• Journal of KIISE
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• v.41 no.12
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• pp.1090-1098
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• 2014

In this paper, an improved ACDE (Adaptive Cauchy Differential Evolution) algorithm with faster convergence speed, called ACDE2, is suggested. The baseline ACDE algorithm uses a "DE/rand/1" mutation strategy to provide good population diversity, and it is appropriate for solving multimodal optimization problems. However, the convergence speed of the mutation strategy is slow, and it is therefore not suitable for solving unimodal optimization problems. The ACDE2 algorithm uses a "DE/current-to-best/1" mutation strategy in order to provide a fast convergence speed, where a control parameter initialization operator is used to avoid converging to local optimization. The operator is executed after every predefined number of generations or when every individual fails to evolve, which assigns a value with a high level of exploration property to the control parameter of each individual, providing additional population diversity. Our experimental results show that the ACDE2 algorithm performs better than some state-of-the-art DE algorithms, particularly in unimodal optimization problems.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.05a
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• pp.859-865
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• 2007

This paper presents a method to analyze the unbalance response of a high speed polygon mirror scanner motor supported by sintered bearing and flexible supporting structures by using the finite element method and the mode superposition method. The appropriate finite element equations for polygon mirror are described by rotating annular sector element using Kirchhoff plate theory and von Karman non-linear strain, and its rigid body motion is also considered. The rotating components except for the polygon mirror are modeled by Timoshenko beam element including the gyroscopic effect. The flexible supporting structures are modeled by using a 4-node tetrahedron element and 4-node shell element with rotational degrees of freedom. Finite element equations of each component of the polygon mirror scanner motor and the flexible supporting structures are consistently derived by satisfying the geometric compatibility in the internal boundary between each component. The rigid link constraints are also imposed at the interface area between sleeve and sintered bearing to describe the physical motion at this interface. A global matrix equation obtained by assembling the finite element equations of each substructure is transformed to a state-space matrix-vector equation, and both damped natural frequencies and modal damping ratios are calculated by solving the associated eigenvalue problem by using the restarted Arnoldi iteration method. Unbalance responses in time and frequency domain are performed by superposing the eigenvalues and eigenvectors from the free vibration analysis. The validity of the proposed method is verified by comparing the simulated unbalance response with the experimental results. This research also shows that the flexibility of supporting structures plays an important role in determining the unbalance response of the polygon mirror scanner motor.

• Korean Journal of Animal Reproduction
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• v.27 no.4
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• pp.309-315
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• 2003

DNA methylation at CpG sites, which is a epigenetic modification, is associated with gene expression without change of DNA sequences. During early mouse embryogenesis, dynamic changes of DNA methylation occur. In this study, DNA methylation patterns of porcine embryos produced in vivo and in vitro were examined at various developmental stages by the immunocytochemical staining method. Interestingly, active demethylation was not observed on the paternal pronucleus of porcine zygotes. However, differences were detected in the passive demethylation process between in vivo and in vitro embryos. There was no change in the DNA methylation state until the blastocyst stage of in vivo embryos, whereas partial demethylation was observed in several blastomeres from a 4 cell stage to a morula stage of in vitro embryos. The whole genome of inner cell mass (ICM) and trophectoderm (TE) cells in porcine blastocysts were evenly methylated without de novo methylation. Our findings demonstrate that genome-wide demethylation does not occur in pig embryos during preimplantation development unlike murine and bovine embryos. It indicates that the machinery regulating epigenetic reprogramming may be different between species.

