• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2355-2359
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• 2015

Background: Combination chemotherapy of 5 fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin, mainly FOLFOX regimens, has shown considerable antitumor activity and a tolerable toxicity profile in gastric cancer. The goal of this study was to retrospectively compare the efficacy and toxicity of modified FOLFOX-6 (mFOLFOX6) regimen in advanced gastric cancer (AGC) patients with good and poor performance status (PS). Materials and Methods: AGC patients receiving the mFOLFOX6 regimen including oxaliplatin $85mg/m^2$, bolus of 5-FU $400mg/m^2$ and LV $400mg/m^2$ on the first day, followed by $2400mg/m^2$ of 5- FU as a continious infusion over 46 hour for first-line treatment were eligible for the study. Results: A total 58 patients with a median age of 59.5 (32-81) were included. The median follow up of the study was 9.2 months. Thirty patients (51.7%) with an ECOG PS 0-1 were assigned to the good PS arm, while 28 patients (48.3%) with ECOG PS 2 were in the poor PS arm. Overall response rates were 36.6 and 28.8%, respectively (p=0.91). Median PFS was 6.7 and 6.3 months in good PS and poor PS arms (p=0.50) and median OS was 9.6 and 10.4 months (p=0.55). As compared with good PS arm, poor PS arm was associated with more grade 3-4 neutropenia and anemia. Dose reduction and dose delays were also significantly higher. Conclusions: In this study, mFOLFOX6 was similarly effective in both arms. Although hematologic toxicity was significantly higher in patients with poor PS, it remained manageable. Our results suggest that this regimen may be an effective treatment option for AGC patients with poor PS.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.3
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• pp.134-142
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• 2012

Objectives : Childhood depressive disorder one of the most prevalent chronic health conditions affecting school aged children. The objective of this study was to examine the prevalence and epidemiological characteristics of childhood depressive disorder in Korea. Methods : In this study, a survey was conducted of elementary school children in the Cheonan area from September 2009 to August 2010. A total of 12,084 children were included in the analyses. The primary measure of depression was the 27-item Kovacs' Children's Depression Inventory (CDI), the Korean Dupaul attention-deficit hyperactivity disorder Rating Scales (K-ARS), Autism Spectrum Screening Questionnaire (ASSQ) and Restless Legs Syndrome Questionnaire (RLSQ) were also administered. Results : The prevalence rate of childhood depressive disorder was 3.07%. The mean age was $9.21{\pm}1.81$ years for the control group (5,969 male, 6,054 female) and $9.91{\pm}1.83$ years for the depression group (CDI score${\geq}$22 ; 159 male, 210 female). Age, height, weight, and economic status were similar for the two groups. However, there were statistically significant differences in the distribution of sex. The distribution of school grade also differed between the two groups. Scores for CDI, K-ARS, and ASSQ in the depressive group were higher than those of the control group. Conclusions : This is the first large-scale population-based study to report on the prevalence of childhood depressive disorder in South Korea. Increased rates of childhood depressive disorder, as reported by primary caretakers, might reflect the increasing negative impact of environmental risk factors on neurobehavioral health. Longitudinal study of the prevalence of childhood depressive disorder should be considered for further evaluation.

• Proceedings of the Korean Society of Community Living Science Conference
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• 2009.09a
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• pp.78-78
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• 2009

