• 대한한의학방제학회지
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• 제16권2호
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• pp.163-169
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• 2008

The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.

• Tribology and Lubricants
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• 제25권4호
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• pp.256-260
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• 2009

Fretting is a kind of wear which effects on reliability and durability. When machine parts are joined joint in parts such as a bolt or a rivet or a pin, fretting phenomenon is occurred by micro relative movement. When fretting occurs in joint parts, there is wear which is the cause of fatigue crack. Recently, although the ways of assessment of fatigue and damage tolerance are established, there is no way to evaluate fatigue crack initiation life by fretting phenomenon. Consequently, the prediction of life and prevention plan caused by fretting are needed to improve reliability. The objective of this paper is to predict fretting wear by using a experimental method and contact analysis considering wear process. For prediction of fretting wear volume, systematic and controlled experiments with a disc-plate contact under gross slip fretting conditions were carried out. A modified Archard equation is used to calculate wear depths from the contact pressure and stroke using wear coefficients obtained from the disc-plate fretting tests.

• 의학교육논단
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• 제15권2호
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• pp.93-99
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• 2013

As a result of the globalization of diseases and the delivery of health care, physicians today are required to understand global health (GH) including the global burden of disease, health inequities, and effective medical aid. Interest in GH among medical students has also increased significantly. To meet these needs and to reflect an increasing focus on social accountability in medical education, global health education (GHE) programs have already been well-established, particularly in North America. Korea's official developmental aid (ODA) volume almost tripled from 2006 to 2011. Korea has committed to double its ODA/gross national income ratio over the next three years. With these increases, interest in GH among medical students has significantly increased. Despite significant interest among medical students, GHE programs have not been properly established in Korea. To develop GHE programs in Korea, proposed GHE curriculum frameworks were reviewed and core values, guiding principles, and GH competencies were identified in the context of the current literature. To identify key themes essential to the development of GHE programs in Korea, the curriculum frameworks should be focused on a global context and should be taught from the perspective of the social, political, and economic causes of ill health.

• The Korean Journal of Physiology and Pharmacology
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• 제16권6호
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• pp.455-462
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• 2012

This study was designed to determine the protective effect of Rumex Aquaticus Herba extracts containing quercetin-3-${\beta}$ -D-glucuronopyranoside (ECQ) on experimental reflux esophagitis. Reflux esophagitis was induced by surgical procedure. The rats were divided into seven groups, namely normal group, control group, ECQ (1, 3, 10, 30 mg/kg) group and omeprazole (30 mg/kg) group. ECQ and omeprazole groups received intraduodenal administration. The Rats were starved for 24 hours before the experiments, but were freely allowed to drink water. ECQ group attenuated the gross esophagitis significantly compared to that treated with omeprazole in a dose-dependent manner. ECQ decreased the volume of gastric juice and increased the gastric pH, which are similar to those of omeprazole group. In addition, ECQ inhibited the acid output effectively in reflux esophagitis. Significantly increased amounts of malondialdehyde (MDA), myeloperoxidase (MPO) activity and the mucosal depletion of reduced glutathione (GSH) were observed in the reflux esophagitis. ECQ administration attenuated the decrement of the GSH levels and affected the MDA levels and MPO activity. These results suggest that the ECQ has a protective effect which may be attributed to its multiple effects including anti-secretory, anti-oxidative and anti-inflammatory actions on reflux esophagitis in rats.

• 대한약침학회지
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• 제26권1호
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• pp.86-93
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• 2023

Objectives: This study aimed to evaluate the potential toxicity of a recently developed and clinically used No-Pain pharmacopuncture (NPP) solution. We also assessed the lethal dose of the NPP agent following a single intramuscular injection in Sprague-Dawley (SD) rats. Methods: Animals were divided into two groups: the NPP test material group and the normal saline control group. A single intramuscular injection of the NPP agent (1.0 mL/animal) was administered to rats of the NPP test material group. The control group rats received the same volume of normal saline. Both female and male rats were included in each group. All rats were monitored for clinical signs and body weight changes for 14 days after administration of the test substance or saline. At the end of the observation period, a gross necropsy was conducted and localized tolerance at the injection site was analyzed. Results: No mortality was observed in the NPP test material and control groups. Moreover, no test substance-related effects were observed on clinical signs, body weight, necropsy findings, and localized tolerance at the injection site. Conclusion: The approximate lethal dose of the NPP agent is greater than 1.0 mL/animal under the conditions used in this study. Additional toxicity evaluations and clinical studies are needed to confirm the safety of NPP use in clinical practice.

