• 말소리와 음성과학
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• 제3권4호
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• pp.63-70
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• 2011

Recent studies on English $L^*$ (low pitch accent) have revealed the difference of changes in acoustic manifestation between utterances produced by Koreans and those produced by native speakers of English. However, not much effort has been made to compare $L^*$ focused constituents and non-focused constituents. At the same time, most previous works on focus realization are lacking in terms of normalization of acoustic measurement. Therefore, this research is dedicated to comparing the $L^*$ focused items and non-focused items realized by Koreans and Americans and to examining the realization of English $L^*$ produced by the two language groups with improved normalization of the acoustic features (F0, intensity and duration). Within-group analysis comparing focused words and non-focused words showed both Americans and Koreans prolonged the $L^*$ focused syllables but the effect size of syllable lengthening made by Koreans was far less than that made by Americans. Furthermore, significant F0 lowering was found in Americans but not in Koreans. However, the effect of intensity change caused by $L^*$ focus was not significant within each group. The effect of focused words was tested between the two groups revealing that Koreans implemented English $L^*$ focus with higher F0, lower intensity and shorter duration than Americans. In the instances in which a significant Group x Focus Location (initial, middle and final of a sentence) interaction was found, further analysis testing the effect of Group on each Focus Location was conducted. The testing showed that the Koreans produced shorter syllables at initial and middle of a sentence and higher F0 at initial of a sentence than Americans. Implications for the intonation training were also discussed.

• 비교문화연구
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• 제45권
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• pp.109-143
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• 2016

본 연구는 번역된 텍스트들에 전형적으로 나타나는 언어적 특성들인 번역 보편소(translation universals)에 관한 코퍼스 기반 연구이다. 지금까지의 번역 보편소 연구는 언어계통상 서로 밀접한 관련이 있는 영어와 다른 유럽어 사이의 번역에 집중되어 왔으며, 다른 한편으로 주로 문학 장르의 분석에 치중되어 있다는 아쉬움을 지닌다. 본 연구에서는 관련 연구가 지닌 이러한 두 가지 주요 문제점을 보완하고자 하는 노력의 일환으로 한국어를 원문으로 하는 영어 번역 가운데 비문학 장르인 신문언어 텍스트를 분석대상으로 선택하였다. 먼저, 번역된 신문영어 텍스트와 비번역 신문영어 텍스트를 정해진 기준에 따라 수집하여 번역과 비번역 영어(translated and non-translated English)로 구성된 대응코퍼스(comparable corpora)를 구축하였다. 이렇게 구축된 대응 코퍼스를 바탕으로 기존 문헌에서 논의된 번역 보편소 가설 가운데 가장 대표적인 단순화(simplification), 명시화(explicitation), 규범화(normalization), 평준화(leveling-out) 현상이 한국어 신문의 영어 번역 텍스트에서 어떠한 양상을 보이는지 살펴봄으로써 각 가설들이 지니는 타당성을 검증해보고자 하였다. 본 연구의 분석결과를 종합해보면, 단순화와 규범화를 제외한 나머지 하위가설의 언어적 특성들은 모든 언어쌍과 모든 텍스트 장르에 걸쳐 일반화하기에 다소 한계가 있는 것으로 나타났다. 또한, 번역 보편소의 개념 규정이나 분석지표의 정교화, 그리고 결과의 일반화에는 신중한 접근이 필요할 것으로 보인다.

• 한국정보통신학회논문지
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• 제10권12호
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• pp.2283-2288
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• 2006

최근 생명 정보학 기술의 발달로 마이크로 단위의 실험조작이 가능해짐에 따라 하나의 chip상에서 전체 genome의 expression pattern을 관찰할 수 있게 되었고, 동시에 수 만개의 유전자들 간의 상호작용도 연구 가능하게 되었다. 이처럼 DNA 마이크로어레이 기술은 복잡한 생물체를 이해하는 새로운 방향을 제시해주게 되었다. 따라서 이러한 기술을 통해 얻어진 대량의 유전자 정보들을 효과적으로 분석하는 방법이 시급하다. 본 논문에서는 실험용 데이터로 하버드대학교의 바이오인포메틱스 코어 그룹의 샘플데이터 이용하여 마이크로어레이 실험에서 다양한 원인에 의해 발생하는 잡음(noise)을 줄이거나 제거하는 과정인 표준화 과정을 거쳐 특징 추출방법인 베이지안 알고리즘 ASA(Adaptive Simulated Annealing) 방법을 이용하여 데이터를 2개의 클래스로 나누고, 정확도를 평가하는 시스템을 설계하고 구현하였다. Lowess 표준화 후 98.23%의 정확도를 보였다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2003년도 춘계학술발표논문집 (하)
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• pp.1623-1626
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• 2003

