition and Health
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    • v.31 no.2
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    • pp.153-158
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    • 1998
  • The purpose of this study was to investigate the effect of vitamin E supplementation on the lipid peroxidation and activities of antioxidative enzymes in the pancreas of diabetic KK mice. KK mice were fed high ft diet containing 20% corn oil(wt/wt), and sacrificed at 2 months of diabetes. A hish vitamin E diet consisted of the high fat diet supplemented with an excessive amount of 이-$\alpha$-tocopheryl acetate (2080IU/kg diet). The incidence of diabetes mellitus was 61% when mice were fed the high fat diet, but was 44% when mice were fed the high vitamin E diet, Vitamin E supplementation fhus seems to have the effect of decreasing of decreasing the onset of diaetes. In the diabetic group, we found increases of MDA (malondialdehyde) and antioxidative enzyme activities. Treatment with vitamin E did not modify the level of fasting blood glucose. However, MDA and antiosicative enzyme activities in diabetic mice were decreased by the high vitamin E diet. Increased levels of lipid peroxidation products suggests the occurrence of oxidative damage in the pancreas of diabetic mice. The increased level of antiosicative enzyme activities could be due to an adaptive response to conditions of increased peroxidative stress. Significant normalization on catalase activity was noted in vitamin E supplemented animals.

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A Numerical Study of the Turbulent Flow Characteristics in the Inlet Transition Square Duct Based on Roof Configuration (4각 안내덕트 루프형상에 의한 난류특성변화 수치해석)

  • Yoo, Geun-Jong;Choi, Hoon-Ki;Choi, Kee-Lim;Shin, Byeong-Ju
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.33 no.7
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    • pp.541-551
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    • 2009
  • Configuration of the inlet transition square duct (hereinafter referred to as "transition duct") for heat recovery steam generator (hereinafter referred to as "HRSG") in combined cycle power plant is limited by the construction type of HRSG and plant site condition. The main purpose of the present study is to analyze the effect of a variation in turbulent flow pattern by roof slop angle change of transition duct for horizontal HRSG, which is influencing heat flux in heat transfer structure to the finned tube bank. In this study, a computational fluid dynamics(CFD) is applied to predict turbulent flow pattern and comparisons are made to 1/12th scale cold model test data for verification. Re-normalization group theory (RNG) based k-$\epsilon$ turbulent model, which improves the accuracy for rapidly strained flow and swirling flow in comparison with standard k-$\epsilon$ model, is used for the results cited in this study. To reduce the amount of computer resources required for modeling the finned tube bank, a porous media model is used.

Development of quantitative index evaluating anticancer or carcinogenic potential of diet: the anti-cancer food scoring system 1.0

  • Rim, Chai Hong
    • Nutrition Research and Practice
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    • v.12 no.1
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    • pp.52-60
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    • 2018
  • BACKGROUND/OBJECTIVE: Cancer is closely related to diet. One of the most reliable reports of the subject is the expert report from the World Cancer Research Fund & American Institute of Cancer Research (WCRF&AICR). However, majority of the studies including above were written with academic terms and in English. The aim of this study is to create a model, named Anti-Cancer Food Scoring System (ACFS), to provide a simple index of the anticancer potential of food. SUBJECTS/METHODS: We created ACFS codes of various food groups. The evidence of the ACFS codes was provided by the literature at a level comparable to that suggested in the WCRF&AICR report or from the WCRF&AICR report. The ACFS grade was calculated considering food group, cooking, and normalization. Application was performed for Koreans' 20 common meals, which encompass multinational recipes. RESULT: We calculated the ACFS grades of Koreans' 20 common meals. The results were not significantly different from the WCRF&AICR guidelines or information from the National Cancer Information Center of Korea. The grades were briefly interpreted as follows: grade S. ideal for cancer prevention; grade A. good for cancer prevention; grade B, might have anticancer potential; grade C, difficult to be regarded as preventive or carcinogenic; grade D, might against cancer prevention; grade E, probably against cancer prevention. CONCLUSIONS: The ACFS provides a simple index of anticancer potential of diets. This indicator can be useful for the people without expertise, and is effective in evaluating the diets including Asian foods. The ACFS can help design of future clinical or nutritional studies of cancer prevention.

