• Journal of the Institute of Convergence Signal Processing
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• v.19 no.3
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• pp.118-124
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• 2018

Obecity in pregnancy causes many problems and increases risk of pregnancy complications at the time of childbirth. But there is a lack of comprehensive analysis of factors that are negatively affected during pregnancy. Therefore, this study is intended to analyze seven factors of high-risk maternal diseases by the degree of obesity using body mass index(BMI). We conducted a cross tabulation analysis and regression analysis to analisized relationship between variables : Gestational Hypertension(GH), Gestational Diabetes Mellitus(GDM), Thyroid Stimulation Hormone(TSH), Age, Blood Urea Nitrogen Test(BUN), Total-Cholesterol(T-C), and newborn's weight. As a result, the more the obesity level of mothers increases, the more the proportion of mothers with GH, GDM, TSH increases. And there was a positive relationship between the BMI of mothers and their age, T-C, and Newborn weight, and a negative relationship to the BUN.

• Reproductive and Developmental Biology
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• v.30 no.4
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• pp.235-245
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• 2006

Di-n-butyl phthalate (DBP), diisononyl phthalate (DINP) and di-(2-ethylhexyl) adipate (DEHA) are ubiquitously distributed chemicals that are widely used as plasticizers and also found at low levels in foods. The aims of this study were to determine whether perinatal exposure to DBP, DINP and DEHA could alter normal patterns of neonatal development. Dams were provided with pulverized soy-free diet containing 20, 200, 2,000 and 10,000 ppm of DBP, 40, 400, 4.000 and 20,000 ppm of DINP, or 480, 2,400 and 12,000 ppm of DEHA from gestational day 15 to postnatal day 21. Exposure to the high doses of DBP, DINP and DEHA during gestational period significantly decreased food consumption and body weight gain of dams. These chemicals reduced neonatal body weight as well as that of the after maturation. Also, exposure to DINP of all the doses used and the higher doses (2,400 and 12,000 ppm) of DEHA decreased AGD at PND 1 in male neonates, though that to DBP did not affect AGD in males. In female neonates, an increase in AGD was observed in DBP- and DINP-exposed animals at the highest doses. Moreover, these chemicals affected survival rate of pups at PND 5, and delayed onset of eye opening in all chemica1-exposed groups at PND 17. These results suggest that perinatal exposure to these chemicals may affect the normal development and/or growth of offspring.

• Journal of Preventive Medicine and Public Health
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• v.22 no.1 s.25
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• pp.71-80
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• 1989

The adverse effect of diving on the fetus may extend beyond n gestational process and outcome. Primiparous Sprague-Dawley rats were assigned to one of ten exposure schedules during gestatred $PO_2$ level, the following question about the effect of exposing a pregnant female to high partial pressure of inspired oxygen has been raised. 'What effect does an increased maternal $PIO_2$ have on fetal arterial $PO_2$ and therefore on possible fetal oxygen poisoning?' This study was carried out to observe the effects of maternal hyperoxia on gestational process and outcome. Primiparous Sprague-Dawley rats were assigned to one of ten exposure schedules during gestation. The treatment groups were subjected to either the high concentration of oxygen, or the high atmospheric pressure. On day 21 of gestation, laparotomy was performed to examine for number and distribution of implantations and live and resorbing embryos. Fetuses were weighed, and examined for gross malformations. Subsequently, they were fixed, measured in physical parameters, and examined for visceral anomalies. Minor visceral anomalies and anatomical variation was not found. Similarily, there were no significant differences when number of resorptions, mean fetal weights, pregnancy interruption rate were compared by analysis of variance. These results indicate that exposing rats to oxygen at increased atmospheric pressure doese not affect fetal health or survival.

• Clinical and Experimental Pediatrics
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• v.63 no.6
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• pp.226-231
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• 2020