학교급식에 대한 기호를 충족시키고, 식습관 개선을 위한 방안을 모색하여 급식의 효과를 증대시키기 위한 목적으로 본 연구를 실시하였다. 학교급식으로 제공되는 메뉴를 중심으로 음식의 맛을 잘 표현할 수 있는 4, 5, 6학년(남학생 273명, 여학생 209명)을 대상으로 급식 만족도와 기호도를 조사했다. 전반적인 급식만족도는 5점 척도로 3.20점을 보여 대체로 만족하였으며, 그 이유는 좋아하는 메뉴가 나와서(57%)가 가장 높은 빈도를 보였다. 급식에 바라는 점도 역시 맛있는 음식제공(44%)을 우선 원하는 것으로 나타났다. 불만족의 이유는 싫어하는 메뉴가 나와서(50%), 기다리는 시간이 길어서(23.9%), 청결하지 않아서(13.3%), 배식담당자가 불친절(12.2%)해서의 순이었다. 전반적인 급식만족은 성별에 따른 유의적 차이는 없었으며, 식단에 대한 만족도로서 새로운 메뉴 및 양, 환경 만족도로서 위생환경과 서비스 모두 3.0을 넘는 평균값을 보였다. 음식조리별 기호도를 보면, 밥류는 흰쌀밥(3.59)과 보리밥(3.63)이 기호도가 높았고, 일품요리는 스파게티(3.91)와 김치볶음밥(3.70)이 가장 높은 기호도를 보였으며, 오징어덮밥(2.95)이 가장 낮았다. 국류의 기호도는 어묵국(3.37), 수제비국(3.26)을 비교적 선호했으며, 북어국(2.56)을 가장 낮게 평가하였다. 찌개류는 부대찌개(3.61), 김치찌개(3.56)를 좋아했으며, 탕류는 육개장(3.85), 갈비탕(3.77)을 선호하였다. 볶음류 중에서는 떡볶이(4.05)와 소시지볶음(4.04)을 선호하였고, 잡채는 여학생이 남학생보다 더 좋아하였다. 조림류로 돈육메추리알조림(3.48)은 선호하지만, 생선조림(2.78), 콩조림(2.37)은 기호도가 낮았다. 튀김류는 대부분 높은 점수를 보였고(핫도그 3.80, 돈까스, 3.66), 무침류는 쫄면(3.43), 골뱅이무침(3.05), 찜류는 닭찜(3.61), 고추장갈비찜(3.54), 계란찜(3.51) 순으로 좋아하였으며, 전류는 계란말이(3.93), 김치전(3.57), 쌈류는 무쌈(3.36), 상추쌈(3.25)을 좋아하였다. 샐러드류는 감자샐러드(3.25), 과일떡샐러드(3.39)를 좋아하였고, 후식류는 여학생이 꿀떡(4.06), 메론(4.03)을 선호하였고, 방울토마토(3.44)는 가장 낮은 기호도를 보였다. 대체로 성별 차이는 보이지 않았으나, 육류 및 육가공품에 대한 기호가 높은 반면, 채소류나 어패류의 기호도는 낮으므로 이들을 이용한 다양한 조리법과 새로운 메뉴 개발에 대해 연구할 필요가 있다. 또한 기호도가 낮아도 영양적으로 우수한 음식은 식단에 사용하되 영양교육을 통하여 섭취를 권장하는 방안도 필요하다. 학교급식에 대한 불만족요인을 해소하기 위해서는 메뉴 개선 외에 기다리는 시간을 줄이고, 청결한 위생관리와 친절한 태도 등을 위한 노력이 필요할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6585-6590
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• 2013

Background: Although FOLFOX (infusional fluorouracil/leucovorin plus oxaliplatin) is established as a standard chemotherapeutic regimen, the long term efficacy of adjuvant XELOX (oral capecitabine plus intravenous oxaliplatin) in Asian colorectal cancer (CRC) patients remains anecdotal. Moreover, uncertainties persist as to whether pharmacogenetic differences in Asian populations preclude equally tolerable and effective administration of these drugs. Method: One hundred consecutive patients with resected colorectal cancer received adjuvant XELOX (oxaliplatin 130 $mg/m^2$ on day 1 plus capecitabine 900 $mg/m^2$ twice daily on day 1 to 14 every 3 weeks for 8 cycles) at Queen Mary Hospital, Hong Kong. Endpoints monitored during follow-up were disease-free survival (DFS) and disease recurrence, overall survival (OS) and adverse events (AEs). Results: The median patient age was 56 years, 56% were diagnosed with rectal cancer and 44% with colonic cancer. After a median follow-up of 4.3 years (95% confidence interval, 3.2-4.7), 24 recurrences were confirmed including 13 patients who died due to progressive disease. Four-year DFS was 81% in colon cancer patients and 67% in rectal cancer patients (p=0.06 by log-rank test). For the cohort as a whole, OS was 90% at 3 years and 84% at 5 years. Treatment-related AEs led to early withdrawal in four patients. The commonest non-hematological AEs were neuropathy (91%), hand-foot syndrome (49%) and diarrhea (46%), while the commonest grade 3/4 AEs were neutropenia (11%) and diarrhea (10%). Conclusion: These results confirm the favourable long term survival benefit with good tolerability in using adjuvant XELOX in treating East Asian colorectal cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6287-6292
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• 2013

