• Journal of Agricultural Extension & Community Development
• /
• v.22 no.4
• /
• pp.465-479
• /
• 2015

The purpose of this study is to explains consumers' medical discourse embedded in the consumption of oriental medicine and health functional foods. Despite the fact that both of oriental medicine and western medicine is legally accepted, people tend to recognize that accurate diagnosis is possible only in the latter. As the discourse that oriental medicine, compared with western medicine, has an auxiliary position is widely spreaded, the rivalry between herbal medicine and health functional foods come to be formed. And it led to a close correlation between the decrease of herbal medicine consumption and the growth of health supplement market. Herbal medicine is compared to red ginseng, one of the representative health supplement. Negative notion such as using an Asian herb from China and side effect of hepatotoxicity influences herbal medicine consumption. This study argues two conclusion. First, the correlation between the consumption of herbal medicine and that of health functional foods results from the discourse of scientific reconstruction, standardization, and commercialization all of which come from globalization discourse. Second, medical discourse embedded in these commodity, in the end, has impact on agricultural production.

• Journal of Society of Preventive Korean Medicine
• /
• v.18 no.2
• /
• pp.89-100
• /
• 2014

Objective : The co-administration effects of Gongjindan (GJD) on the pharmacokinetics (PK) of sorafenib were observed as a process of the comprehensive and integrative medicine. Methods : After sorafenib treatment, GJD was administered within 5 min. The plasma were collected at 30min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24hrs after end of GJD treatment, and plasma concentrations of sorafenib were analyzed using LC-MS/MS methods. PK parameters of sorafenib ($T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with sorafenib single administered rats. Results : The absorption of sorafenib were significantly increased at 30min, 1, 6 and 6hrs after co-administration with GJD as compared with sorafenib single treated rats. Accordingly, the $AUC_{0-t}$ (47.20%) of sorafenib was significantly increased but $t_{1/2}$ (-30.63%) and $MRT_{inf}$ (-34.11%) in co-administered rats were non-significantly decreased. These findings are considered as direct evidences that GJD increased the oral bioavailability of sorafenib through increase of the absorption, when they co-administered within 5min. Conclusion : Based on the results, co-administration of GJD increased the oral bioavailability of sorafenib through increase of the gastrointestinal absorption. It is considered that the more detail pharmacokinetic studies should be tested to conclude the effects of GJD on the pharmacokinetics of sorafenib, when they were co-administered, like the effects after co-administration with reasonable intervals considering the $T_{max}$ of sorafenib (about 3.5hr-intervals) and after repeated co-administrations.Hence, concomitant uses of GJD with sorafenib may require close monitoring for potential drug interactions.

• Journal of Society of Preventive Korean Medicine
• /
• v.19 no.1
• /
• pp.145-159
• /
• 2015

Objective : In the previous study, co-administration of Gongjindan-gamibang (GJD) with sorafenib increased oral bioavailability of sorafenib through augment the absorption, therefore, the effects of GJD co-administration on the pharmacokinetics of sorafenib were observed after single and 7-day repeated oral co-administration with 3.5 hr-intervals in the present study. Method : After 50 mg/kg of sorafenib treatment, GJD 100 mg/kg was administered with 3.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of first and last 7th sorafenib treatment, and plasma concentrations of sorafenib were analyzed using LC-MS/MS methods. PK parameters of sorafenib ($T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with sorafenib single administered rats. Results : GJD markedly inhibited the absorption of sorafenib, from 1 hr to 24 hrs after end of first 3.5 hr-interval co-administration, the $C_{max}$ (-43.27%), $AUC_{0-t}$ (-56.29%) and $AUC_{0-inf}$ (-66.70%) of sorafenib in co-administered rats were dramatically decreased as compared with sorafenib single treated rats. However, GJD significantly increased the absorption of sorafenib, from 4 hr to 8 hrs after end of last 7th 3.5 hr-interval co-administration, the $AUC_{0-t}$ (34.08%) and $AUC_{0-inf}$ (37.31%) of sorafenib in co-administered rats were dramatically increased as compared with sorafenib single treated rats. Conclusion : Although GJD decreased the oral bioavailability of sorafenib through inhibition of gastrointestinal absorptions after end of first 3.5 hr-interval co-administration, it is observed that GJD increases the oral bioavailability of sorafenib as facilitated the absorption after end of last 7th repeated co-administration. Hence, the co-administration of GJD and sorafenib should be avoided in the combination therapy of sorafenib with GJD on anticancer therapy.

• Korean Journal of Oriental Medicine
• /
• v.18 no.2
• /
• pp.151-157
• /
• 2012

In this research, the genotoxic effect of Bupleuri Radix (BR), the dried roots of Bupleurum falcatum Linne has been traditionally used as anti-inflammatory agent, was evaluated using the mouse micronucleus test. BR aqueous extract (yield = 16.52%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide (CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus (MN) in polychromatic erythrocyte (PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Although significant (p<0.01) increase of the number of PCE with one or more nuclei (MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of BR extracts treated mice with over 0.30 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that BR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels the limit dosage in rodents.

