• Asian-Australasian Journal of Animal Sciences
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• v.33 no.3
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• pp.506-514
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• 2020

Objective: We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods: Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6℃) or warm (28℃) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers. Results: Prenatal Cu exposure increased ewe plasma triiodothyronine (T₃) and thyroxine concentration (T₄) (p<0.01) but prenatal Cu exposure had no effect on lamb plasma concentrations of T₃, T₄, glucose, or nonesterified fatty acid concentration (p≥0.08). The high level of prenatal Cu exposure depressed 48-h rectal temperature (p = 0.03). Cold exposure decreased BAT norepinephrine (NE) and increased BAT dopamine (p≤0.01), but prenatal Cu exposure had no effect on BAT cytochrome C oxidase activity or BAT NE or dopamine (p≥0.07). However, BAT of lambs from high-Cu ewes maintained higher uncoupling protein-1 (UCP1) gene expression than BAT of lambs from low- and medium-Cu ewes following warm or cold exposure in environmental chambers (p = 0.02). Cold exposure caused near depletion of BAT lipid by 48 h (p<0.001), increased BAT cytochrome c oxidase activity (p<0.01), and depressed plasma fatty acid concentrations (p<0.001). Conclusion: Although prenatal Cu exposure increased BAT UCP1 expression during warm and cold exposure, prenatal cold Cu exposure depressed 48-h rectal temperature. Cold exposure decreased BAT lipid content by over 80% and decreased lamb plasma fatty acid concentration by over 40%, indicating that fuel reserves for thermogenesis were nearly depleted by 48 h of cold exposure.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10367-10374
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• 2015

Background: Cancer and non-communicable diseases are a major issue not only for the developed but also developing countries. Public health and primary care nursing offer great potential for primary and secondary prevention of these diseases through community and family-based approaches. Within Thailand there are related established educational curricula but less is known about how graduate practitioners enact ideas in practice and how these can influence policy at local levels. Aim: The aim of this inquiry was to develop family nursing practice in primary care settings in the Isaan region or Northeastern Thailand and to distill what worked well into a nursing model to guide practice. Materials and Methods: An appreciative inquiry approach involving analysis of written reports, focus group discussions and individual interviews was used to synthesize what worked well for fourteen family nurses involved in primary care delivery and to build the related model. Results: Three main strategies were seen to offer a basis for optimal care delivery, namely: enacting a participatory action approach mobilizing families' social capital; using family nursing process; and implementing action strategies within communities. These were distilled into a new conceptual model. Conclusions: The model has some features in common with related community partnership models and the World Health Organization Europe Family Health Nurse model, but highlights practical strategies for family nursing enactment. The model offers a basis not only for planning and implementing family care to help prevent cancer and other diseases but also for education of nurses and health care providers working in communities. This articulation of what works in this culture also offers possible transference to different contexts internationally, with related potential to inform health and social care policies, and international development of care models.

• Journal of Korean Academy of Nursing
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• v.15 no.3
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• pp.21-30
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• 1985

The purpose of this study is to determine values and value changes of the four year course nursing college students. The survey was conducted against 262 students of the nursing college, from all classes (freshman, sophomre, junior and senior). This study was conducted during the period of first through 15th of December 1984 in accordance with the L.V. Gordon's“Survey of Interpersonal Values (SIV)”. The results of the study were as follows: 1. Those nursing students surveyed show that conformity (16.32) took the highest place and reconition (10.21) lowest in the general value orientation. In accordance with the Cordon's SIV, those of other woman college students indicate 14%ile-65%ile, respectively. 2. Changes in values by class indicate that freshman, sohpomore and senior students showed similar Pattern but junior students showed significantly lower than other classes. The difference should be considered on the basis of statistics (p <.05). Accordingly, the hypho-thesis 1 of this study has been supported. 3. Significant variation has been shown by each class in each factor such as support, conformity, independence and benevolence but no variation has been indicated in leadership and recognition. 4. There was difference in values between higher class (jounior and senior) students with clinical experience and starting class (freshman and sophomore) students without clinical experience. The study indicates the values of higher class. students is lower than that of starting class. students (P <.05). Therefor, the hyphothesis 2 of this study has been supported. 5. There was no significant difference in values between entering students and graduating students (p<.05), Thus, the hyphothesis 3 of this study has been rejected. The results of the finding of the study show that there is no positive influence in forming the values. for the students. Therefore, it is concluded that new strategy and special educational program should be established for formulation of the right values for the nursing college students.