• 대한조선학회논문집
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• 제60권3호
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• pp.175-185
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• 2023

Many small vessels such as fishing boats operate in the world's oceans; accordingly, interest in these small vessels' exhaust-gas problem is increasing. Research on the application of electric-propulsion technology has been steadily conducted; however, the subject is limited to research ships or leisure boats, while research on application efficiency remains insufficient. This study attempts to apply lithium-battery electric-propulsion technology to small ships. A gross tonnage of 9.77, a representative fishing boat, is to be redesigned as a fully electrified ship. Without changing the main cabin's dimensions and fuel tanks, the ship's propulsion system is redesigned based on a lithium-battery electric-propulsion system. In addition, the redesigned system is compared with the original sample ship's diesel-propulsion system for application-effect analysis. The results indicate that under controlled sailing conditions, the weight and volume of the electric-propulsion system are 9.5 and 10.5 times those of the diesel-propulsion system, respectively. These values indicate that the system cannot meet fishing boats' high endurance requirements. Therefore, under the existing technical conditions, applying the full lithium-battery electric-propulsion system to solve the problem of high emissions from fishing boats shows limited feasibility.

• Computers and Concrete
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• 제32권4호
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• pp.411-423
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• 2023

The rapid development of road transport has increased the number of bridges that require widening. A critical issue in the construction of bridge widening is the influence of vibrations of the old bridge on the casting of wet joint concrete between the old and new bridges owing to the running traffic. Typically, the bridge is closed to traffic during the pouring of wet joint concrete, which negatively affects the existing transportation network. In this study, a newly developed microscopic traffic load modeling approach and the vehicle-bridge interaction theory are incorporated to develop a refined numerical framework for the analysis of random traffic-bridge coupled dynamics. This framework was used to investigate traffic-induced vibrations at the wet joint of a widened bridge. Based on an experimental study on the vibration resistance of wet joint concrete, traffic control strategies were proposed to ensure the construction performance of cast-in-site wet joint concrete under random traffic without interruption. The results show that the vibration displacement and frequency of the old bridge, estimated by the proposed framework, were comparable with those obtained from field measurements. Based on the target peak particle velocity and vibration amplitude of the wet joint concrete, it was found that traffic control measures, such as limiting vehicle gross weight and limiting traffic volume by closing an additional traffic lane, could ensure the construction performance of the wet joint concrete.

• 동아시아경상학회지
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• 제12권2호
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• pp.19-28
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• 2024

Purpose: In the era of global economic integration, China's doors of openness have widened, leading to increasingly frequent economic and trade exchanges between countries. Exchange rates, as a crucial economic lever for regulating foreign markets, play a vital role in the balanced development of a nation's international trade. Therefore, the relationship between exchange rate fluctuations and foreign trade has garnered widespread attention. Research design, data and methodology: This study utilizes import and export trade data between China and five ASEAN countries from 1998 to 2019. It employs regression analysis to examine the specific impact of the real effective exchange rate of the Renminbi on China's import and export trade with these ASEAN nations. Results: The empirical analysis yields the following conclusions: Firstly, the real effective exchange rate of the Renminbi exhibits a long-term stable relationship with China's import and export trade with the five ASEAN countries. Renminbi appreciation contributes to an increase in export trade volume but is detrimental to import trade. While this conclusion may deviate from classical trade theories, it aligns with the practical realities of China's foreign trade. Secondly, the coefficients before Gross Domestic Product (GDP) all display positive values, indicating that the growth of total economic demand has a stimulating effect on China's import and export trade.

