• Journal of Applied Biological Chemistry
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• v.58 no.3
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• pp.219-226
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• 2015

The anticancer activity of a methanolic extract from lemon leaves (MLL) was assessed in MCF-7-SC human breast cancer stem cells. MLL induced apoptosis in MCF-7-SC, as evidenced by increased apoptotic body formation, sub-G1 cell population, annexin V-positive cells, Bax/Bcl-2 ratio, as well as proteolytic activation of caspase-9 and caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein. Concomitantly, MLL induced the formation of acidic vesicular organelles, increased LC3-II accumulation, and reduced the activation of Akt, mTOR, and p70S6K, suggesting that MLL initiates an autophagic progression in MCF-7-SC via the Akt/mTOR pathway. Epithelial-mesenchymal transition (EMT), a critical step in the acquisition of the metastatic state, is an attractive target for therapeutic interventions directed against tumor metastasis. At low concentrations, MLL induced anti-metastatic effects on MCF-7-SC by inhibiting the EMT process. Exposure to MLL also led to an increase in the epithelial marker E-cadherin, but decreased protein levels of the mesenchymal markers Snail and Slug. Collectively, this study provides evidence that lemon leaves possess cytotoxicity and anti-metastatic properties. Therefore, MLL may prove to be beneficial as a medicinal plant for alternative novel anticancer drugs and nutraceutical products.

• Journal of the Korean association of regional geographers
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• v.12 no.2
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• pp.305-322
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• 2006

An increasing number of cities employ rescaling strategies that not only construct metropolitan production network scaled down from national context, but also tune up new governance to effectively control local geographies of the city. In this context, urban redevelopment has emerged a key 'global' strategy to empower governmental institutions of the city, which not only eliminate such threatening spatial variables as deteriorated housing, working-class ghettos, and crime areas, but also increase and extract exchange value of those spaces. I view such practices a process of 'glurbanization'. This paper investigates how state/city government employs the discourse of urban re/development for 'inventing' poverty at an urban scale: how it institutionalizes the discourse for implementing concrete projects: and how urban institutional apparatus appropriate their discursive practices of redevelopment for their own ends in the city. By particularly focusing on the California Redevelopment Law and the Community Redevelopment Agency of the City of Los Angeles, this paper analyzes the ways in which the law and the agency extract value from what they define 'blight areas' by means of eminent domain and tax increment revenues. For empirical analysis I employ discourse analysis and institutional ethnography. I conclusively argue that the urban spaces stigmatized as 'blight areas' are increasingly entrapped by the urban redevelopment agency, which extracts increased exchange value from the areas and redirects it for supporting external investors, private developers, and the body of the agency itself.

• Journal of Information Management
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• v.40 no.4
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• pp.93-108
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• 2009

In order to achieve the growth of traditional Chinese medicine, the chinese government has annually released "China Statistical Yearbook of Chinese Medicine" to the world since "State Administration of Traditional Chinese Medicine of the People's Republic of China" established in 1988. It is believed that the chinese government intends to secure the early dominance of the global medical market by systematic management of its own medicine infrastructures. Although the statistics of "China Statistical Yearbook of Chinese Medicine" weren't systematically organized at the beginning, it has becoming richer, more systematic, and more standardized in the data construction and system as time has passed. Furthermore, we can take a look at China's effort to take the initiative of oriental medicine by expanding investment in several core areas - medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses. This article will show how china has been trying to develop the chinese medicine, focusing on two parts. One is specific analysis of the book "China Statistical Yearbook of Chinese Medicine". It is divided into analysis of its construction system, the degree of data construction, and its statistical system. The other is analysis of annual changes in areas of medicine resources, operation of medical instruments, service, medicine education, medicine science research, and working expenses.