• Child Health Nursing Research
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• v.15 no.4
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• pp.383-391
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• 2009

Purpose: The purpose of study was to describe knowledge and attitude to Attention Deficit Hyperactive Disorder (ADHD) in preschool teachers in Korea. Methods: Survey methodology using a self administered questionnaire was employed as the research design. Knowledge and attitude were measured with a questionnaire modified from Jerome, Gordon, and Hustler (1994) and Ghanizadeh, Bahredar, and Moeini (2006). Of 223 questionnaires mailed out to 42 daycare centers in one district in Seoul, 164 questionnaires (73.5%) were used for data analysis. Data analysis was done using SPSS.WIN 15.0. Results: The mean score on knowledge for the teachers was 11.27 (59.3%) out of maximum score of 19. For question items, the percentage of correct answers related to etiology of ADHD was under 10% and the correct rate regarding treatment of ADHD was over 90%. Preschool teachers had a mean score on attitude of 20.77 out of 33. Less than 50% of the teachers reported positive attitudes toward the child with ADHD and over 90% agreed that the child with ADHD needs a special environment and specially trained teachers. Age (r=.236, p=.002) and marital status (t=-3.661, p=.000) were significantly related to attitude toward the child with ADHD. Knowledge and attitude had a significant positive correlation (r=.245, p=.001). Conclusion: These results suggest that educational programs and strategies should be developed to increase knowledge of preschool teachers on ADHD. Public health nurses also need to develop and implement education programs for teachers at daycare centers and others involved in child care in the community.

• Journal of Korean Society of Forest Science
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• v.84 no.2
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• pp.186-197
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• 1995

Site-specific allometric equations relating aboveground tree component biomass and leaf area to tree diameter, basal area, sapwood cross-sectional area and sapwood volume were developed using the destructive harvesting method for Pinus rigida Mill., Larix leptolepis Gordon, and Quercus serrata Thunb. stands in Yangpyeong, Kyonggi Province. There were significantly strong correlations between aboveground tree component biomass or leaf area and diameter at breast height (DBH), basal area, sapwood area and sapwood volume. For a similar diameter tree, the three species had a similar stem wood biomass. However, carbon allocation patterns to stem bark, foliage, branch and total aboveground biomass differed among the three species. Specific leaf area and the ratio of leaf area to sapwood cross-sectional area of the three species were significantly different. Allometric equations seemed To be related to leaf habit or leaf longevity. To elucidate the effect of leaf habit or leaf longevity on allometry and canopy characteristics clearly, more intensive studies are needed.

• Clinical and Experimental Reproductive Medicine
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• v.44 no.1
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• pp.40-46
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• 2017

Objective: To describe in vitro development of human embryos derived from an individual with a homozygous pathogenic variant in NLRP7 (19q13.42) and recurrent hydatidiform mole (HM), an autosomal recessive condition thought to occur secondary to an oocyte defect. Methods: A patient with five consecutive HM pregnancies was genomically evaluated via next generation sequencing followed by controlled ovarian hyperstimulation, in vitro fertilization (IVF) with intracytoplasmic sperm injection, embryo culture, and preimplantation genetic screening. Findings in NLRP7 were recorded and embryo culture and biopsy data were tabulated as a function of parental origin for any identified ploidy error. Results: The patient was found to have a pathogenic variant in NLRP7 (c.2810+2T>G) in a homozygous state. Fifteen oocytes were retrieved and 10 embryos were available after fertilization via intracytoplasmic sperm injection. Developmental arrest was noted for all 10 embryos after 144 hours in culture, thus no transfer was possible. These non-viable embryos were evaluated by karyomapping and all were diploid biparental; two were euploid and eight had various aneuploidies all of maternal origin. Conclusion: This is the first report of early human embryo development from a patient with any NLRP7 mutation. The pathogenic variant identified here resulted in global developmental arrest at or before blastocyst stage. Standard IVF should therefore be discouraged for such patients, who instead need to consider oocyte (or embryo) donation with IVF as preferred clinical methods to treat infertility.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1243-1249
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• 2016

Background: Expression of p53, cyclin D1, p21 (WAF1) and Ki-67 (MIB1) was evaluated in oral squamous cell carcinoma (OSCC) to test whether levels of these markers at invasive tumour fronts (ITFs) could predict the development of local recurrence. Materials and Methods: Archived paraffin-embedded specimens from 51 patients with T1/T2 tumours were stained immunohistochemically and analysed quantitatively. Local recurrence-free survival was tested with Kaplan-Meier survival plots (log-rank test) using median values to define low and high expression groups and with a Cox's proportional hazards model in which the expression scores were entered as continuous variables. Results: The assessment of expression of all markers was highly reliable, univariate analysis showing that patients with clear surgical margins, with low cyclin D1 and high p21 expression at the ITF had the best local recurrence-free survival. Multivariate analysis showed that these three parameters were independent prognostic factors but that neither p53 nor MIB1 expression were of prognostic value. Conclusions: Assessment of p53, cyclin D1, p21 (WAF1), and Ki-67 (MIB1) at the ITF could help to predict local recurrence in early stage oral squamous cell carcinoma cases.