인터넷의 발달과 인터넷 이용자수의 급격한 증가로 정보 검색 시스템의 필요성이 커지고 있다. 또한 대용량의 문서에서 사용자가 원하는 정보를 정확하게 찾기가 점점 어려워지고 있다. 현재 대부분의 검색 시스템들은 문서 길이에 대한 정규화를 처리하고 있다. 현재 문서 길이 정보도 검색 시스템의 검색성능에 기여를 하고 있다. 일반적으로 TREC이나 HANTEC2.0을 이용한 검색 성능 평가를 했을 때문서 길의 정규화를 하지 않는 것보다 한 것이 우수한 성능을 보여 주고 있다. 본 논문에서는 KISTAL2000을 이용하여 위치 정보를 사용하여 문서 길의 정규화 방법에 제시하고 이에 대한 실험하였다.

• 한국강구조학회 논문집
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• 제15권6호통권67호
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• pp.649-660
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• 2003

본 논문은 비균열 무근콘크리트에 매입된 익스팬션 앵커의 인발내력을 평가하기 위한 실험적 연구이다. 앵커의 인발실험은 익스 팬션 앵커에 해당하는 고하중 앵커와 웨지 앵커를 대상으로 대상으로 삽입깊이, 콘크리트 강도 및 연단거리을 변수로 하여 실험을 수행하였다. 후시공 앵커의 설계식은 EOTA와 ACI 318-02 규준의 근거가 되는 CCD 방법이 제안되어 있다. 본 연구에서는 비균열 무근콘트리트에 매입된 익스팬션 앵커의 콘크리트 콘 파괴강도에 관한 설계식을 분석하였으며, 고하중 앵커와 웨지 앵커의 실험값을 CCD 방법의 예측값과 비교 평가하였다. 실험 결과, 비균열 무근콘크리트에 매입된 웨지 앵커의 콘크리트 콘 파괴 시 공칭강도의 계수는 CCD 방법에 근거하여 9.94임을 알 수 있었다. 고하중 앵커의 콘크리트 콘 파괴 시 공칭강도의 계수는 CCD 방법에 근거하여 11.50임을 알 수 있었다.

• 환경위생공학
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• 제18권2호
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• pp.60-66
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• 2003

This study was carried out to elucidate the preventive mechanism of molybdenum on lead-induced neuropathy, An animal model of lead neuropathy was induced by feeding diet containing lead to Sprague-Dawley rat for three weeks. Four weeks aged Sprague-Dawley rats were divided into four groups : normal control group, 10ppm-lead treated group, 1mg/kg-molybdenum treated group, 10ppm-lead and 1mg/kg-molybdenum treated group. The parameters on neuropathy were examined by measuring concentration of myo-inositol and myo-inosito uptake in sciatic nerve. In the lead-treated rats, myo-inositol concentration and myo-inositol uptake rate were reduced by from 54% to 33% respectively. This deficit results from that myo-inositol uptake system which is carrier mediated and sodium-potassium dependent was inhibited by the lead treatment. However, the molybdenum administration significantly eliminated the impairment and maintained myo-inositol concentration to about 82% of normal level. These results suggest that lead-induced neurotoxicity was significantly reduced by administration of molybdenum and the mechanism might be partly normalization of myo-inositol uptake system in sciatic nerve.