Background: Probiotics and prebiotics have strain-specific effects on the host. Synbiotics, a mixture of probiotics and prebiotics, are proposed to have more beneficial effects on the host than either agent has alone. Purpose: We performed a randomized controlled trial to investigate the effect of Lactobacillus and Bifidobacterium together with oligosaccharides and lactoferrin on the development of necrotizing enterocolitis (NEC) or sepsis in very low birth weight neonates. Methods: Neonates with a gestational age ≤32 weeks and birth weight ≤1,500 g were enrolled. The study group received a combination of synbiotics and lactoferrin, whereas the control group received 1 mL of distilled water as placebo starting with the first feed until discharge. The outcome measures were the incidence of NEC stage ≥2 or late-onset cultureproven sepsis and NEC stage ≥2 or death. Results: Mean birth weight and gestational age of the study (n=104) and the control (n=104) groups were 1,197±235 g vs. 1,151±269 g and 29±1.9 vs. 28±2.2 weeks, respectively (P>0.05). Neither the incidence of NEC stage ≥2 or death, nor the incidence of NEC stage ≥2 or late-onset culture-proven sepsis differed between the study and control groups (5.8% vs. 5.9%, P=1; 26% vs. 21.2%, P=0.51). The only significant difference was the incidence of all stages of NEC (1.9% vs. 10.6%, P=0.019). Conclusion: The combination of synbiotics and lactoferrin did not reduce NEC severity, sepsis, or mortality.

• Advances in pediatric surgery
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• v.6 no.1
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• pp.1-9
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• 2000

Despite of advances in perinatal management and treatment modalities congenital diaphragmatic hernia(CDH) remains a frustrating problem. Although the sheep has proven to be a reliable experimental model for the production of intrauterine CDH, the rabbit may have some advantages. These include lower cost, smaller body size, year-round availability, high number of fetuses per pregnancy, and short gestational period. To evaluate the feasibility of the rabbit model of CDH, twenty-seven pregnant New Zealand rabbits were utilized. Hysterotomy and an operative procedure for creating a diaphragmatic defect on gestational day 24 or 25, in two fetuses of each pregnant rabbit were performed. In one fetus of one cornu of the uterus, the left fetal diaphragm was excised through an open thoracotomy(DH group). In another fetus in the other cornu, CDH was created and the trachea clipped(Surgiclip, USSC, Norwalk, Conn., USA) (TL group). Delivery was by Cesarean section on 30 days of gestation. Among twenty- seven pregnant rabbits, 12 in the DH group and eight in the TL group were born alive. The most common herniated organ was the left lobe of the liver. In thee DH group, the lungs were hypoplastic with decreased lung weight/body weight ratio, reduced numbers of alveoli, thicker media of the pulmonary arteries, and immature alveoli. In TL group, the alveoli were more mature and did not differ from the control animals. In conclusion, (1) pulmonary hypoplasia develops in the fetal rabbit diaphragmatic hernia model and (2) simultaneous tracheal ligation prevents pulmonary hypoplasia.

• Women's Health Nursing
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• v.11 no.3
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• pp.218-224
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• 2005

Purpose: The Purpose of this study was to investigate the relationship between state anxiety and maternal fetal attachment of unmarried mothers in a welfare center. Methods: The subjects were 25 unmarried mothers in a welfare center. The data was collected through personal interviews using a questionnaire. The instruments used for this study were the modified Spielberger's state anxiety inventory and Cranley's Maternal-Fetal Attachment Scale. Data was analyzed descriptive statistics, mean, standard deviation, t-test and the pearson correlation coefficient with the SPSS computer program. Results: The age of the subjects ranged from 15 to 25, and their average age was 20.0. The mean score of state anxiety was 58.2. There was significant difference in the degree of maternal state anxiety between the group whose pregnancy was known by their family and the group whose pregnancy was hidden. The group whose pregnancy was known showed a low state anxiety score. There was a significant difference in the degree of maternal state anxiety by the gestational period. The group who were in the second and third gestational trimester showed lower state anxiety score than in the first trimester. The mean score of maternal-fetal attachment(MFA) was 64.9. There were significant differences in the degree of maternal fetal attachment, by an ultrasound scan experience. The most frequently practiced attachment item was "I think the fetus is able to feel(mean 3.8)". Unmarried mothers degree of state anxiety showed a negative correlation with the degree of maternal fetal attachment(r=-.25), but there was no significant difference between the two variables. Conclusions: The unmarried mothers made an effort in striving to reduce their high state anxiety and to enhance maternal fetal attachment. They also realize how to take care of their state anxiety.

• Environmental Analysis Health and Toxicology
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• v.26
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• pp.6.1-6.8
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• 2011

Objectives: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. Methods: MWCNTs were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0, 8, 40, 200, and 1000 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, oxidant-antioxidant status, gross findings, organ weights, and Caesarean section findings were examined. Results: All animals survived to the end of the study. A decrease in thymus weight was observed in the highest dose group. However, maternal body weight, food consumption, serum biochemical parameters, and oxidant-antioxidant balance in the kidneys were not affected by treatment with MWCNTs. No treatment-related differences in gestational index, embryo-fetal mortality, or fetal and placental weights were observed between treated and control groups. Conclusions: The results show that 14-day repeated oral dosing of MWCNTs during pregnancy induces minimal maternal toxicity at 1000 mg/kg/day in rats. Under these experimental conditions, the no-observed-adverse-effect level of MWCNTs is considered to be 200 mg/kg/day for dams and 1000 mg/kg/day for embryonic development.