• Archives of Plastic Surgery
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• v.43 no.5
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• pp.451-456
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• 2016

Background Comprehensive aesthetic surgery training continues to be a challenge for residency programs. Our residency program developed a rhinoplasty-based objective structured clinical examination (OSCE) based upon validated methods as part of the residency education curriculum. We report our experience with the rhinoplasty-based OSCE and offer guidance to its incorporation within residency programs. Methods The encounter involved resident evaluation and operative planning for a standardized patient desiring a rhinoplasty procedure. Validated OSCE methods currently used at our medical school were implemented. Residents were evaluated on appropriate history taking, physical examination, and explanation to the patient of treatment options. Examination results were evaluated using analysis of variance (statistical significance P<0.05). Results Twelve residents completed the rhinoplasty OSCE. Medical knowledge assessment showed increasing performance with clinical year, 50% versus 84% for postgraduate year 3 and 6, respectively (P<0.005). Systems-based practice scores showed that all residents incorrectly submitted forms for billing and operative scheduling. All residents confirmed that the OSCE realistically represents an actual patient encounter. All faculty confirmed the utility of evaluating resident performance during the OSCE as a useful assessment tool for determining the Next Accreditation System Milestone level. Conclusions Aesthetic surgery training for residents will require innovative methods for education. Our examination showed a program-educational weakness in billing/coding, an area that will be improved upon by topic-specific lectures. A thoroughly developed OSCE can provide a realistic educational opportunity to improve residents' performance on the nonoperative aspects of rhinoplasty and should be considered as an adjunct to resident education.

• Journal of Advanced Marine Engineering and Technology
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• v.26 no.1
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• pp.59-67
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• 2002

The comparison of $J_{Rice}$-resistance considering a few strength ratio in Rice J-integral formula and $J_{\delta}$-resistance curves converted from experimental CTOD using appropriate strength chosen according to strain hardening level, n=10.6 (A533B steel) and n=8.1 (BS4360 steel) is carried out. The optimal dimensionless strength ratio like the factor of revision, (see full text)reflecting strain hardening level in Rice\`s experimental formula is found out and the reliability of appropriate reference strength chosen according to strain hardening level in different materials is investigated through doing that CTOD is transformed from $J_{\delta}$-integral using relationship between J-integral and CTOD. The results are as follows; 1) The optimal factor of revision is when m equals to 3 in (see full text) for Rice's and the above optimal factor of revision multiplies by coefficient, η in Rice's experimental formula instead of n=2, 2) and the pertinent reference strength for high strain hardening material like BS4360 steel is ultimate strength, $\sigma_{u}$ and for material like A533B steel is ultimate-flow strength, $\sigma_{u-f}$. The incompatible of the behavior of both experimental J-resistance curves using Rice's formula and CTOD-resistance curves for A533B and BS4360 steel by Gordon, et al., could be corrected using the optimal factor of revision in Rice\`s and the pertinent reference strength in J=$m_{j}$${\times}$$\sigma_{i}$${\times}$CTOD.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.6
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• pp.862-867
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• 1999

The present study was undertaken to determine the effect of administration of exogenous progesterone early in gestation on uterine levels of IGF-I mRNA and on embryo survival at day 25 of gestation in the pig. Forty-one prepubertal gilts were induced into oestrus with PG600 and artificially inseminated at their subsequent naturally occurring oestrus. Gilts were then randomly assigned to one of three groups. Gilts in the two treatment groups were injected intramuscularly with 50 mg of progesterone either from day 2 to 14 (N=14) or from day 4 to 14 (N=15) after breeding while those in the control group (N=12) were given corn oil (0.5 ml) from day 2 to 14. Between days 25 and 28 of gestation, gilts were slaughtered and reproductive tracts were recovered. Endometrial tissue (1 g) was collected and analysed for IGF-I mRNA levels using a reverse transcription-polymerase chain reaction, Progesterone treatment, starting either on day 2 or 4 after breeding, neither significantly increased embryo survival rate by day 25 of gestation nor altered IGF-I mRNA levels in uterine tissue. However, across all samples, the IGF-I mRNA level in the uterus was highly correlated with embryo survival rate (r=0.8193, p<0.01), supporting the involvement of IGF-I in the regulation of porcine embryo development.