• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.952-957
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• 2003

To certify the protective effect of herbal medicine against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using LDH activity and TBARS assay in the presence of Jisilhaebaekgyejitang(JHGT) extracts or single constituents of this prescription, In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a cell damage such as increases in LDH activity in culture medium and lipid peroxidation in cultured myocardial cells. In the effect of JHGT extract and its single constituents, which are Fructus Ponciri Seu Aurantii Immaturus (FPSAI), Cortex Magnoliae Officinalis (CMO), Bulbus Allii Macrostemi (BAM), Ramulus Cinnamomi (RC) and Fructus Trichosanthis (FT), they showed the prevention from the XO/HX-induced cardiotoxicity by the decrease of LDH activity and lipid peroxidation. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rat, and it suggests that JHGT, FPSAI, PT, CMO, BAM, RC and FT extracts are positively effective in the blocking in XO/HX-induced cardiotoxicity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.6
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• pp.1207-1213
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• 2007

This paper has researched water supply facilities management using real-time water utility monitoring system based on USN(Ubiquitous Sensor Network) which is consisted of wireless sensors transferring waterworks facilities md treatment information about a valve-room and flowmeter-room of water supply installation. In the manholes, it was installed with flowmeter, pressure sensors, vibration sensors, Co-sensors, and hydro-thermograph sensors. These measurement values which are received by PDA are used for facilities operation on the spot safely and conveniently. It has also provided safe installation management via CDMA(Code Division Multiple Access) network which transfers data to remote servers to monitoring at a distance place. With safety management system of water supply facilities on USN technology convenience and safety is increased in real situation, and it is expected that we can supply clean water to people as much safer and more effective water supply installation management.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.347-347
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• 2017

본 연구에서는 한강유역에 발생한 가뭄 분석을 위해 표준강수지수를 활용하였으며, 가뭄분석을 위해 한강유역에 실제로 발생한 가뭄사상 중에 한강유역에 조금 더 많은 피해를 미친 것으로 조사된 2000 - 2001년에 대해 가뭄과 수량 스트레스 관계를 살펴보았다. 수량 스트레스값은 강수에만 영향을 받고 있는 값보다는 실제 가뭄 피해의 영향정도를 살펴보기 위해 수량 스트레스의 결과값과 상호 비교하였다. 이는 실제 발생한 기상학적 가뭄으로 인한 피해가 수량 스트레스 변화에 어떠한 영향을 미치는지를 상호 비교함으로써 보다 정확한 가뭄 피해 발생 시기를 확인하고자 함이다. 표준강수지수 SPI3, SPI6, SPI12을 분석하기 위해 2000년 1월 - 2001년 12월까지의 데이터를 구축하였다. 이와 함께 수량 스트레스의 경우 월별 최대 NDI 값을 추출하여 월단위 자료를 구축하였다. 표준강수지수와 NDI 값을 상호 비교한 결과 2000 - 2001년에 발생한 가뭄 사상의 경우, 실제 피해가 발생한 시점은 2001년 3월 - 5월에 발생한 동아시아 지역의 가뭄의 영향이 큰 것으로 나타났다. 한강유역의 대부분에서 수량 스트레스가 발생하는 시기와 SPI3로 인한 가뭄 발생시기가 유사한 패턴으로 나타났다. SPI6와 비교분석해본 결과 기존 SPI3에서 나타낸 2001년 5월에 발생된 가뭄 발생은 실제 수량 스트레스가 발생하는 2001년 5월 이후와 유사한 패턴을 보이는 것으로 나타났지만, 실제 수량 스트레스 발생 시기와는 상관성이 떨어지는 것을 확인할 수 있었다. SPI12에서는 대부분의 유역에서 2000년에는 가뭄이 발생하지 않은 것으로 분석되었다. 이는 한강유역에 발생한 가뭄 피해를 생각해보면, 2001년에 발생한 가뭄 자체가 단기적인 가뭄의 영향이 아닌 장기적인 가뭄의 영향을 띄고 있는 것으로 해석 할 수 있으며, 2000년대 초반 극심한 가뭄 피해를 입힌 2001년 가뭄은 지속적인 가뭄 동반한 장기 적 가뭄 피해임을 확인할 수 있었다. 즉, 수량 스트레스와 가뭄을 연계하여 가뭄 해석에 활용한다면, 추후에 좀 더 정확한 가뭄 피해를 사전에 예측할 수 있을 것으로 판단된다.