Slope Stability Evaluation System of Sanitary Landfill on Soft Ground and Its Reliability (연약지반상 위생매립지 안정성 평가에 대한 문제점 분석과 개선방향)

  • 우동찬;송좌빈
    • Proceedings of the Korean Geotechical Society Conference
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    • 1997.03a
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    • pp.161-168
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    • 1997
  • The purpose of this study is to evaluate the possibility of normalization of the distibutions of soil parameters taken from soft ground and the reliability of the safety factors of specific objects on it, including sanitary landfill. Through this study it is found that distributions of soil parameters could be adjusted to appropriate normal distributions as possibility density functions(PDF), and that especially the group of initial cohesions and the coresponding safety factors has a perfect linear correlation. According to those results the PDF to initial cohesion as possibility parameter can not only be tmsformed to the PDF to safety factor but also, conseqently, the reliability of the safety factor(SF) simply based on the mean value of soil parameter(Co) can be calculated or easily picked up from the standrad normal distribution table. It is therefore concluded that even though calculated values of safety factors are over any standard requirements some possibility of risk both to the objects and natural soft ground could be still existing, and also a new standard value for this slope stability control system should be derived just by adjusting old one according to the magnitude of risk possibility.

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Analysis of Obesity and Sarcopenia among COPD Patients in Korea (한국 COPD 환자의 비만도와 근감소증 분석)

  • Jekal, Yoonsuk
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.3
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    • pp.604-612
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    • 2020
  • The purpose of this study is to analyze the level of obesity and sarcopenia among chronic obstructive pulmonary disease(COPD) patients in Korea. The current study recruited 75 patients with COPD who visited the department of respiratory medicine at J University Hospital in J-do. Height, body weight, waist circumference, and hip circumference were measured, and body composition, muscle strength, and flexibility were assessed. The levels of obesity were classified with body mass index(BMI), waist-hip circumference ratio(WHR) and percent body fat, and sarcopenia was classified with the value of skeletal muscle mass and muscle strength by Asian Working Group for Sarcopenia. In results, it was found that the level of obesity was very high as 43% by BMI, 88% by WHR, and 64% by percent body fat. The lower level of muscle strength was 15.50% in males and 23.50% in females. The lower level of muscle mass was 24.10% in males and .00% in females. Males who had one sarcopenia factors were 22.40%, and females were 23.50%, respectively. Males with sarcopenia were 6.90%, and females were .00%. In conclusion, regular resistance exercise is essential not only for the development of motor skills, but also for the normalization of skeletal muscle function and prevention of muscle dystrophy among COPD patients.

A Study on the Types and Supply of Elderly Housing in Japan (일본 노인주거시설의 종류와 공급특성에 관한 연구)

  • Kwon, Soonjung
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.16 no.3
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    • pp.49-56
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    • 2010
  • In Japan, a lot of elderly housing types have been developed in order to meet various needs of the older person and the change of social situations. Elderly housings can be divided into three categories elderly housings for healthy older persons, elderly care homes for the healthy and elderly care facilities for the unhealthy. Elderly housings include public and private rental housings. Sometimes they can be designated only for the elderly. Elderly care homes for the healthy elderly include full fee charging elderly housing, elderly homes, low fee charging elderly homes and care houses. Elderly care facilities for the unhealthy elderly consist of full fee charging elderly care homes, group homes for the dementia, elderly health facilities, nursing homes, elderly hospitals, and so on. However "elderly care facilities" have been proved not to be efficient for the delivery of elderly welfare services nor satisfactory to the frail older person. Therefore, based on the concept of the "Normalization", daily services have been provided for the elderly in order that they can live at their own home in the community for themselves. As a result, Japan aims not only to reduce elderly welfare expenses but also to increase elderly users' satisfaction. Emphasis on non-institutionalization and in-home services, regional characterization, harmony between Hard and Soft, user oriented services, substantiality, universal design and so on are sought for the sake of those goals.