Background: Surgery is the only curative treatment for operable non-small lung cancer (NSCLC) and the importance of adjuvant chemotherapy for stage IB patients is unclear. Herein, we evaluated prognostic factors for survival and factors related with adjuvant treatment decisions for stage I and IIA NSCLC patients without lymph node metastasis. Materials and Methods: We retrospectively analyzed 302 patients who had undergone curative surgery for prognostic factors regarding survival and clinicopathological factors related to adjuvant chemotherapy. Results: Nearly 90% of the patients underwent lobectomy or pneumonectomy with mediastinal lymph node resection. For the others, wedge resection were performed. The patients were diagnosed as stage IA in 35%, IB in 49% and IIA in 17%. Histopathological type (p=0.02), tumor diameter (p=0.01) and stage (p<0.001) were found to be related to adjuvant chemotherapy decisions, while operation type, lypmhovascular invasion (LVI), grade and the presence of recurrence were important factors in predicting overall survival (OS), and operation type, tumor size greater than 4 cm, T stage, LVI, and visceral pleural invasion were related with disease free survival (DFS). Multivariate analysis showed operation type (p<0.001, hazard ratio (HR):1.91) and the presence of recurrence (p<0.001, HR:0.007) were independent prognostic factors for OS, as well visceral pleural invasion (p=0.01, HR:0.57) and LVI (p=0.004, HR:0.57) for DFS. Conclusions: Although adjuvant chemotherapy is standard for early stage lymph node positive NSCLC, it has less clear importance in stage I and IIA patients without lymph node metastasis.

• Research in Community and Public Health Nursing
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• v.15 no.2
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• pp.277-288
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• 2004

Purpose: This study was to provide basic information for preventing high school students from smoking by examining their actual smoking condition and their knowledge and attitude about smoking. Method: The subjects were 515 students selected from six(6), high schools in Jecheon. Data were collected using a questionnaire from the 1st to the 17th of December 2002. The author prepared the tool by modifying the scale of knowledge and attitude about smoking developed by Moon(2001). Data were analyzed with SPSS/WIN program using frequencies, percentages, $x^2$-test, t-test, ANOVA. Duncan test and Pearson's correlation coefficient. Result: 1. The percentage of ex-smoking students was 29.9% of male students and 18.6% of female ones. The percentage of currently smoking students was 23.9% of male students and 3.0% of female ones. The percentage of non-smoking students was 46.2% of male students and 78.4% of female ones, 2. There were not significant differences in smoking knowledge according to smoking status in male and female students. 3. There were significant differences in smoking attitude according to smoking status in male(F=32.70, p=.000) and female(F=11.15, p=.000) students. 4. In smoking status according to general characteristics, there were significant differences according to the type of school($x^2$=32.93, p=.000), grade($x^2$=11.91, p=.018), educational level of the father($x^2$=30.52, p=.000) and the mother($x^2$=14.23, p=.027), monthly allowance($x^2$=17.19, p=.028), harmony of family members($x^2$=15.23, p=.019), school life($x^2$=26.96, p=.00l) and school record($x^2$=30.24, p=.000). 5. In smoking status according to smoking-related characteristics, there were significant differences according to experience in cigarette purchase($x^2$=150.04. p=.000), experience in errands for cigarette($x^2$=20.00, p=.000), knowledge of cigarette price($x^2$=72.52, p=.000), close friends' smoking($x^2$=107.41. p=.000) and smoking of brothers and sisters($x^2$=16.97, p=.002). 6. There were significant correlation between knowledge and attitude about smoking in the whole students(r=.337. p=.000), ex-smokers(r=.324. p=.000), non-smokers(r=.369. p=.000) but there was not a significant correlation between knowledge and attitude about smoking in current smokers(r=.128. p=.30l). Conclusion: Smoking prevention education should considered students' smoking status. Current smokers need smoking prevention education aiming to change their attitude toward smoking in order for them to reduce smoking and to practice smoking cessation.

