• 한국임상약학회지
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• 제8권1호
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• pp.1-12
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• 1998

Rheumatoid arthritis (RA) is a common systemic inflammatory disease which DMARDS have been widely used as a treatment modality both as monotherapy and combination therapy Bucillamine, one of newer DMARDS, has recently proven its efficacy as monotherapy in the treatment of RA. The objective of this study was to compare the efficacy and the safety of bucillamine monotherapy and bucillamine plus methotrexate combination therapy in the treatment of rheumatoid arthritis. Forty-nine mild RA patients were enrolled in this prospective, open-trial and were assigned to receive bucillamine 200 mg/day (n=18) or bucillamine 200 mg/day and methotrexate 7.5-15 mg/week (n=31) orally for 16 weeks. Concomitant use of NSAID and prednisolone <5 mg/day or equivalent dose of steroid were allowed. Both monotherapy group and combination therapy group have shown significant improvement in disease activities (Ritchie index, painful joints, swollen joints, morning stiffness, grip strength, ESR, RF, CRP, patient's self assessment of pain, physician's global assessment of disease activity) from the baseline. However, there was no statistically significant difference between two groups. The adverse effects were more frequently shown in combination therapy group than monotherapy group. In conclusion, in patients with mild RA monotherapy has shown to be equally efficacious as combination therapy with less side effects.

• 대한기계학회논문집
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• 제16권5호
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• pp.873-882
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• 1992

본 연구에서는 축대칭 형상의 하이드로 미케니칼 디프드로잉 공정을 강소성 유한요소법으로 해석하는 것이다. 본 논문에서는 Fig.1에서 보이는 바와 같은 경우 에 대하여 평두 펀치(flat headed punch)를 사용한 공정을 강소성 유한요소법으로 해 석하였으며 펀치 행정에 따른 챔버내의 압력 및 플랜지부의 압력분포를 구하였다. 접촉부의 처리는 플랜지부의 압력분포를 구하였다. 접촉부의 처리는 Yang등이 제안 한 방법을 적용하였다. 이론해석의 타당성을 알아보기 위하여 금형을 설계, 제작하 고 실험을 수행하여 결과를 비교 검토하였다.

• 한국해양환경ㆍ에너지학회지
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• 제17권1호
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• pp.36-41
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• 2014

부유식 해양구조물은 설계수명동안 파랑에 의한 압축력, 굽힘하중, 전단력 등의 작용으로 인해 좌굴이 발생할 가능성이 높다. 이는 부재의 면내 강성 저하를 유발하여 국부 구조물 뿐만 아니라 전체구조의 최종강도에도 영향을 미치게 된다. 본 연구에서는 부유식 진자형 파력발전장치의 수실부와 감쇠판을 연결하는 원통부재의 최종강도에 대해 조사하였다. 탄성좌굴해석을 통해 얻어진 1차 좌굴모드를 초기처짐으로 가정하여 탄소성대변형해석을 수행하였으며 최종강도 특성을 바탕으로 부유식 파력발전장치의 연결부인 원통부재의 최적설계인자를 도출하였다. 이를 통해, 원통부재의 직경을 크게하거나, 판의 두께를 두껍게 하는 방법과 보강재를 사용하여 단면적을 크게하는 것이 최종강도를 증가시킬 수 있음을 확인하였다.

• 한국재난정보학회 논문집
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• 제8권2호
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• pp.188-196
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• 2012

고유진동수와 같은 동적파라미터는 구조물 전체의 강성에 대한 정보를 제공할 수 있어 격납건물과 같은 대형구조물의 건전성 모니터링에 유용하게 사용될 수 있다. 이러한 동적특성을 구조물의 사용성에 지장을 주지 않고 추출하기 위해서는 상시진동을 이용한 모달해석 기법의 적용이 필수적이다. 이 연구에서는 상시진동 측정자료를 이용하여 월성 2호기 격납건물의 동적파라미터를 산정하였다. 연구의 가능성은 격납건물의 수치해석모델을 이용하여 검증하였다. 월성 2호기 격납건물에서 측정된 상시진동에 대한 모달해석 결과 해석모드와 충분한 상관성을 갖는 동적파라미터를 산정할 수 있었다.

