• 제목/요약/키워드: Gil-ho Kim

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공학규모 파이로 실증시설 개념연구

  • 정원명;구정희;조일제;이호희;문성인;유길성;김호동
    • 한국방사성폐기물학회:학술대회논문집
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    • 한국방사성폐기물학회 2012년도 춘계학술논문요약집
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    • pp.119-120
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    • 2012

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Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-κB and ERK1/2 pathways in colon cancer

  • Kim, Eui Joo;Kwon, Kwang An;Lee, Young Eun;Kim, Ju Hyun;Kim, Se-Hee;Kim, Jung Ho
    • Journal of Ginseng Research
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    • 제42권3호
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    • pp.288-297
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    • 2018

  • Background: The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which KRGE regulates EMT of CRC in hypoxic conditions. Methods: Human CRC cell lines HT29 and HCT116 were incubated under hypoxic (1% oxygen) and normoxic (21% oxygen) conditions. Western blot analysis and real-time PCR were used to evaluate the expression of EMT markers in the presence of KRGE. Furthermore, we performed scratched wound healing, transwell migration, and invasion assays to monitor whether KRGE affects migratory and invasive abilities of CRC cells under hypoxic conditions. Results: KRGE-treated HT29 and HCT116 cells displayed attenuated vascular endothelial growth factor (VEGF) mRNA levels and hypoxia-inducible $factor-1{\alpha}$ ($HIF-1{\alpha}$) protein expression under hypoxic conditions. KRGE repressed Snail, Slug, and Twist mRNA expression and integrin ${\alpha}V{\beta}6$ protein levels. Furthermore, hypoxia-repressed E-cadherin was restored in KRGE-treated cells; KRGE blocked the invasion and migration of colon cancer cells by repressing $NF-{\kappa}B$ and ERK1/2 pathways in hypoxia. Conclusions: KRGE inhibits hypoxia-induced EMT by repressing $NF-{\kappa}B$ and ERK1/2 pathways in colon cancer cells.

  • https://doi.org/10.1016/j.jgr.2017.03.008 인용 PDF KSCI

초고압 GIL을 위한 $SF_6/N_2$ 혼합가스의 절연특성 (Dielectric Characteristics of $SF_6/N_2$ Mixture Insulation Gas for HV GIL)

  • 장용무;김철호;김정태;구자윤
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2010년도 하계학술대회 논문집
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    • pp.49-49
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    • 2010

  • In this paper, a full scaled gas discharge chamber was designed and fabricated for evaluating the dielectric performance of SF6/N2 mixture gases. And it describes work on AC and lightning impulse dielectric characteristics of SF6/N2 mixture insulation gas from experiments and full scale models.

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2세 여아의 항문 및 항문 주위 첨형 콘딜로마 1예 (Anal and Perianal Condyloma Acuminatum in a 2 Years Old Girl)

  • 김현영;이경희;김나래;박연호
    • Advances in pediatric surgery
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    • 제16권1호
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    • pp.32-36
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    • 2010

  • Condyloma acuminatum is an uncommon disease but there is an increased incidence reported in recent years in prepubertal children. Anal and perianal condyloma accuminatum in children may suggest sexual abuse and treatment should include the thorough social evaluation as well as medical treatment. A 25 month old girl presented with multiple sessile nodules around her anal and perianal area, Biopsy confirmed the diagnosis of condyloma accuminatum. There was no definite evidence of sexual abuse, but her father had condyloma accuminatum involving his penis. The patient's lesions were excised totally. At three week follow up there was no anal stricture but there were newly developed small lesions around perianal area. Imiquimod onit was applied for 2 weeks and the recurred lesion disappeared completely. At postoperative 5 month, the operative area was fully epithelialized without recurrence.

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