• Journal of Sasang Constitutional Medicine
• /
• v.25 no.1
• /
• pp.34-42
• /
• 2013

Objectives The purpose of this study was analyzing the equality between the MeSH terms and the keyword used in the papers published in Journal of Sasang Constitutional Medicine and investigating how to use an appropriate MeSH terms as keyword in the papers. Methods A total of 704 keyword used in 177 papers published from 2009 to 2012 in Journal of Sasang Constitutional Medicine were analyzed to investigate the equality between the keyword and the MeSH terms. The collected data was analyzed using SPSS 17.0 software for frequency analysis. Results Among the 704 keyword, 107 keyword(15.2%) was perfectly matched with the MeSH terms. 64 keyword(9.1%) showed partial difference was with the MeSH terms, and 11 keyword(1.7%) showed partial difference was with the Entry terms. 127 keyword(18.0%) were included in the exception item due to the nature of journal, and 395 keyword(56.1%) were not perfectly matched with the MeSH terms. In the yearly analysis result, the number of papers that keyword and MeSH terms perfectly matched was not significant changed, however the number of papers that keyword and MeSH terms did not matched was continuously increased, which clearly indicate use of MeSH terms as the keyword of the papers published in the journal of Sasang constitution medicine is insufficient. Conclusions The papers published in journal of Sasang constitutional medicine need to be cited in various fields and the paper's finding need to affect in other studies for the development of Korean medicine and Sasang constitutional medicine. The use of proper keyword aligned with the international standards is necessary to accomplish the globalization of them.

• Journal of Korea Multimedia Society
• /
• v.15 no.2
• /
• pp.250-257
• /
• 2012

Recently oriental medicine has become a new issue in the global medical field because of increasing demands for the treatment of old people. Western medical equipment is becoming popular with big companies related to IT, communication and medical treatment. But globalization of oriental medicine techniques is inadequate due to lack of knowledge about oriental medicine. The cupping equipment has great growth potential because it is easy for old people to use the equipment. The purpose of this paper is to promote the portable multi electrical cupping system. The system may be used by patients themselves without any help from others. By using many cupping cups at the same time and regulating the timer and vacuum pressure. The patient can decrease itching and relax the hardened muscles. The system is expected to grow in the future as oriental medicine will be in high demand in aging society with IT convergence industry.

• Korean Journal of Acupuncture
• /
• v.33 no.1
• /
• pp.12-17
• /
• 2016

Objectives : This study aimed to overview the current education status of a traditional medicine by medical schools in Japan. Methods : We surveyed the literatures regarding a traditional medicine education in Japan, and get the information via email-interview with an officer of medical schools in Japan as well as from their websites. Results : Japan's education ministry presented the appropriateness of education for traditional medicine to medical students in 2001, and most of medical schools begun to set up the classes in Japan. We received the detail information of the traditional medicine education from 21 medical schools. Nineteen colleges(approximately 90%) of those have the regular classes for traditional medicine while two colleges don't have the education program for the traditional medicine. Most of medical schools have single class for introduction of traditional medicine, and have average $16.2{\pm}8.8$ hours during the $4^{th}$ grade(61.9%). Conclusions : We presented the general feature of education for traditional medicine in Japan, and this result would be basic information for an establishment of a strategy regarding the enhancement of national competitiveness of traditional Korean medicine.

• Journal of Society of Preventive Korean Medicine
• /
• v.16 no.1
• /
• pp.81-89
• /
• 2012

Objectives : In this research, the genotoxic effect of $Scutellariae$ $Radix$(SR), the dried roots of $Scutellaria$ $baicalensis$ Georgi has been traditionally used as antipyretic agent, was evaluated using the mouse micronucleus test. Methods : SR aqueous extract(yield = 27.2%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide(CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus(MN) in polychromatic erythrocyte(PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Results and Conclusions : Although significant(p<0.01) increase of the number of PCE with one or more nuclei(MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of SR extracts treated mice with over 0.33 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that SR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels - the limit dosage in rodents.

• Journal of Evidence-Based Herbal Medicine
• /
• v.2 no.2
• /
• pp.9-15
• /
• 2009

In order to build up the infrastructure of the globalization of herbal material, the system of culture, distribution, treatment and sale should be established on the basis of the official documents. In this context, the state compendium needs to be theoretically established in perfection 0in order that it may be globally authoritative. The ultimate goal of this study is to clarify the origin and description of the herbal material unregistered in the official documents, as well as to establish the criteria of assessment. The technical books on herbage, published in the country and other countries, were compared with each other. Also, on-the-spot surveys were made to learn specialists' know-how. The description of the collected drug-stuffs Were analyzed in connection with external morphology, internal morphology and microscopy. And the laboratory test was performed to differentiate such drug-stuffs.

• Journal of Society of Preventive Korean Medicine
• /
• v.12 no.2
• /
• pp.73-83
• /
• 2008

The rapid change of the health and medical environment and the globalization of medicine has driven doctors to converge and analyse of new and up-to-date medical information and decide to what to make decision for diagnosis and treatments in clinical practice. Medical environment goes with the changes with social environment such as rapid increase of aging population, changes of disease pattern, formation of new area of experts except doctors, government intervention for the medical system, medical insurance of the charges of medical treatment, a increased desire for human rights. These trends should be adopted rapidly to the education system for the students of medical school. The learning objectives of the preventive medicine was developed in 1995 and underwent necessary revision of the contents to create the first revision in 2006. However, the required educational contents of health promotion and disease prevention have been changed by the new trends of medical education such as PBL and integrated curriculum and the 2006 revision does not satisfy these needs. We formed a task force which surveyed all the Western and Traditional Korean medical colleges to describe the state of preventive medicine education in Korea, analyzed the changing education demand according to the change of health environment and quantitatively measured the validity and usefulness of each learning objective in the previous curriculum. With these results, for the good education for preventive medicine, each Traditional Korean medicine schools need more preventive medicine faculties and teaching assistants and opening of some required subjects such as Yangsaeng and Qigong. And future studies of the learning process and ongoing development of teaching materials according to the new learning objectives should be undertaken with persistence in order to ensure the progress of preventive medicine education.