• Structural Monitoring and Maintenance
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• 제2권3호
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• pp.269-282
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• 2015

Civil structures should be designed with the lowest cost and longest lifetime possible and without service failure. The efficient and sustainable use of materials in building design and construction has always been at the forefront for civil engineers and environmentalists. Timber is one of the best contenders for these purposes particularly in terms of aesthetics; fire protection; strength-to-weight ratio; acoustic properties and seismic resistance. In recent years, timber has been used in commercial and taller buildings due to these significant advantages. It should be noted that, since the launch of the modern building standards and codes, a number of different structural systems have been developed to stabilise steel or concrete multistorey buildings, however, structural analysis of high-rise and multi-storey timber frame buildings subjected to lateral loads has not yet been fully understood. Additionally, timber degradation can occur as a result of biological decay of the elements and overloading that can result in structural damage. In such structures, the deficient members and joints require strengthening in order to satisfy new code requirements; determine acceptable level of safety; and avoid brittle failure following earthquake actions. This paper investigates performance assessment and damage assessment of older multi-storey timber buildings. One approach is to retrofit the beams in order to increase the ductility of the frame. Experimental studies indicate that Sprayed Fibre Reinforced Polymer (SFRP) repairing/retrofitting not only updates the integrity of the joint, but also increases its strength; stiffness; and ductility in such a way that the joint remains elastic. Non-linear finite element analysis ('pushover') is carried out to study the behaviour of the structure subjected to simulated gravity and lateral loads. A new global index is re-assessed for damage assessment of the plain and SFRP-retrofitted frames using capacity curves obtained from pushover analysis. This study shows that the proposed method is suitable for structural damage assessment of aged timber buildings. Also SFRP retrofitting can potentially improve the performance and load carrying capacity of the structure.

• 국제초고층학회논문집
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• 제7권4호
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• pp.375-387
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• 2018

This paper presents a review on progressive collapse mechanism of steel framed buildings exposed to fire. The influence of load ratios, strength of structural members (beam, column, slab, connection), fire scenarios, bracing systems, fire protections on the collapse mode and collapse time of structures is comprehensively reviewed. It is found that the key influencing factors include load ratio, fire scenario, bracing layout and fire protection. The application of strong beams, high load ratios, multi-compartment fires will lead to global downward collapse which is undesirable. The catenary action in beams and tensile membrane action in slabs contribute to the enhancement of structural collapse resistance, leading to a ductile collapse mechanism. It is recommended to increase the reinforcement ratio in the sagging and hogging region of slabs to not only enhance the tensile membrane action in the slab, but to prevent the failure of beam-to-column connections. It is also found that a frame may collapse in the cooling phase of compartment fires or under travelling fires. This is because that the steel members may experience maximum temperatures and maximum displacements under these two fire scenarios. An edge bay fire is more prone to induce the collapse of structures than a central bay fire. The progressive collapse of buildings can be effectively prevented by using bracing systems and fire protections. A combination of horizontal and vertical bracing systems as well as increasing the strength and stiffness of bracing members is recommended to enhance the collapse resistance. A protected frame dose not collapse immediately after the local failure but experiences a relatively long withstanding period of at least 60 mins. It is suggested to use three-dimensional models for accurate predictions of whether, when and how a structure collapses under various fire scenarios.

• Steel and Composite Structures
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• 제30권2호
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• pp.81-96
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• 2019

The behavior of a new Three-Tube Buckling-Restrained Brace (TTBRB) with circumference pre-stress (${\sigma}_{{\theta},pre}$) in core tube are investigated through a verified finite element model. The TTBRB is composed of one core tube and two restraining tubes. The core tube is in the middle to provide the axial stiffness, to carry the axial load and to dissipate the earthquake energy. The two restraining tubes are at inside and outside of the core tube, respectively, to restrain the global and local buckling of the core tube. Based on the yield criteria of fringe fiber, a design method for restraining tubes is proposed. The applicability of the proposed design equations are verified by TTBRBs with different radius-thickness ratios, with different gap widths between core tube and restraining tubs, and with different levels of ${\sigma}_{{\theta},pre}$. The outer and inner tubes will restrain the deformation of the core tube in radius direction, which causes circumference stress (${\sigma}_{\theta}$) in the core tube. Together with the ${\sigma}_{{\theta},pre}$ in the core tube that is applied through interference fit of the three tubes, the yield strength of the core tube in the axial direction is improved from 160 MPa to 235 MPa. Effects of gap width between the core tube and restraining tubes, and ${\sigma}_{{\theta},pre}$ on hysteretic behavior of TTBRBs are presented. Analysis results showed that the gap width and the ${\sigma}_{{\theta},pre}$ can significantly affect the hysteretic behavior of a TTBRB.