• Journal of Technologic Dentistry
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• v.29 no.2
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• pp.17-34
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• 2007

This study was conducted to research into the recognition level of employment and overseas employment on 173 students majoring in dental technology at two colleges in Daegu metropolitan city and Jeju self-governing island through questionnaires which are recorded individually. The results are as follows. 1. About 31.8% students chose dental technician department taking their aptitude into consideration when they entered college. 52% students gained information about dental technology through internet, and 57.3% students among them, which was the highest level, were under age 20. 2. 48.6% students responded that they thought the level of satisfaction with major was average and there was a difference according to their ages among the level of satisfaction or dissatisfaction with their major and the previous knowledge of major they had gained before entering college. 75.1% students said they wouldn't transfer to other major even if they were given the chance, which was much higher than the opposite case. And only 2.3% students had dissatisfaction at their major, which means students majoring dental technology evaluate their major positively. 3. Most students(58.4%) wanted to get a job for living cost and 53.2% students took advice from their seniors or elderly people in choosing their jobs. 64.7% students answered they should have professional skills to get a good job, which was different according to their ages. In addition, 51.4% students of dental technology department regarded the opportunities to exert their abilities as the most important element in choosing their jobs. That means students value self-decision and selfrealization when they choose their jobs. 4. The majority of students(32.9%) preferred to work at the dental laboratory in dental college hospital as their workplace. Moreover, seniors over age 21 wanted to work in the field of porcelain and juniors under age 20 preferred to work in the implant part concerning the field which students wants to work. 5. About 91.3% students have ever heard about overseas employment and wanted to work abroad if given the opportunities(77.5%). This points out students have much interest in overseas employment and positive attitude. And there was a difference according to age and grade in case of the preferred country when they work abroad 6. The main barrier to overseas employment was a lack of communication ability(63.0%), therefore, students thought foreign language education should be activated to improve overseas employment(26.0%). To show this more specifically, juniors thought foreign language education and internship are most important factors(both are 21.4% alike), while seniors thought foreign language education is essential(24.6%) as a way to improve overseas employment. Students also thought that participation in language study club helps to prepare for overseas employment(69.4%). When putting all these survey results together, it's very important to develop people in advance who have job ability and language ability necessary for overseas employment as well as to improve job awareness in the field of dental technology. Consequently, it's needed to seek for various ways to get a overseas job through foreign language education and overseas internship.

• The Korean Journal of Emergency Medical Services
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• v.13 no.2
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• pp.5-15
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• 2009

Purpose : This study was to examine the secondary traumatic stress(STS) and related factors of emergency medical technicians. Methods : This study was conducted among 190 emergency medical technicians, over the age of 25, with the 1st or 2nd grade qualification, who serve at fire stations in U and P city of Korea. The collected data for this study was analyzed using SPSS 12.0. Result : The average character type of A-type personality technicians was 43.25 points and the average of B-type personality technicians was 37.82 points. It suggested that the former was higher than the latter. State anxiety did not show statistically significant difference between A-Type group and B-Type group with the score of 48.51 for A-Type and 47.91 for B-Type. Physical symptoms showed statistically significant difference between the two groups with the higher score of 28.45 for A-type group than that of 28.13 for B-Type group. The level of STS related to the volunteers' job characteristics was found to be low when the volunteers were satisfied with their job and didn't want to transfer to another division. Those on duty who had slept more than seven hours that day had the highest points. The number of points was highest when the frequency for the onset of trauma was between 20~30 times. Furthermore it was found that for most technicians, 71.05%, the period of symptoms lasted for a few weeks at most, and this was where the STS was the lowest, whereas on the other hand the highest STS occurred when the symptoms lasted for a period of up to six months. The findings showed significant correlations with a relation of r=.24 between STS and level of anxiety and r=.45 between STS and physical symptoms. However, no significant correlation was found between the level of anxiety and physical symptoms. Conclusion : The more emergency medical technicians are exposed to accidents, the more serious the STS are. Those with an A-type personality are especially prone to have higher STS. The higher the STS level is, the higher the level of physical states and anxiety is.

