• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.443-446
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• 2003

To investigate the protective effect of Bulbus Allii Macrostemi (BAM) on the damage by pulmonary vascular endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen free radical, Neutral Red (NR) and protein kinase c (PKC) activity assay were used. The results were obtained as follows ; The viability of vascular endothelial cells treated with XO/HX was decreased. And activation of PKC represented a maximal increase in group treated with XO/HX for 15 mins in vasvular pulmonary endothelial cells. But pretreated groups with BAM extracts were not inhibited the increase of PKC activation by XO/HX in a dose-dependent fashion. These results show that XO/HX elicits toxic effects in cultured pulmonary vascular endothelial cells, and suggest that BAM extract is very effective in the prevention of XO/HX-induced PKC activation.

• The Journal of Korean Society of Virology
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• v.29 no.1
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• pp.39-44
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• 1999

Warts, or verrucae, are benign epithelial proliferations of the skin and mucosa caused by infection with human papillomaviruses (HPV). It is now recognized that there are many different HPV types. Especially type3 is most frequently observed in flat wart. Other types, such as type2, 10, 14, 27, 28, 29, 38, and 41 are rarely encounted in flat wart. We describe here a simple and economic method for detection and identification of epidermodysplasia verruciformis-associated HPV. The method is based on polymerase chain reaction (PCR) amplification and restriction analysis. The method has been developed with cloned HPV DNA and DNA from clinical samples. Clinical samples are from either frozen tissue or paraffin-embedded tissue. Genomic fragments were obtained from two different HPV types (3 and 10). The amplification fragments were identified by a form of miniature fingerprinting, with a set of restriction enzymes that gave a unique digestion pattern for each HPV type. We have tested 74 clinical samples. Only type3 among these clinical samples is detected, and one sample is involved in neither type3 nor type10.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.60-60
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• 2009

본 연구는 보론이 첨가된 저합금강 용접 열영향부에서의 보론 편석 거동 연구를 위해 보론이 10ppm 첨가된 저합금강을 이용하여 다양한 용접 입열량 및 외부 응력에 따른 용접부 CGHAZ의 보론 편석거동을 분석하였다. 이를 위해 Gleeble 시스템을 이용하여 다양한 입열량에 따른 CGHAZ를 열 및 열-응력 사이클을 통하여 재현하였다. 재현된 시편의 미세조직은 OM을 통하여 분석하고, 보론의 편석거동을 SIMS와 PTA 분석법을 통하여 분석하였다. 그 결과 입열량에 따른 보론의 편석 거동은 최초 입열량이 증가함에 따라 보론의 편석이 증가하다가 다시 감소하였는데 이는 비평형 편석 후 고온에서 유지시간이 길어짐에 따라 back diffusion 발생에 따른 영향으로 판단된다. 또한 외부 응력에 의한 보론 편석 거동 분석 결과, 용접 열 사이클 중 작용하는 외부 응력에 의해 결정립계 편석 감소하였는데 이는 외부 응력에 의한 오스테나이트 결정립 크기 감소에 따른 결정립계 증가의 영향으로 판단된다.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.4
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• pp.233-236
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• 2006

A 67-year-old man with a history of chronic obstructive pulmonary disease (COPD) underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for staging of gastric cancer. The projection images of F-18 FDG PET/CT showed intensely increased F-18 FDG uptake in the anterior neck, chest wall, and upper abdomen. We suspected distant metastases of cervical lymph nodes, ribs, and peritoneum in gastric canter. However, the transaxial images of F-18 FDG PET/CT showed abnormal F-18 FDG uptake in scalene muscles of anterior neck, intercostal muscles of chest wall, and diaphragm of upper abdomen. Patients with COPD use respiratory muscles extensively on the resting condition. These excessive physiologic use of respiratory muscles causes increased F-18 FDG uptake as a result of increased glucose metabolism. The F-18 FDG uptake in respiratory muscles of gastric cancer patient with COPD mimicked distant metastases in cervical lymph nodes, ribs, and peritoneum.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2005.11b
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• pp.92-106
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• 2005

The head-end processes of spent TRISO fuel have been reviewed to understand the current status and the limitations of the reported processes. The main concerns in the TRISO treatment are to effectively breach and separate the carbon and SiC layers composing the TRISO particles. The crush-bum scheme which was considered in the early stages of the development has been replaced by the crush-leach or $CO_2$ burning and the succeeding CO decomposition process because of a sequestration problem of $CO_2$ containing $^{14}C$. However there are still many obstacles to overcome in the reported processes. Hence, innovative thermomechanical and pyrochemical concepts to breach the coating layers of the TRISO particle with a minimized amount of second waste are proposed in this paper and their principles are described in detail.