• Earthquakes and Structures
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• 제22권6호
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• pp.539-548
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• 2022

Steel plate shear walls (SPSWs) are one of the most important and widely used lateral load-bearing systems. The reason for this is easier execution than reinforced concrete (RC) shear walls, faster construction time, and lower final weight of the structure. However, the main drawback of SPSWs is premature buckling in low drift ratios, which affects the energy absorption capacity and global performance of the system. To address this problem, two groups of SPSWs under cyclic loading were investigated using the finite element method (FEM). In the first group, several series of circular rings have been used and in the second group, a new type of SPSW with concentric circular rings (CCRs) has been introduced. Numerous parameters include in yield stress of steel plate wall materials, steel panel thickness, and ring width were considered in nonlinear static analysis. At first, a three-dimensional (3D) numerical model was validated using three sets of laboratory SPSWs and the difference in results between numerical models and experimental specimens was less than 5% in all cases. The results of numerical models revealed that the full SPSW undergoes shear buckling at a drift ratio of 0.2% and its hysteresis behavior has a pinching in the middle part of load-drift ratio curve. Whereas, in the two categories of proposed SPSWs, the hysteresis behavior is complete and stable, and in most cases no capacity degradation of up to 6% drift ratio has been observed. Also, in most numerical models, the tangential stiffness remains almost constant in each cycle. Finally, for the innovative SPSW, a relationship was suggested to determine the shear capacity of the proposed steel wall relative to the wall slenderness coefficient.

• 콘크리트학회논문집
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• 제22권3호
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• pp.381-388
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• 2010

이 논문에서는 내진상세가 적용되지 않은 RC골조의 지진 거동 특성을 파악하였다. 해석 대상 건물은 내진 규준의 적용을 받지 않고 중력하중만을 고려하여 설계되었다. 원형철근이 주철근으로 사용되었으며, 부재는 낮은 수준의 전단력을 견딜 수 있는 최소한의 스터럽이 사용되어 코어 부분의 구속효과는 거의 없다. 평면비정형성을 가진 건물의 경우, 푸쉬오버 해석을 통해서는 비틀림으로 인한 평면상에서 연단부의 손상집중을 파악할 수 없으므로 비선형 동적해석을 사용하는 것이 바람직하다. 섬유요소를 이용한 비선형 동적해석은 양방향 지진하중과 비틀림 거동의 영향을 받는 RC골조의 거동을 성공적으로 예측할 수 있었다. 하지만, 보다 진보된 응답 예측을 위해서는 부착 미끄러짐과 같은 보-기둥 접합부의 국부거동을 정밀하게 나타내는 모델링 요소의 개발이 필요하다.

• 한국해안·해양공학회논문집
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• 제27권5호
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• pp.315-323
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• 2015

이상 기후현상으로 인해 폭풍의 강도가 커지고, 지속시간 또한 길어지고 있어 연안 피해가 점차 대규모화 되고 있다. 이러한 변화에 대응하기 위하여 기존 방파제에 대한 평가기준과 신설 방파제의 설계기준이 강화되고 있다. 최근 케이슨식 방파제의 구조적 안정성을 향상시키기 위하여 개별 케이슨이 독립적으로 파에 저항하도록 하였던 방파제 케이슨을 서로 인터로킹시키는 방안이 관심을 받고 있다. 이는 각각의 케이슨에 작용하는 힘을 분산시켜 이상파랑이 발생할 경우에도 최대파력이 저감되어 방파제의 안정성을 확보할 수 있도록 한 것이다. 본 연구에서는 케이블을 이용하여 케이슨 상부를 방파제 기준선방향으로 인터로킹시켰을 때의 파력의 분산특성에 대해서 분석하였다. 수치계산의 효율을 위해 지반과 연결 케이블은 선형 스프링으로 모형화하고 케이슨은 강체로 가정한 정적 선형모델을 개발하였다. 수치해석 결과, 입사각이 커질수록 케이블을 통하여 전달되는 파력비가 높아지고, 인터로킹 케이블의 강성이 클수록 전달 파력비가 증대되어 파력분산 효과가 높아지는 특성을 확인할 수 있었다.