• Journal of the Computational Structural Engineering Institute of Korea
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• v.17 no.2
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• pp.215-222
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• 2004

Drift design methods using resizing techniques have been presented as a practical drift control methods of high-rise buildings. Most drift design methods using the resizing techniques have adopted the cross-sectional area as the design variables for all structural members in a structure. However, the cross-sectional area is not always governing sectional property for the structural members, but the governing sectional property of each member is dependent on the characteristics of member forces. In this paper, a drift design method using the sectional property related to the governing displacement participation factor as the design variable of each member is presented and applied to the drift design of 20-story steel frame-shear wall system. It can be noted from example test that drift design method considering member characteristics shows similar or somewhat better results in the view point of structural weights and the accuracy of displacement estimation.

• Journal of Welding and Joining
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• v.31 no.5
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• pp.7-14
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• 2013

The legitimacy of dominating factor in the high accuracy prediction of welding distortion was investigated for butt welding and fillet welding. When out-of-plane distortion was measured by the experiment objecting to butt welding, if tack welding was easily performed, the position of a neutral axis was variously changed by the irregularity. Then, there have been a case that out-of-plane distortion was generated in the unexpected direction. This case should be especially noted. New model for the experiment was proposed so as to solve this problem. As it was elucidated by the case of fillet welding, it was verified that the analysis should be carried out with satisfying the yield condition (especially at high temperature above 700 degree Celsius) and with closely simulating the penetration shape (heat input in weld metal) in order to solve the proposition that is the high accuracy prediction of welding distortion. It was confirmed that residual stress is highly predicted because welding distortion is highly predicted, too.

• Steel and Composite Structures
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• v.18 no.3
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• pp.565-582
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• 2015

This paper is concerned with the dynamic analysis of simply-supported steel-concrete composite beams under moving loads. Considering the interface slip between steel girder and concrete slab, the governing motion equations are derived from the direct balanced method. By variable separation approach, the analytical solution of natural frequencies and mode shapes are obtained, as well as the orthogonal conditions. Then the dynamic responses of the composite beam under moving loads are analyzed, and compared with the experimental results. The analysis results show that the governing motion equations become more complicated when interface slip is taken into account, and the dynamic behaviors are significantly influenced by the shear connection stiffness. In the dynamic calculation of composite beams, the global stiffness should not be reduced as the same factor to all orders, but as different ones according to the dynamic stiffness reduction factor (DSRF), to which should be paid more attention in calculation, design and experiment, or else great deviation is inevitable.

• Genomics & Informatics
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• v.19 no.1
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• pp.2.1-2.10
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• 2021

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in the majority of cases. Although secondary mutations in the mitogen-activated protein kinase signaling pathway are known to be responsible for this phenomenon, the molecular mechanisms governing acquired resistance are not known in more than half of patients. Here we report a genome- and transcriptome-wide study investigating the molecular mechanisms of acquired resistance to BRAF inhibitors. A microfluidic chip with a concentration gradient of vemurafenib was utilized to rapidly obtain therapy-resistant clones from two melanoma cell lines with the BRAF V600E mutation (A375 and SK-MEL-28). Exome and transcriptome data were produced from 13 resistant clones and analyzed to identify secondary mutations and gene expression changes. Various mechanisms, including phenotype switching and metabolic reprogramming, have been determined to contribute to resistance development differently for each clone. The roles of microphthalmia-associated transcription factor, the master transcription factor in melanocyte differentiation/dedifferentiation, were highlighted in terms of phenotype switching. Our study provides an omics-based comprehensive overview of the molecular mechanisms governing acquired resistance to BRAF inhibitor therapy.

• Nuclear Engineering and Technology
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• v.33 no.4
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• pp.409-422
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• 2001

The dynamic character of a system of the governing differential equations for the one- dimensional two-fluid model, where the momentum flux parameters are employed to consider the velocity and void fraction distribution in a flow channel, is investigated. In response to a perturbation in the form of a＇traveling wave, a linear stability analysis is peformed for the governing differential equations. The expression for the growth factor as a function of wave number and various flow parameters is analytically derived. It provides the necessary and sufficient conditions for the stability of the one-dimensional two-fluid model in terms of momentum flux parameters. It is demonstrated that the one-dimensional two-fluid model employing the physical momentum flux parameters for the whole range of dispersed flow regime, which are determined from the simplified velocity and void fraction profiles constructed from the available experimental data and $C_{o}$ correlation, is stable to the linear perturbations in all wave-lengths. As the basic form of the governing differential equations for the conventional one-dimensional two-fluid model is mathematically ill posed, it is suggested that the velocity and void distributions should be properly accounted for in the one-dimensional two-fluid model by use of momentum flux parameters.s.