• Natural Product Sciences
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• v.14 no.1
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• pp.62-67
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• 2008

The leaf extract of Ligularia stenocephala showed the highest anti-platelet aggregating activity in large numbers of edible and herbal plants. The active fraction fractionationed from L. stenocephala extract by using preparative HPLC inhibited the platelet aggregation up to above 80% and its blood coagulating time (PT and APTT) also showed similar effect to aspirin (0.2 ${\mu}g/mL$), known as an anti-thrombus compound. Two antithrombus active compounds were purified and identified as 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid, respectively, on the basis of NMR and FAB-MS spectroscopic data. Two active compounds has not only antiplatelet aggregating activity, but also has anticoagulating activity.

• Journal of Korean Society for Quality Management
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• v.43 no.4
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• pp.499-510
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• 2015

Purpose: This paper treats the improvement of the quality and reliability of military weapon systems based on the maintenance data. Methods: The proposed method of the data integration and refinement are used to obtain the component reliability information and to find the frequently failed components based on the Pareto analysis. Based on the reliability information and the number of failed component frequencies, the target components of quality improvement are determined and improved by multiple methods such as engineering changes, special meetings, additional training and revising maintenance manuals. Results: Based on the proposed process, we find some components which need to be improved in order to enhance the quality and reliability. Conclusion: A process is developed for improving the quality and reliability of weapon systems. This process will be adopted by various weapon systems to enhance the quality and reliability, as well as reduce military spending.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.511-511
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• 2012

핵 융합로는 고밀도, 고에너지 플라즈마에 지속적으로 노출되며 고열부하 및 중성자, 플라즈마 이온에 의한 물성변화에 대한 다양한 핵 융합로 구축 재질의 실험데이터가 요구된다. 특히 핵 융합 반응의 핵심연료인 삼중수소의 재질별 누설거동 특성은 삼중수소의 블랑켓에서의 증식율, 열 교환기 및 공급과 회수과정에서의 손실율, 저장, 취급 및 차폐 등의 계산에 활용되므로 핵 융합로의 안전성과 경제성 확보 측면에서 매우 중요하다. 따라서 핵 융합로 구축 재질 선정시 삼중수소의 누설거동 특성은 반드시 고려되어야 한다. 본 연구는 삼중수소 누설거동 특성 해석을 위한 기초실험으로, 수소동위원소를 사용하는 누설거동실험 장치를 설계 제작하여 누설 거동실험을 수행하였다. 누설 가스로는 수소를 사용하였고, 시편은 스테인레스 스틸(SUS-304)을 사용하였으며, 시편의 가열온도는 500, 600, 700, $800^{\circ}C$에서 각각 수소누설거동 실험을 실시하였다. 수소에 대한 SUS-304 재질의 permeability, diffusivity, solubility에 대한 실험 결과를 발표하고자 한다.

• Applied Microscopy
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• v.27 no.4
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• pp.391-402
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• 1997

Using the electron microscopical method, this study was attempted to investigate the ultrastructural characteristics of glomeruli in FGS/Kist mice showing high proteinuria. The mucus-like substances were observed in glomerular capillary lumen which were usually narrowed by the widening of mesangial area filled with electron-dense deposits. Some portions of basal lamina in capillary wall were projecting to urinary space. Moreover, many vacuoles were observed in the cytoplasm of visceral epithelial cells, and an irregular-shaped fusion or effacement of foot processes were often shown in areas adjacent to basal lamina of glomeruli.

• Applied Microscopy
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• v.18 no.1
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• pp.21-34
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• 1988

Comparative study on the synaptic types of the nuclei accumbens septi and fundus striati of the chick and the rat was carried out. Basic synaptic types were established according to the size of synaptic vesicles, development of synaptic vesicles, development of synaptic thickening, kind of postsynaptic structures, etc. Comparing the synaptic types and appearance-ratio within the neuropils, the following results were obtained (see the data in the Table 1). 1. In the nucleus accumbens of the rat, the axo-spinous synapses are far less than those in the nucleus fundus striati (13.7%/68.2%). 2. In the nucleus accumbens, there found much more axo-dendritic types(II, III and V) than those appearing in the nucleus fundus striati(79.1%/27.1%). 3. In the nucleus accumbens of the chick, on the contrary to the case of the rat, more axo-spinous types(70.1%/31.4%) and less axo-dendritic types(12.3%/60.0%) were found as compared to those appearing in the nucleus fundus striati. 4. There found no large-sized synaptic vesicles in the chick nuclei accumbens septi and the fundus striati.