• 대한두개안면성형외과학회지
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• 제25권1호
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• pp.17-21
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• 2024

Background: The pain caused by local anesthetic injection can lead to patient anxiety prior to surgery, potentially necessitating sedation or general anesthesia during the excision procedure. In this study, we aim to compare the pain relief efficacy and safety of using a digital automatic anesthetic injector for local anesthesia. Methods: Thirty-three patients undergoing excision of a benign soft tissue tumor under local anesthesia were prospectively enrolled from September 2021 to February 2022. A single-blind, randomized controlled study was conducted. Patients were divided into two groups by randomization: the experimental group with digital automatic anesthetic injector method (I-JECT group) and the control group with conventional injection method. Before surgery, the Amsterdam preoperative anxiety information scale was used to measure the patients' anxiety. After local anesthetic was administered, the Numeric Pain Rating Scale was used to measure the pain. The amount of anesthetic used was divided by the surface area of the lesion was recorded. Results: Seventeen were assigned to the conventional group and 16 to the I-JECT group. The mean Numeric Pain Rating Scale was 1.75 in the I-JECT group and 3.82 in conventional group. The injection pain was lower in the I-JECT group (p< 0.01). The mean Amsterdam preoperative anxiety information scale was 11.00 in the I-JECT group and 9.65 in conventional group. Patient's anxiety did not correlate to injection pain regardless of the method of injection (p= 0.47). The amount of local anesthetic used per 1 cm² of tumor surface area was 0.74 mL/cm² in the I-JECT group and 2.31 mL/cm² in the conventional group. The normalization amount of local anesthetic was less in the I-JECT group (p< 0.01). There was no difference in the incidence of complications. Conclusion: The use of a digital automatic anesthetic injector has shown to reduce pain and the amount of local anesthetics without complication.

• 말소리와 음성과학
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• 제11권1호
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• pp.1-8
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• 2019

Formant trajectories reflect the continuous variation of speakers' articulatory movements over time. This study examined formant trajectories of English vowels produced by ninety-three American men and women; the values were normalized using the scale function in R and compared using generalized additive mixed models (GAMMs). Praat was used to read the sound data of Hillenbrand et al. (1995). A formant analysis script was prepared, and six formant values at the corresponding time points within each vowel segment were collected. The results indicate that women yielded proportionately higher formant values than men. The standard deviations of each group showed similar patterns at the first formant (F1) and the second formant (F2) axes and at the measurement points. R was used to scale the first two formant data sets of men and women separately. GAMMs of all the scaled formant data produced various patterns of deviation along the measurement points. Generally, more group difference exists in F1 than in F2. Also, women's trajectories appear more dynamic along the vertical and horizontal axes than those of men. The trajectories are related acoustically to F1 and F2 and anatomically to jaw opening and tongue position. We conclude that scaling and nonlinear testing are useful tools for pinpointing differences between speaker group's formant trajectories. This research could be useful as a foundation for future studies comparing curvilinear data sets.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6565-6570
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• 2014

Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rh-endostatin+DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin+DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.

• Preventive Nutrition and Food Science
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• 제9권3호
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• pp.253-258
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• 2004

Stress is a global menace exacerbated by the advancement of industrialization. Failure of stress management is to a breakdown of the psychological and physiological protection mechanisms against stress. The aim of present study was to investigate the anti-stress potential of ginseng against immobilization stress. Male Sprague-Dawley rats (n=24) were divided into three groups; (i) control, (ii) immobilization stress (2hr daily, for 2 weeks), and (iii) immobilization stress (2 hr daily, for 2 weeks) plus oral administration of ginseng (200 mg/kg BW Id). Immobilization stress resulted in a significant inhibition of body weight gain by 45 % and a significant decrease in the tissue weights of thymus and spleen (p < 0.05). The concentrations of blood GOT and GPT were significantly increased in the immobilization-stressed group compared to the control group (p < 0.05). There were no differences in the blood cholesterol levels among groups. Ginseng administration in the immobilization-stressed group tended to reverse the lack of body weight gain and food intake, though not significantly. The ginseng-administered group showed a significant reversal in the stress-induced effect on spleen and thymus weight, increasing the tissue weights by 16% and 20%, respectively, compared to immobilization-stressed group (p<0.05). The plasma corticosterone level was significantly increased in the stressed group by 39 % compared to the control group (p<0.05), but ginseng administration significantly reversed the stress-induced increase in plasma corticosterone by 15 % compared to the immobilization-stressed group. The present study suggests that the anti-stress effect of ginseng is mediated by normalization of stress-induced changes in the circulating hormones and a reversal of tissue weight loss, thereby returning the body to normal homeostasis.