• Journal of Trauma and Injury
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• v.34 no.2
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• pp.98-104
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• 2021

Purpose: Severe pelvic fractures are associated with genitourinary injuries, but the relationship between pelvic trauma and concomitant urethral injuries has yet to be elucidated. This study evaluated the incidence, mechanism, site, and extent of urethral injuries in male patients with pelvic fractures. Methods: A retrospective cohort study was performed involving patients with urethral injuries accompanying pelvic fractures who visited Pusan National University Hospital from January 1, 2014 to December 31, 2019. Demographics, mechanisms of injury, clinical features of the urethral injuries, concomitant bladder injuries, methods of management, and the configuration of the pelvic fractures were analyzed. Results: The final study population included 24 patients. The overall incidence of urethral injury with pelvic fracture was 2.6%, with the most common mechanism of urethral injury being traffic accidents (62.5%). Complete urethral disruption (16/24, 66.7%) was more common than partial urethral injuries (8/24, 33.3%), and unstable pelvic fractures were the most common type of pelvic fracture observed (70.8%). There was no definitive relationship between the extent of urethral injury and pelvic ring stability. Conclusions: The present study provides a 6-year retrospective review characterizing the incidence, mechanism, and clinical features of urethral injury-associated pelvic fractures. This study suggests that the possibility of urethral injury must be considered, especially in unstable pelvic fracture patients, and that treatment should be chosen based on the clinical findings.

• The Journal of Korean Physical Therapy
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• v.33 no.6
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• pp.278-285
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• 2021

Purpose: This study investigated the effects of open kinetic chain (OKC) exercise for the gastrocnemius (GCM) and tibialis anterior (TA) muscles on static and dynamic balance and muscle strength. Methods: We recruited 21 healthy participants, dividing them into 3 groups (GCM, TA, and non-exercise). Each group contains 7 participants. Two exercise groups (GCM and TA) performed OKC exercise with elastic bands twice per week for 4 weeks, while non-exercise group did nothing. We obtained the data for static and dynamic balance and muscle strength before and after the intervention. We used the Kruskal-Wallis test to compare and analyze the pre-post-intervention differences among the groups. Results: For static balance, the stability index of the TA group was the lowest for the dynamic platform (p<0.05). The dynamic balance of the TA group increased for the anterior and posteromedial directions (p<0.05). The peak torque increased in the TA group for dorsiflexion (D/F) movement and in the GCM group for plantar flexion movement compared with the other groups, except for the left direction during D/F (p<0.05). Conclusion: OKC exercises with elastic bands were effective for selectively increasing muscle strength. It is clinically thought that strength training for TA muscles will be effective among the muscles of the ankle.

• The Journal of Korean Physical Therapy
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• v.35 no.3
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• pp.57-63
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• 2023

Purpose: The aim of this study was to conduct a systematic review of randomized controlled studies from 2012 to present that explore the diagnostic accuracy of clinical tests used for diagnosing anterior cruciate ligament (ACL) injury. Methods: Study design: Systematic review. Literature search of the PubMed and Scholar databases was conducted using keywords related to diagnostic accuracy of clinical tests for ACL injury. The PRISMA Guidelines were followed to conduct this study. The Cochrane Risk of Bias Tool was utilized to assess the quality of each included study. Results: As a result, 8 studies were included, and 6 clinical tests used in ACL tears were evaluated for diagnostic accuracy. The pivot shift test was reported as having the highest +LR (29.5) value with a sensitivity of 59% and a specificity of 98%. However, the test with the lowest -LR value was the lever test, and the values were as follows: -LR (0.08), +LR (4.7), specificity (80%), sensitivity (94%). Conclusion: In this study, it was concluded that a single clinical test is not sufficient to determine the presence of ACL injury. Test combinations have a higher diagnostic accuracy than a single test. In this study, the accuracy of the clinical tests was examined without considering the amount of ACL rupture and acute-chronic condition. Further research is required to examine the impact of these two factors on diagnostic accuracy of clinical test.