• 대한방사선치료학회지
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• 제30권1_2호
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• pp.153-160
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• 2018

목 적 : 부분절제술 시행 후 좌측 유방암 환자의 방사선 치료 시 적용된 각 방사선 치료 기법 별 선량을 후향적으로 분석하여 정상장기와 종양용적의 선량적 결과를 전형적인 분할치료 선량(EQD2)을 고려한 선량 결과를 도출함으로써 임상적 참고 지표로 활용하고자 한다. 대상 및 방법 : 본원에서 시행한 좌측 유방암 환자 중 부분절제술을 시행한 40명을 대상으로 3가지의 치료기법으로 구분하여 적용하였다. 각 치료법의 총 종양용적과 임상적 표적용적에서 HI(homogeneity index), $D_{95%}$, 그리고 CI(conformity index)값, 그리고 $V_{hot}$ 수치를 도출한 후 치료계획을 평가하였다. 사이버나이프를 이용한 경우 종양용적은 타 기법에서의 고선량 용적과 동일하여 임상적 표적용적는 고려하지 않았다. 정상장기에 대한 평가는 평균선량을 비교하였다. 결 과 : 세가지 치료법의 HI는 3D-CRT, VMAT, RIMRT 모두 큰 차이를 보이지 않았다. 체적조절 호형 방사선치료(VMAT)을 이용한 치료의 경우 임상적 표적용적의 $D_{95%}$의 경우 $95.84{\pm}0.75%$로 3차원 입체조형 방사선 치료(3D-CRT) 치료법에 비해 높은 값을 나타냈다. 총 종양용적의 $D_{95%}$값은 다른 치료법들에 비해 미세하게 높은 결과를 보여줬다. 사이버나이프를 이용한 치료법은 정상장기들에 조사되는 선량이 타 치료법에 비해 현저하게 낮았다. 결 론 : 3D-CRT의 경우 DIBH를 동반하여 치료할 경우 전반적으로 심장을 보호하는데 유용한 치료 기법이며 VMAT의 경우 탁월한 TARGET COVERAGE를 나타내지만 저 선량 영역이 타 기법에 비해 넓은 것을 알 수 있다. 그러나 앞선 두 가지 치료법에서 치료계획 평가를 위한 대부분의 선량적 지표에서 비슷한 값을 보여 치료 계획 결과 및 평가에서는 큰 차이가 없는 것으로 환자의 해부학적 구조나 호흡 조절 가능 유무에 따라 치료기법 선택이 가능할 것으로 사료된다. 사이버나이프를 이용한 치료의 경우 종양용적에 정확한 고 선량을 주며 정상장기 보호에 매우 유용한 치료법이지만 국소부위 치료만 가능한 점, 치료시간이 상대적으로 긴 점, 치료 전 침습적 시술인 금침 삽입술을 해야 하는 제약이 있다.

• Journal of Radiation Protection and Research
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• 제26권2호
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• pp.59-66
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• 2001

정위적분할방사선치료(FSRT)는 병소경계에 대한 공간상위치와 형태를 정확히 결정하는 것이 큰 쟁점이다. 본 연구는 나선형 CT를 이용하여 4명의 뇌종양 환자와 팬톰(파라핀)으로부터 연속적인 횡축 단면상을 얻었다. K-mean 분류 알고리즘을 적용하여 CT영상의 초기정보값을 평균화소값으로 변화시켰다. 영상의 구성은 병소영역, 정상영역, 혼합영역, 바탕영역, 가음영영역의 5영역으로 분류하였다. 주된 관심은 혼합영역 내에서 정상영역과 혼합영역을 어떻게 분리하는 가였다. 5영역 평균화소값 중에서 정상영역과 병소영역에 상대적인 평균편차 분석법을 적용하여 2영역 평균편차 화소값 사이의 최대점을 구하였다. IDL 프로그램을 이용한 반자동윤곽법으로 혼합영역내의 최대점을 연결함으로서 GTV의 경계선을 그렸다. 균일한 팬톰의 관심영역 경계선은 ${\pm}1%$ 이내의 오차로 평가되었다. 환자 4명의 경우는 방사선 전문의들이 그린 병소영역과 K-mean 알고리즘과 상대적인 평균편차 분석법에 의해 자동적으로 묘사된 병소영역과 거의 일치하였다. 이러한 방법들을 사용하여 불분명한 정상영역과 병소영역의 경계선을 명확하게 나타낼 수 있었다. 그러므로 CT 영상이 MRI 영상과 비교하여 간헐적으로 병소윤곽을 보여주지 못할 경우 이 방법은 치료계획을 결정할 때 유용한 CT영상 자료로 활용될 수 있음을 확인하였다.