• Journal of Families and Better Life
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• v.3 no.1
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• pp.77-91
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• 1985

This study was carried out to learn about the contents of communication between mother and her adolescents in this country, and possible differences in the contents of communication with demographic variables. In particular, I wanted to find out the following; 1)contents of communication between mother and her adolescents. 2)Contents of communication between parents with adolescents. 3)Possible differences in the contents of communication with differences in the level of education, employment status, and age of mother, family income level, and sex, and birth order of children. To test these hypotheses, I distributed questionnaires to 600 mothers of selected high school juniors(11th grade) in Seoul. Four hundred and fourty-eight questionnaires were returned, and the results were analyzed using frequency distribution, percentage, and x2-test. The results were as following; 1) In general, mothers communicated well with their adolescents, especially in topics related to studying, friends, school, parents and family, and future career. Communication on sex-education or sex-role, however, was rather limited in contents. ool, parents and family. Communication on sex-education or sex-role of adolescent was almost never attempted. This result showed similarity with 1 above. 3) (1) contents of communication and educational level of mother; contents of communication between mother and her adolescents differed significantly with educational level on all topics except parents and family, indicating that the educational level of mother, the more diverse was contents of communication between mother and her adolescents. (2) Contents of communication and employment status of mother: On all topics except sex-education, communication between mother and her adolescents differed significantly between employed and unemployed mothers, indicating that unemployed mothers communicate on greater number of topics with their adolescents than employed mothers do. (3) contents of communication and family income level; Family income level did not affect contents of communication between mother and her adolescents significantly. (4) contents of communication and age of mother; Age of mother did not affect a contents of communication between mother and her adolescents significantly. (5) contents of communication and sex of adolescent; Thee were significant differences in contents of communication on certain topics; On virginity, sex, marriage, and dating, mother communicate more diversely with daughters than with sons. This result certainly reflects the deep-rooted traditional value system among koreans, with permissive attitude toward males, and far more strict attitude toward females, on sex-related matters. (6) Contents of communication and birth order of adolescents; The birth order of adolescents did not affect contents of communication between mother and her adolescents significantly.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8969-8974
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• 2014

Background: The aim of this study was to determine the predictors of health promoting lifestyle behaviour among medical students attending seven of the medical schools in Turkey. Materials and Methods: This crosssectional descriptive study was performed during the second semester of the first and last (sixth) years of study from March to May 2011. A questionnaire with two sections was specifically designed. The first section contained questions on demographic characteristics; the second consisted of the Health Promoting Lifestyle Profile II (HPLP) Scale. From a total of 2,309 medical students, 2,118 (response rate 91.7%) completed the questionnaire. Data were analyzed using descriptive statistics, t, Anova, Tukey test and binary logistic regression analysis. The research was approved by the Ethics Committee of Erciyes University. Results: The mean age was $20.7{\pm}2.9$ years and it was found that 55.1% were men, 62.3% were in the first year. The overall prevalence of smoking was 19.1%, and for drinking alcohol was 19.4%. HPLP point averages of the first year students were $129.2{\pm}17.7$, and for last year $125.5{\pm}19.0$. The overall mean score for the HPLP II was $2.5{\pm}0.4$. They scored highest on the spiritual growth subscale ($2.9{\pm}0.5$), interpersonal relations ($2.8{\pm}0.5$), health responsibility subscale ($2.3{\pm}0.5$), nutrition subscale ($2.3{\pm}0.5$), stress management subscale ($2.3{\pm}0.4$), and the lowest subscale physical activity ($2.0{\pm}0.5$). It is established that student's grade, educational level of parents, economic status of family, marital status, smoking and general health perception of the students resulted in a significant difference in HPLP Scale total score average and the mean score of majority of subscales. There was no statistically significant difference between the total HPLP when evaluated for gender, chronic disease, alcohol drinking status and BMI. Conclusions: Based on these results, particularly in the curriculum of medical students in order to increase positive health behaviours including physical activity, health promotion issues, and giving more space to aim at behaviour change in these matters is recommended.