• Science of Emotion and Sensibility
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• v.21 no.3
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• pp.83-102
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• 2018

The process model of emotion regulation suggests that cognitive reappraisal and expressive suppression engage at different time points in the regulation process. Although multiple brain regions and networks have been identified for each strategy, no articles have explored changes in network characteristics or network connectivity over time. The present study examined (a) the whole-brain network and six other resting-state networks, (b) their modularity and global efficiency, which is an index of the efficiency of information exchange across the network, (c) the degree and betweenness centrality for 160 brain regions to identify the hub nodes with the most control over the entire network, and (d) the intra-network and inter-network functional connectivity (FC). Such investigations were performed using a traditional large-scale FC analysis and a relatively recent sliding window correlation analysis. The results showed that the right inferior orbitofrontal cortex was the hub region of the whole-brain network for both strategies. The present findings of temporally altering functional activity of the networks revealed that the default mode network (DMN) activated at the early stage of reappraisal, followed by the task-positive networks (cingulo-opercular network and fronto-parietal network), emotion-processing networks (the cerebellar network and DMN), and sensorimotor network (SMN) that activated at the early stage of suppression, followed by the greater recruitment of task-positive networks and their functional connection with the emotional response-related networks (SMN and occipital network). This is the first study that provides neuroimaging evidence supporting the process model of emotion regulation by revealing the temporally varying network efficiency and intra- and inter-network functional connections of reappraisal and suppression.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.8
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• pp.728-740
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• 2016

Korea developed several satellites through government-led satellite development projects, and now operates earth observation satellites of various sensors, science and technology satellites, and communication satellites. Satellites can be utilized in many fields, and Satellite Information, Global Navigation Satellite System, Satellite Communications and Broadcasting, Space Solar Power System are typical application fields. Now that we have developed and operated several satellites, we have to concentrate more efforts on satellite application. In this paper, we reviewed the current states of the technologies of four satellite application fields mentioned above and analyzed the future prospects of them.

• The Journal of the Korea Contents Association
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• v.9 no.5
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• pp.137-144
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• 2009

Culture contents industry in Gyeongbuk province has consumption system, being small-scale, an lacking infrastructure, imbalance, a shortage of strategy, and so on. But, culture contents industry in Gyeongbuk province has great possibilities in abundant culture resources, a prospect of the culture contents industry and future effective promotion strategy. And the promotion plans are the digitalization of the cultural original form, the edutainment of the Confucianism culture, construction of a traditional cultural digital center, location marketing, establishment of Documentary Film Council, culture literacy, an orientation of small film, promotion of the global city and the culture base city, development of killer contents, exploitation of tourism resource, discriminating strategy, and so on. Actually Gyeongbuk province should need to promote the culture contents industry because of high added value, an effect on related industries, utility of the digital culture contents, extension of a market scale, a rapid growth speed, and so on.

• Steel and Composite Structures
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• v.17 no.4
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• pp.471-495
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• 2014

The responses of steel buildings with perimeter moment resisting frames (PMRF) with medium size columns (W14) are estimated and compared with those of buildings with deep columns (W27), which are selected according to two criteria: equivalent resistance and equivalent weight. It is shown that buildings with W27 columns have no problems of lateral torsional, local or shear buckling in panel zone. Whether the response is larger for W14 or W27 columns, depends on the level of deformation, the response parameter and the structural modeling under consideration. Modeling buildings as two-dimensional structures result in an overestimation of the response. For multiple response parameters, the W14 columns produce larger responses for elastic behavior. The axial load on columns may be significantly larger for the buildings with W14 columns. The interstory displacements are always larger for W14 columns, particularly for equivalent weight and plane models, implying that using deep columns helps to reduce interstory displacements. This is particularly important for tall buildings where the design is usually controlled by the drift limit state. The interstory shears in interior gravity frames (GF) are significantly reduced when deep columns are used. This helps to counteract the no conservative effect that results in design practice, when lateral seismic loads are not considered in GF of steel buildings with PMRF. Thus, the behavior of steel buildings with deep columns, in general, may be superior to that of buildings with medium columns, using less weight and representing, therefore, a lower cost.