• Journal of Nutrition and Health
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• v.32 no.8
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• pp.877-886
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• 1999

To assess the effect of an antenatal nutritional status on pregnancy outcome, especially neonatal birty weight, one-day 24hr-recall and two-day recording methods for dietary survey and interview for general and obstetric characteristics of each subject were completed and pregnancy outcome was recorded by phone after delivery. 147 pregnant women attending routinely public health centers in Ulsan were divided into 1st trimester(n=36), 2nd trimester(n=102), 3rd trimester(n=71) by LMP(Last Menstrual Period) because some subjects attended repeatedly in different trimester. The subjects were aged 27.9$\pm$2.9 as mean and the level of education was senior high school and more. 20.4% of subjects experienced spontaneous abortion and 30.0% experienced induced abortion in previous pregnancy. Mean intakes of all nutrients except ascorbic acid were significantly different but dietary composition of energy intakes was not different between trimester. Mineral of calcium, iron and zinc did not meet the RDA for pregnancy outcome was about 20%, which consists of spontaneous abortion (3.4%), caesarian section(15.6%), premature delivery(0.7%) and still births(0.7%). The mean birth weight of neonates is 3.31kg the rate of neonatal birth weight below 10th percentile was 8.4% and the rate of low birth weight(<2.5kg) was 3.1%. By analysis of nutrient factors that influence on the neonatal birth weight (NBW), iron intake correlated negatively and zinc intake correlated positively with NBW in 1st trimester but fat and iron intakes correlated with NBW positively in 3rd trimester. Prepregnancy weight, gestational age at delivery and No. of induced abortion had a positive effects on NBW and No. of spontaneous abortion and te severity of morning sickness had a negative effects on NBW.

• Women's Health Nursing
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• v.26 no.2
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• pp.161-170
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• 2020

Purpose: This study was conducted to identify the influences of the attitudes of pregnant women and their husbands towards sex during pregnancy on sexual function. Additional purpose was to compare the frequency of sexual dysfunction according to gender and gestational trimester and to describe the changes in sexual behavior according to the gestational trimester. Methods: In this study, 231 pregnant couples completed self-report questionnaires during their visits to women's hospitals or community health centers. The questionnaires assessed general characteristics, maternal/paternal sexual attitudes towards sex during pregnancy (Maternal Sex during Pregnancy Scale, MSP/Paternal Sex during Pregnancy Scale, PSP), and sexual function (using the Female Sexual Function Index and International Index of Erectile Function, respectively). Multiple regression analysis was done to test the research model using SPSS version 23.0. Results: In this study, 74.9% of pregnant women and 38.5% of their husbands reported sexual dysfunction. Sexual dysfunction was prevalent in pregnant women in the first trimester and prevalent in husbands in the third trimester. MSP (β=.44, p<.001) in pregnant women and PSP (β=.39, p<.001) and being in the first trimester (β=.17, p=.012) in husbands influenced sexual function during pregnancy. In the first trimester, the scores for attitudes towards sex during pregnancy were the lowest in pregnant women, while they were the highest in their husbands. Conclusion: Positive attitudes about sex during pregnancy are important for sexual function in pregnant couples. Because the difference in attitudes towards sex during pregnancy between pregnant women and their husbands was greatest in the first trimester, sexual health interventions need to be provided in early pregnancy.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.293-301
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• 2021

The aim of this study was to evaluate the difference of self-care and self-efficacy before and after childbirth in pregnant women with diabetes mellitus. Data were collected from 24 May 2018 to 23 May 2020 for 40 pregnant women over the 24th week of pregnancy. The collected data were analyzed by matched paired t-test using the SPSS 27.0 software program. 27 subjects (67.5%) were under the age of 35, and 13 subjects (32.5%) were over the age of 35. Self-care and self-effectiveness scores were lower in postpartum than in prenatal, which was statistically significant (p< .000). Therefore, it is necessary to develop a nursing intervention program to enhance self-care and self-efficacy after childbirth.