• Journal of Welding and Joining
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• v.31 no.5
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• pp.1-6
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• 2013

In carrying out the elastic-plastic analysis, four conditions (equilibrium equation, constitutive equation, condition of compatibility and yield condition) should be satisfied. In welding, the temperature largely changed from a melting temperature to a room temperature. So, yield stress of materials largely changed, too. In particular, yield stress becomes about zero over $700^{\circ}C$. The analysis should be carried out under the condition that equivalent stress generated in temperature increment ${\Delta}T$ did not exceed yield stress of materials at high temperature over $700^{\circ}C$. It should be sufficiently recognized that the obtained results were not reliable if this condition was not satisfied.

• Advances in materials Research
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• v.4 no.1
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• pp.31-44
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• 2015

This paper presents a simple n-order four variable refined theory for buckling analysis of functionally graded plates. By dividing the transverse displacement into bending and shear parts, the number of unknowns and governing equations of the present theory is reduced, and hence, makes it simple to use. The present theory is variationally consistent, uses the n-order polynomial term to represent the displacement field, does not require shear correction factor, and eliminates the shear stresses at the top and bottom surfaces. A power law distribution is used to describe the variation of volume fraction of material compositions. Equilibrium and stability equations are derived based on the present n-order refined theory. The non-linear governing equations are solved for plates subjected to simply supported boundary conditions. The thermal loads are assumed to be uniform, linear and non-linear distribution through-the-thickness. The effects of aspect and thickness ratios, gradient index, on the critical buckling are all discussed.

• Transactions of The Korea Fluid Power Systems Society
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• v.8 no.1
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• pp.1-9
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• 2011

The main design factors which effect on operating speed of linear actuator for valve operation are mass of plunger, electromagnetic motive force, inductance, and return spring, and these factors are not independent but related with each other in view point of design and electromagnetic theory. It is impossible to increase the operating speed by only change the value of any one design factor. The change of any one value results in change of any value related it in various design factors. This paper presents a speed increasing method of linear actuator using a solenoid design method by some governing equations which are composed of electromagnetic theory and empirical knowledge and permanent magnets as assistant material, and proved the propriety by experiments.

• Steel and Composite Structures
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• v.7 no.2
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• pp.119-133
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• 2007

Based on stability theory of current rigid steel frames and using the three-column subassemblage model, the governing equations for determining the effective length factor (${\mu}$-factor) of the columns in semirigid composite frames are derived. The effects of the nonlinear moment-rotation characteristics of beam-to-column connections and composite action of slab are considered. Furthermore, using a two-bay three-storey composite frame with semi-rigid connections as an example, the effects of the non-linear moment-rotation characteristics of connections and load value on the ${\mu}$-factor are numerically studied and the ${\mu}$-factors obtained by the proposed method and Baraket-Chen's method are compared with those obtained by the exact finite element method. It was found that the proposed method has good accuracy and can be used in stability analysis of semi-rigid composite frames.

• Journal of Mechanical Science and Technology
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• v.15 no.9
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• pp.1217-1225
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• 2001

The governing equations are derived for the analysis of a stepped labyrinth gas seal generally used in high performance compressors, gas turbines, and steam turbines. The bulk-flow is assumed for a single cavity control volume set up in a stepped labyrinth cavity and the flow is assumed to be completely turbulent in the circumferential direction. The Moodys wall-friction-factor model is used for the calculation of wall shear stresses in the single cavity control volume. For the reaction force developed by the stepped labyrinth gas seal, linearized zeroth-order and first-order perturbation equations are developed for small motion about a centered position. Integration of the resultant first-order pressure distribution along and around the seal defines the rotordynamic coefficients of the stepped labyrinth gas seal. The resulting leakage and rotordynamic characteristics of the stepped labyrinth gas seal are presented and compared with Scharrers theoretical analysis using Blasius wall-friction-factor model. The present analysis shows a good qualitative agreement of leakage characteristics with Scharrers analysis, but underpredicts by about 20%. For the rotordynamic coefficients, the present analysis generally yields smaller predictied values compared with Scharrers analysis.