• The Journal of the Acoustical Society of Korea
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• v.23 no.2
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• pp.90-102
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• 2004

According to the Mutual Recognition Arrangement (MRA), the calibration and/or test laboratories should satisfy the management and technical requirements ISO 17025 or equivalent. Chapter 5, Section 5.10.4 of the technical requirement of ISO 17025 suggests the required informations for calibration certificates, one of them is to state the uncertainty of measurement. The uncertainties of measurement in reciprocity calibration of standard laboratory microphone were calculated. The expanded uncertainties for 1 and 1/2 inch microphones were 0.03 dB in the middle frequency range and they increased up to 0.10 dB and 0.11 dB at 20 Hz, 0.07 dB and 0.08 dB at high frequency, respectively.

• Journal of Korean Society for Atmospheric Environment
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• v.13 no.2
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• pp.161-170
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• 1997

The concentrations of dimethylsulfide (DMS) were determined using samples collected from a station located at Kosan, Cheju Island during two field campaigns held in December 1996 and January 1997. The atmospheric DMS concentrations measured at 6-hr intervals during the entire campaign periods, after excluding a few extreme values, spanned in the range of 14 to 410 pptv with mean and 1 SD value of 127 $\pm$ 94 pptv (N=42). Between two month periods during which the field campaigns were conducted, a notable reduction in DMS levels was observed which was comparable to the dramatic shift in air temperature. A considerable difference was also noted in DMS levels, when data were grouped by day/night basis. The cause of unexpected, high day-to-night DMS ratios is best explained in terms of high efficiency of daytime source processes relative to low efficiency of nighttime sink processes due to the characteristics of the study location. The surface water DMS of the study site, although scarcely measured, also behaved similarly to its atmospheric counterpart with its range from 0.3 to 19 nM (N=11). When correlation analysis was conducted between the atmospheric DMS concentration and other concurrently determined parameters, significant correlations were observed from most basic meteorological parameters such as windspeed, relative humidy, and air temperature. However, the existence of "not-so-strong" correlations between air temperature and DMS concentrations relative to other ones indicated that the effect of temperature on DMS behavior must be reflected in more complicated manners at the study site. The sea-to-air flux of DMS was approximated through an application of the mass-balance flux calculation method of Wylie and de Mora (1996) under the assumption that sink mechanism within the marine boundary layer is in steady-state condition with its counterpart, source mechanism. Based on this estimation method, we reached a conclusion that oceanic DMS emitted from the southwest sea of the Korean Peninsula can amount to approximately 9 $\sim$ 36 Gg S $yr^{-1}$.$yr^{-1}$.

• Journal of Pharmacopuncture
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• v.19 no.1
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• pp.7-15
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• 2016

Objectives: Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials drug which is more target specific. Malarial parasites harbor a plastid-like organelle known as the 'apicoplast', which is thought to provide an exciting new outlook for the development of drugs to be used against the parasite. This review elaborates on the current state of development of novel compounds targeted againstemerging malaria parasites. Methods: The apicoplast, originates by an endosymbiotic process, contains a range of metabolic pathways and housekeeping processes that differ from the host body and thereby presents ideal strategies for anti-malarial drug therapy. Drugs are designed by targeting the unique mechanism of the apicoplasts genetic machinery. Several anabolic and catabolic processes, like fatty acid, isopenetyl diphosphate and heme synthess in this organelle, have also been targeted by drugs. Results: Apicoplasts offer exciting opportunities for the development of malarial treatment specific drugs have been found to act by disrupting this organelle's function, which wouldimpede the survival of the parasite. Conclusion: Recent advanced drugs, their modes of action, and their advantages in the treatment of malaria by using apicoplasts as a target are discussed in this review which thought to be very useful in desigining anti-malarial drugs. Targetting the genetic machinery of apicoplast shows a great advantange regarding anti-malarial drug design. Critical knowledge of these new drugs would give a healthier understanding for deciphering the mechanism of action of anti-malarial drugs when targeting apicoplasts to overcome drug resistance.