• Korean Journal of Food Science and Technology
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• v.39 no.3
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• pp.299-303
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• 2007

The objective of this study was the development of immunochromatography (ICG) for the rapid and accurate detection of Listeria monocytogenes. Here, monoclonal antibodies (MAb) were conjugated with 40 nm colloidal gold particles, where the conjugate was used as the detection reagent in the ICG. The ICG was composed of three pads (sample, conjugate, and absorbance pads) and one nitrocellulose membrane. The colloidal gold-MAb conjugate was applied to the conjugate pad, and the test line and control line on the membrane were treated with MAb (FKLM-3BI2-37) and anti-mouse IgG, respectively. The detection limit of the ICG was $10^{5}$ cell/mL and it showed no cross-reaction to food borne pathogens. We inoculated meat and lettuce samples with various counts of L. monocytogenes, and analyzed them by ICG. All the inoculated meat samples gave positive results after enrichment for 24 h in LEB. These results indicate that ICG was able to serve as a primary screening tool for L. monocytogenes in various foods and agricultural products within 20 min after enrichment.

• Journal of Microbiology and Biotechnology
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• v.17 no.7
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• pp.1152-1161
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• 2007

An immunochromatography (ICG) strip test based on a monoclonal antibody for the rapid detection of L. monocytogenes in meat and processed-meat samples was developed in this study. A monoclonal antibody (MAb) specific to L. monocytogenes was produced from cloned hybridoma cells (FKLM-3B12-37) and used to develop an ICG strip test. The antibody showed a stronger binding to L. monocytogenes than other Listeria species, and a weak cross-reaction to S. aureus based on an ELISA. The detection limit of the ICG strip test was $10^5\;cell/ml$. In total, 116 meat and processed-meat samples were collected and analyzed using both the ICG strip test and a PCR. The ICG strip test and PCR indicated L. monocytogenes contamination in 34 and 27 meat samples, respectively. The 7 meat samples not identified as L. monocytogenes positive by the PCR were also tested using an API kit and found to be contaminated by Listeria species. In conclusion, the ICG strip test results agreed well with those obtained using the PCR and API kit. Thus, the developed ICG has potential use as a primary screening tool for L. monocytogenes in various foods and agricultural products, generating results within 20 min without complicated steps.

• Korean Journal of Veterinary Research
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• v.40 no.4
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• pp.719-727
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• 2000

A study was conducted to determine the susceptibility of swine to Korean foot-and-mouth disease virus (FMDV; subtype O, isolated from Chungju province) in April, 2ooo. One holstein cow was inoculated intradermolingually with suspension of homogenized tissue from a Korean native cow naturally infected with Korean FMDY. Infected cow was housed with one susceptible cow and one susceptible pig (contact sentinels). Four additional susceptible pigs were housed in the same room but caged separately (non-contacted sentinels). The contacted pig and cow as well as non-contact pigs developed typical clinical signs after 2, 3, and 7 days post exposure, respectively. We compared neutralizing antibody from the animals to FMDV $O_1$ Lombardy, O Taiwan, $O_1$ Campos, and $O_1$ Manisa after 0, 4, 7, 10, 14, 21, 28 days post challenge and post-exposure. The highest viral neutralization titer could be interpreted that serotype O Korea (Chungju isolate) is antigenically more related to $O_1$ Manisa. In addition, immunohistochemistry was used to further characterize Korean FMDV from tissues of infected pigs. Korean FMDV antigen was observed in the tongue, hoof, esophagus, and tonsil tissues of sentinel pigs. These findings suggest that Korean FMD virus isolated from cattle can be rapidly transmitted to pigs both directly and indirectly contrast field observation in which only cattle were clinically ill.

• The Journal of Korean Medicine
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• v.27 no.1 s.65
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• pp.204-219
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• 2006

Objectives : This study is to report the proceeding of the project sponsored by the ministry of science and technology of Korea for the stroke study titled as 'fundamental study for standardization and objectification of differentiation and pattern identification of symptoms of Oriental Medicine in stroke'. Methods and Results : We works for clinical research and molecular epidemiology center and we are in charge of the development of case report form, education of the investigators, data entry, data validation, and analysis. In the process of this project, we need to development of standard operating procedures for development and education for the case report form. Conclusions : This study is to let researchers for Traditional Korean Medicine and clinical research know how to develop of case report form and standard operating procedures in clinical researches and maintain the resource document and data.