Adaptive low-resolution palmprint image recognition based on channel attention mechanism and modified deep residual network

  • Xu, Xuebin;Meng, Kan;Xing, Xiaomin;Chen, Chen
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.16 no.3
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    • pp.757-770
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    • 2022
  • Palmprint recognition has drawn increasingly attentions in the past decade due to its uniqueness and reliability. Traditional palmprint recognition methods usually use high-resolution images as the identification basis so that they can achieve relatively high precision. However, high-resolution images mean more computation cost in the recognition process, which usually cannot be guaranteed in mobile computing. Therefore, this paper proposes an improved low-resolution palmprint image recognition method based on residual networks. The main contributions include: 1) We introduce a channel attention mechanism to refactor the extracted feature maps, which can pay more attention to the informative feature maps and suppress the useless ones. 2) The ResStage group structure proposed by us divides the original residual block into three stages, and we stabilize the signal characteristics before each stage by means of BN normalization operation to enhance the feature channel. Comparison experiments are conducted on a public dataset provided by the Hong Kong Polytechnic University. Experimental results show that the proposed method achieve a rank-1 accuracy of 98.17% when tested on low-resolution images with the size of 12dpi, which outperforms all the compared methods obviously.

Objective Effects and Satisfaction of Mouth Gymnastics Program (입체조 프로그램의 객관적 효과와 만족도 조사)

  • Jang, Kyeung-Ae;Hwang, In-Chul
    • The Journal of the Korea Contents Association
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    • v.11 no.10
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    • pp.388-395
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    • 2011
  • This study was performed to grasp the relation between the effect and the satisfaction of a mouth gymnastics program on the promotion of oral function of old persons. The experimental group of 47 old persons conducted a mouth gymnastics exercise two times every week for 12 weeks, while the control group of 39 old persons carrying out physical examinations. The mean salivary secretion in the experimental group was 0.075 ml and more than 0.046 ml in the control group. Maximum mouth opening in the experimental group, 4.12 cm, was higher than 3.92 cm in the control. Oral diadochokinesis in experimental and control group was 1.69 times per second and 1.65, respectively. The result of principal component analysis by Quartimax method with Kaiser normalization showed that program prevalence prediction of mouth-gymnastics exercise was high, and it is estimated that this exercise program would be more popular for health promotion of old persons. From the correlation analysis, mouth gymnastics exercise made salivary flow increase(r=.592), this exercise should be recommended actively for improving mouth health of old persons. Also more modification is required for old persons with difficulty in mouth gymnastics exercise. Some movements of the mouth gymnastics exercise need be modified, and then the exercise should be publicized as one of the ways to improve holistic health of the aged.

Clinical significance of serum alanine aminotransferase and lifestyle intervention in children with nonalcoholic fatty liver disease

  • Kwon, Kyoung Ah;Chun, Peter;Park, Jae Hong
    • Clinical and Experimental Pediatrics
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    • v.59 no.9
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    • pp.362-367
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    • 2016
  • Purpose: This study aimed to investigate the clinical significance of serum alanine aminotransferase (ALT) levels in children with nonalcoholic fatty liver disease (NAFLD) and the effect of lifestyle intervention on NAFLD. Methods: The clinical data of 86 children diagnosed with NAFLD were reviewed retrospectively. Forty-six patients belonged to the elevated ALT group and 40 to the normal ALT group. The clinical parameters of patients with NAFLD were also compared based on the status of ALT levels after lifestyle intervention. Results: Patients with elevated ALT had significantly higher body mass index (BMI) scores than those with normal ALT (P<0.05). Of all the patients with elevated ALT, 89% exhibited moderate or severe degree of fatty change in the liver on ultrasonographic examination, whereas most patients with normal ALT exhibited mild or moderate degree changes. Liver biopsy was performed in 15 children with elevated ALT and all showed mild histological changes. Of all patients with elevated ALT, 49% achieved normal ALT levels after lifestyle intervention. Those with more severe histological changes tended to have continuously increasing ALT levels. There was no correlation between the normalization of posttreatment ALT level and BMI, as well as ultrasonographic findings at diagnosis. Conclusion: ALT elevation in NAFLD is highly associated with higher BMI scores and more severe degree of fatty changes on ultrasonographic examination. Lifestyle intervention can significantly improve ALT in children with NAFLD. The degree of histologic changes appears to be a predictor of the treatment response to NAFLD.