• Fire Science and Engineering
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• v.24 no.3
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• pp.131-138
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• 2010

Experimental and numerical studies were conducted to investigate the thermal and chemical characteristics of heptane fires in a full-scale ISO 9705 room. Representative fire conditions were considered for over-ventilated fire (OVF) and under-ventilated fire (UVF). Fuel flow rate and doorway width were changed to create OVF and UVF conditions. Detailed comparisons of temperature and species concentrations between experimental and numerical data were presented in order to validate the predictive performance of FDS (Fire Dynamic Simulator). The OVF and UVF were explicitly characterized with distributions of temperature and product formation measured in the upper layer, as well as combustion efficiency and global equivalence ratio. It was shown that the numerical results provided a quantitatively realistic prediction of the experimental results observed in the OVF conditions. For the UVF, the numerically predicted temperature showed reasonable agreement with the measured temperature. The predicted steady-state volume fractions of $O_2$, $CO_2$, CO and THC also agreed quantitatively with the experimental data. Although there were some limitations to predict accurately the transient behavior in terms of CO production/consumption in the UVF condition, it was concluded that the current FDS was very useful tool to predict the fire characteristics inside the compartment for the OVF and UVF.

• Journal of the Korean Home Economics Association
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• v.43 no.6 s.208
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• pp.113-131
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• 2005

The purpose of this study was to investigate older people's planning for estate distribution by examining the factors associated with their will-holding status. This study used data from the 1994 Assets and Health Dynamics among the Oldest Old (AHEAD) Survey, Wave One. The objectives of this study were (a) to establish profiles of older people who have a written will and to compare their financial portfolios across will-holding status; (b) to identify factors that influence the decision to make a will, and (c) to draw implications for family economists, financial educators, planners, and policy makers. The results suggested that a household's financial resources (i.e., liquid and illiquid assets, housing equity, and household income) positively influence the probability of having a will. Older people who resided in a community property state and who were in poor health were less likely to be will-holders than their counterparts, holding financial resources and other variables constant. Demographic characteristics such as age, education, and race, and behavioral characteristic also were significant determinants of the likelihood of having a will. Volunteer participation and charitable contribution, which are proxies for altruism, increased the likelihood of having a will. The probability of having a will also was higher among those who had life insurance and had gwen inter-vivos gifts of more than $\$5,000$ to their children or grandchildren in the past 10 years. On the other hand, the likelihood of having a will declined with increasing number of biological children. From the findings, implications for financial planners and educators were suggested along with directions for future research.

• Journal of the Economic Geographical Society of Korea
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• v.20 no.4
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• pp.503-521
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• 2017

Demands in a sustainable coffee certification program have increased steadily in the global coffee market. Along with this trend, recently the introduction of sustainable coffee certification programs in Vietnam has increased significantly. However, Vietnam's the coffee certification programs led by a single state-owned company, which is called Vinacafe, shows some differentiations from other sustainable coffee programs certified in other countries. The structure of exclusive decision-making in Vinacafe has been interfered with economic impacts in accordance with the introduction of sustainable coffee certification programs in Vietnam. Therefore, the purpose of this paper is to identify changes in and limits of the value chain of the coffee industry with the introduction of Vietnam's sustainable coffee certification program by investigating the case of Vinacafe. To this end, the research has attempted 1) to concern with the role of Vinacafe in the process of growth in the coffee industry in central highland of Vietnam, 2) to analyze changes stemmed from the introduction of Vinacafe's sustainable coffee certification programs, and 3) to examine the limits to the introduction of sustainable coffee certification programs in Vietnam. As a result, it found out that Vinacafe subsidiaries shifted the losses resulted in the payment of additional environmental costs to produce sustainable certification coffee onto coffee farmers depended on Vinacafe subsidiaries, because the price of premium emerged from supports for certificated coffee production has not been guaranteed by Vinacafe mother firm.

• Spatial Information Research
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• v.12 no.4 s.31
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• pp.299-305
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• 2004

According to the facility of effective search and user-friendly access to various spatial data by building GIS, the demand for application of information and social effect has been increased. To meet such domestic demands, it has become necessary to develop local, regional, and global SDI(Spatial Data Infrastructure) which can support discovery, access, and use of spatial information in the decision-making process. Many developed countries are implementing and managing GSDI in accordance with their state and purpose. There are two typical international cases; U.S. Geospatial One-Stop and European Geo-Portal. These systems are observed the international standards so they provide standardization and interoperability of GI. In domestic cases, however, each sector is managing separately geospatial data management systems. From this point of view, this paper proposed implementation approaches of GOS that can provide interchange of geospatial information between supplier and user. This paper focused on standardization, considered technical and political factors and analyzed two cases of GOS such as U.S. and Europe cases into our spatial information environments. It is possible to search and access geospatial data effectively by introducing GOS. In addition, it is possible to promote popularization of geospatial information and development of GIS industy.

• Journal of Korea Water Resources Association
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• v.48 no.4
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• pp.269-279
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• 2015

Nowadays, the world has suffered by natural disaster of climate change due to global warming. Korea has also faced with similar situation. To prevent these natural disaster, Four Major River Management has conducted. One of conducted content in Four Major River Management is the levee maintenance which classified into fill-up the inland, levee of reinforcement and so on. These maintenances may make the characteristics of groundwater flow change and affect to the levee safety (piping phenomenon). Therefore, analysis on groundwater fluctuation according to level of riverside and inland should be required. This study focus on levee of Hoe stream, which is connected to Nakdong river, and piping safety factor in the levee analyzed by using pore water pressure. Besides, groundwater fluctuation, which is depended on level of riverside and inland, is simulated by using the SEEP/W (2D ground water model). This simulation considered steady flow and unsteady flow. As a result, piping safety factor increased due to rising the inland level. Piping safety factor of riverside was effected by only river water level. Therefore, external levee factor considering inland level raising and suitable control of river water level is need to increase piping safety factor.

• Journal of the Korean association of regional geographers
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• v.5 no.2
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• pp.29-45
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• 1999

This study reviewed theories on entrepreneurial local governance and inquired the changing regional policy in Chonnam region. The region became exposure as the direct investment unit of global capital by globalization of capital, the inter-regional competition and the relative reduction of the role and function of nation state. Therefore local government have the relative autonomy and the region is effected as the chosen space by capital according to the free movement of capital. It has been argued that there has been a reorientation of urban governance away from the local provision of welfare and services to a more outward-orientated stance designed to foster and encourage local growth and economic development. These profound changes in the way that cities operate have seen the public sector taking over characteristics once distinctive to the private sector leading many commentators to term such modes of governance as entrepreneurial. In Chonnam region, many local governments are introducing entrepreneurial policies for regional development. It appears as place marketing strategy to attract capital and tourists. This strategy is very important to used identity or culture of region in order to make the attractive region. The entrepreneurial characteristics and strategies appear as image unification of region, commodity development of natural or cultural resource, event and business projects. From this point of view, the entrepreneurial policy that is based upon regional growth can cause the problem of social justice like distributional distortion and inequality.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.281-289
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• 2013

As the number of clinical trials conducted in Korea increases, the need of the Electronic Data Capture (EDC) system for effective clinical data management is also increased. Recently, the Korea Food and Drug Association published 'Guideline for the Electronic Clinical Trial Data Management and Processing' and it would be the foundation for establishing regulation of electronic clinical data management. In this research, we conducted the survey regarding adoption rate of EDC system in clinical trials in hospitals, Contract Research Organizations (CRO), and pharmaceutical companies. And the perceived importance and the ease of application for the Guideline were investigated. The adoption rates of EDC system was 77.6% but it mostly applied to less than five trials. Also EDC system was mostly used in phase I and phase II trials and the utilization rate of CRO was the highest. The perceived importance for the Guideline was high among all three organizations but, in case of the perceived ease of its application, CRO was the highest. Also, the perceived importance of the clinical data standard was high and the standard for data collection was mostly required. However, the comprehension for the global standard of the electronic data was relatively low, so that education is required. This result would be the foundation to increase the electronic clinical trials and develop proper regulation and principles for clinical data standards in Korea.